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Establishment of an IL-1-related gene-manipulated mouse library and dissection of the gene-targeted mice, aiming at identifying new therapeutic targets for diseases

Research Project

Project/Area Number 24220011
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionTokyo University of Science

Principal Investigator

Iwakura Yoichiro  東京理科大学, 研究推進機構生命医科学研究所, 教授 (10089120)

Co-Investigator(Kenkyū-buntansha) 西城 忍  千葉大学, 真菌医学研究センター, 准教授 (60396877)
海部 知則  東京理科大学, 生命医科学研究所, 助教 (90343037)
島津 朋之  東京理科大学, 研究推進機構生命医科学研究所, 助教 (20616437)
Project Period (FY) 2012-05-31 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥218,010,000 (Direct Cost: ¥167,700,000、Indirect Cost: ¥50,310,000)
Fiscal Year 2016: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2015: ¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000)
Fiscal Year 2014: ¥51,090,000 (Direct Cost: ¥39,300,000、Indirect Cost: ¥11,790,000)
Fiscal Year 2013: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Fiscal Year 2012: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
KeywordsIL-1 / CTRP / C型レクチン / サイトカイン / 遺伝子改変マウス / C1qTNF / 免疫学 / 実験動物
Outline of Final Research Achievements

In this project, we aimed to find target molecules for the development of new drugs by generating gene-targeted mice of the IL-1 and its down-stream genes, and tried to distribute these mice to researchers in need. We found that excess IL-1 signaling causes Th17 cell differentiation and induce IL-17 in γδ T cells. Excess IL-1 signaling also affects clonal selection of CD4+ T cells in the thymus and causes autoimmune arthritis. We also showed that many of C-type lectins play important roles in the host defense against fungal and mycobacterium infection. We also found that CTRP3 and CTRP6, which are induced downstream of IL-1, can suppress the development of inflammatory diseases such as autoimmune arthritis, suggesting a possibility that these molecules could be used as medicines. To enhance the research in this field, we distributed these gene-targeted mice to 256 research groups in these 5 years.

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(9 results)
  • 2017 Research Progress Assessment (Verification Result) ( PDF )
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (302 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (145 results) (of which Int'l Joint Research: 29 results,  Peer Reviewed: 143 results,  Open Access: 54 results,  Acknowledgement Compliant: 13 results) Presentation (128 results) (of which Int'l Joint Research: 16 results,  Invited: 72 results) Book (22 results) Remarks (4 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Absence of DCIR1 reduces the rate of endotoxemic hepatitis in mice.2017

    • Author(s)
      Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y ,Inaba K, Takahara K.
    • Journal Title

      Eur J Immunol.

      Volume: 47 Issue: 4 Pages: 704-712

    • DOI

      10.1002/eji.201646814

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin.2017

    • Author(s)
      Takagi N, Kawakami K, Kanno E, Tanno H, Takeda A, Ishii K, Imai Y, Iwakura Y, Tachi M.
    • Journal Title

      Dermatol.

      Volume: 26 Issue: 2 Pages: 137-144

    • DOI

      10.1111/exd.13115

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preferentially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice.2017

    • Author(s)
      Inoue SI, Niikura M, Asahi H, Iwakura Y, Kawakami Y, Kobayashi F.
    • Journal Title

      Eur J Immunol.

      Volume: 47 Issue: 4 Pages: 685-691

    • DOI

      10.1002/eji.201646699

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells.2017

    • Author(s)
      Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H.
    • Journal Title

      J Immunol.

      Volume: 198 Issue: 1 Pages: 61-70

    • DOI

      10.4049/jimmunol.1502393

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells.2017

    • Author(s)
      Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
    • Journal Title

      Stem Cells.

      Volume: 35 Issue: 4 Pages: 989-1002

    • DOI

      10.1002/stem.2524

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation of joint-infiltrating cells.2016

    • Author(s)
      Akitsu A, Iwakura Y.
    • Journal Title

      Bio-Protocol.

      Volume: 6 Issue: 17

    • DOI

      10.21769/bioprotoc.1911

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.2016

    • Author(s)
      Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.
    • Journal Title

      Immunity.

      Volume: 45(6) Issue: 6 Pages: 1299-1310

    • DOI

      10.1016/j.immuni.2016.11.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection.2016

    • Author(s)
      Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G.
    • Journal Title

      Immun Inflamm Dis.

      Volume: 4 Issue: 4 Pages: 401-412

    • DOI

      10.1002/iid3.121

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.2016

    • Author(s)
      Kimura Y., Inoue A.., Hangai S.., Saijo S., Negishi H., Nishio J., Yamasaki S., Iwakura Y., Yanai H., Taniguchi T.
    • Journal Title

      Proc. Natl. Acad. Sci. U S A.

      Volume: 113 Issue: 49 Pages: 14097-14102

    • DOI

      10.1073/pnas.1617903113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two types of IL-17A-producing γδ T cells in protection against pulmonary infection with Klebsiella pneumoniae2016

    • Author(s)
      Murakami T., Hatano S., Yamada H., Iwakura Y., Yoshikai Y.
    • Journal Title

      J. Infect.Dis.

      Volume: 214 Issue: 11 Pages: 1752-1761

    • DOI

      10.1093/infdis/jiw443

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] IL-21 inhibits IL-17A-producing γδ T cell response after infection with Bacillus Calmette-Guerin via induction of apoptosis2016

    • Author(s)
      Huang Y., Matsumura Y., Hatano, S., Noguchi N., Murakamia, T., Iwakura Y., Sun X., Oharad N., Yoshikai Y.
    • Journal Title

      Innate Immun.

      Volume: 22 Issue: 8 Pages: 588-597

    • DOI

      10.1177/1753425916664125

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets.2016

    • Author(s)
      Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.
    • Journal Title

      Diabetes.

      Volume: 65 Issue: 8 Pages: 2462-2462

    • DOI

      10.2337/db16-ec08a

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IL-17A exacerbates cisplatin-based resistance of OVCA via upregulating the expression of ABCG2 and MDR1 through Gli1-mediated Hh signaling.2016

    • Author(s)
      Niu X, Liu W, Wang Y, Liu X, Zhang H, Li Z, Li H, Iwakura Y, Deng W.
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 0

    • DOI

      10.18632/oncotarget.10655

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The potential for repositioning antithyroid agents as antiasthma drugs2016

    • Author(s)
      Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 138 Issue: 5 Pages: 1458

    • DOI

      10.1016/j.jaci.2016.04.047

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.2016

    • Author(s)
      Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 9 Pages: 1206-14

    • DOI

      10.1111/cas.13005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.2016

    • Author(s)
      Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.
    • Journal Title

      J Biol Chem.

      Volume: 291 Issue: 34 Pages: 17629-38

    • DOI

      10.1074/jbc.m116.741256

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adiponectin enhances antibacterial activity of hematopoietic cells by suppressing bone marrow inflammation.2016

    • Author(s)
      Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, Iwakura Y, Yoshimura A, Kadowaki T, Kurokawa M
    • Journal Title

      Immunity

      Volume: 44 Issue: 6 Pages: 1422-33

    • DOI

      10.1016/j.immuni.2016.05.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.2016

    • Author(s)
      Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA.
    • Journal Title

      J Immunol.

      Volume: 197 Issue: 1 Pages: 278-87

    • DOI

      10.4049/jimmunol.1502485

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis2016

    • Author(s)
      Fabio Yoshikawa, Rikio Yabe, Yoichiro Iwakura, Sandro Rogerio de Almeida, Shinobu Saijo
    • Journal Title

      Innate Immunity

      Volume: in press Issue: 5 Pages: 316-24

    • DOI

      10.1177/1753425916645392

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension.2016

    • Author(s)
      Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS.
    • Journal Title

      Hypertension

      Volume: 68 Issue: 1 Pages: 167-74

    • DOI

      10.1161/hypertensionaha.116.07493

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system.2016

    • Author(s)
      Shishikura, M., Nakamura, F., Yamashita, N., Uetani, N., Iwakura, Y., and Goshima, Y.
    • Journal Title

      Brain Res.

      Volume: 1642 Pages: 244-254

    • DOI

      10.1016/j.brainres.2016.03.030

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] T cell-intrinsic ASC critically prootes Th17-mediated experimental autoimmune encephalomyelitis.2016

    • Author(s)
      Martin, B. N. , et al.
    • Journal Title

      Nat. Immunol.

