Project/Area Number |
23KF0109
|
Research Category |
Grant-in-Aid for JSPS Fellows
|
Allocation Type | Multi-year Fund |
Section | 外国 |
Review Section |
Basic Section 37030:Chemical biology-related
|
Research Institution | The University of Tokyo |
Principal Investigator |
菅 裕明 東京大学, 大学院理学系研究科(理学部), 教授 (00361668)
|
Co-Investigator(Kenkyū-buntansha) |
RICHAUD ALEXIS 東京大学, 大学院理学系研究科(理学部), 外国人特別研究員
|
Project Period (FY) |
2023-07-26 – 2026-03-31
|
Project Status |
Granted (Fiscal Year 2023)
|
Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2025: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 2024: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2023: ¥900,000 (Direct Cost: ¥900,000)
|
Outline of Research at the Start |
In fiscal year 2023, we will focus on optimizing the ribosomal translation using UBPs as it has never been done strictly in a reproducible and efficient way. By December 2023, we hope to have a strong protocol for genetic code expansion using one extra UBP and efficient aminoacylation of the non-standard tRNA by mean of Flexizyme. Incorporation of 8 unnatural amino-acids into the system should be sufficient to generate a high impact publication. Future work will focus on the development of the modified RaPID system for the discovery of new compounds against undruggable targets.
|