Establishment of an IL-1-related gene-manipulated mouse library and dissection of the gene-targeted mice, aiming at identifying new therapeutic targets for diseases

• Project/Area Number: 24220011
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Laboratory animal science
• Research Institution: Tokyo University of Science
• Principal Investigator: Iwakura Yoichiro 東京理科大学, 研究推進機構生命医科学研究所, 教授 (10089120)
• Co-Investigator(Kenkyū-buntansha): 西城 忍 千葉大学, 真菌医学研究センター, 准教授 (60396877) ; 海部 知則 東京理科大学, 生命医科学研究所, 助教 (90343037) ; 島津 朋之 東京理科大学, 研究推進機構生命医科学研究所, 助教 (20616437)
• Project Period (FY): 2012-05-31 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥218,010,000 (Direct Cost: ¥167,700,000、Indirect Cost: ¥50,310,000); Fiscal Year 2016: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000); Fiscal Year 2015: ¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000); Fiscal Year 2014: ¥51,090,000 (Direct Cost: ¥39,300,000、Indirect Cost: ¥11,790,000); Fiscal Year 2013: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000); Fiscal Year 2012: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
• Keywords: IL-1 / CTRP / C型レクチン / サイトカイン / 遺伝子改変マウス / C1qTNF / 免疫学 / 実験動物

Outline of Final Research Achievements

In this project, we aimed to find target molecules for the development of new drugs by generating gene-targeted mice of the IL-1 and its down-stream genes, and tried to distribute these mice to researchers in need. We found that excess IL-1 signaling causes Th17 cell differentiation and induce IL-17 in γδ T cells. Excess IL-1 signaling also affects clonal selection of CD4+ T cells in the thymus and causes autoimmune arthritis. We also showed that many of C-type lectins play important roles in the host defense against fungal and mycobacterium infection. We also found that CTRP3 and CTRP6, which are induced downstream of IL-1, can suppress the development of inflammatory diseases such as autoimmune arthritis, suggesting a possibility that these molecules could be used as medicines. To enhance the research in this field, we distributed these gene-targeted mice to 256 research groups in these 5 years.

Assessment Rating

Verification Result (Rating)

A

Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Research Products

• [Journal Article] Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice (2017)
  • Author(s): Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y ,Inaba K, Takahara K.
  • Journal Title: Eur. J. Immunol. Volume: 47 Pages: 704-712
  • DOI: 10.1002/eji.201646814
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin (2017)
  • Author(s): Takagi N, Kawakami K, Kanno E, Tanno H, Takeda A, Ishii K, Imai Y, Iwakura Y, Tachi M.
  • Journal Title: Exp Dermatol. Volume: 26 Pages: 137-144
  • DOI: 10.1111/exd.13115
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preferencially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice (2017)
  • Author(s): Inoue SI, Niikura M, Asahi H, Iwakura Y, Kawakami Y, Kobayashi F.
  • Journal Title: Eur J Immunol Volume: 47 Pages: 685-691
  • DOI: 10.1002/eji.201646699
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells. (2017)
  • Author(s): Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H.
  • Journal Title: J Immunol Volume: 198 Pages: 61-70
  • DOI: 10.4049/jimmunol.1502393
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pre-Transplantation Blockade of TNF-alpha-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells (2017)
  • Author(s): Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
  • Journal Title: Stem Cells Volume: 35 Pages: 989-1002
  • DOI: 10.1002/stem.2524
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Isolation of joint-infiltrating cells. (2016)
  • Author(s): Akitsu A, Iwakura Y.
  • Journal Title: Bio-Protocol. Volume: 6
  • DOI: 10.21769/bioprotoc.1911
  • Peer Reviewed / Open Access
• [Journal Article] Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation (2016)
  • Author(s): Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.
  • Journal Title: Immunity Volume: 45(6) Pages: 1299-1310
  • DOI: 10.1016/j.immuni.2016.11.010
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection. Immun (2016)
  • Author(s): Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G.
  • Journal Title: Immunity, Inflammation and Disease Volume: 4 Pages: 401-412
  • DOI: 10.1002/iid3.121
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis (2016)
  • Author(s): Kimura Y., Inoue A.., Hangai S.., Saijo S., Negishi H., Nishio J., Yamasaki S., Iwakura Y., Yanai H., Taniguchi T.
  • Journal Title: Proceedings of National Academy of Sciences of the United States of America Volume: 113 Pages: 14097-14102
  • DOI: 10.1073/pnas.1617903113
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Two types of IL-17A-producing γδ T cells in protection against pulmonary infection with Klebsiella pneumoniae. (2016)
  • Author(s): Murakami T., Hatano S., Yamada H., Iwakura Y., Yoshikai Y.
  • Journal Title: J Infect Dis. Volume: 214 Pages: 1752-1761
  • DOI: 10.1093/infdis/jiw443
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IL-21 inhibits IL-17A-producing γδ T cell response after infection with Bacillus Calmette-Guerin via induction of apoptosis. (2016)
  • Author(s): Huang Y., Matsumura Y., Hatano, S., Noguchi N., Murakamia, T., Iwakura Y., Sun X., Oharad N., Yoshikai Y.
  • Journal Title: Innate Immun. Volume: 22 Pages: 588-597
  • DOI: 10.1177/1753425916664125
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. (2016)
  • Author(s): Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.
  • Journal Title: Diabetes. Volume: 65
  • DOI: 10.2337/db16-ec08a
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] IL-17A exacerbates cisplatin-based resistance of OVCA via upregulating the expression of ABCG2 and MDR1 through Gli1-mediated Hh signaling. (2016)
  • Author(s): Niu X, Liu W, Wang Y, Liu X, Zhang H, Li Z, Li H, Iwakura Y, Deng W.
  • Journal Title: Oncotarget Volume: 印刷中
  • DOI: 10.18632/oncotarget.10655
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The potential for repositioning antithyroid agents as antiasthma drugs (2016)
  • Author(s): Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
  • Journal Title: J Allergy Clin Immunol Volume: 138 Pages: 1458-1461
  • DOI: 10.1016/j.jaci.2016.04.047
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] IL-17A-producing CD30+ Vδ1 T cells drive inflammation-induced cancer progression (2016)
  • Author(s): Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
  • Journal Title: Cancer Sci Volume: 107 Pages: 1106-1214
  • DOI: 10.1111/cas.13005
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells. (2016)
  • Author(s): Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.
  • Journal Title: J Biol Chem. Volume: 291 Pages: 17629-17638
  • DOI: 10.1074/jbc.m116.741256
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Adiponectin enhances antibacterial activity of hematopoietic cells by suppressing bone marrow inflammation. (2016)
  • Author(s): Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, Iwakura Y, Yoshimura A, Kadowaki T, Kurokawa M.
  • Journal Title: Immunity Volume: 44 Pages: 1422-1433
  • DOI: 10.1016/j.immuni.2016.05.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity. (2016)
  • Author(s): Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA.
  • Journal Title: J Immunol. Volume: 197 Pages: 278-287
  • DOI: 10.4049/jimmunol.1502485
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis. (2016)
  • Author(s): Fabio Yoshikawa, Rikio Yabe, Yoichiro Iwakura, Sandro Rogerio de Almeida, Shinobu Saijo
  • Journal Title: Innate Immun. Volume: in press Pages: 316-24
  • DOI: 10.1177/1753425916645392
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. (2016)
  • Author(s): Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS.
  • Journal Title: Hypertension Volume: 68 Pages: 167-74
  • DOI: 10.1161/hypertensionaha.116.07493
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system (2016)
  • Author(s): Shishikura, M., Nakamura, F., Yamashita, N., Uetani, N., Iwakura, Y., and Goshima, Y.
  • Journal Title: Brain Res Volume: 1642 Pages: 244-254
  • DOI: 10.1016/j.brainres.2016.03.030
  • Peer Reviewed / Open Access
• [Journal Article] T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. (2016)
  • Author(s): Martin, B. N. , et al.
  • Journal Title: Nat Immunol. Volume: 17 Pages: 583-592
  • DOI: 10.1038/ni.3389
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy. (2016)
  • Author(s): Javed, N., Xue, G., Lu, A., Xing, Y., Iwakura, Y., Xiao, H., Lecoeur, H., Spath, G. F., and Meng, G.
  • Journal Title: Cytokine Volume: 81 Pages: 101-108
  • DOI: 10.1016/j.cyto.2016.03.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo. (2016)
  • Author(s): Ciraci, C., Janczy, J. R., Jain, N., Haasken, S., Pecli, E. Silva, C., Benjamim, C. F., Sadler, J. J., Olivier. A. K., Iwakura, Y., Shayakhmetov, D. M., Sutterwala, F. S., and Cassel, S. L.
  • Journal Title: Plos One Volume: 11
  • DOI: 10.1371/journal.pone.0151252
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-17-producing γ δ T cells enhance bone regeneration (2016)
  • Author(s): Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, Takayanagi H.
  • Journal Title: Nat Commun. Volume: 7 Pages: 10928-10928
  • DOI: 10.1038/ncomms10928
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye. (2016)
  • Author(s): Lee, E. J., Brown, B. R., Vance, E. E., Snow, P. E., Silver, P. B., Heinrichs, D., Lin, X., Iwakura, Y., Wells, C. A., Caspi, R. R., and Rosenzweig, H. L.
  • Journal Title: J Immunol. Volume: 196 Pages: 3148-3158
  • DOI: 10.4049/jimmunol.1502355
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. (2016)
  • Author(s): Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., and Divanovic, S.
  • Journal Title: Plos One Volume: 11
  • DOI: 10.1371/journal.pone.0149783
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice (2016)
  • Author(s): Kawabe, T., Suzuki, N., Yamaki, S., Sun, S. L., Asao, A., Okuyama, Y., So, T., Iwakura, Y., and Ishii, N.
  • Journal Title: Eur J Immunol Volume: 46 Pages: 1119-1131
  • DOI: 10.1002/eji.201545907
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway. (2016)
  • Author(s): Mai, J., Nanayakkara, G., Lopez-Pastrana, J., Li, X., Li, Y. F., Wang, X., Song, A., Virtue, A., Shao, Y., Shan, H., Liu, F., Autieri, M. V., Kunapuli, S. P., Iwakura, Y., Jiang, X., Wang, H., Yang, X. F.
  • Journal Title: J Biol Chem. Volume: 291 Pages: 4939-4954
  • DOI: 10.1074/jbc.m115.690081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bone marrow transplantation alters lung antigen-presenting cells to promote Th17 reponse and the development of pneumonitis and fibrosis following gammaherpesvirus infection. (2016)
  • Author(s): Zhou, X., Loomis-King, H., Gurczynski, S. J., Wilke, C. A., Konopka, K. E., Ptaschinski, C., Coomes, S. M., Iwakura, Y., van Dyk, L. F., Lukacs, N. W., and Moore, B. B.
  • Journal Title: Mucosal Immunol Volume: 9 Pages: 610-20
  • DOI: 10.1038/mi.2015.85
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-1 receptor antagonist inhibits pancreatic cancer growth by abrogating NF-κB activation. (2016)
  • Author(s): Zhuang, Z. N., Ju, H. Q., Aguilar, M., Gocho, T., Li, H., Iida, T., Lee, H., Fan, X., Zhou, H., Ling, J., Li, Z., Fu, J., Wu, M., Li, M., Melisi, D., Iwakura, Y., Xu, K., Fleming, J. B., and Chiao, P. J.
  • Journal Title: Clin. Cancer Res. Volume: 22 Pages: 1432-1444
  • DOI: 10.1158/1078-0432.ccr-14-3382
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis (2016)
  • Author(s): Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A.
  • Journal Title: Inflamm Res. Volume: 65 Pages: 235-244
  • DOI: 10.1007/s00011-015-0910-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae. (2016)
  • Author(s): Akahori Y, Miyasaka T, Toyama M, Matsumoto I, Miyahara A, Zong T, Ishii K, Kinjo Y, Miyazaki Y, Saijo S, Iwakura Y, Kawakami K.