      Volume: 17 Issue: 5 Pages: 583-592

    • DOI

      10.1038/ni.3389

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy.2016

    • Author(s)
      Javed, N., Xue, G., Lu, A., Xing, Y., Iwakura, Y., Xiao, H., Lecoeur, H., Spath, G. F., and Meng, G.
    • Journal Title

      Cytokine

      Volume: 81 Pages: 101-108

    • DOI

      10.1016/j.cyto.2016.03.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immune complexes indirectly suppress the generation of Th17 responses in vivo.2016

    • Author(s)
      Ciraci, C., Janczy, J. R., Jain, N., Haasken, S., Pecli, E. Silva, C., Benjamim, C. F., Sadler, J. J., Olivier. A. K., Iwakura, Y., Shayakhmetov, D. M., Sutterwala, F. S., and Cassel, S. L.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 3 Pages: e0151252-e0151252

    • DOI

      10.1371/journal.pone.0151252

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-17-producing γδ T cells enhance bone regeneration2016

    • Author(s)
      Ono T, et al.
    • Journal Title

      Nat Commun

      Volume: 7 Issue: 1 Pages: 10928-10928

    • DOI

      10.1038/ncomms10928

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mincle activation and the Syk/Card9 signaling axis are cetral to the development of autoimmune disease of the eye.2016

    • Author(s)
      Lee, E. J., Brown, B. R., Vance, E. E., Snow, P. E., Silver, P. B., Heinrichs, D., Lin, X., Iwakura, Y., Wells, C. A., Caspi, R. R., and Rosenzweig, H. L.
    • Journal Title

      J. Immunol.

      Volume: 196 Issue: 7 Pages: 3148-3158

    • DOI

      10.4049/jimmunol.1502355

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of inflammation by IL-1A and IL-17F modulates non-alcholic fatty liver disease pathogenesis.2016

    • Author(s)
      Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., and Divanovic, S.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 2 Pages: e0149783-e0149783

    • DOI

      10.1371/journal.pone.0149783

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the samall intestine in mice.2016

    • Author(s)
      Kawabe, T., Suzuki, N., Yamaki, S., Sun, S. L., Asao, A., Okuyama, Y., So, T., Iwakura, Y., and Ishii, N.
    • Journal Title

      Eur. J. Immunol.

      Volume: 46 Issue: 5 Pages: 1119-1131

    • DOI

      10.1002/eji.201545907

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interleukin-17A promotes aortic endothelial cell activation via transcriptionally and post-transcriptionally activating p38 MAPK pathway.2016

    • Author(s)
      Mai, J., Nanayakkara, G., Lopez-Pastrana, J., Li, X., Li, Y. F., Wang, X., Song, A., Virtue, A., Shao, Y., Shan, H., Liu, F., Autieri, M. V., Kunapuli, S. P., Iwakura, Y., Jiang, X., Wang, H., Yang, X. F.
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 10 Pages: 4939-4954

    • DOI

      10.1074/jbc.m115.690081

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bone marrow transplantation alters lung antigen-presenting cells to promote Th17 reponse and the development of pneumonitis and fibrosis following gammaherpesvirus infection.2016

    • Author(s)
      Zhou, X., Loomis-King, H., Gurczynski, S. J., Wilke, C. A., Konopka, K. E., Ptaschinski, C., Coomes, S. M., Iwakura, Y., van Dyk, L. F., Lukacs, N. W., and Moore, B. B.
    • Journal Title

      Mucosal Immunol.

      Volume: 9 Issue: 3 Pages: 610-620

    • DOI

      10.1038/mi.2015.85

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-1 receptor antagonist inhibits pancreatic cancer growth by abrogating NF-κB activation.2016

    • Author(s)
      Zhuang, Z. N., Ju, H. Q., Aguilar, M., Gocho, T., Li, H., Iida, T., Lee, H., Fan, X., Zhou, H., Ling, J., Li, Z., Fu, J., Wu, M., Li, M., Melisi, D., Iwakura, Y., Xu, K., Fleming, J. B., and Chiao, P. J.
    • Journal Title

      Clin. Cancer Res.

      Volume: 22 Issue: 6 Pages: 1432-1444

    • DOI

      10.1158/1078-0432.ccr-14-3382

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae2016

    • Author(s)
      Akahori Y, Miyasaka T, Toyama M, Matsumoto I, Miyahara A, Zong T, Ishii K, Kinjo Y, Miyazaki Y, Saijo S, Iwakura Y, Kawakami K.
    • Journal Title

      BMC Immunol

      Volume: 17 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s12865-015-0139-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-1 Receptor Type 2 Suppresses Collagen-Induced Arthritis by Inhibiting IL-1 Signal on Macrophages.2015

    • Author(s)
      Shimizu K, Nakajima A, Sudo K, Liu Y, Mizoroki A, Ikarashi T, Horai R, Kakuta S, Watanabe T, Iwakura Y.
    • Journal Title

      J Immunol.

      Volume: 194(7) Issue: 7 Pages: 3156-3168

    • DOI

      10.4049/jimmunol.1402155

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.2015

    • Author(s)
      Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T.:
    • Journal Title

      Blood

      Volume: 125 Issue: 19 Pages: 3014-23

    • DOI

      10.1182/blood-2014-12-615781

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mast cells mediate malignant pleural effusion formation.2015

    • Author(s)
      Giannou, A. D. et al
    • Journal Title

      J. Clin. Invest.

      Volume: 125 Issue: 6 Pages: 2317-2334

    • DOI

      10.1172/jci79840

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DDCIR is important for bone homeostasis by regulating IFN-γ production in T cells.2015

    • Author(s)
      Maruhashi T*, Kaifu T*, Yabe R, Seno A, Chung SH, Fujikado N, and Iwakura Y
    • Journal Title

      J. Immunol.

      Volume: 194 Issue: 12 Pages: 5681-91

    • DOI

      10.4049/jimmunol.1500273

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD11c+ DCs accelerate the rejection of older cardiac transplants via IL-17A.2015

    • Author(s)
      Oberhuber, R., Heinbokel, T., Cetina Biefer, H. R., Boenisch, O., Hock, K., Bronson, R. T., Wilhelm, M. J., Iwakura, Y., Edtinger, K., Uehara, H., Quante, M., Voskuil, F., Krenzien, F., Slegtenhorst, B., Abdi, R., Pratschke, J., Elkhal, A., and Tullius, S. G.
    • Journal Title

      Circulation

      Volume: 132 Issue: 2 Pages: 122-131

    • DOI

      10.1161/circulationaha.114.014917

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging2015

    • Author(s)
      Wakabayashi et al.
    • Journal Title

      Neurosci. Lett.

      Volume: 599 Pages: 20

    • DOI

      10.1016/j.neulet.2015.05.019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells.2015

    • Author(s)
      Akitsu A, Ishigame H, Kakuta S, Chung SH, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 7464-7464

    • DOI

      10.1038/ncomms8464

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.2015

    • Author(s)
      Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
    • Journal Title

      Nat Commun

      Volume: 10;6 Issue: 1 Pages: 7514-7514

    • DOI

      10.1038/ncomms8514

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor.2015

    • Author(s)
      Seno, A., Maruhashi, T., Kaifu, T., Yabe, R., Fujikado, N., Ma, G., Ikarashi, T., Kakuta, S., and Iwakura, Y.
    • Journal Title

      Exp. Anim.

      Volume: 64 Pages: 109-119

    • NAID

      130005069862

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mouse model for PTPRD associations with WED/RLS and addiction: reduced expansion alters locomotion, sleep behaviors and cocaine-conditioned place preference.2015

    • Author(s)
      Drgonova, J., Walther, D., Wang, K. J., Hartstein, G. L., Lochte, B., Troncoso, J., Uetani, N., Iwakura, Y., and Uhl, G. R.
    • Journal Title

      Mol. Med.

      Volume: 21 Issue: 1 Pages: 717-725

    • DOI

      10.2119/molmed.2015.00017

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 1.Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus- mediated regulatory T cell expansion in the intestine.2015

    • Author(s)
      Ce Tang, Tomonori Kamiya, Yang Liu, Motohiko Kadoki, Shigeru Kakuta, Kenshiro Oshima, Masahira Hattori, Kozue Takeshita, Takanori Kanai, Shinobu Saijo and Yoichiro Iwakura
    • Journal Title

      Cell Host & Microbe

      Volume: 18 Issue: 2 Pages: 183-197

    • DOI

      10.1016/j.chom.2015.07.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Local IL-17 production exerts a protective role in murine experimental glomerulonephritis.2015

    • Author(s)
      Hamour, S., Gan, P. Y., Pepper, R., Florez Barros, F., Wang, H. H., O'Sullivan, K., Iwakura, Y., Cook, T., Pusey, C., Holdsworth, S., and Salama, A.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 8 Pages: e0136238-e0136238

    • DOI

      10.1371/journal.pone.0136238

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense.2015

    • Author(s)
      Cai, S., Batra, S., Langohr, I., Iwakura, Y., and Jeyaseelan, S.
    • Journal Title

      Mucosal Immunol.

