Project/Area Number |
23KF0041
|
Research Category |
Grant-in-Aid for JSPS Fellows
|
Allocation Type | Multi-year Fund |
Section | 外国 |
Review Section |
Basic Section 43050:Genome biology-related
|
Research Institution | Kyoto University |
Principal Investigator |
ウォルツェン クヌート 京都大学, iPS細胞研究所, 准教授 (50589489)
|
Co-Investigator(Kenkyū-buntansha) |
MARTINEZ GALVEZ GABRIEL 京都大学, iPS細胞研究所, 外国人特別研究員
|
Project Period (FY) |
2023-04-25 – 2024-03-31
|
Project Status |
Granted (Fiscal Year 2023)
|
Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2023: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
Outline of Research at the Start |
Tandem repeat copy-number variations have been correlated with changes in gene expression and are probable causes of human disease. We are developing gene editing and computational biology methods to efficiently generate repeat-variant disease models in human induced pluripotent stem (iPS) cells. Moreover, we are developing technologies to produce intermediate copy-number variants. As proof-of-concept, we completed the generation of a repeat-copy variants in iPS cells at two loci with known clinically relevance, and aim to apply these methods genome-wide.
|