  • Journal Title: BMC Immunol. Volume: 17 Pages: 1-1
  • DOI: 10.1186/s12865-015-0139-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interleukin-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting interleukin-1 signal on macrophages. (2015)
  • Author(s): Shimizu K, Nakajima A, Sudo K, Liu Y, Mizoroki A, Ikarashi T, Horai R, Kakuta S, Watanabe T, Iwakura Y.
  • Journal Title: J. Immunol Volume: 194(7) Pages: 3156-3168
  • DOI: 10.4049/jimmunol.1402155
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. (2015)
  • Author(s): Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T.:
  • Journal Title: Blood Volume: 125 Pages: 3014-23
  • DOI: 10.1182/blood-2014-12-615781
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mast cells mediate malignant pleural effusion formation. (2015)
  • Author(s): Giannou, A. D. et al
  • Journal Title: J. Clin. Invest. Volume: 125 Pages: 2317-2334
  • DOI: 10.1172/jci79840
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DCIR maintains bone homeostasis by regulating IFN-g;production in T cells. (2015)
  • Author(s): Maruhashi T*, Kaifu T*, Yabe R, Seno A, Chung SH, Fujikado N, and Iwakura Y
  • Journal Title: J. Immunol. Volume: 194 Pages: 5681-5691
  • DOI: 10.4049/jimmunol.1500273
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CD11c+ DCs accelerate the rejection of older cardiac transplants via IL-17A. (2015)
  • Author(s): Oberhuber, R., Heinbokel, T., Cetina Biefer, H. R., Boenisch, O., Hock, K., Bronson, R. T., Wilhelm, M. J., Iwakura, Y., Edtinger, K., Uehara, H., Quante, M., Voskuil, F., Krenzien, F., Slegtenhorst, B., Abdi, R., Pratschke, J., Elkhal, A., and Tullius, S. G.
  • Journal Title: Circulation Volume: 132 Pages: 122-131
  • DOI: 10.1161/circulationaha.114.014917
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like hehavior by aging. (2015)
  • Author(s): Wakabayashi et al.
  • Journal Title: Neuroscience Letters Volume: 599 Pages: 20-25
  • DOI: 10.1016/j.neulet.2015.05.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells. (2015)
  • Author(s): Akitsu A, Ishigame H, Kakuta S, Chung SH, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y.
  • Journal Title: Nat. Commun. Volume: 6 Pages: 7464-7464
  • DOI: 10.1038/ncomms8464
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia (2015)
  • Author(s): Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
  • Journal Title: Nat. Commun. Volume: 10;6 Pages: 7514-7514
  • DOI: 10.1038/ncomms8514
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor. (2015)
  • Author(s): Seno, A., Maruhashi, T., Kaifu, T., Yabe, R., Fujikado, N., Ma, G., Ikarashi, T., Kakuta, S., and Iwakura, Y.
  • Journal Title: Exp. Anim. Volume: 64 Pages: 109-119
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mouse model for PTPRD associations with WED/RLS and addiction: reduced expansion alters locomotion, sleep behaviors and cocaine-conditioned place preference. (2015)
  • Author(s): Drgonova, J., Walther, D., Wang, K. J., Hartstein, G. L., Lochte, B., Troncoso, J., Uetani, N., Iwakura, Y., and Uhl, G. R.
  • Journal Title: Mol. Med. Volume: 21 Pages: 717-725
  • DOI: 10.2119/molmed.2015.00017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine. (2015)
  • Author(s): Ce Tang, Tomonori Kamiya, Yang Liu, Motohiko Kadoki, Shigeru Kakuta, Kenshiro Oshima, Masahira Hattori, Kozue Takeshita, Takanori Kanai, Shinobu Saijo and Yoichiro Iwakura
  • Journal Title: Cell Host Microbe Volume: 18 Pages: 183-197
  • DOI: 10.1016/j.chom.2015.07.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Local IL-17 production exerts a protective role in murine experimental glomerulonephritis. (2015)
  • Author(s): Hamour, S., Gan, P. Y., Pepper, R., Florez Barros, F., Wang, H. H., O'Sullivan, K., Iwakura, Y., Cook, T., Pusey, C., Holdsworth, S., and Salama, A.
  • Journal Title: PLoS One Volume: 10
  • DOI: 10.1371/journal.pone.0136238
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense. (2015)
  • Author(s): Cai, S., Batra, S., Langohr, I., Iwakura, Y., and Jeyaseelan, S.
  • Journal Title: Mucosal Immunol Volume: 9 Pages: 718-29
  • DOI: 10.1038/mi.2015.95
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. (2015)
  • Author(s): Murayama A.M, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi H-H, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y
  • Journal Title: Nat. Commun. Volume: 6 Pages: 1-12
  • DOI: 10.1038/ncomms9483
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dendritic cell immunoreceptor 1 alters neutrophil response in the development of experimental colitis. (2015)
  • Author(s): Tokieda, S., Komori, M., Ishiguro, Iwakura, Y., Takahara, K.* and Inaba, K.
  • Journal Title: BMC Immunol Volume: 16 Pages: 64-64
  • DOI: 10.1186/s12865-015-0129-5
  • Peer Reviewed / Open Access
• [Journal Article] Interdependence between interleukin-1 and tumor necrosis factor regulates TNF-dependent control of Mycobacterium tuberculosis infection. (2015)
  • Author(s): Di Paolo, N. C., Shafiani, S., Day, T., Papayannoupoulou, T., Russell, D. W., Iwakura, Y., Sherman, D., Urdahl, K., and Shayakhmetov, D. M.
  • Journal Title: Immunity Volume: 43 Pages: 1125-36
  • DOI: 10.1016/j.immuni.2015.11.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-1R Type 2 Suppresses Collagen-Induced Arthritis Inhibiting IL-1 Signal on Macrophages. (2015)
  • Author(s): Shimizu K, Nakajima A, Sudo K, Yang L, Mizoroki A, Ikarashi T, Horai R, Kakuta S, Watanabe T, and Iwakura Y.
  • Journal Title: J Immunol. Volume: 194（７） Pages: 3156-68
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes. (2015)
  • Author(s): Yabe, R., Shimizu, K., Shimizu, S., Azechi, S., Choi, B. I., Sudo, K., Kubo, S., Nakae, S., Ishigame, H., Kakuta, S., and Iwakura, Y.
  • Journal Title: Int. Immunol. Volume: 27（４） Pages: 169-181
  • Peer Reviewed
• [Journal Article] NLRP3 deficiency exacerbates hyperoxia-induced lethality through Stat3 signaling independently of interleukin-1β (2015)
  • Author(s): Mizushina, Y., Shirasuna, K., Usui, F., Karasawa, T., Kawashima, A., Kimura, H., Kobayashi, M., Komada, T., Inoue, Y., Mato, N., Yamasawa, H., Latz, E., Iwakura, Y., Kasahara, T., Bando, M., Sugiyama, Y., and Takahashi, M.
  • Journal Title: J. Biol. Chem. Volume: 290（8） Pages: 5065-5077
  • Peer Reviewed
• [Journal Article] Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans. (2015)
  • Author(s): Nakamura, Y., Sato, K., Yamamoto, H., Matsumura, K., Matsumoto, I., Nomura, T., Miyasaka, T., Ishii, K., Kanno, E., Tachi, M., Yamasaki, S., Saijo, S., Iwakura, Y., Kawakami, K.
  • Journal Title: Infect. Immun. Volume: 83(2) Pages: 671-681
  • Peer Reviewed
• [Journal Article] Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. (2015)
  • Author(s): Oyoshi, M. K., Beaupre;, J., Venturelli, N., Lewis, C. N., Iwakura, Y., Geha, R. S.
  • Journal Title: J. Allergy Clin. Immunol., Volume: 未定
  • Peer Reviewed
• [Journal Article] Phaocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigates. (2015)
  • Author(s): Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell MA, Saijo S, Mostowy S, Shaunak S, Armstrong-James D.
  • Journal Title: EMBO Mol Med. Volume: 7 Pages: 240-258
  • Peer Reviewed
• [Journal Article] Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization. (2015)
  • Author(s): Jee, J., Bonnegarde-Bernard, A., Duverger, A., Iwakura, Y., Cormet-Boyaka, E., Martin, T. L., Steiner, H. E., Bachman, R. C., and Boyaka, P. N.
  • Journal Title: Mucosal Immunol., Volume: 未定
  • Peer Reviewed
• [Journal Article] A cruciall role of RORγt in the development of spontaneous sialadenitis-like Sjogren’s syndrome. (2015)
  • Author(s): Iizuka, M., Tsuboi, H., Matsuo, N., Asashima, H., Hirota, T., Kondo, Y., Iwakura, Y., Takahashi, S., Matsumoto, I., Sumida, T.
  • Journal Title: J. Immunol. Volume: 194(1) Pages: 56-67
  • Peer Reviewed
• [Journal Article] Antibiotic-killed Staphyococcus aureus induces detructive arthritis in mice. (2015)
  • Author(s): Ali, A., Zhu, X., Kwiecinski, J., Gjertsson, I., Lindholm, C., Iwakura, Y., Wang, X., Lycke, N., Josefsson, E., Pullerits, R., and Jin, T.
  • Journal Title: Arthritis Rheumatol. Volume: 67（1） Pages: 107-116
  • Peer Reviewed
• [Journal Article] Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor. (2015)
  • Author(s): Seno, A., Maruhashi, T., Kaifu, T., Yabe, R., Fujikado, N., Ma, G., Ikarashi, T., Kakuta, S., and *Iwakura, Y.
  • Journal Title: Exp. Anim. Volume: 未定
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immune complexes inhibit IL-1 secretion and inflammasome activation. (2014)
  • Author(s): Janczy, J. R., Ciraci, C., Haasken, S., Iwakura, Y., Olivier, A. K., Cassel, S. L., and Sutterwala, F. S.
  • Journal Title: J. Immunol., Volume: 193(10) Pages: 5190-5198
  • Peer Reviewed
• [Journal Article] Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin. (2014)
  • Author(s): Natsuaki, Y., Egawa, G., Nakamizo, S., Ono, S., Hanakawa, S., Okada, T., Kusuba, N., Otsuka, A., Kitoh, A., Honda, T., Nakajima, S., Tsuchiya, S., Sugimoto, Y., Ishii, K. J , Tsutsui, H., Yagita, H., Iwakura, Y., Kubo, M., Ng, L. G., Hashimoto, T., Fuentes, J., Guttman-Yassky, E., Miyachi, Y., and Kabashima, K.
  • Journal Title: Nat. Immunol. Volume: 15（11） Pages: 1064-1069
  • Peer Reviewed
• [Journal Article] The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. (2014)
  • Author(s): Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Munoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.
  • Journal Title: PLoS Pathog. Volume: 10
  • Peer Reviewed / Open Access
• [Journal Article] Gene targeting study reveals unexpected expression of brain expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice. (2014)
  • Author(s): Ito, K., Yamazaki, S., Yamamoto, R., Tajima, Y., Yanagida, A., Kobayashi, T., Kato-Itoh, M., Kakuta, S., Iwakura, Y., Nakauchi, H., and Kamiya, A.
  • Journal Title: J. Biol. Chem. Volume: 289(43) Pages: 29892-29911
  • Peer Reviewed
• [Journal Article] Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock. (2014)
  • Author(s): Shimura, E., Shibui, A., Narushima, S., Nambu, A., Yamaguchi, S., Akitsu, A., Leonard, W. J., Iwakura, Y., Matsumoto, K., Suto, H., Okumura, K., Sudo, K., and Nakae, S.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 453(1) Pages: 1-6
  • Peer Reviewed
• [Journal Article] Mast cell-derived IL-1β contributes to uric acid crystal-induced acute arthritis in mice. (2014)
  • Author(s): Reber, L. L., Marichal, T., Sokolove, J., Starkl, P., Gaudenzio, N., Iwakura, Y., Karasuyama, H., Schwartz, L. B., Robinson, W. H., Tsai, M., and Galli, S. J.