      Volume: 9 Issue: 3 Pages: 718-729

    • DOI

      10.1038/mi.2015.95

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.2015

    • Author(s)
      Murayama A.M, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi H-H, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 1-12

    • DOI

      10.1038/ncomms9483

    • NAID

      120006986869

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis.2015

    • Author(s)
      Tokieda, S., Komori, M., Ishiguro, Iwakura, Y., Takahara, K.* and Inaba, K.
    • Journal Title

      BMC Immunol.

      Volume: 16 Issue: 1 Pages: 64-64

    • DOI

      10.1186/s12865-015-0129-5

    • NAID

      120005689211

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis2015

    • Author(s)
      Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A
    • Journal Title

      Inflamm Res

      Volume: 65 Issue: 3 Pages: 235

    • DOI

      10.1007/s00011-015-0910-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interdependence between interleukin-1 and tumor necrosis factor regulates TNF-dependent control of Mycobacterium tuberculosis infection.2015

    • Author(s)
      Di Paolo, N. C., Shafiani, S., Day, T., Papayannoupoulou, T., Russell, D. W., Iwakura, Y., Sherman, D., Urdahl, K., and Shayakhmetov, D. M.
    • Journal Title

      Immunity

      Volume: 43 Issue: 6 Pages: 1125-36

    • DOI

      10.1016/j.immuni.2015.11.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-1R Type 2 Suppresses Collagen-Induced Arthritis Inhibiting IL-1 Signal on Macrophages.2015

    • Author(s)
      Shimizu K, Nakajima A, Sudo K, Yang L, Mizoroki A, Ikarashi T, Horai R, Kakuta S, Watanabe T, and Iwakura Y.
    • Journal Title

      J Immunol.

      Volume: 194(7) Pages: 3156-68

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes.2015

    • Author(s)
      Yabe, R., Shimizu, K., Shimizu, S., Azechi, S., Choi, B. I., Sudo, K., Kubo, S., Nakae, S., Ishigame, H., Kakuta, S., and Iwakura, Y.
    • Journal Title

      Int. Immunol.

      Volume: 27(4) Pages: 169-181

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NLRP3 deficiency exacerbates hyperoxia-induced lethality through Stat3 signaling independently of interleukin-1β2015

    • Author(s)
      Mizushina, Y., Shirasuna, K., Usui, F., Karasawa, T., Kawashima, A., Kimura, H., Kobayashi, M., Komada, T., Inoue, Y., Mato, N., Yamasawa, H., Latz, E., Iwakura, Y., Kasahara, T., Bando, M., Sugiyama, Y., and Takahashi, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 290(8) Pages: 5065-5077

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans.2015

    • Author(s)
      Nakamura, Y., Sato, K., Yamamoto, H., Matsumura, K., Matsumoto, I., Nomura, T., Miyasaka, T., Ishii, K., Kanno, E., Tachi, M., Yamasaki, S., Saijo, S., Iwakura, Y., Kawakami, K.
    • Journal Title

      Infect. Immun.

      Volume: 83(2) Pages: 671-681

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus.2015

    • Author(s)
      Oyoshi, M. K., Beaupre;, J., Venturelli, N., Lewis, C. N., Iwakura, Y., Geha, R. S.
    • Journal Title

      J. Allergy Clin. Immunol.,

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phaocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigates.2015

    • Author(s)
      Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell MA, Saijo S, Mostowy S, Shaunak S, Armstrong-James D.
    • Journal Title

      EMBO Mol Med.

      Volume: 7 Pages: 240-258

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization.2015

    • Author(s)
      Jee, J., Bonnegarde-Bernard, A., Duverger, A., Iwakura, Y., Cormet-Boyaka, E., Martin, T. L., Steiner, H. E., Bachman, R. C., and Boyaka, P. N.
    • Journal Title

      Mucosal Immunol.,

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cruciall role of RORγt in the development of spontaneous sialadenitis-like Sjogren’s syndrome.2015

    • Author(s)
      Iizuka, M., Tsuboi, H., Matsuo, N., Asashima, H., Hirota, T., Kondo, Y., Iwakura, Y., Takahashi, S., Matsumoto, I., Sumida, T.
    • Journal Title

      J. Immunol.

      Volume: 194(1) Pages: 56-67

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibiotic-killed Staphyococcus aureus induces detructive arthritis in mice.2015

    • Author(s)
      Ali, A., Zhu, X., Kwiecinski, J., Gjertsson, I., Lindholm, C., Iwakura, Y., Wang, X., Lycke, N., Josefsson, E., Pullerits, R., and Jin, T.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 67(1) Pages: 107-116

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor.2015

    • Author(s)
      Seno, A., Maruhashi, T., Kaifu, T., Yabe, R., Fujikado, N., Ma, G., Ikarashi, T., Kakuta, S., and *Iwakura, Y.
    • Journal Title

      Exp. Anim.

      Volume: 未定

    • NAID

      130005069862

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Immune complexes inhibit IL-1 secretion and inflammasome activation.2014

    • Author(s)
      Janczy, J. R., Ciraci, C., Haasken, S., Iwakura, Y., Olivier, A. K., Cassel, S. L., and Sutterwala, F. S.
    • Journal Title

      J. Immunol.,

      Volume: 193(10) Pages: 5190-5198

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.2014

    • Author(s)
      Natsuaki, Y., Egawa, G., Nakamizo, S., Ono, S., Hanakawa, S., Okada, T., Kusuba, N., Otsuka, A., Kitoh, A., Honda, T., Nakajima, S., Tsuchiya, S., Sugimoto, Y., Ishii, K. J , Tsutsui, H., Yagita, H., Iwakura, Y., Kubo, M., Ng, L. G., Hashimoto, T., Fuentes, J., Guttman-Yassky, E., Miyachi, Y., and Kabashima, K.
    • Journal Title

      Nat. Immunol.

      Volume: 15(11) Pages: 1064-1069

    • NAID

      120005477231

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis.2014

    • Author(s)
      Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Munoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.
    • Journal Title

      PLoS Pathog.

      Volume: 10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene targeting study reveals unexpected expression of brain expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.2014

    • Author(s)
      Ito, K., Yamazaki, S., Yamamoto, R., Tajima, Y., Yanagida, A., Kobayashi, T., Kato-Itoh, M., Kakuta, S., Iwakura, Y., Nakauchi, H., and Kamiya, A.
    • Journal Title

      J. Biol. Chem.

      Volume: 289(43) Pages: 29892-29911

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.2014

    • Author(s)
      Shimura, E., Shibui, A., Narushima, S., Nambu, A., Yamaguchi, S., Akitsu, A., Leonard, W. J., Iwakura, Y., Matsumoto, K., Suto, H., Okumura, K., Sudo, K., and Nakae, S.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 453(1) Pages: 1-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell-derived IL-1β contributes to uric acid crystal-induced acute arthritis in mice.2014

    • Author(s)
      Reber, L. L., Marichal, T., Sokolove, J., Starkl, P., Gaudenzio, N., Iwakura, Y., Karasuyama, H., Schwartz, L. B., Robinson, W. H., Tsai, M., and Galli, S. J.
    • Journal Title

      Arthritis Rheumatol.,

      Volume: 66(10) Pages: 2881-2891

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoke primes the pulmonary environment to IL-1α/CXCR-2-dependent nontypeable haemophilus influenzae-exacerbated neutrophillia in mice.2014

    • Author(s)
      Nikota, J. K., Shen, P., Morissette, M. C., Fernandes, K., Roos, A., Chu, D. K., Barra, N. G., Iwakura, Y., Kolbeck, R., Humbles, A. A., and Stampfli, M. R.
    • Journal Title

      J. Immunol.

      Volume: 193(6) Pages: 3134-3145

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1 receptor antagonist originating from bone marrow-derived cells and non-bone marrow-derived cells helps to suppress arterial inflammation and reduce neointimal formation after injury.2014

    • Author(s)
      Isoda, K., Akita, K., Isobe, S., Niida, T., Adachi, T., Iwakura, Y., and Daida, H.
    • Journal Title

      J. Atheroscler. Thromb.

      Volume: 21(11) Pages: 1208-1218

    • NAID

      130004690941

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of Mycobacteria.2014

    • Author(s)
      Yonekawa A, Saijo S, Hosino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-hora M, Akashi K, Yamasaki S.
    • Journal Title

      Immunity.

