| Project/Area Number |
23KF0126
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
猪原 匡史 国立研究開発法人国立循環器病研究センター, 病院, 部長 (00372590)
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| Co-Investigator(Kenkyū-buntansha) |
BHASKAR SONU 国立研究開発法人国立循環器病研究センター, 病院, 外国人特別研究員
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| Project Period (FY) |
2023-07-26 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2024: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2023: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | stroke |
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| Outline of Research at the Start |
This study aims to uncover the impact of WML topography on reperfusion therapy outcomes in patients with acute ischemic stroke. Additionally, it seeks to foster an international cerebrovascular disease consortium to enhance collaboration and knowledge-sharing in stroke research and care. The results hold promise for optimizing treatment approaches and improving patient management in acute ischemic stroke and leukoaraiosis.
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| Outline of Annual Research Achievements |
Dr Bhaskar is actively involved in clinical research with Japanese collaborators at the National Cerebral and Cardiovascular Centre. Data from the Osaka’s National Cerebral and Cardiovascular Center (NCVC) Stroke registry was used in the current study. NCVC Stroke registry is a single-center registry of more than 5500 consecutive patients with AIS, intracerebral hemorrhage, and transient ischemic attack (TIA) who are emergently managed in the stroke care unit in the NCVC, a flagship stroke center in Suita, Japan. The inclusion criteria are as follows: (a) acute ischaemic stroke patients receiving intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT), (b) hemispheric stroke, (c) patients aged 18 years or above, (d) availability of pre-intervention T2 FLAIR MRI to assess WML volume in different regions of the brain. In the WFN SG ADCD 2024, Biennial meeting of World Federation of Neurology, Dr. Bhaskar gave a talk about his recent progress, entitled ‘Clinical and Imaging aspects of SVD and Dementia’. Some papers are being submitted to international peer-reviewed journals with Dr Bhaskar as a co-author. Dr. Bhaskar is one of the authors of a recent paper published in Journal of Stroke, entitiled 'Pupillometer-Based Neurological Pupil Index Differential: A Potential Predictor of Post-Stroke Delirium'. This paper reported usefulness of pupillometer in neurological assessment in the acute phase of stroke.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
Dr Bhaskar is actively involved in clinical research with Japanese collaborators at the National Cerebral and Cardiovascular Centre. Some papers are being submitted to international peer-reviewed journals with Dr Bhaskar as a co-author.
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| Strategy for Future Research Activity |
Further papers with Dr Bhaskar as a co-author will be submitted to international peer-reviewed journals.
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