  • Journal Title: Arthritis Rheumatol., Volume: 66(10) Pages: 2881-2891
  • Peer Reviewed
• [Journal Article] Cigarette smoke primes the pulmonary environment to IL-1α/CXCR-2-dependent nontypeable haemophilus influenzae-exacerbated neutrophillia in mice. (2014)
  • Author(s): Nikota, J. K., Shen, P., Morissette, M. C., Fernandes, K., Roos, A., Chu, D. K., Barra, N. G., Iwakura, Y., Kolbeck, R., Humbles, A. A., and Stampfli, M. R.
  • Journal Title: J. Immunol. Volume: 193(6) Pages: 3134-3145
  • Peer Reviewed
• [Journal Article] Interleukin-1 receptor antagonist originating from bone marrow-derived cells and non-bone marrow-derived cells helps to suppress arterial inflammation and reduce neointimal formation after injury. (2014)
  • Author(s): Isoda, K., Akita, K., Isobe, S., Niida, T., Adachi, T., Iwakura, Y., and Daida, H.
  • Journal Title: J. Atheroscler. Thromb. Volume: 21（11） Pages: 1208-1218
  • Peer Reviewed / Open Access
• [Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of Mycobacteria. (2014)
  • Author(s): Yonekawa A, Saijo S, Hosino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-hora M, Akashi K, Yamasaki S.
  • Journal Title: Immunity. Volume: 41(3) Pages: 402-413
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease. Emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory disease. (2014)
  • Author(s): Yamanaka, K., Nakanishim, T., Saito, H., Maruyamam, J., Isoda, K., Yokochi, A., Imanaka-Yoshida, K., Tsuda, K., Kakeda, M., Okamoto, R., Fujita, S., Iwakura, Y., Suzuki, N., Ito, M., Maruyama, K., Gabazza, E. C., Yoshida, T., Shimaoka, M., and Mizutani, H.
  • Journal Title: PLoS One Volume: 9（8）
  • Peer Reviewed / Open Access
• [Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. (2014)
  • Author(s): Chiba, S., Ikushima, H., Ueki, H., Yanai, H., Kimura, Y., Hangai, S., Nishio, J., Negishi, H., Tamura, T., Saijo, S., Iwakura, Y., and Taniguchi T.
  • Journal Title: Elife Volume: 3
  • Peer Reviewed / Open Access
• [Journal Article] Dectin-2 promotes house dust mite-induced T helper type 2 and type 17 cell differentiation and allergic airway inflammation in mice. (2014)
  • Author(s): Norimoto A, Hirose K, Iwata A, Tamachi T, Yokota M, Takahashi K, Saijo S, Iwakura Y, Nakajima H.
  • Journal Title: Am J Respir Cell Mol Biol. Volume: 51(2) Pages: 201-209
  • Peer Reviewed
• [Journal Article] IL-17A as an inducer for Th2 immune responses in murine atopic dermatitits models. (2014)
  • Author(s): Nakajima, S., Kitoh, A., Egawa, G., Natsuaki, Y., Nakamizo, S., Sagita, Moniaga, C., Otsuka, A., Honda, T., Hanakawa, S., Amano, W., Iwakura, Y., Nakae, S., Kubo, M., Miyachi, Y., and Kabashima, K.
  • Journal Title: J. Invest. Dermatol. Volume: 134(8) Pages: 2122-2130
  • Peer Reviewed
• [Journal Article] Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation. (2014)
  • Author(s): Lai, C. Y., Yamazaki, S., Okabe, M., Suzuki, S., Maeyama, Y., Iimura, Y., Onodera. M., Kakuta, S., Iwakura, Y., Nojima, M., Otsu, M., and Nakauchi, H.
  • Journal Title: Stem Cells Volume: 32(7) Pages: 1929-1942
  • Peer Reviewed
• [Journal Article] Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages. (2014)
  • Author(s): Ohman T, Teirila; L, Lahesmaa-Korpinen AM, Cypryk W, Veckman V, Saijo, S. Wolff H, Hautaniemi S, Nyman TA, Matikainen S.
  • Journal Title: J Immunol. Volume: 192(12) Pages: 5952-5962
  • Peer Reviewed
• [Journal Article] Targeting IL-1b and IL-17A driven inflammation during influenza-induced exacerbations of chronic lung inflammation. (2014)
  • Author(s): Sichelstiel, A., Yadava, K., Trompette, A., Salami, O., Iwakura, Y., Nicod, L. P., and Marsland, B. J.
  • Journal Title: PLoS One Volume: 9(2)
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy. (2014)
  • Author(s): Wu, L., Ong, S., Talor, M. V., Barin, J. G., Baldeviano, G. C, Kass,D.A., Bedja, D., Zhang, H., Sheikhm, A., Margolick, J. B., Iwakura, Y., Rose, N. R., and Cihakova, D.
  • Journal Title: J. Exp. Med. Volume: 211(7) Pages: 1449-1464
  • Peer Reviewed / Open Access
• [Journal Article] Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. (2014)
  • Author(s): Song, X., Gao, H., Lin, Y., Yao, Y,. Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, and Qian Y.
  • Journal Title: Immunity Volume: 40(1) Pages: 140-152
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of IL-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut moter dysfunction. (2014)
  • Author(s): Akiho, H., Tokita, Y., Nakamura, K., Satoh, K., Nishiyama, M., Tsuchiya, N., Tsuchiya, K., Ohbuchi, K., Iwakura, Y., Ihara, E., Takayanagi, R., and Yamamoto, M.
  • Journal Title: PLoS One Volume: 9(5)
  • Peer Reviewed / Open Access
• [Journal Article] An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. (2014)
  • Author(s): Yasukawa, S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K., Yasuda, T., Natsuaki, Y., Mi-Ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B., Ohno, N., Furue, M., Yoshida, H., and Hara, H.
  • Journal Title: Nat. Commun., Volume: 5 Pages: 3755-3755
  • Peer Reviewed
• [Journal Article] The role of C-type lectin receptors in host defense against microbial pathogens. (2014)
  • Author(s): Yabe, R., Iwakura, Y., and Saijo, S.
  • Journal Title: Glycoscinece: Biology and Medicine Volume: - Pages: 1319-1329
  • Peer Reviewed
• [Journal Article] Multiple CD11c+ cells collaboratively express IL-1β to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth. (2014)
  • Author(s): Benahmed, F., Chyou, S., Dasoveanu, D., Chen, J., Kumar, V., Iwakura, Y., and Lu, T. T.
  • Journal Title: J. Immunol. Volume: 192(9) Pages: 4153-4163
  • Peer Reviewed
• [Journal Article] NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes. (2014)
  • Author(s): Inoue, Y., Shirasuna, K., Kimura, H., Usui, F., Kawashima, A., Karasawa, T., Tago, K., Dezaki, K., Nishimura, S., Sagara, J., Noda, T., Iwakura, Y., Tsutsui, H., Taniguchi, S., Yanagisawa, K., Yada, T., Yasuda, Y., and Takahashi, M.
  • Journal Title: J. Immunol. Volume: 192(9) Pages: 4342-4351
  • Peer Reviewed
• [Journal Article] Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in vial infection. (2014)
  • Author(s): .Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y., and Sun, J.
  • Journal Title: J. Immunol. Volume: 192(7) Pages: 3289-3300
  • Peer Reviewed / Open Access
• [Journal Article] Chemokine receptor CCR8 is required for lipopolysassharide-triggered cytokine production in mouse peritoneal macrophages. (2014)
  • Author(s): Oshio, T., Kawashima, R., Kawamura, Y. I., Hagiwara, T., Mizutani, N., Okada, T., Otsubo, T., Inagaki-Ohara, K., Matsukawa, A., Haga, T., Kakuta, S., Iwakura, Y., Hosokawa, S., and Dohi, T.
  • Journal Title: PLoS One Volume: 9(4)
  • Peer Reviewed / Open Access
• [Journal Article] Defect of CARD9 leads to impaired accululation of IFN-g-producing memory-phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans. (2014)
  • Author(s): Yamamoto, H., Nakamura, Y., Sato, K., Takahashi, Y., Nomura, T., Miyasaka, T., Ishii, K., Hara, H., Yamamoto, N., Kanno, E., Iwakura, Y., and Kawakami, K.
  • Journal Title: Infect. Immun. Volume: 82(4) Pages: 1606-1615
  • Peer Reviewed / Open Access
• [Journal Article] Rag2-deficient IL-1 receptor antagonist-deficient mice are a novel colitis model in which innate lymphoid cell-derived IL-17 is involved in the pathogenesis. (2014)
  • Author(s): Akitsu, A., Kakuta, S., Saijo, S., and Iwakura, Y.
  • Journal Title: Exp. Anim. Volume: 63(2) Pages: 235-246
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Involvement of Gr-1dull+ cellsin the production of TNF-a and IL-17 and exacerbated systemic inflammatory response caused by lipopolysaccharide. (2014)
  • Author(s): Tanno, D., Akahori, Y., Toyama, M., Sato, K., Kudo, D., Abe, Y., Miyasaka, T., Yamamoto, H., Ishii, K., Kanno, E., Maruyama, R., Kushimoto, S., Iwakura, Y., and Kawakami, K.
  • Journal Title: Inflammation Volume: 37 Pages: 186-195
  • DOI: 10.1007/s10753-013-9729-5
  • Peer Reviewed
• [Journal Article] Mechanism of pro-tumorigenic effect of BMP-6: Neovascularizatioon involving tumor-associated macrophages and IL-1a. (2014)
  • Author(s): Kwon, S. J., Lee, G. T., Lee, J. H., Iwakura, Y., Kim, W. J., and Kim, I. Y.
  • Journal Title: Prostate Volume: 74 Pages: 121-133
  • DOI: 10.1002/pros.22734
  • Peer Reviewed
• [Journal Article] CTRP3 plays an important role in the development of collagen-induced arthritis in mice. (2014)
  • Author(s): Murayama MA, Kakuta S, Maruhashi T, Shimizu K, Seno A, Kubo S, Sato N, Saijo S, Hattori M, Iwakura Y.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 443 Pages: 42-48
  • DOI: 10.1016/j.bbrc.2013.11.040
  • Peer Reviewed
• [Journal Article] NF-kB/TNF-a positive feedback loop with active proteasome machinery supports myeloid leukemia initiating cell capacity. (2014)
  • Author(s): Kagoya Y, Yoshimi A, Kataoka K, Nakagawa M, Kumano K, Arai S, Kobayashi H, Saito T, Iwakura Y, Kurokawa M.
  • Journal Title: Journal of Clinical Investigation Volume: 124 Pages: 528-42
  • DOI: 10.1172/jci68101
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Critical role for inflammasome-independent IL-1b production in osteomyelitis. (2014)
  • Author(s): Lukens, J. R., Gross, J. M., Calabrese, C., Iwakura, Y., Lamkanfi, M., Vogel, P., and Kanneganti, T. D.
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A. Volume: 111 Pages: 1066-1071
  • DOI: 10.1073/pnas.1318688111
  • Peer Reviewed
• [Journal Article] Inflammasome-independent IL-1b mediates autoinflammatory diseases in Pstpip2-deficient mice. (2014)
  • Author(s): Cassel, S. L., Janczy, J. R., Bing, X., Wilson, S. P., Olivier, A. K., Otero, J. E., Iwakura, Y., Shayakhmetov, D. M., Bassuk, A. G., Abu-Amer, Y., Brogden, K. A., Burns, T. L., Sutterwala, F. S., and Ferguson, P. J.
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A. Volume: 111 Pages: 1072-1077
  • DOI: 10.1073/pnas.1318685111
  • Peer Reviewed
• [Journal Article] Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-b-induced Foxp3 expression. (2014)
  • Author(s): Ikeda S, Saijo S, Murayama MA, Shimizu K, Akitsu A, Iwakura Y.
  • Journal Title: J. Immunol. Volume: 192 Pages: 1449-1458
  • DOI: 10.4049/jimmunol.1300387
  • Peer Reviewed
• [Journal Article] Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. (2014)
  • Author(s): Parsons MW, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA.
  • Journal Title: J. Immunol. Volume: 192 Pages: 1361-1371
  • DOI: 10.4049/jimmunol.1301809
  • Peer Reviewed
• [Journal Article] A non-agonistic Dectin-1 ligand transforms CpG into a multitask nano-particulate TLR9 agonist. (2014)
  • Author(s): Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ.