      Volume: 41(3) Pages: 402-413

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease. Emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory disease.2014

    • Author(s)
      Yamanaka, K., Nakanishim, T., Saito, H., Maruyamam, J., Isoda, K., Yokochi, A., Imanaka-Yoshida, K., Tsuda, K., Kakeda, M., Okamoto, R., Fujita, S., Iwakura, Y., Suzuki, N., Ito, M., Maruyama, K., Gabazza, E. C., Yoshida, T., Shimaoka, M., and Mizutani, H.
    • Journal Title

      PLoS One

      Volume: 9(8)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.2014

    • Author(s)
      Chiba, S., Ikushima, H., Ueki, H., Yanai, H., Kimura, Y., Hangai, S., Nishio, J., Negishi, H., Tamura, T., Saijo, S., Iwakura, Y., and Taniguchi T.
    • Journal Title

      Elife

      Volume: 3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dectin-2 promotes house dust mite-induced T helper type 2 and type 17 cell differentiation and allergic airway inflammation in mice.2014

    • Author(s)
      Norimoto A, Hirose K, Iwata A, Tamachi T, Yokota M, Takahashi K, Saijo S, Iwakura Y, Nakajima H.
    • Journal Title

      Am J Respir Cell Mol Biol.

      Volume: 51(2) Pages: 201-209

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17A as an inducer for Th2 immune responses in murine atopic dermatitits models.2014

    • Author(s)
      Nakajima, S., Kitoh, A., Egawa, G., Natsuaki, Y., Nakamizo, S., Sagita, Moniaga, C., Otsuka, A., Honda, T., Hanakawa, S., Amano, W., Iwakura, Y., Nakae, S., Kubo, M., Miyachi, Y., and Kabashima, K.
    • Journal Title

      J. Invest. Dermatol.

      Volume: 134(8) Pages: 2122-2130

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation.2014

    • Author(s)
      Lai, C. Y., Yamazaki, S., Okabe, M., Suzuki, S., Maeyama, Y., Iimura, Y., Onodera. M., Kakuta, S., Iwakura, Y., Nojima, M., Otsu, M., and Nakauchi, H.
    • Journal Title

      Stem Cells

      Volume: 32(7) Pages: 1929-1942

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages.2014

    • Author(s)
      Ohman T, Teirila; L, Lahesmaa-Korpinen AM, Cypryk W, Veckman V, Saijo, S. Wolff H, Hautaniemi S, Nyman TA, Matikainen S.
    • Journal Title

      J Immunol.

      Volume: 192(12) Pages: 5952-5962

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting IL-1b and IL-17A driven inflammation during influenza-induced exacerbations of chronic lung inflammation.2014

    • Author(s)
      Sichelstiel, A., Yadava, K., Trompette, A., Salami, O., Iwakura, Y., Nicod, L. P., and Marsland, B. J.
    • Journal Title

      PLoS One

      Volume: 9(2)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy.2014

    • Author(s)
      Wu, L., Ong, S., Talor, M. V., Barin, J. G., Baldeviano, G. C, Kass,D.A., Bedja, D., Zhang, H., Sheikhm, A., Margolick, J. B., Iwakura, Y., Rose, N. R., and Cihakova, D.
    • Journal Title

      J. Exp. Med.

      Volume: 211(7) Pages: 1449-1464

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis.2014

    • Author(s)
      Song, X., Gao, H., Lin, Y., Yao, Y,. Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, and Qian Y.
    • Journal Title

      Immunity

      Volume: 40(1) Pages: 140-152

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of IL-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut moter dysfunction.2014

    • Author(s)
      Akiho, H., Tokita, Y., Nakamura, K., Satoh, K., Nishiyama, M., Tsuchiya, N., Tsuchiya, K., Ohbuchi, K., Iwakura, Y., Ihara, E., Takayanagi, R., and Yamamoto, M.
    • Journal Title

      PLoS One

      Volume: 9(5)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.2014

    • Author(s)
      Yasukawa, S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K., Yasuda, T., Natsuaki, Y., Mi-Ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B., Ohno, N., Furue, M., Yoshida, H., and Hara, H.
    • Journal Title

      Nat. Commun.,

      Volume: 5 Pages: 3755-3755

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of C-type lectin receptors in host defense against microbial pathogens.2014

    • Author(s)
      Yabe, R., Iwakura, Y., and Saijo, S.
    • Journal Title

      Glycoscinece: Biology and Medicine

      Volume: - Pages: 1319-1329

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple CD11c+ cells collaboratively express IL-1β to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth.2014

    • Author(s)
      Benahmed, F., Chyou, S., Dasoveanu, D., Chen, J., Kumar, V., Iwakura, Y., and Lu, T. T.
    • Journal Title

      J. Immunol.

      Volume: 192(9) Pages: 4153-4163

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.2014

    • Author(s)
      Inoue, Y., Shirasuna, K., Kimura, H., Usui, F., Kawashima, A., Karasawa, T., Tago, K., Dezaki, K., Nishimura, S., Sagara, J., Noda, T., Iwakura, Y., Tsutsui, H., Taniguchi, S., Yanagisawa, K., Yada, T., Yasuda, Y., and Takahashi, M.
    • Journal Title

      J. Immunol.

      Volume: 192(9) Pages: 4342-4351

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in vial infection.2014

    • Author(s)
      .Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y., and Sun, J.
    • Journal Title

      J. Immunol.

      Volume: 192(7) Pages: 3289-3300

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemokine receptor CCR8 is required for lipopolysassharide-triggered cytokine production in mouse peritoneal macrophages.2014

    • Author(s)
      Oshio, T., Kawashima, R., Kawamura, Y. I., Hagiwara, T., Mizutani, N., Okada, T., Otsubo, T., Inagaki-Ohara, K., Matsukawa, A., Haga, T., Kakuta, S., Iwakura, Y., Hosokawa, S., and Dohi, T.
    • Journal Title

      PLoS One

      Volume: 9(4)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Defect of CARD9 leads to impaired accululation of IFN-g-producing memory-phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans.2014

    • Author(s)
      Yamamoto, H., Nakamura, Y., Sato, K., Takahashi, Y., Nomura, T., Miyasaka, T., Ishii, K., Hara, H., Yamamoto, N., Kanno, E., Iwakura, Y., and Kawakami, K.
    • Journal Title

      Infect. Immun.

      Volume: 82(4) Pages: 1606-1615

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rag2-deficient IL-1 receptor antagonist-deficient mice are a novel colitis model in which innate lymphoid cell-derived IL-17 is involved in the pathogenesis.2014

    • Author(s)
      Akitsu, A., Kakuta, S., Saijo, S., and Iwakura, Y.
    • Journal Title

      Exp. Anim.

      Volume: 63(2) Pages: 235-246

    • NAID

      130003391627

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of Gr-1dull+ cellsin the production of TNF-a and IL-17 and exacerbated systemic inflammatory response caused by lipopolysaccharide.2014

    • Author(s)
      Tanno, D., Akahori, Y., Toyama, M., Sato, K., Kudo, D., Abe, Y., Miyasaka, T., Yamamoto, H., Ishii, K., Kanno, E., Maruyama, R., Kushimoto, S., Iwakura, Y., and Kawakami, K.
    • Journal Title

      Inflammation

      Volume: 37 Issue: 1 Pages: 186-195

    • DOI

      10.1007/s10753-013-9729-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of pro-tumorigenic effect of BMP-6: Neovascularizatioon involving tumor-associated macrophages and IL-1a.2014

    • Author(s)
      Kwon, S. J., Lee, G. T., Lee, J. H., Iwakura, Y., Kim, W. J., and Kim, I. Y.
    • Journal Title

      Prostate

      Volume: 74 Issue: 2 Pages: 121-133

    • DOI

      10.1002/pros.22734

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CTRP3 plays an important role in the development of collagen-induced arthritis in mice.2014

    • Author(s)
      Murayama MA, Kakuta S, Maruhashi T, Shimizu K, Seno A, Kubo S, Sato N, Saijo S, Hattori M, Iwakura Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 443 Issue: 1 Pages: 42-48

    • DOI

      10.1016/j.bbrc.2013.11.040

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.2014

    • Author(s)
      Kagoya Y, Yoshimi A, Kataoka K, Nakagawa M, Kumano K, Arai S, Kobayashi H, Saito T, Iwakura Y, Kurokawa M.
    • Journal Title

      J Clin Invest.

      Volume: 124 Issue: 2 Pages: 528-542

    • DOI

      10.1172/jci68101

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role for inflammasome-independent IL-1b production in osteomyelitis.2014

    • Author(s)
      Lukens, J. R., Gross, J. M., Calabrese, C., Iwakura, Y., Lamkanfi, M., Vogel, P., and Kanneganti, T. D.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 111 Issue: 3 Pages: 1066-1071

    • DOI

      10.1073/pnas.1318688111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammasome-independent IL-1b mediates autoinflammatory diseases in Pstpip2-deficient mice.2014

    • Author(s)
      Cassel, S. L., Janczy, J. R., Bing, X., Wilson, S. P., Olivier, A. K., Otero, J. E., Iwakura, Y., Shayakhmetov, D. M., Bassuk, A. G., Abu-Amer, Y., Brogden, K. A., Burns, T. L., Sutterwala, F. S., and Ferguson, P. J.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 111 Issue: 3 Pages: 1072-1077

    • DOI

      10.1073/pnas.1318685111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-β-induced Foxp3 expression.2014

    • Author(s)
      Ikeda S, Saijo S, Murayama MA, Shimizu K, Akitsu A, Iwakura Y.
    • Journal Title

      J Immunol.

