| Project/Area Number |
23KF0096
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 48020:Physiology-related
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| Research Institution | National Institutes of Natural Sciences |
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Principal Investigator |
根本 知己 大学共同利用機関法人自然科学研究機構(機構直轄研究施設), 生命創成探究センター, 教授 (50291084)
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| Co-Investigator(Kenkyū-buntansha) |
CHANG CHING-PU 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 外国人特別研究員
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| Project Period (FY) |
2023-04-25 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2024: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2023: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Outline of Research at the Start |
Hibernators adapt to unfavorable environments by reducing body temperature and metabolism. However, how hibernators respond to temperature cues to maintain such an extraordinary state is unclear. I recently found the unique UCP1 expression in the hypothalamus of the hamster brain, suggesting a possible local heating capacity for brain-UCP1 in hibernators which is independent of BAT thermogenesis. I will investigate the role of brain-UCP1 in the thermoregulation and metabolism in the hamster during hibernation using both ex vivo and in vivo recordings to monitor the intracellular temperature.
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