  • Journal Title: Proc.Natl.Acad Sci. Volume: 111 Pages: 3086-3091
  • DOI: 10.1073/pnas.1319268111
  • Peer Reviewed
• [Journal Article] Ectopic cerebellar cell migration causes maldevelopment of purkinje cells and abnormal motor behavior in CXCR4 null mice. (2014)
  • Author(s): Huang, G. J., Edwards, A., Tsai, C. Y., Lee, Y. S., Peng, L., Era, T., Hirabayashi, Y., Tsai, C. Y., Nishikawa, S., Iwakura, Y., Chen, S. J., and Flint, J.
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0086471
  • Peer Reviewed
• [Journal Article] Rag2-deficient IL-1 receptor antagonist deficient mice are a novel colitis model in which innate lymphoid cell-derived IL-17 is involved in the pathogenesis. (2014)
  • Author(s): Akitsu A., Kakuta S., Saijo S., Iwakura Y.
  • Journal Title: Exp. Anim. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Dectin-2 promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation in mice (2014)
  • Author(s): Norimoto, A., Hirose, K., Iwata, A., Tamachi, T., Yokota, M., Takahashi, K., Saijo, S., Iwakura, Y., and Nakajima, H.
  • Journal Title: Am J Respir Cell Mol Biol. Volume: 印刷中 Pages: 201-209
  • DOI: 10.1165/rcmb.2013-0522oc
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in vial infection. (2014)
  • Author(s): Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y., and Sun, J.
  • Journal Title: J. Immunol. Volume: 192 Pages: 3289-3300
  • DOI: 10.4049/jimmunol.1303281
  • Peer Reviewed
• [Journal Article] Multiple CD11c+ cells collaboratively express IL-1b to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth. (2014)
  • Author(s): Benahmed, F., Chyou, S., Dasoveanu, D., Chen, J., Kumar, V., Iwakura, Y., and Lu, T. T.
  • Journal Title: J. Immunol. Volume: 印刷中
  • DOI: 10.4049/jimmunol.1301765
  • Peer Reviewed
• [Journal Article] Regulatory T cells are strong promoters of acute ischemia stroke in mice by inducing dysfunction of the cerebral microvasculature. (2013)
  • Author(s): Kleinschnitz, C., Kraft, P., Dreykluft, A., Hagedorn, I., Gobel, K., Schuhmann, M. K., Langhauser, F., Helluy, X., Schwarz, T., Bittner, S., Mayer, C. T., Brede, M., Varallyay. C., Pham, M., Bendszus, M., Jakob, P., Magnus, T., Meuth, S. G., Iwakura, Y., Zernecke, A. et al.
  • Journal Title: Blood Volume: 121 Pages: 679-691
  • DOI: 10.1182/blood-2012-04-426734
  • Peer Reviewed
• [Journal Article] IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment. (2013)
  • Author(s): Erdmann, H., RoBnagel, C., Bohme, J., Iwakura, Y., Jacobs, T., Schaible, U. E., and Holscher, C.
  • Journal Title: Immunobiology Volume: 218, Pages: 910-923
  • DOI: 10.1016/j.imbio.2012.10.005
  • Peer Reviewed
• [Journal Article] Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation. (2013)
  • Author(s): Silverpil, E., Wright, A. K., Hansson, M., Jirholt, P., Henningsson, L., Smith, M. E., Gordon, S. B., Iwakura, Y., Gjertsson, I., Glader, P., and Linden, A.
  • Journal Title: Innate Immun. Volume: 19 Pages: 479-492
  • DOI: 10.1177/1753425912470470
  • Peer Reviewed
• [Journal Article] Visceral Adipose Tissue-derived Serine Proteinase Inhibitor Inhibits Apoptosis of Endothelial Cells as a Ligand for the Cell-Surface GRP78/Voltage-dependent Anion Channel Complex. (2013)
  • Author(s): Nakatsuka A
  • Journal Title: Circulation Research Volume: 112(5) Pages: 771-780
  • DOI: 10.1161/circresaha.111.300049
  • Peer Reviewed
• [Journal Article] IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice. (2013)
  • Author(s): Etsuko Kurimoto
  • Journal Title: Respir Res. Volume: 14 Pages: 5-5
  • DOI: 10.1186/1465-9921-14-5
  • Peer Reviewed
• [Journal Article] Cyclosporine A drives a Th17- and Th2-mediated posttransplant obliterative airway disease. (2013)
  • Author(s): Lemaitre, P. H., Vokaer, B., Charbonnier, L. M., Iwakura, Y., Field, K. A., Estenne, M., Goldman, M., Leo, O., Remmelink, M., and Le Moine, A.
  • Journal Title: Am. J. Transplant. Volume: 13 Pages: 611-620
  • DOI: 10.1111/ajt.12067
  • Peer Reviewed
• [Journal Article] SMAP1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia． (2013)
  • Author(s): Kon et al.
  • Journal Title: J Clin Invest Volume: 123 Pages: 1123-1137
  • DOI: 10.1172/jci63711
  • Peer Reviewed
• [Journal Article] MFGE8 inhibits inflammasome-induced IL-1b production and limits postischemic cerebral injury. (2013)
  • Author(s): Deroide, N., Li, X., Lerouet, D., Van Vre, E., Baker, L., Harrison, J., Poittevin, M. Masters, L., Nih, L., Margaill, I., Iwakura, Y., Ryffel, B., Pocard, M., Tedgui, A., Kubis, N., and Mallat, Z.
  • Journal Title: J. Clin. Invest. Volume: 123 Pages: 1176-1181
  • DOI: 10.1172/jci65167
  • Peer Reviewed
• [Journal Article] Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation. (2013)
  • Author(s): Shepardson, K. M., Ngo, L. Y., Aimanianda, V., Latge, J.-P., Barker, B. M., Blosser, S. J., Iwakura, Y., Hohl, T. M., and Cramer, R. A.
  • Journal Title: Microbe. Infect. Volume: 15 Pages: 259-269
  • DOI: 10.1016/j.micinf.2012.11.010
  • Peer Reviewed
• [Journal Article] Mature dendritic cell suppression by IL-1 receptor antagonist on retinal pigment epithelium cells. (2013)
  • Author(s): Sugita S, Kawazoe Y, Imai A, Usui Y, Iwakura Y, Isoda K, Ito M, Mochizuki M
  • Journal Title: Invest. Ophthalmol. Vis. Sci. Volume: 54巻 Pages: 3240-3249
  • DOI: 10.1167/iovs.12-11483
  • Peer Reviewed
• [Journal Article] C-Type Lectin MCL Is an FcR<gamma>-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor (2013)
  • Author(s): Miyake Y, Ynmasaki S, et al.
  • Journal Title: Immunity Volume: 38 Pages: 1050-1062
  • DOI: 10.1016/j.immuni.2013.03.010
  • Peer Reviewed
• [Journal Article] Neutrophils are essential as a source of IL-17 in the effector phase of arthritis. (2013)
  • Author(s): Katayama, M., Ohmura, K., Yukawa, N., Terao, C., Hashimoto, M., Yoshifuji, H., Kawabata, D., Fujii, T., Iwakura, Y., and Mimori, T.
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/annotation/5fedb3bf-c9c2-4862-9ad5-23c8ae484ad5
  • Peer Reviewed
• [Journal Article] Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse (2013)
  • Author(s): Kuriya G, Uchida T, Akazawa S, Kobayashi M, Nakamura K, Satoh T, Horie I, Kawasaki E, Yamasaki H, Yu L, Iwakura Y, Sasaki H, Nagayama Y, Kawakami A, Abiru N.
  • Journal Title: Diabetologia Volume: 56 Pages: 1773-1780
  • DOI: 10.1007/s00125-013-2935-8
  • Peer Reviewed
• [Journal Article] RIP1-driven autoinflammation targets IL-1a independently of inflammasomes and RIP3. (2013)
  • Author(s): Lukens, J. R., Vogel, P., Johnson, G. R., Kelliher, M. A., Iwakura, Y., Lamkanfi, M., and Kanneganti, T. D.
  • Journal Title: Nature Volume: 498 Pages: 224-227
  • DOI: 10.1038/nature12174
  • Peer Reviewed
• [Journal Article] Obesity-induced gut microbial metabolite prootes liver cancer through senescence secretome. (2013)
  • Author(s): Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., Honda, K., Ishikawa, Y., Hara, E., and Ohtani, N.
  • Journal Title: Nature Volume: 499 Pages: 97-101
  • DOI: 10.1038/nature13004
  • Peer Reviewed
• [Journal Article] IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages. (2013)
  • Author(s): Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, Iwakura Y, Okada H, Suzuki T, Shimokawa C, and Hisaeda
  • Journal Title: European journal of immunology Volume: 43 Pages: 2696-2706
  • DOI: 10.1002/eji.201343493
  • Peer Reviewed
• [Journal Article] The Arf GAP SMAP2 is necessary for organized vesicle budding from the Trans-Golgi-network and subsequent acrosome formation in spermiogenesis. (2013)
  • Author(s): Funaki T, Kon S, Tanabe K, Natsume W, Sato S, Shimizu T, Yoshida N, Wong WF, Ogura A, Ogawa T, Inoue K, Ogonuki N, Miki H, Mochida K, Endoh K, Yomogida K, Fukumoto M, Horai R, Iwakura Y, Ito C, Toshimori K, Watanabe T, Satake M.
  • Journal Title: Molecular Biology of the Cel Volume: 24 Pages: 2633-2644
  • DOI: 10.1091/mbc.e13-05-0234
  • Peer Reviewed
• [Journal Article] Pam3CSK4 enhanced beta cell loss and diabetogenesis: The roles of IFN-gamma and IL-17. (2013)
  • Author(s): Al Shamsi, M., Shahin, A., Iwakura, Y., Lukic, M. L., and Mensah-Brown, E. P.
  • Journal Title: Clin. Immunol. Volume: 149 Pages: 86-96
  • DOI: 10.1016/j.clim.2013.06.001
  • Peer Reviewed
• [Journal Article] Interleukin-1b induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. (2013)
  • Author(s): Shigematsu, Y., Niwa, T., Rehnberg, E., Toyoda, T., Yoshida, S., Mori, A., Wakabayashi, M., Iwakura, Y., Ichinose, M., Kim, Y. J., and Ushijima, T.
  • Journal Title: Cancer Lett. Volume: 340 Pages: 141-147
  • DOI: 10.1016/j.canlet.2013.07.034
  • Peer Reviewed
• [Journal Article] IL-17A mediates early post-translpant lesions agter teterotopic trachea allotransplantation in mice. (2013)
  • Author(s): Lemaitre, P. H., Vokaer, B., Charbonnier, L. M., Iwakura, Y., Estenne, M., Goldman, M., Leo, O., Remmelink, M., and Le Moine, A.
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0070236
  • Peer Reviewed
• [Journal Article] Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation. (2013)
  • Author(s): Soeno Y, Fujita K, Kudo T, Asagiri M, Kakuta S, Taya Y, Shimazu Y, Sato K, Tanaka-Fujita R, Kubo S, Iwakura Y, Nakamura Y, Mori S, and Aoba T
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0072105
  • Peer Reviewed
• [Journal Article] Fatty acid-inudced mitochondrial uncoupling elicits inflammasome-independent IL-1a and sterile vascular inflammation in atherosclerosis. (2013)
  • Author(s): Freigang, S., Ampenberger, F., Weiss, A., Kanneganti, T. D., Iwakura, Y., Hersberger, M., and Kopf, M.
  • Journal Title: Nat. Immunol. Volume: 14 Pages: 1045-1053
  • DOI: 10.1038/ni.2704
  • Peer Reviewed
• [Journal Article] Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis. (2013)
  • Author(s): Chang, Y., Al-Alwan, L., Audusseau, S., Chouiali, F., Carlevaro-Fita, J., Iwakura, Y., Baglole, C. J., Eidelman, D. H., and Hamid, Q.