      Volume: 192 Issue: 4 Pages: 1449-1458

    • DOI

      10.4049/jimmunol.1300387

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization.2014

    • Author(s)
      Parsons MW, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA.
    • Journal Title

      J Immunol.

      Volume: 192 Issue: 4 Pages: 1361-1371

    • DOI

      10.4049/jimmunol.1301809

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.2014

    • Author(s)
      Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 8 Pages: 3086-3091

    • DOI

      10.1073/pnas.1319268111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic cerebellar cell migration causes maldevelopment of purkinje cells and abnormal motor behavior in CXCR4 null mice.2014

    • Author(s)
      Huang, G. J., Edwards, A., Tsai, C. Y., Lee, Y. S., Peng, L., Era, T., Hirabayashi, Y., Tsai, C. Y., Nishikawa, S., Iwakura, Y., Chen, S. J., and Flint, J.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 2 Pages: e86471-e86471

    • DOI

      10.1371/journal.pone.0086471

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rag2-deficient IL-1 receptor antagonist deficient mice are a novel colitis model in which innate lymphoid cell-derived IL-17 is involved in the pathogenesis.2014

    • Author(s)
      Akitsu A., Kakuta S., Saijo S., Iwakura Y.
    • Journal Title

      Exp. Anim.

      Volume: 印刷中

    • NAID

      130003391627

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-2 promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation in mice.2014

    • Author(s)
      Norimoto, A., Hirose, K., Iwata, A., Tamachi, T., Yokota, M., Takahashi, K., Saijo, S., Iwakura, Y., and Nakajima, H.
    • Journal Title

      Am. J. Respir. Cell Mol. Biol.

      Volume: 印刷中 Issue: 2 Pages: 201-9

    • DOI

      10.1165/rcmb.2013-0522oc

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in vial infection.2014

    • Author(s)
      Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y., and Sun, J.
    • Journal Title

      J. Immunol.

      Volume: 192 Issue: 7 Pages: 3289-3300

    • DOI

      10.4049/jimmunol.1303281

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple CD11c+ cells collaboratively express IL-1b to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth.2014

    • Author(s)
      Benahmed, F., Chyou, S., Dasoveanu, D., Chen, J., Kumar, V., Iwakura, Y., and Lu, T. T.
    • Journal Title

      J. Immunol.

      Volume: 印刷中 Issue: 9 Pages: 4153-4163

    • DOI

      10.4049/jimmunol.1301765

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory T cells are strong promoters of acute ischemia stroke in mice by inducing dysfunction of the cerebral microvasculature.2013

    • Author(s)
      Kleinschnitz, C., Kraft, P., Dreykluft, A., Hagedorn, I., Gobel, K., Schuhmann, M. K., Langhauser, F., Helluy, X., Schwarz, T., Bittner, S., Mayer, C. T., Brede, M., Varallyay. C., Pham, M., Bendszus, M., Jakob, P., Magnus, T., Meuth, S. G., Iwakura, Y., Zernecke, A. et al.
    • Journal Title

      Blood

      Volume: 121 Issue: 4 Pages: 679-691

    • DOI

      10.1182/blood-2012-04-426734

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment.2013

    • Author(s)
      Erdmann, H., RoBnagel, C., Bohme, J., Iwakura, Y., Jacobs, T., Schaible, U. E., and Holscher, C.
    • Journal Title

      Immunobiology

      Volume: 218, Issue: 6 Pages: 910-923

    • DOI

      10.1016/j.imbio.2012.10.005

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation.2013

    • Author(s)
      Silverpil, E., Wright, A. K., Hansson, M., Jirholt, P., Henningsson, L., Smith, M. E., Gordon, S. B., Iwakura, Y., Gjertsson, I., Glader, P., and Linden, A.
    • Journal Title

      Innate Immun.

      Volume: 19 Issue: 5 Pages: 479-492

    • DOI

      10.1177/1753425912470470

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex.2013

    • Author(s)
      Nakatsuka A
    • Journal Title

      Cir Res

      Volume: 112(5) Issue: 5 Pages: 771-780

    • DOI

      10.1161/circresaha.111.300049

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice2013

    • Author(s)
      Etsuko Kurimoto
    • Journal Title

      Respiratory Research

      Volume: 14 Issue: 1 Pages: 5-5

    • DOI

      10.1186/1465-9921-14-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclosporine A drives a Th17- and Th2-mediated posttransplant obliterative airway disease.2013

    • Author(s)
      Lemaitre, P. H., Vokaer, B., Charbonnier, L. M., Iwakura, Y., Field, K. A., Estenne, M., Goldman, M., Leo, O., Remmelink, M., and Le Moine, A.
    • Journal Title

      Am. J. Transplant.

      Volume: 13 Issue: 3 Pages: 611-620

    • DOI

      10.1111/ajt.12067

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia.2013

    • Author(s)
      Kon et al.
    • Journal Title

      J. Clin. Invest.

      Volume: 123 Issue: 3 Pages: 1123-1137

    • DOI

      10.1172/jci63711

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MFGE8 inhibits inflammasome-induced IL-1b production and limits postischemic cerebral injury.2013

    • Author(s)
      Deroide, N., Li, X., Lerouet, D., Van Vre, E., Baker, L., Harrison, J., Poittevin, M. Masters, L., Nih, L., Margaill, I., Iwakura, Y., Ryffel, B., Pocard, M., Tedgui, A., Kubis, N., and Mallat, Z.
    • Journal Title

      J. Clin. Invest.

      Volume: 123 Issue: 3 Pages: 1176-1181

    • DOI

      10.1172/jci65167

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation.2013

    • Author(s)
      Shepardson, K. M., Ngo, L. Y., Aimanianda, V., Latge, J.-P., Barker, B. M., Blosser, S. J., Iwakura, Y., Hohl, T. M., and Cramer, R. A.
    • Journal Title

      Microbe. Infect.

      Volume: 15 Issue: 4 Pages: 259-269

    • DOI

      10.1016/j.micinf.2012.11.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mature Dendritic Cell Suppression by IL- 1 Receptor Antagonist on Retinal Pigment Epithelium Cells2013

    • Author(s)
      Sugita S, Kawazoe Y, Imai A, Usui Y, Iwakura Y, Isoda K, Ito M, Mochizuki M
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54巻 Issue: 5 Pages: 3240-3249

    • DOI

      10.1167/iovs.12-11483

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-Type lectin is an FcRr-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor2013

    • Author(s)
      Miyake Y, Ynmasaki S, et al.
    • Journal Title

      Immunity

      Volume: 38 Issue: 5 Pages: 1050-62

    • DOI

      10.1016/j.immuni.2013.03.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophils are essential as a source of IL-17 in the effector phase of arthritis.2013

    • Author(s)
      Katayama, M., Ohmura, K., Yukawa, N., Terao, C., Hashimoto, M., Yoshifuji, H., Kawabata, D., Fujii, T., Iwakura, Y., and Mimori, T.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 12

    • DOI

      10.1371/annotation/5fedb3bf-c9c2-4862-9ad5-23c8ae484ad5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse.2013

    • Author(s)
      Kuriya G, Uchida T, Akazawa S, Kobayashi M, Nakamura K, Satoh T, Horie I, Kawasaki E, Yamasaki H, Yu L, Iwakura Y, Sasaki H, Nagayama Y, Kawakami A, Abiru N.
    • Journal Title

      Diabetologia

      Volume: 56 Issue: 8 Pages: 1773-1780

    • DOI

      10.1007/s00125-013-2935-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RIP1-driven autoinflammation targets IL-1a independently of inflammasomes and RIP3.2013

    • Author(s)
      Lukens, J. R., Vogel, P., Johnson, G. R., Kelliher, M. A., Iwakura, Y., Lamkanfi, M., and Kanneganti, T. D.
    • Journal Title

      Nature

      Volume: 498 Issue: 7453 Pages: 224-227

    • DOI

      10.1038/nature12174

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Obesity-induced gut microbial metabolite prootes liver cancer through senescence secretome.2013

    • Author(s)
      Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., Honda, K., Ishikawa, Y., Hara, E., and Ohtani, N.
    • Journal Title

      Nature

      Volume: 499 Issue: 7488 Pages: 97-101

    • DOI

      10.1038/nature13004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages2013

    • Author(s)
      Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, Iwakura Y, Okada H, Suzuki T, Shimokawa C, and Hisaeda
    • Journal Title

      Eur. J. Immunol.

