Budget Amount *help |
¥512,850,000 (Direct Cost: ¥394,500,000、Indirect Cost: ¥118,350,000)
Fiscal Year 2016: ¥65,000,000 (Direct Cost: ¥50,000,000、Indirect Cost: ¥15,000,000)
Fiscal Year 2015: ¥82,550,000 (Direct Cost: ¥63,500,000、Indirect Cost: ¥19,050,000)
Fiscal Year 2014: ¥132,600,000 (Direct Cost: ¥102,000,000、Indirect Cost: ¥30,600,000)
Fiscal Year 2013: ¥106,600,000 (Direct Cost: ¥82,000,000、Indirect Cost: ¥24,600,000)
Fiscal Year 2012: ¥126,100,000 (Direct Cost: ¥97,000,000、Indirect Cost: ¥29,100,000)
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Outline of Final Research Achievements |
The molecular mechanism of extracellular electron transfer (EET) was clarified through the direct observation of the dynamics, leading to the development of the methodologies for reversible regulation and collective activation of cellular metabolisms. It was also revealed that microorganisms with EET ability are widely distributed in natural environments. Furthermore, we successfully applied the concept of the EET to mammalian cells that do not possess EET ability by developing cytocompatible electron mediators. Based on the systematic understandings of the EET obtained through the present study, novel methodologies and perspectives were provided to various fields, including measurement/regulation of circadian clocks and cancer cells, and proposal of new ecosystem supported by electricity.
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