  • Journal Title: Am. J. Physiol. Lung Cell Mol. Physiol. Volume: 306
  • DOI: 10.1152/ajplung.00111.2013
  • Peer Reviewed
• [Journal Article] Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. (2013)
  • Author(s): Schmitt, E. G., Haribhai, D., Jeschke, J. C., Co, D. O., Ziegelbauer, J., Yan, K., Iwakura, Y., Mishra, M. K., Simpson, P., Salzman, N. H., and Williams, C. B.
  • Journal Title: J. Immunol. Volume: 191 Pages: 5460-5476
  • DOI: 10.4049/jimmunol.1301576
  • Peer Reviewed
• [Journal Article] Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and gd T cells. (2013)
  • Author(s): Do, J. S., Visperas, A., Freeman, M. L., Iwakura, Y., Oukka, M., and Min, B.
  • Journal Title: Immunol. Cell Biol. Volume: 92 Pages: 90-98
  • DOI: 10.1038/icb.2013.70
  • Peer Reviewed
• [Journal Article] Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine. (2013)
  • Author(s): Miyasaka T, Akahori Y, Toyama M, Miyamura N, Ishii K, Saijo S, Iwakura Y, Kinjo Y, Miyazaki Y, Oishi K, Kawakami K.
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0078611
  • Peer Reviewed
• [Journal Article] Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilliate obesity-associated airway hyperreactivity. (2013)
  • Author(s): Kim, H. Y., Lee, H. J., Chang, Y. J., Pichavant, M., Shore, S. A., Fitzgerald, K. A., Iwakura, Y., Israel, E., Bolger, K., Faul, J., Dekruyff, R. H., and Umetsu, D. T.
  • Journal Title: Nat. Med. Volume: 20 Pages: 54-61
  • DOI: 10.1038/nm.3423
  • Peer Reviewed
• [Journal Article] Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infecion in mouse cells. (2013)
  • Author(s): Tada, T., Kadoki, M., Yang, L., Tokunaga, K. and Iwakura, Y.
  • Journal Title: Frontiers in Microbiology Volume: 4 Pages: 377-377
  • DOI: 10.3389/fmicb.2013.00377
  • Peer Reviewed
• [Journal Article] Evaluation of Kampo medicines used to treat rheumatoid arthritis in collagen-induced arthritic and pX transgenic mice. (2013)
  • Author(s): Ono, Y., Ogihara, Y., Saijo, S., Iwakura, Y., and Inoue, M.
  • Journal Title: Mod. Rheumatol. Volume: 13 Pages: 50-56
  • DOI: 10.3109/s101650300007
  • Peer Reviewed
• [Journal Article] IL-22+CD4+T細胞による大腸炎誘導と抑制． (2013)
  • Author(s): 角木基彦、岩倉洋一郎
  • Journal Title: 臨床免疫・アレルギー科 Volume: 59 Pages: 405-410
• [Journal Article] 遺伝子改変マウスによる疾患発症機構の解析． (2013)
  • Author(s): 岩倉洋一郎
  • Journal Title: 感染・炎症・免疫 Volume: 43 Pages: 313-319
• [Journal Article] Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia. (2013)
  • Author(s): von Banchet, G. S.
  • Journal Title: Mol. Cell Neurosci. Volume: 52 Pages: 152-160
  • DOI: 10.1016/j.mcn.2012.11.006
  • Peer Reviewed
• [Journal Article] IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic refection responses. (2012)
  • Author(s): Lee, J.
  • Journal Title: J. Immunol. Volume: 189 Pages: 1928-1936
  • Peer Reviewed
• [Journal Article] Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-assoiated sialidase. (2012)
  • Author(s): Yamaguchi, K.,
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Osteopontin-regulates interleukin-17 production in hepatitis. (2012)
  • Author(s): Diao, H.
  • Journal Title: Cytokine Volume: 60 Pages: 129-137
  • Peer Reviewed
• [Journal Article] Potential roles of interleukin 17A in the development of skin fibrosis. (2012)
  • Author(s): Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, T akehara K
  • Journal Title: Arthritis Rheum. Volume: 64 Pages: 3726-35
  • DOI: 10.1002/art.34643
  • Peer Reviewed
• [Journal Article] Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell surface GRP78/MTJ-1 complex. (2012)
  • Author(s): Nakatsuka, A.
  • Journal Title: Diabetes Volume: 61 Pages: 2823-2832
  • Peer Reviewed
• [Journal Article] The NLRP12 inflammasome recognizes Yershinia pestis. (2012)
  • Author(s): Vladimer, G. I.
  • Journal Title: Immunity Volume: 37 Pages: 96-107
  • Peer Reviewed
• [Journal Article] Agaricus barasiliensis-derived β-glucans exert immunoenhancing effects via a dectin-1-dependent pathway. (2012)
  • Author(s): Yamanaka, D.
  • Journal Title: Int. Immunopharmacol., Volume: 14 Pages: 311-319
  • Peer Reviewed
• [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. (2012)
  • Author(s): Suzukawa, M.
  • Journal Title: J. Immunol. Volume: 189 Pages: 3641-3652
  • Peer Reviewed
• [Journal Article] Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1alpha-dependent in mice. (2012)
  • Author(s): Botelho, F. M.
  • Journal Title: Respir. Res. Volume: 13 Pages: 81-81
  • Peer Reviewed
• [Journal Article] IL-36α exerts pro-inflammatory effects in the lungs of mice. (2012)
  • Author(s): Ramadas, R. A.
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. (2012)
  • Author(s): Sadik, C. D.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109 Pages: 18647-18648
  • Peer Reviewed
• [Journal Article] Expression of RORγt marks a pathogenic T-regulatory cell subset in human colon cancer. (2012)
  • Author(s): Blatner, N. R.
  • Journal Title: Science Translational Medicine Volume: 164
  • Peer Reviewed
• [Journal Article] IL-23 in colitis: Targeting the progenitors. (2012)
  • Author(s): Ce, T.
  • Journal Title: Immunity Volume: 37 Pages: 957-959
  • Peer Reviewed
• [Presentation] Roles of C-type lectins in host defense against pathogens and homeostasis of the immune system. (2017)
  • Author(s): Yoichiro Iwakura
  • Organizer: Genomics Research Center Seminar Series
  • Place of Presentation: Taipei, ROC
  • Year and Date: 2017-03-02
  • Int'l Joint Research / Invited
• [Presentation] 低分子βグルカンによる腸管免疫の制御 (2017)
  • Author(s): 岩倉洋一郎
  • Organizer: 第１回プロバイオティクス学術セミナー
  • Place of Presentation: アパホテル＆リゾート東京ベイ幕張
  • Year and Date: 2017-02-24
  • Invited
• [Presentation] 炎症性腸疾患と食物アレルギーの病態制御におけるDectin-1と短鎖βグルカンの役割の解析 (2017)
  • Author(s): 唐策、岩倉洋一郎
  • Organizer: Glyco-Immunology 2017糖鎖免疫研究会
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2017-01-25
  • Invited
• [Presentation] 炎症性疾患及び免疫系の恒常性維持におけるIL－17の役割 (2017)
  • Author(s): 岩倉洋一郎
  • Organizer: 第40回皮膚脈管・膠原病研究会
  • Place of Presentation: コラッセ福島
  • Year and Date: 2017-01-21
  • Invited
• [Presentation] Pathogenic Mechanisms of Psoriasis: Lessons from Mouse Models (2016)
  • Author(s): Yoicihiro Iwakura
  • Organizer: 日本研究皮膚科学会第41回年次学術大会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-12-10
  • Int'l Joint Research / Invited
• [Presentation] A novel role of Dectin-1 signaling in controlling food antigen-induced mouse intestinal allergy (2016)
  • Author(s): 唐策、濱田有史、岩倉洋一郎
  • Organizer: 第45回日本免疫学会学術集会.
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2016-12-05
• [Presentation] Identification of novel IL-17-producing T cell populations, γδ TCR-CD4-CD8- cells, in TCRδ -deficient mice. (2016)
  • Author(s): Aoi Akitsu, Yoichiro Iwakura.
  • Organizer: 4th Annual Meeting of the International Cytokine & Interferon Society (ICIS).
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2016-10-16
  • Int'l Joint Research
• [Presentation] 補体制御因子CTRP6と炎症性疾患 (2016)
  • Author(s): 村山正承、岩倉洋一郎
  • Organizer: 第3回日本リウマチ学会ベーシックリサーチカンファレンス
  • Place of Presentation: 富士ソフト アキバプラザ 5階アキバホール
  • Year and Date: 2016-10-14
• [Presentation] 低分子βグルカンによる腸管炎症抑制 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: バイオジャパン
  • Place of Presentation: 東京理科大学
  • Year and Date: 2016-10-12
  • Invited
• [Presentation] 疾患モデルを用いた自己免疫および感染防御機構の解析と創薬への展開 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 自治医科大学大学院特別講義（医学研究科教育委員会主催）
  • Place of Presentation: 自治医科大学
  • Year and Date: 2016-10-04
  • Invited
• [Presentation] The role of C-type lectin receptors in the homeostasis of the intestinal immune system. (2016)
  • Author(s): Yoichiro Iwakura
  • Organizer: National Defense Medical Center (Sponsored by Prof. Ann Chen)
  • Place of Presentation: Taipei, ROC
  • Year and Date: 2016-09-16
  • Int'l Joint Research / Invited
• [Presentation] 短鎖βグルカンによる腸管免疫恒常性の維持 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 日本臨床免疫学会シンポジウム
  • Place of Presentation: 京王プラザ、東京
  • Year and Date: 2016-09-08
  • Int'l Joint Research / Invited
• [Presentation] 自然免疫受容体を介した真菌の認識と免疫系の修飾 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 日本医真菌学会教育講演
  • Place of Presentation: 都立産業貿易センター
  • Year and Date: 2016-09-08
  • Int'l Joint Research / Invited
• [Presentation] 短鎖βグルカンによる腸内細菌を介した免疫制御 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 東海大学医学部講演会
  • Place of Presentation: 東海大学医学部
  • Year and Date: 2016-09-06
  • Invited
• [Presentation] DCIR－糖鎖間相互作用による骨代謝制御機構 (2016)
  • Author(s): 矢部力朗、海部知則、丸橋拓海、西城忍、舘野浩章、平林淳、岩倉洋一郎
  • Organizer: 第35回日本糖質年会
  • Place of Presentation: 高知市文化プラザかる ぽーと
  • Year and Date: 2016-09-01
• [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine. (2016)
  • Author(s): Ce Tang, Tomonori Kamina, Yoichiro Iwakura.
  • Organizer: International Congress of Immunology (ICI) 2016
  • Place of Presentation: Melbourne, Australia.
  • Year and Date: 2016-08-21
• [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells. (2016)
  • Author(s): Aoi Akitsu, Yoichiro Iwakura.
  • Organizer: International Congress of Immunology (ICI) 2016
  • Place of Presentation: Melbourne, Australia.
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] 自己免疫疾患と感染防御におけるIL－17ファミリーの役割 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: Psoriasis and IL-17A Forum 2016 in Kyushu
  • Place of Presentation: 博多エクセルホテル東急
  • Year and Date: 2016-07-30
  • Invited
• [Presentation] 自己免疫疾患と感染防御におけるIL－17ファミリーの役割 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 四国４大学皮膚科研究会
  • Place of Presentation: 松山全日空ホテル
  • Year and Date: 2016-07-23
  • Invited
• [Presentation] Complement regulator CTRP6 and inflammatory diseases. (2016)
  • Author(s): Masanori A. Murayama, Kenzo Matsuo, Kaori Yoshida, Nanako Katagiri, Yoichiro Iwakura.
  • Organizer: 9th International Conference on Complement Therapeutics.
