| Project/Area Number |
23KF0285
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 44010:Cell biology-related
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
清光 智美 沖縄科学技術大学院大学, 細胞分裂動態ユニット, 准教授 (10503443)
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| Co-Investigator(Kenkyū-buntansha) |
VAN TOORN MARVIN 沖縄科学技術大学院大学, 細胞分裂動態ユニット, 外国人特別研究員
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| Project Period (FY) |
2023-11-15 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2025: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2024: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2023: ¥500,000 (Direct Cost: ¥500,000)
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| Outline of Research at the Start |
This research aims to understand the cell cycle-dependent regulation of dynein-dynactin-adaptor (DDA) complexes and its effects on mitotic fidelity. To this end, biochemical and live cell imaging approaches will be combined to purify and analyse DDA complexes throughout the cell cycle and subsequently analyse the effects of DDA complex regulators on the progression of mitosis. In addition to somatic cells, embryos from Japanese Medaka will also be used to uncover embryo-specific mechanisms of dynein adaptor switching.
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