      Volume: 43 Issue: 10 Pages: 2696-2706

    • DOI

      10.1002/eji.201343493

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis.2013

    • Author(s)
      Funaki T, Kon S, Tanabe K, Natsume W, Sato S, Shimizu T, Yoshida N, Wong WF, Ogura A, Ogawa T, Inoue K, Ogonuki N, Miki H, Mochida K, Endoh K, Yomogida K, Fukumoto M, Horai R, Iwakura Y, Ito C, Toshimori K, Watanabe T, Satake M.
    • Journal Title

      Mol. Biol. Cell

      Volume: 24 Issue: 17 Pages: 2633-44

    • DOI

      10.1091/mbc.e13-05-0234

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pam3CSK4 enhanced beta cell loss and diabetogenesis: The roles of IFN-gamma and IL-17.2013

    • Author(s)
      Al Shamsi, M., Shahin, A., Iwakura, Y., Lukic, M. L., and Mensah-Brown, E. P.
    • Journal Title

      Clin. Immunol.

      Volume: 149 Issue: 1 Pages: 86-96

    • DOI

      10.1016/j.clim.2013.06.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1b induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis.2013

    • Author(s)
      Shigematsu, Y., Niwa, T., Rehnberg, E., Toyoda, T., Yoshida, S., Mori, A., Wakabayashi, M., Iwakura, Y., Ichinose, M., Kim, Y. J., and Ushijima, T.
    • Journal Title

      Cancer Lett.

      Volume: 340 Issue: 1 Pages: 141-147

    • DOI

      10.1016/j.canlet.2013.07.034

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17A mediates early post-translpant lesions agter teterotopic trachea allotransplantation in mice.2013

    • Author(s)
      Lemaitre, P. H., Vokaer, B., Charbonnier, L. M., Iwakura, Y., Estenne, M., Goldman, M., Leo, O., Remmelink, M., and Le Moine, A.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 7 Pages: e70236-e70236

    • DOI

      10.1371/journal.pone.0070236

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation2013

    • Author(s)
      Soeno Y, Fujita K, Kudo T, Asagiri M, Kakuta S, Taya Y, Shimazu Y, Sato K, Tanaka-Fujita R, Kubo S, Iwakura Y, Nakamura Y, Mori S, and Aoba T
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 8 Pages: e72105-e72105

    • DOI

      10.1371/journal.pone.0072105

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatty acid-inudced mitochondrial uncoupling elicits inflammasome-independent IL-1a and sterile vascular inflammation in atherosclerosis.2013

    • Author(s)
      Freigang, S., Ampenberger, F., Weiss, A., Kanneganti, T. D., Iwakura, Y., Hersberger, M., and Kopf, M.
    • Journal Title

      Nat. Immunol.

      Volume: 14 Issue: 10 Pages: 1045-1053

    • DOI

      10.1038/ni.2704

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis.2013

    • Author(s)
      Chang, Y., Al-Alwan, L., Audusseau, S., Chouiali, F., Carlevaro-Fita, J., Iwakura, Y., Baglole, C. J., Eidelman, D. H., and Hamid, Q.
    • Journal Title

      Am. J. Physiol. Lung Cell Mol. Physiol.

      Volume: 306 Issue: 2 Pages: L132-L143

    • DOI

      10.1152/ajplung.00111.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression.2013

    • Author(s)
      Schmitt, E. G., Haribhai, D., Jeschke, J. C., Co, D. O., Ziegelbauer, J., Yan, K., Iwakura, Y., Mishra, M. K., Simpson, P., Salzman, N. H., and Williams, C. B.
    • Journal Title

      J. Immunol.

      Volume: 191 Issue: 11 Pages: 5460-5476

    • DOI

      10.4049/jimmunol.1301576

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and gd T cells.2013

    • Author(s)
      Do, J. S., Visperas, A., Freeman, M. L., Iwakura, Y., Oukka, M., and Min, B.
    • Journal Title

      Immunol. Cell Biol.

      Volume: 92 Issue: 1 Pages: 90-98

    • DOI

      10.1038/icb.2013.70

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine.2013

    • Author(s)
      Miyasaka T, Akahori Y, Toyama M, Miyamura N, Ishii K, Saijo S, Iwakura Y, Kinjo Y, Miyazaki Y, Oishi K, Kawakami K.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 10 Pages: e78611-e78611

    • DOI

      10.1371/journal.pone.0078611

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilliate obesity-associated airway hyperreactivity.2013

    • Author(s)
      Kim, H. Y., Lee, H. J., Chang, Y. J., Pichavant, M., Shore, S. A., Fitzgerald, K. A., Iwakura, Y., Israel, E., Bolger, K., Faul, J., Dekruyff, R. H., and Umetsu, D. T.
    • Journal Title

      Nat. Med.

      Volume: 20 Issue: 1 Pages: 54-61

    • DOI

      10.1038/nm.3423

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells.2013

    • Author(s)
      Tada, T., Kadoki, M., Yang, L., Tokunaga, K. and Iwakura, Y.
    • Journal Title

      Front. Microbiol.

      Volume: 4 Pages: 377-377

    • DOI

      10.3389/fmicb.2013.00377

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Kampo medicines used to treat rheumatoid arthritis in collagen-induced arthritic and pX transgenic mice.2013

    • Author(s)
      Ono, Y., Ogihara, Y., Saijo, S., Iwakura, Y., and Inoue, M.
    • Journal Title

      Mod. Rheumatol.

      Volume: 13 Issue: 1 Pages: 50-56

    • DOI

      10.3109/s101650300007

    • NAID

      10015486726

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-22+CD4+T細胞による大腸炎誘導と抑制.2013

    • Author(s)
      角木基彦、岩倉洋一郎
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 59 Pages: 405-410

    • NAID

      40019636556

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 遺伝子改変マウスによる疾患発症機構の解析.2013

    • Author(s)
      岩倉洋一郎
    • Journal Title

      感染・炎症・免疫

      Volume: 43 Pages: 313-319

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia.2013

    • Author(s)
      von Banchet, G. S.
    • Journal Title

      Mol. Cell Neurosci.

      Volume: 52 Pages: 152-160

    • DOI

      10.1016/j.mcn.2012.11.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic refection responses.2012

    • Author(s)
      Lee, J.
    • Journal Title

      J. Immunol.

      Volume: 189 Pages: 1928-1936

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-assoiated sialidase.2012

    • Author(s)
      Yamaguchi, K.,
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin-regulates interleukin-17 production in hepatitis.2012

    • Author(s)
      Diao, H.
    • Journal Title

      Cytokine

      Volume: 60 Pages: 129-137

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential roles of interleukin 17A in the development of skin fibrosis2012

    • Author(s)
      Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, T akehara K
    • Journal Title

      Arthritis Rheum

      Volume: 64 Issue: 11 Pages: 3726-35

    • DOI

      10.1002/art.34643

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell surface GRP78/MTJ-1 complex.2012

    • Author(s)
      Nakatsuka, A.
    • Journal Title

      Diabetes

      Volume: 61 Pages: 2823-2832

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The NLRP12 inflammasome recognizes Yershinia pestis.2012

    • Author(s)
      Vladimer, G. I.
    • Journal Title

      Immunity

      Volume: 37 Pages: 96-107

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Agaricus barasiliensis-derived β-glucans exert immunoenhancing effects via a dectin-1-dependent pathway.2012

    • Author(s)
      Yamanaka, D.
    • Journal Title

      Int. Immunopharmacol.,

      Volume: 14 Pages: 311-319

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.2012

    • Author(s)
      Suzukawa, M.
    • Journal Title

      J. Immunol.

      Volume: 189 Pages: 3641-3652

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1alpha-dependent in mice.2012

    • Author(s)
      Botelho, F. M.
    • Journal Title

      Respir. Res.