  • Place of Presentation: Rhodes, Greece
  • Year and Date: 2016-06-28
  • Int'l Joint Research
• [Presentation] 真菌によるIL-17産生機構 (2016)
  • Author(s): 西城忍
  • Organizer: AMED-CREST若手研究会
  • Place of Presentation: 大阪アカデミア
  • Year and Date: 2016-06-15
  • Invited
• [Presentation] 炎症および感染防御におけるIL－17AとIL－17Fの役割 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 皮膚科学会モーニングセミナー
  • Place of Presentation: 京都国際会館
  • Year and Date: 2016-06-04
  • Invited
• [Presentation] 自己免疫疾患と感染防御におけるIL－17ファミリーの役割 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 御茶ノ水乾癬勉強会
  • Place of Presentation: TKRガーデンシティー御茶ノ水
  • Year and Date: 2016-05-21
  • Invited
• [Presentation] The role of C-type lectin receptors in the homeostasis of the intestinal immune system. (2016)
  • Author(s): Yoichiro Iwakura
  • Organizer: Korean Society for Biochemistry and Molecular Biology (KSBMB) International Conference 2016
  • Place of Presentation: Korea, Coex, Seoul
  • Year and Date: 2016-05-18
  • Int'l Joint Research / Invited
• [Presentation] 補体制御因子CTRP6と炎症性疾患 (2016)
  • Author(s): 村山正承、松尾謙蔵、吉田佳織、片桐菜々子、岩倉洋一郎
  • Organizer: 第81回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 長崎大学坂本キャンパス良順会館
  • Year and Date: 2016-05-13
• [Presentation] IL-1Ra KOマウスにおける胸腺T細胞分化の解析. (2016)
  • Author(s): 秋津葵、岩倉洋一郎
  • Organizer: 第26回Kyoto T cells conference.
  • Place of Presentation: 比叡山延暦寺内比叡山会館
  • Year and Date: 2016-05-13
• [Presentation] 自然免疫による病原体防御の新展開 (2016)
  • Author(s): 西城忍
  • Organizer: 第8回に本インターフェロン・サイトカイン学術集会
  • Place of Presentation: 長崎大学良順会館
  • Year and Date: 2016-05-13
  • Invited
• [Presentation] シンポジウム17「リウマチ性疾患における自己免疫と自然免疫」 (2016)
  • Author(s): 岩倉洋一郎
  • Organizer: 第６０回日本リウマチ学会総会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-04-23
  • Invited
• [Presentation] 腸管免疫の恒常性維持に於けるC型レクチンの役割 (2015)
  • Author(s): 岩倉洋一郎
  • Organizer: 千葉大学真菌医学 研究センターセミナー
  • Place of Presentation: 千葉大学真菌医学研究センター
  • Year and Date: 2015-12-15
  • Invited
• [Presentation] The roles of C-type lectin receptors in the homeostasis of the intestinal immune system (2015)
  • Author(s): Yoichiro Iwakura
  • Organizer: Advanced Institute for Medical Sciences
  • Place of Presentation: Dalian Medical University
  • Year and Date: 2015-12-09
  • Invited
• [Presentation] The roles of C-type lectin receptors in the homeostasis of the intestinal immune system (2015)
  • Author(s): Yoichiro Iwakura
  • Organizer: Shenzhen Institute of Advanced Technology
  • Place of Presentation: Chinese Academy of Science, Shenzhen,
  • Year and Date: 2015-12-07
  • Int'l Joint Research / Invited
• [Presentation] 関節リウマチのモデル動物 第９回 in vivo実験医学シンポジウム「免疫疾患における動物モデルを用いた病態解明と治療への応用」 (2015)
  • Author(s): 岩倉洋一郎
  • Organizer: 公益財団法人実験動物中央研究所主催
  • Place of Presentation: 学士会館
  • Year and Date: 2015-12-03
  • Invited
• [Presentation] DCIR maintains bone homeostasis by regulating IFN-g; production in T cells. (2015)
  • Author(s): Tomonori Kaifu, Takumi Maruhashi, Rikio Yabe, Soo-hyun Chung,N, Yoichiro Iwakura.
  • Organizer: 第44回日本免疫学会総会・学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] 自己免疫疾患および感染防御におけるIL-17A、IL-17Fの役割の解明 (2015)
  • Author(s): 岩倉洋一郎
  • Organizer: 野口英世記念医学賞受賞記念講演
  • Place of Presentation: 猪苗代町体験交流館学びいなホール
  • Year and Date: 2015-11-07
  • Invited
• [Presentation] C型レクチン受容体DCIR欠損マウスで認められた関節強直と骨量増加の病態解析 (2015)
  • Author(s): 海部知則、丸橋拓海、矢部力朗、鄭琇絢、妹尾彬正、藤門範行、岩倉洋一郎
  • Organizer: 日本リウマチ学会第2回JCRベーシックリサーチカンファレンス
  • Place of Presentation: 東京大学
  • Year and Date: 2015-10-02
• [Presentation] Basic Research for Infection, Inflammation, and Immunity Using Gene-Modified Mice (2015)
  • Author(s): Yoichiro Iwakura
  • Organizer: Dalian Medical University (Sponsored by Prof. Yigjie Wu)
  • Place of Presentation: Dalian Medical University
  • Year and Date: 2015-08-30
  • Int'l Joint Research / Invited
• [Presentation] The roles of C-type lectin receptors in the homeostasis of the intestinal immune system (2015)
  • Author(s): Yoichiro Iwakura
  • Organizer: National Defense Medical Center, (Sponsored by Prof. Ann Chen)
  • Place of Presentation: National Defense Medical Center, Taipei
  • Year and Date: 2015-08-21
  • Int'l Joint Research / Invited
• [Presentation] 自己免疫発症における補体第二経路特異的制御因子CTRP6の役割 (2015)
  • Author(s): 村山正承、吉田佳織、松尾謙蔵、岩倉洋一郎
  • Organizer: 第52回日本補体学会学術集会
  • Place of Presentation: 名古屋大学医学部附属病院
  • Year and Date: 2015-08-21
• [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine. (2015)
  • Author(s): Ce Tang, Tomonori Kamina, Yoichiro Iwakura.
  • Organizer: Third Annual Meeting of the International Cytokine & Interferon Society (ICIS).
  • Place of Presentation: Bamberg, Germany
  • Year and Date: 2015-08-11
  • Int'l Joint Research
• [Presentation] DCIR maintains bone homeostasis by regulating IFN-γ production in T cells. (2015)
  • Author(s): Tomonori Kaifu, Takumi Maruhashi, Rikio Yabe, Soo-hyun Chung, Akimasa Seno, Noriyuki Fujikado, Yoichiro Iwakura.
  • Organizer: Third Annual Meeting of the International Cytokine & Interferon Society (ICIS).
  • Place of Presentation: Bamberg, Germany
  • Year and Date: 2015-08-11
  • Int'l Joint Research
• [Presentation] CTRP6, complement regulator, effectively treats induced arthritis. (2015)
  • Author(s): Masanori Murayama, Yoichiro Iwakura.
  • Organizer: Third Annual Meeting of the International Cytokine & Interferon Society (ICIS).
  • Place of Presentation: Bamberg, Germany
  • Year and Date: 2015-08-11
  • Int'l Joint Research
• [Presentation] C型レクチンによる感染防御機構 (2015)
  • Author(s): 西城忍
  • Organizer: 第34回に本糖質学会
  • Place of Presentation: 東京大学安田講堂
  • Year and Date: 2015-07-31
  • Invited
• [Presentation] The role of Dectin-1 in the homeostasis of the intestinal immune system (2015)
  • Author(s): Yoichiro Iwakura
  • Organizer: International Symposium of the Center for Animal Disease Models 2015
  • Place of Presentation: Gakushi-kaikan, Tokyo
  • Year and Date: 2015-07-21
  • Int'l Joint Research / Invited
• [Presentation] IL-17産生性γδT細胞によるIL-1Ra KOマウスの関節炎発症メカニズム. (2015)
  • Author(s): 秋津葵、角田茂、 西城忍、 岩倉洋一郎.
  • Organizer: 第80回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2015-07-17
• [Presentation] 新たな補体制御因子CTRP6による補体制御機構および関節リウマチに対する治療効果の検討. (2015)
  • Author(s): 村山正承、岩倉洋一郎
  • Organizer: 第80回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2015-07-17
• [Presentation] 大腸炎発症におけるIL-1受容体II型の機能解析. (2015)
  • Author(s): 吉田佳織、清水謙次、村山正承、岩倉洋一郎
  • Organizer: 第80回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2015-07-17
• [Presentation] マウスモデルを用いた関節リウマチ発症機構の解析と治療への応用 (2015)
  • Author(s): 岩倉洋一郎
  • Organizer: 第26回に本生体防御学会
  • Place of Presentation: 台東区生涯学習センターミレミアムホール
  • Year and Date: 2015-07-11
  • Invited
• [Presentation] 細菌・真菌の細胞壁構成成分とC型レクチン受容体による認識 (2015)
  • Author(s): 西城忍
  • Organizer: 第24回内毒素・LPS研究会
  • Place of Presentation: 東京大学農学部中島薫一郎記念ホール
  • Year and Date: 2015-06-27
  • Invited
• [Presentation] 炎症および感染防御に於けるIL-17AとIL-17Fの機能 (2015)
  • Author(s): 岩倉洋一郎
  • Organizer: 第114回日本皮膚科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-05-29
  • Invited
• [Presentation] 新規大腸炎モデルRag2-/-Il1rn-/-マウスはILC3 細胞由来IL-17A が病態形成に重要な役割を果たしている (2015)
  • Author(s): 秋津葵、角田茂、 西城忍、 岩倉洋一郎.
  • Organizer: 第62回日本実験動物学会
  • Place of Presentation: 京都テルサ
  • Year and Date: 2015-05-28
• [Presentation] 東京理科大学生命医科学研究所実験動物研究部門における遺伝子改変マウス供給について. (2015)
  • Author(s): 久保幸子、海部知則、岩倉洋一郎
  • Organizer: 第62回日本実験動物学会
  • Place of Presentation: 京都テルサ
  • Year and Date: 2015-05-28
• [Presentation] 炎症および感染防御に於けるIL-17AとIL-17Fの機能 (2015)
  • Author(s): 岩倉洋一郎
  • Organizer: ふじのくに乾癬Expert Meeting
  • Place of Presentation: 静岡市グランディエール ブケ・トーカイ
  • Year and Date: 2015-04-16
  • Invited
• [Presentation] 炎症および感染防御に於けるIL-17AとIL-17Fの機能 (2015)
  • Author(s): 岩倉洋一郎
  • Organizer: Psoriasis and IL-17A Forum 2015
  • Place of Presentation: 東京六本木ミッドタウンホール、東京都
  • Year and Date: 2015-03-07
  • Invited
• [Presentation] 自己炎症、自己免疫に於けるIL-1の役割 (2015)
  • Author(s): 岩倉洋一郎
  • Organizer: 第8回自己炎症疾患研究会
  • Place of Presentation: フクラシア東京ステーション、東京都
  • Year and Date: 2015-02-07
  • Invited
• [Presentation] Pathogenic mechanisms of rheumatoid arthritis revealed by animal models. (2015)
  • Author(s): 岩倉洋一郎
  • Organizer: The Fourth Bizan Immunology Symposium at University of Tokushima (BISUT4) “Immune System Development, Deviation, and Regulation”
  • Place of Presentation: Fujii Memorial Hall, University of Tokushima,Tokushima
  • Year and Date: 2015-01-29 – 2015-01-30
  • Invited
• [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to an intrinsic defect in IL-17-producing gammadelta T cells. (2015)
  • Author(s): 秋津葵
  • Organizer: The Fourth Bizan Immunology Symposium at University of Tokushima (BISUT4) “Immune System Development, Deviation, and Regulation”
  • Place of Presentation: Fujii Memorial Hall, University of Tokushima,Tokushima
  • Year and Date: 2015-01-29 – 2015-01-30
• [Presentation] Dectin-1の腸管免疫に果たす役割 (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: 糖鎖免疫研究会Glyco-Immunology2014
  • Place of Presentation: 東京医科歯科大学
  • Invited
• [Presentation] IFN-γ is an osteoblatogenic factor for increasing the bone volume in DCIR-deficient mice. (2014)
  • Author(s): 海部知則
  • Organizer: 第43回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] CTRP3 plays an important role in the development of collagen-induced arthritis (2014)
  • Author(s): 村山正承
  • Organizer: 第43回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to an intrinsic defect in IL-17-producing gammadelta T cells. (2014)
  • Author(s): 秋津葵
  • Organizer: 第43回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Dectin-1 signaling modifies colonic microflora by inducing IL-17F-dependent antimicrobial peptide S100A8 expression. (2014)
  • Author(s): 神谷知憲
  • Organizer: 第43回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Interleukin-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting interleukin-1 signal on macrophages. (2014)
  • Author(s): 清水謙次
  • Organizer: 第43回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine. (2014)
  • Author(s): 唐策
  • Organizer: 第43回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] 抑制型Ｃ型レクチン受容体Dendritic Cell ImmunoReceptor (DCIR)とIFN-ｇによる骨代謝制御 (2014)
  • Author(s): 海部知則
  • Organizer: 第181回日仏生物学会例会
  • Place of Presentation: 京都産業大学むすびわざ館、京都府
  • Year and Date: 2014-12-06
• [Presentation] 免疫系、および骨代謝系の恒常性維持に於けるDCIRの役割 (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: 糖鎖科学コンソーシアムシンポジウムー糖鎖創薬を目指して、感染、炎症、免疫と糖鎖科学―、
  • Place of Presentation: 東京医科歯科大学、東京都
  • Year and Date: 2014-12-04 – 2014-12-05
  • Invited
• [Presentation] Gene manipulated mice as a tool to develop new drugs. (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: China-US innovation dialogue on gene engineering animal models and medical research international forum.
