| Project/Area Number |
23KJ1880
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 国内 |
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| Review Section |
Basic Section 10040:Experimental psychology-related
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| Research Institution | Keio University |
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Principal Investigator |
廣康 衣里紗まり 慶應義塾大学, 文学部(三田), 特別研究員(PD)
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| Project Period (FY) |
2023-04-25 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Dopamine / Parkinson's disease / Timing |
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| Outline of Research at the Start |
First, I will be investigating whether modality dependent temporal dysfunctions is observed in clinical patients (Study 1). Then, I plan to investigate whether differences in temporal cognition of patients stem from the sensory cortices by seeing whether there is modality, as well as attentional differences, in neural signals of patients with varying degrees of positive symptoms of schizophrenia (Study 2). Last, I plan to investigate whether patients with SZ and healthy controls have differences in neural signatures of temporal regularity when processing of rhythmic stimuli (Study 3)
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| Outline of Annual Research Achievements |
My main focus this year was to identify predictors of finger tapping (spontaneous and subjective pacing of one-second) in both Parkinson's patients (PD) and healthy control patients. Results showed that the Trail Making Task part A (TMT-A) could be a better cognitive measure than the Montreal Cognitive Assessment (MoCA) in predicting finger tapping. This paper is now in preparation for getting published. As for my study about explicit and implicit timing, I have written the program for the data collection with PD patients, presented to the doctors that I will be collaborating with, and gotten IRB ethical approval for collecting data at Showa University Hospital.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
This year, the progress on my project about explicit and implicit timing in Parkinson's disease has been slower than expected due to delays in collaboration. Sorting out the schedule with the doctors who I am collaborating with, and getting the IRB ethical review board to approve my experiments to be conducted with Parkinson's patients took more time than I had planned.
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| Strategy for Future Research Activity |
Now that I have gotten the IRB ethical approval at Showa University Hospital, data collection will begin. I will be recruiting approximately 60 patients with Parkinson's disease. Moreover, once I know that the planned experiment works with patients with Parkinson's disease, and no modifications is needed for the script, I will also be collecting data from an age-matched healthy control group at Keio University. Moreover, I will be collaborating with other researchers for other experiments about pre-pulse inhibition in patients with Parkinson's disease.
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