      Volume: 13 Pages: 81-81

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-36α exerts pro-inflammatory effects in the lungs of mice.2012

    • Author(s)
      Ramadas, R. A.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling.2012

    • Author(s)
      Sadik, C. D.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Pages: 18647-18648

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of RORγt marks a pathogenic T-regulatory cell subset in human colon cancer.2012

    • Author(s)
      Blatner, N. R.
    • Journal Title

      Science Translational Medicine

      Volume: 164

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 in colitis: Targeting the progenitors.2012

    • Author(s)
      Ce, T.
    • Journal Title

      Immunity

      Volume: 37 Pages: 957-959

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Roles of C-type lectins in host defense against pathogens and homeostasis of the immune system.2017

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Genomics Research Center Seminar Series
    • Place of Presentation
      Taipei, ROC
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 低分子βグルカンによる腸管免疫の制御2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      第1回プロバイオティクス学術セミナー
    • Place of Presentation
      アパホテル&リゾート東京ベイ幕張
    • Year and Date
      2017-02-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 炎症性腸疾患と食物アレルギーの病態制御におけるDectin-1と短鎖βグルカンの役割の解析2017

    • Author(s)
      唐策、岩倉洋一郎
    • Organizer
      Glyco-Immunology 2017糖鎖免疫研究会
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 炎症性疾患及び免疫系の恒常性維持におけるIL-17の役割2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      第40回皮膚脈管・膠原病研究会
    • Place of Presentation
      コラッセ福島
    • Year and Date
      2017-01-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Pathogenic Mechanisms of Psoriasis: Lessons from Mouse Models2016

    • Author(s)
      Yoicihiro Iwakura
    • Organizer
      日本研究皮膚科学会第41回年次学術大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A novel role of Dectin-1 signaling in controlling food antigen-induced mouse intestinal allergy2016

    • Author(s)
      唐策、濱田有史、岩倉洋一郎
    • Organizer
      第45回日本免疫学会学術集会.
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of novel IL-17-producing T cell populations, γδ TCR-CD4-CD8- cells, in TCRδ -deficient mice.2016

    • Author(s)
      Aoi Akitsu, Yoichiro Iwakura.
    • Organizer
      4th Annual Meeting of the International Cytokine & Interferon Society (ICIS).
    • Place of Presentation
      San Francisco, USA.
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 補体制御因子CTRP6と炎症性疾患2016

    • Author(s)
      村山正承、岩倉洋一郎
    • Organizer
      第3回日本リウマチ学会ベーシックリサーチカンファレンス
    • Place of Presentation
      富士ソフト アキバプラザ 5階アキバホール
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低分子βグルカンによる腸管炎症抑制2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      バイオジャパン
    • Place of Presentation
      東京理科大学
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 疾患モデルを用いた自己免疫および感染防御機構の解析と創薬への展開2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      自治医科大学大学院特別講義(医学研究科教育委員会主催)
    • Place of Presentation
      自治医科大学
    • Year and Date
      2016-10-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The role of C-type lectin receptors in the homeostasis of the intestinal immune system.2016

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      National Defense Medical Center (Sponsored by Prof. Ann Chen)
    • Place of Presentation
      Taipei, ROC
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 短鎖βグルカンによる腸管免疫恒常性の維持2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      日本臨床免疫学会シンポジウム
    • Place of Presentation
      京王プラザ、東京
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自然免疫受容体を介した真菌の認識と免疫系の修飾2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      日本医真菌学会教育講演
    • Place of Presentation
      都立産業貿易センター
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 短鎖βグルカンによる腸内細菌を介した免疫制御2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      東海大学医学部講演会
    • Place of Presentation
      東海大学医学部
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DCIR-糖鎖間相互作用による骨代謝制御機構2016

    • Author(s)
      矢部力朗、海部知則、丸橋拓海、西城忍、舘野浩章、平林淳、岩倉洋一郎
    • Organizer
      第35回日本糖質年会
    • Place of Presentation
      高知市文化プラザかる ぽーと
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine.2016

    • Author(s)
      Ce Tang, Tomonori Kamina, Yoichiro Iwakura.
    • Organizer
      International Congress of Immunology (ICI) 2016
    • Place of Presentation
      Melbourne, Australia.
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells.2016

    • Author(s)
      Aoi Akitsu, Yoichiro Iwakura.
    • Organizer
      International Congress of Immunology (ICI) 2016
    • Place of Presentation
      Melbourne, Australia.
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自己免疫疾患と感染防御におけるIL-17ファミリーの役割2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      Psoriasis and IL-17A Forum 2016 in Kyushu
    • Place of Presentation
      博多エクセルホテル東急
    • Year and Date
      2016-07-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 自己免疫疾患と感染防御におけるIL-17ファミリーの役割2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      四国4大学皮膚科研究会
    • Place of Presentation
      松山全日空ホテル
    • Year and Date
      2016-07-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Complement regulator CTRP6 and inflammatory diseases.2016

    • Author(s)
      Masanori A. Murayama, Kenzo Matsuo, Kaori Yoshida, Nanako Katagiri, Yoichiro Iwakura.
    • Organizer
      9th International Conference on Complement Therapeutics.
    • Place of Presentation
      Rhodes, Greece
    • Year and Date
      2016-06-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 真菌によるIL-17産生機構2016

    • Author(s)
      西城忍
    • Organizer
      AMED-CREST若手研究会
    • Place of Presentation
      大阪アカデミア
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 炎症および感染防御におけるIL-17AとIL-17Fの役割2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      皮膚科学会モーニングセミナー
    • Place of Presentation
      京都国際会館
    • Year and Date
      2016-06-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 自己免疫疾患と感染防御におけるIL-17ファミリーの役割2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      御茶ノ水乾癬勉強会
    • Place of Presentation
      TKRガーデンシティー御茶ノ水
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The role of C-type lectin receptors in the homeostasis of the intestinal immune system.2016

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Korean Society for Biochemistry and Molecular Biology (KSBMB) International Conference 2016
    • Place of Presentation
      Korea, Coex, Seoul
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 補体制御因子CTRP6と炎症性疾患2016

    • Author(s)
      村山正承、松尾謙蔵、吉田佳織、片桐菜々子、岩倉洋一郎
    • Organizer
      第81回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      長崎大学坂本キャンパス良順会館
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] IL-1Ra KOマウスにおける胸腺T細胞分化の解析.2016

    • Author(s)
      秋津葵、岩倉洋一郎
    • Organizer
      第26回Kyoto T cells conference.
    • Place of Presentation
      比叡山延暦寺内比叡山会館
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自然免疫による病原体防御の新展開2016

    • Author(s)
      西城忍
    • Organizer
      第8回に本インターフェロン・サイトカイン学術集会
    • Place of Presentation
      長崎大学良順会館
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] シンポジウム17「リウマチ性疾患における自己免疫と自然免疫」2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      第60回日本リウマチ学会総会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 腸管免疫の恒常性維持に於けるC型レクチンの役割2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      千葉大学真菌医学 研究センターセミナー
    • Place of Presentation
      千葉大学真菌医学研究センター
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The roles of C-type lectin receptors in the homeostasis of the intestinal immune system2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Advanced Institute for Medical Sciences
    • Place of Presentation
      Dalian Medical University
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The roles of C-type lectin receptors in the homeostasis of the intestinal immune system2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Shenzhen Institute of Advanced Technology
    • Place of Presentation
      Chinese Academy of Science, Shenzhen,
    • Year and Date
      2015-12-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 関節リウマチのモデル動物 第9回 in vivo実験医学シンポジウム「免疫疾患における動物モデルを用いた病態解明と治療への応用」2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      公益財団法人実験動物中央研究所主催
    • Place of Presentation
      学士会館
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] DCIR maintains bone homeostasis by regulating IFN-g; production in T cells.2015

    • Author(s)
      Tomonori Kaifu, Takumi Maruhashi, Rikio Yabe, Soo-hyun Chung,N, Yoichiro Iwakura.
    • Organizer
      第44回日本免疫学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自己免疫疾患および感染防御におけるIL-17A、IL-17Fの役割の解明2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      野口英世記念医学賞受賞記念講演
    • Place of Presentation
      猪苗代町体験交流館学びいなホール
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] C型レクチン受容体DCIR欠損マウスで認められた関節強直と骨量増加の病態解析2015

    • Author(s)
      海部知則、丸橋拓海、矢部力朗、鄭琇絢、妹尾彬正、藤門範行、岩倉洋一郎
    • Organizer
      日本リウマチ学会第2回JCRベーシックリサーチカンファレンス
    • Place of Presentation
      東京大学
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Basic Research for Infection, Inflammation, and Immunity Using Gene-Modified Mice2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Dalian Medical University (Sponsored by Prof. Yigjie Wu)
    • Place of Presentation
      Dalian Medical University
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The roles of C-type lectin receptors in the homeostasis of the intestinal immune system2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      National Defense Medical Center, (Sponsored by Prof. Ann Chen)
    • Place of Presentation
      National Defense Medical Center, Taipei
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自己免疫発症における補体第二経路特異的制御因子CTRP6の役割2015

    • Author(s)
      村山正承、吉田佳織、松尾謙蔵、岩倉洋一郎
    • Organizer
      第52回日本補体学会学術集会
    • Place of Presentation
      名古屋大学医学部附属病院
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine.2015

    • Author(s)
      Ce Tang, Tomonori Kamina, Yoichiro Iwakura.
    • Organizer
      Third Annual Meeting of the International Cytokine & Interferon Society (ICIS).
    • Place of Presentation
      Bamberg, Germany
    • Year and Date
      2015-08-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DCIR maintains bone homeostasis by regulating IFN-γ production in T cells.2015

    • Author(s)
      Tomonori Kaifu, Takumi Maruhashi, Rikio Yabe, Soo-hyun Chung, Akimasa Seno, Noriyuki Fujikado, Yoichiro Iwakura.
    • Organizer
      Third Annual Meeting of the International Cytokine & Interferon Society (ICIS).
    • Place of Presentation
      Bamberg, Germany
    • Year and Date
      2015-08-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CTRP6, complement regulator, effectively treats induced arthritis.2015

