| Project/Area Number |
23KF0268
|
|---|
| Research Category |
Grant-in-Aid for JSPS Fellows
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 外国 |
|---|
| Review Section |
Basic Section 50010:Tumor biology-related
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
李 桃生 長崎大学, 原爆後障害医療研究所, 教授 (50379997)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAN CHEN 長崎大学, 原爆後障害医療研究所, 外国人特別研究員
|
|---|
| Project Period (FY) |
2023-11-15 – 2026-03-31
|
| Project Status |
Granted (Fiscal Year 2023)
|
| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2025: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2024: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2023: ¥600,000 (Direct Cost: ¥600,000)
|
|---|
| Outline of Research at the Start |
Senescent cancer stem cells (CSCs) are thought to be therapeutic-resistant, leading to long-term recurrence and metastasis. In this study, we will confirm whether senescent CSCs return to a proliferative state. Then, we will investigate the changes of mitophagy in the reversal of senescent CSCs. Finally, we will investigate the potential role and the detailed mechanism of mitophagy in regulating the reversal of senescent CSCs and senescence-induced stemness of CSCs, further developing novel therapeutic strategies/approaches for cancers.
|