  • Place of Presentation: Dalian, China
  • Year and Date: 2014-11-22 – 2014-11-24
  • Invited
• [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to an intrinsic defect in IL-17-producing gammadelta T cells. (2014)
  • Author(s): 秋津葵
  • Organizer: The International Cytokine and International Society 2014 Annual Meeting.
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2014-10-26 – 2014-10-29
• [Presentation] Dectin-1 modifies colonic microflora by inducing cytokine-dependent antimicrobial peptide secretion from intestinal epithelial cells. (2014)
  • Author(s): 神谷知憲
  • Organizer: The International Cytokine and International Society 2014 Annual Meeting.
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2014-10-26 – 2014-10-29
• [Presentation] Interleukin-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting interleukin-1 signal on macrophages. (2014)
  • Author(s): 清水謙次
  • Organizer: The International Cytokine and International Society 2014 Annual Meeting.
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2014-10-26 – 2014-10-29
• [Presentation] マウスモデルを用いた関節リウマチ発症機構の解析 (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: 第１回アニュアルベーシックコースレクチャー特別講演
  • Place of Presentation: アキバホール、東京都
  • Year and Date: 2014-10-25
  • Invited
• [Presentation] 真菌感染防御機構とC型レクチン (2014)
  • Author(s): 西城忍
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2014-10-15 – 2014-10-18
  • Invited
• [Presentation] The role of DCIR in maintaining the homeostasis of the immune system and the bone. (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: Novo Nordisk Innovation Summit,
  • Place of Presentation: Institute of Medical Science, University of Tokyo,Tokyo
  • Year and Date: 2014-10-01 – 2014-10-02
  • Invited
• [Presentation] 真菌感染防御機構におけるC型レクチンの役割 (2014)
  • Author(s): 西城忍
  • Organizer: 第26回微生物シンポジウム
  • Place of Presentation: 都市センターホテル、東京都
  • Year and Date: 2014-09-19 – 2014-09-20
  • Invited
• [Presentation] 真菌感染に対する生体防御システム (2014)
  • Author(s): 西城忍
  • Organizer: 千葉大学未来医療教育研究機構シンポジウム 第４部「亥鼻キャンパスの特色ある先端研究・教育の紹介」
  • Place of Presentation: ステーションコンファレンス東京６階、東京都
  • Year and Date: 2014-07-26
  • Invited
• [Presentation] 遺伝子改変マウスを用いた関節リウマチ発症機構の解析 (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: 東京理科大学生命医科学研究所ヒト疾患モデル研究センター動物実験棟竣工記念シンポジウム「ヒト疾患モデル研究拠点の構築を目指して」
  • Place of Presentation: 東京理科大学野田薬学部大講堂、千葉県
  • Year and Date: 2014-07-12
  • Invited
• [Presentation] The role of Dectin-1 and Dectin-2 in the host defense against fungi and in intestinal immunity. (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: International Symposium Human Genetics
  • Place of Presentation: Novosibirsk, Russia
  • Year and Date: 2014-06-23 – 2014-06-28
  • Invited
• [Presentation] 抑制性C型レクチン受容体DCIRによるIFN-ｇを介した骨代謝制御機構 (2014)
  • Author(s): 海部知則
  • Organizer: 第79回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北海道大学医学部学友会館フラテホール、北海道
  • Year and Date: 2014-06-19 – 2014-06-20
• [Presentation] 抑制性C型レクチン受容体DCIRによる骨代謝制御機構 (2014)
  • Author(s): 海部知則
  • Organizer: 北海道大学 遺伝子病制御研究所 IGMセミナー
  • Place of Presentation: 北海道大学、北海道
  • Year and Date: 2014-06-18
  • Invited
• [Presentation] 海藻由来βグルカンによる腸管免疫制御 (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: 第16回マリンバイオテクノロジー学会大会「マリンバイオ三重2014」シンポジウム「藻類の機能性とバイオリファイナリーへの展開」
  • Place of Presentation: 三重大学生物資源学部、三重県
  • Year and Date: 2014-06-01
  • Invited
• [Presentation] 創薬に於ける実験動物の役割 (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: 第６１回日本実験動物学会市民公開講座「人々の健康に貢献する動物実験と実験動物の福祉」
  • Place of Presentation: 札幌コンベンションセンター特別会議場、北海道
  • Year and Date: 2014-05-17
  • Invited
• [Presentation] DCIR欠損マウスで認められた骨量増加メカニズムの解明 (2014)
  • Author(s): 海部知則
  • Organizer: 第61回日本実験動物学会総会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] 東京理科大学生命医科学研究所実験動物研究部門における遺伝子改変マウス供給について (2014)
  • Author(s): 久保幸子
  • Organizer: 第61回日本実験動物学会総会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] 関節リウマチモデルにおけるCTRP3の役割の解析 (2014)
  • Author(s): 村山正承
  • Organizer: 第61回日本実験動物学会総会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] Rag2-/-Il1rn-/-マウスはILC3 細胞由来IL-17A が病態形成に重要な役割を果たしている (2014)
  • Author(s): 秋津葵
  • Organizer: 第61回日本実験動物学会総会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] Dectin-1シグナルを介するマウス腸管炎症の抑制による新規な腸疾患治療法開発 (2014)
  • Author(s): 唐策
  • Organizer: 第61回日本実験動物学会総会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] 自己免疫、及び感染防御に於けるIL-17の役割 (2014)
  • Author(s): 岩倉洋一郎
  • Organizer: 第10回皮膚免疫疾患研究会
  • Place of Presentation: ヒルトン大阪、大阪府
  • Year and Date: 2014-04-10
  • Invited
• [Presentation] Dcir-deficient mice as a novel model for ankylosing spondylitis (2013)
  • Author(s): 岩倉洋一郎
  • Organizer: 第57回日本リウマチ学会シンポジウム３
  • Place of Presentation: 京都国際会館
  • Invited
• [Presentation] The roles of IL-17A and IL-17F in inflammation, tumorigenesis, and host defense against pathogens (2013)
  • Author(s): Iwakura, Y.
  • Organizer: National Defense Medical Center, Taipei (Host: Prof. Ann Chen)
  • Place of Presentation: Taipei
  • Invited
• [Presentation] Novel complement regulator CTRP6 effectively treats induced arthritis (2013)
  • Author(s): Iwakura, Y.
  • Organizer: JSICR-MMCB 2013 Joint Symposium in Tokyo, Toshi Center Hotel
  • Place of Presentation: Tokyo
  • Invited
• [Presentation] The Roles of IL-1 and IL-17 in the Development of Arthritis and Dermatitis in Animal Models (2013)
  • Author(s): Iwakura, Y.
  • Organizer: The 8th annual meeting of the Taiwaneese Society for Investigative Dermatology. Lecture Hall, Medical College of National Taiwan University (Shiou-Hwa Jee, President)
  • Place of Presentation: Taipei
  • Invited
• [Presentation] マウスを使った関節リウマチ治療法の研究 (2013)
  • Author(s): 岩倉洋一郎
  • Organizer: 免疫ふしぎ未来2013
  • Place of Presentation: 日本化学未来館
  • Invited
• [Presentation] Pathways in inflammatory diseases (chair and speaker) (2013)
  • Author(s): Iwakura, Y.
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
  • Invited
• [Presentation] 自然免疫修飾による健康増進を目指した高機能食品開発の試み (2013)
  • Author(s): 岩倉洋一郎
  • Organizer: アグリビジネス創出フェア
  • Place of Presentation: 東京国際展示場
  • Invited
• [Presentation] 腸管免疫に於ける自然免疫の役割 (2013)
  • Author(s): 岩倉洋一郎
  • Organizer: 北海道大学遺伝子病制御研究所講演会
  • Place of Presentation: 北海道大学遺伝子病制御研究所
  • Invited
• [Presentation] L-17およびTh17の自己免疫疾患に於ける役割 (2013)
  • Author(s): 岩倉洋一郎
  • Organizer: ノバルティスScientific Advisory Meeting, The Prince Tower
  • Place of Presentation: Sakura Tower Tokyo,高輪
  • Invited
• [Presentation] Dectin-1 signaling synergistically enhances toll-like receptor-mediated production of interferon beta. (2013)
  • Author(s): Kadoki, M., Sasaki, Y., Tang, C., Kamiya, T., and Iwakura, Y.
  • Organizer: 2013 Inaugural Meeting of the International Cytokine and Interferon Society (ICIS)
  • Place of Presentation: San Francisco, USA
• [Presentation] CCR8 deficiency causes exacerbation of contact hypersensitivity due to enhanced dendritic cell migration. (2013)
  • Author(s): Yabe, R. Shimizu, K. Shimizu, S. Azechi, S. Choi, BI. Kubo, S. Kakuta, S. Nakae, S. and Iwakura, Y.
  • Organizer: 2013 Inaugural Meeting of the International Cytokine and Interferon Society (ICIS)
  • Place of Presentation: San Francisco, USA
• [Presentation] IL-17-producing gamma-delta T cells are crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. (2013)
  • Author(s): Akitsu A., Ishigame H., Kakuta S., Saijo S., Iwakura Y.
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Dendritic Cell ImmunoReceptor (DCIR) is a negative regulator in balancing bone metabolism. (2013)
  • Author(s): Kaifu T., Maruhashi T, Ma G, Yabe R, Seno A, Iwakura Y.
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] 新たな補体制御因子CTRP6の関節リウマチに対する治療効果 (2013)
  • Author(s): 村山正承、米沢朋、岩倉洋一郎.
  • Organizer: 第一回筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学
• [Presentation] インターロイキン－１受容体２型欠損マウスにおけるコラーゲン誘導関節炎の増悪化. (2013)
  • Author(s): 清水謙次、角田茂、溝呂木暁彦、宝来玲子、中嶋明子、岩倉洋一郎
  • Organizer: 第60回日本実験動物学会総会
  • Place of Presentation: つくば国際会議場
• [Presentation] 炎症性大腸炎の病態形成におけるDectin-1の新規の役割解析. (2013)
  • Author(s): 唐策
  • Organizer: 第60回日本実験動物学会総会
  • Place of Presentation: つくば国際会議場
• [Presentation] DCIR欠損マウスを用いたC型レクチン受容体による骨代謝制御機構の解明. (2013)
  • Author(s): 海部知則、丸橋拓海、馬光宇、矢部力朗、妹尾彬正、岩倉洋一郎.
  • Organizer: 第60回日本実験動物学会総会
  • Place of Presentation: つくば国際会議場
• [Presentation] 遺伝子欠損マウスを用いたIL-1の負の調節因子群の機能解析． (2013)
  • Author(s): 五十嵐哲郎、清水謙次、秋津葵、久保幸子、劉陽、中嶋明子、宝来玲子、石亀晴道、松本清司、久和茂、岩倉洋一郎、角田茂．
  • Organizer: 第156回日本獣医学会学術集会
  • Place of Presentation: 岐阜大、岐阜
• [Presentation] 疾患モデルマウスを用いたIL1/IL17ファミリー遺伝子の腸管ポリープ形成における役割． (2013)
  • Author(s): 角田茂、鈴木俊佐、佐々木大和、五十嵐哲郎、渋川茉莉、村山正承、秋津葵、岡江寛明、石亀晴道、松本清司、久和茂、岩倉洋一郎．
  • Organizer: 第156回日本獣医学会学術集会
  • Place of Presentation: 岐阜大、岐阜
• [Presentation] IL-17産生性γδT細胞はリウマチ様関節炎発症に重要である (2012)
  • Author(s): 秋津葵
  • Organizer: 第77回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 神戸商工会議所
• [Presentation] 遺伝子変異マウスを用いたIL-17A/Fの消化管における機能の解析 (2012)
  • Author(s): 角田茂
  • Organizer: 第21回内毒素・LPS研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Rheumatoid Arthritis Models (2012)
  • Author(s): Iwakura, Y.
  • Organizer: Novartis IL-17 Scientific Advisory Board
  • Place of Presentation: Frankfurt, Germany
  • Invited
• [Presentation] 腸管ポリープ形成とIL1/IL17の役割 (2012)
  • Author(s): 角田茂
  • Organizer: 第7回遺伝子栄養学研究会
  • Place of Presentation: 北広島クラッセホテル
• [Presentation] C-type Lectin Receptor DCIR and the Complement System as Targets for the Treatment of Rheumatoid Arthritis (2012)
  • Author(s): Iwakura, Y.
  • Organizer: Translational Inflammation Summit, The International Association of Inflammation Societies (IAIS), “Defining the Frontiers and Translational Pathways of Inflammation Research”
  • Place of Presentation: Bolton Landing, NY
  • Invited
• [Presentation] Dendritic immunoreceptor (DCIR) is a negative regulator in osteoclastogenesis (2012)
  • Author(s): Kaifu, T
  • Organizer: Basic and Clinical Review Course, The 15th Congress of Asia Pacific League of Associations for Rheumatology (APLAR 2012)
  • Place of Presentation: Dead Sea, Jordan
• [Presentation] Animal Models for Rheumatoid Arthritis (2012)
  • Author(s): Iwakura, Y.
  • Organizer: Basic and Clinical Review Course, The 15th Congress of Asia Pacific League of Associations for Rheumatology (APLAR 2012)
  • Place of Presentation: Dead Sea, Jordan
  • Invited
• [Presentation] A novel role of Dectin-1 signaling in promoting intestinal inflammation (2012)
  • Author(s): Tang, C
  • Organizer: 10th joint annual meeting of the interferon and cytokine society and the international society for interferon and cytokine research (Cytokine2012)
  • Place of Presentation: Geneva, Switzerland
• [Presentation] IL-17-producing γδ T cells are crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice (2012)
  • Author(s): Akitsu, A
  • Organizer: 10th joint annual meeting of the interferon and cytokine society and the international society for interferon and cytokine research (Cytokine2012)
  • Place of Presentation: Geneva, Switzerland
• [Presentation] The Roles of IL-17A and IL-17F in Inflammation, Tumorigenesis, and Host Defense against Pathogens (2012)
  • Author(s): Iwakura, Y.
  • Organizer: 10th joint annual meeting of the interferon and cytokine society and the international society for interferon and cytokine research (Cytokine2012)
  • Place of Presentation: Geneva, Switzerland
  • Invited
• [Presentation] 関節炎発症における補体の役割とC1qTNFによる制御 (2012)
  • Author(s): 岩倉洋一郎
  • Organizer: 第４０回日本臨床免疫学会シンポジウム２「分子標的治療から見た病態へのアプローチ」
  • Place of Presentation: 東京
  • Invited
• [Presentation] 疾患モデルを用いた関節リウマチ発症機構の解析 (2012)
  • Author(s): 岩倉洋一郎
  • Organizer: 第１２回臨床免疫セミナー in Kyoto
  • Place of Presentation: 京都
  • Invited
• [Presentation] Roles of IL-17A and IL-17F in host defense against pathogens and intestinal tumors (2012)
  • Author(s): Iwakura, Y.
  • Organizer: The 34th Naito Conference “Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine”
  • Place of Presentation: シャトレーゼ ガトーキングダム サッポロ、札幌
  • Invited
• [Presentation] 疾患モデルを用いた関節リウマチ発症機構の解析 (2012)
  • Author(s): 岩倉洋一郎
  • Organizer: 筑波大学-東京理科大学生命医科学研究所合同シンポジウム「難治性免疫疾患・アレルギー疾患の克服を目指して」
  • Place of Presentation: 学士会館、東京
  • Invited
• [Presentation] 関節炎発症に於ける補体系の役割 (2012)
  • Author(s): 岩倉洋一郎
  • Organizer: 第93回発生工学・疾患モデル研究会“終了記念講演会”
  • Place of Presentation: ホテル東京ガーデンパレス、東京
  • Invited
• [Presentation] IL-17-producing γδ T cells are crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice (2012)
  • Author(s): Akitsu, A
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] DCIR deficient mice as a novel model of ankylosing spondylitis (2012)
  • Author(s): Maruhashi, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Dendritic Cell ImmunoReceptor (DCIR) negatively regulates osteoclastogenesis (2012)
  • Author(s): Kaifu, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Dectin-1 signaling regulates the balance of intestinal microflora (2012)
  • Author(s): Kamiya, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Book] トピックス 「自己免疫疾患に対する新たな治療標的の発見」 (2017)
  • Author(s): 村山正承、岩倉洋一郎
  • Total Pages: 4
  • Publisher: 理大科学フォーラム
• [Book] セミナー室「低分子βグルカン摂取により炎症性腸疾患を予防，改善する」 (2016)
  • Author(s): 唐策、角田茂、岩倉洋一郎
  • Total Pages: 6
  • Publisher: 日本農芸化学会
• [Book] Dendritic Cell Immunoreceptor (DCIR): An ITIM-Harboring C-Type Lectin Receptor. (2016)
  • Author(s): Tomonori Kaifu and Yoichiro Iwakura.
  • Total Pages: 12
  • Publisher: Springer Japan
• [Book] IL－1ファミリー分子による免疫制御 (2016)
  • Author(s): 秋津葵、岩倉洋一郎
  • Total Pages: 7
  • Publisher: 科学評論社
• [Book] 医歯薬出版株式会社 (2016)
  • Author(s): 秋津葵、岩倉洋一郎
  • Total Pages: 5
  • Publisher: 自己免疫性関節炎と病原性T細胞
• [Book] Chronic inflammation (2016)
  • Author(s): Saijo S
  • Total Pages: 12
  • Publisher: Springer Japan
• [Book] C-type lectin receptors in immunity (2016)
  • Author(s): Yabe R. and Saijo S.
  • Total Pages: 12
  • Publisher: Springer Japan
• [Book] C-type Lectin Receptors in Immunity (2016)
  • Author(s): Yabe, R. and Saijo, S
  • Total Pages: 215
  • Publisher: Springer
• [Book] 第1章 インターロイキン「IL-1」 サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 清水謙次、岩倉洋一郎
  • Total Pages: 3
  • Publisher: 洋土社
• [Book] 第1章 インターロイキン「IL-18/33/36/37」 サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 海部知則、岩倉洋一郎
  • Total Pages: 3
  • Publisher: 洋土社
• [Book] 第1章 インターロイキン「IL-12」 サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 矢部力朗、岩倉洋一郎
  • Total Pages: 2
  • Publisher: 洋土社
• [Book] 第1章 インターロイキン「IL-23/35」 サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 唐策、岩倉洋一郎
  • Total Pages: 3
  • Publisher: 洋土社
• [Book] 第1章 インターロイキン「IL-10」 サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 鄭琇絢、岩倉洋一郎
  • Total Pages: 3
  • Publisher: 洋土社
• [Book] 第1章 インターロイキン「IL-19/20/22/24/26」 サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 神谷知憲、岩倉洋一郎
  • Total Pages: 3
  • Publisher: 洋土社
• [Book] 第1章 インターロイキン「IL-17A/17B/17C/17D/17E/17F」 サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 秋津葵、岩倉洋一郎
  • Total Pages: 3
  • Publisher: 洋土社
• [Book] 第1章 インターロイキン「IL-14」「IL-16」「IL-32」サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 村山正承、岩倉洋一郎
  • Total Pages: 3
  • Publisher: 洋土社
• [Book] 第1章 インターロイキン「成長ホルモン」「プロラクチン」サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 米沢朋、丸田大貴、岩倉洋一郎
  • Total Pages: 5
  • Publisher: 洋土社
• [Book] 第2章 インターフェロン「概論」「IFN-α/β」「IFN-γ」「IFN-λファミリー（IL-28, IL-29）」サイトカイン・増殖因子キーワード事典 (2015)
  • Author(s): 角田茂、岩倉洋一郎
  • Total Pages: 10
  • Publisher: 洋土社
• [Book] 【大学発 日本 人と技術】日本を支える研究活動と技術開発 関節リウマチの新たな治療薬開発 (2015)
  • Author(s): 村山正承、岩倉洋一郎
  • Total Pages: 1
  • Publisher: フジサンケイビジネスアイ
• [Book] Current Topics. デクチン1シグナルの阻害は、腸内乳酸桿菌を増殖させ、制御性Ｔ細胞を増加させることによって、大腸炎を抑制する」実験医学2016 (2015)
  • Author(s): 唐策、岩倉洋一郎
  • Total Pages: 4
  • Publisher: 洋土社
• [Book] 実験医学増刊、炎症―全体像を知り慢性炎症を制御するー (2014)
  • Author(s): 矢部力朗、岩倉洋一郎、西城忍
  • Total Pages: 219
  • Publisher: 羊土社
• [Book] サイトカインと自己免疫疾患．EXPERT膠原病・リウマチ 改訂第３版（住田孝之編） (2013)
  • Author(s): 角田茂、岩倉洋一郎
  • Publisher: 診断と治療社
• [Remarks] 東京理科大学生命医科学研究所実験動物学研究部門
  • URL: http://www.rs.tus.ac.jp/iwakuralab/
• [Remarks] 東京理科大学生命医科学研究所ヒト疾患モデル研究センター
  • URL: http://www.ribs.tus.ac.jp/index.php/cadm/
• [Remarks] 千葉大学真菌医学研究センター感染免疫分野
  • URL: http://cytokine.pf.chiba-u.jp/
• [Remarks] 東京理科大学 生命医科学研究所 実験動物学研究部門 岩倉研究室
  • URL: http://www.rs.tus.ac.jp/iwakuralab/
• [Patent(Industrial Property Rights)] 樹状細胞免疫受容体活性化剤、樹状細胞免疫受容体活性化方法、破骨細胞形成抑制剤、破骨細胞形成抑制方法、樹状細胞分化・増殖阻害剤、樹状細胞分化・増殖阻害方法 (2014)
  • Inventor(s): 岩倉洋一郎、海部知則、矢部力朗
  • Industrial Property Rights Holder: 岩倉洋一郎、海部知則、矢部力朗
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-07-11
  • Application Year: 2014
• [Patent(Industrial Property Rights)] CTRP3 plays an important role in the development of collagen-induced arthritis in mice. (2013)
  • Inventor(s): 岩倉洋一郎，村山正承
  • Industrial Property Rights Holder: 東京理科大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-11-15
  • Application Year: 2013
  • Overseas
• [Patent(Industrial Property Rights)] 自己免疫疾患治療及び予防薬としてのCTRP6 (2012)
  • Inventor(s): 岩倉洋一郎，村山正承，石亀晴道，角田茂 (東京大学)
  • Industrial Property Rights Holder: 岩倉洋一郎，村山正承，石亀晴道，角田茂 (東京大学)
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-11-22
  • Application Year: 2012
  • Overseas