    • Author(s)
      Masanori Murayama, Yoichiro Iwakura.
    • Organizer
      Third Annual Meeting of the International Cytokine & Interferon Society (ICIS).
    • Place of Presentation
      Bamberg, Germany
    • Year and Date
      2015-08-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] C型レクチンによる感染防御機構2015

    • Author(s)
      西城忍
    • Organizer
      第34回に本糖質学会
    • Place of Presentation
      東京大学安田講堂
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The role of Dectin-1 in the homeostasis of the intestinal immune system2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      International Symposium of the Center for Animal Disease Models 2015
    • Place of Presentation
      Gakushi-kaikan, Tokyo
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IL-17産生性γδT細胞によるIL-1Ra KOマウスの関節炎発症メカニズム.2015

    • Author(s)
      秋津葵、角田茂、 西城忍、 岩倉洋一郎.
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新たな補体制御因子CTRP6による補体制御機構および関節リウマチに対する治療効果の検討.2015

    • Author(s)
      村山正承、岩倉洋一郎
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大腸炎発症におけるIL-1受容体II型の機能解析.2015

    • Author(s)
      吉田佳織、清水謙次、村山正承、岩倉洋一郎
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウスモデルを用いた関節リウマチ発症機構の解析と治療への応用2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      第26回に本生体防御学会
    • Place of Presentation
      台東区生涯学習センターミレミアムホール
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細菌・真菌の細胞壁構成成分とC型レクチン受容体による認識2015

    • Author(s)
      西城忍
    • Organizer
      第24回内毒素・LPS研究会
    • Place of Presentation
      東京大学農学部中島薫一郎記念ホール
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 炎症および感染防御に於けるIL-17AとIL-17Fの機能2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      第114回日本皮膚科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 新規大腸炎モデルRag2-/-Il1rn-/-マウスはILC3 細胞由来IL-17A が病態形成に重要な役割を果たしている2015

    • Author(s)
      秋津葵、角田茂、 西城忍、 岩倉洋一郎.
    • Organizer
      第62回日本実験動物学会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 東京理科大学生命医科学研究所実験動物研究部門における遺伝子改変マウス供給について.2015

    • Author(s)
      久保幸子、海部知則、岩倉洋一郎
    • Organizer
      第62回日本実験動物学会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 炎症および感染防御に於けるIL-17AとIL-17Fの機能2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      ふじのくに乾癬Expert Meeting
    • Place of Presentation
      静岡市グランディエール ブケ・トーカイ
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 炎症および感染防御に於けるIL-17AとIL-17Fの機能2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      Psoriasis and IL-17A Forum 2015
    • Place of Presentation
      東京六本木ミッドタウンホール、東京都
    • Year and Date
      2015-03-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 自己炎症、自己免疫に於けるIL-1の役割2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      第8回自己炎症疾患研究会
    • Place of Presentation
      フクラシア東京ステーション、東京都
    • Year and Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Pathogenic mechanisms of rheumatoid arthritis revealed by animal models.2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      The Fourth Bizan Immunology Symposium at University of Tokushima (BISUT4) “Immune System Development, Deviation, and Regulation”
    • Place of Presentation
      Fujii Memorial Hall, University of Tokushima,Tokushima
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to an intrinsic defect in IL-17-producing gammadelta T cells.2015

    • Author(s)
      秋津葵
    • Organizer
      The Fourth Bizan Immunology Symposium at University of Tokushima (BISUT4) “Immune System Development, Deviation, and Regulation”
    • Place of Presentation
      Fujii Memorial Hall, University of Tokushima,Tokushima
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] IFN-γ is an osteoblatogenic factor for increasing the bone volume in DCIR-deficient mice.2014

    • Author(s)
      海部知則
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] CTRP3 plays an important role in the development of collagen-induced arthritis2014

    • Author(s)
      村山正承
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to an intrinsic defect in IL-17-producing gammadelta T cells.2014

    • Author(s)
      秋津葵
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dectin-1 signaling modifies colonic microflora by inducing IL-17F-dependent antimicrobial peptide S100A8 expression.2014

    • Author(s)
      神谷知憲
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Interleukin-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting interleukin-1 signal on macrophages.2014

    • Author(s)
      清水謙次
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine.2014

    • Author(s)
      唐策
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抑制型C型レクチン受容体Dendritic Cell ImmunoReceptor (DCIR)とIFN-gによる骨代謝制御2014

    • Author(s)
      海部知則
    • Organizer
      第181回日仏生物学会例会
    • Place of Presentation
      京都産業大学むすびわざ館、京都府
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 免疫系、および骨代謝系の恒常性維持に於けるDCIRの役割2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      糖鎖科学コンソーシアムシンポジウムー糖鎖創薬を目指して、感染、炎症、免疫と糖鎖科学―、
    • Place of Presentation
      東京医科歯科大学、東京都
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Gene manipulated mice as a tool to develop new drugs.2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      China-US innovation dialogue on gene engineering animal models and medical research international forum.
    • Place of Presentation
      Dalian, China
    • Year and Date
      2014-11-22 – 2014-11-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to an intrinsic defect in IL-17-producing gammadelta T cells.2014

    • Author(s)
      秋津葵
    • Organizer
      The International Cytokine and International Society 2014 Annual Meeting.
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-10-26 – 2014-10-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dectin-1 modifies colonic microflora by inducing cytokine-dependent antimicrobial peptide secretion from intestinal epithelial cells.2014

    • Author(s)
      神谷知憲
    • Organizer
      The International Cytokine and International Society 2014 Annual Meeting.
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-10-26 – 2014-10-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Interleukin-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting interleukin-1 signal on macrophages.2014

    • Author(s)
      清水謙次
    • Organizer
      The International Cytokine and International Society 2014 Annual Meeting.
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-10-26 – 2014-10-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウスモデルを用いた関節リウマチ発症機構の解析2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      第1回アニュアルベーシックコースレクチャー特別講演
    • Place of Presentation
      アキバホール、東京都
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 真菌感染防御機構とC型レクチン2014

    • Author(s)
      西城忍
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The role of DCIR in maintaining the homeostasis of the immune system and the bone.2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      Novo Nordisk Innovation Summit,
    • Place of Presentation
      Institute of Medical Science, University of Tokyo,Tokyo
    • Year and Date
      2014-10-01 – 2014-10-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 真菌感染防御機構におけるC型レクチンの役割2014

    • Author(s)
      西城忍
    • Organizer
      第26回微生物シンポジウム
    • Place of Presentation
      都市センターホテル、東京都
    • Year and Date
      2014-09-19 – 2014-09-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 真菌感染に対する生体防御システム2014

    • Author(s)
      西城忍
    • Organizer
      千葉大学未来医療教育研究機構シンポジウム 第4部「亥鼻キャンパスの特色ある先端研究・教育の紹介」
    • Place of Presentation
      ステーションコンファレンス東京6階、東京都
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 遺伝子改変マウスを用いた関節リウマチ発症機構の解析2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      東京理科大学生命医科学研究所ヒト疾患モデル研究センター動物実験棟竣工記念シンポジウム「ヒト疾患モデル研究拠点の構築を目指して」
    • Place of Presentation
      東京理科大学野田薬学部大講堂、千葉県
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The role of Dectin-1 and Dectin-2 in the host defense against fungi and in intestinal immunity.2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      International Symposium Human Genetics
    • Place of Presentation
      Novosibirsk, Russia
    • Year and Date
      2014-06-23 – 2014-06-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 抑制性C型レクチン受容体DCIRによるIFN-gを介した骨代謝制御機構2014

    • Author(s)
      海部知則
    • Organizer
      第79回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      北海道大学医学部学友会館フラテホール、北海道
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抑制性C型レクチン受容体DCIRによる骨代謝制御機構2014

    • Author(s)
      海部知則
    • Organizer
      北海道大学 遺伝子病制御研究所 IGMセミナー
    • Place of Presentation
      北海道大学、北海道
    • Year and Date
      2014-06-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 海藻由来βグルカンによる腸管免疫制御2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      第16回マリンバイオテクノロジー学会大会「マリンバイオ三重2014」シンポジウム「藻類の機能性とバイオリファイナリーへの展開」
    • Place of Presentation
      三重大学生物資源学部、三重県
    • Year and Date
      2014-06-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 創薬に於ける実験動物の役割2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      第61回日本実験動物学会市民公開講座「人々の健康に貢献する動物実験と実験動物の福祉」
    • Place of Presentation
      札幌コンベンションセンター特別会議場、北海道
    • Year and Date
      2014-05-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] DCIR欠損マウスで認められた骨量増加メカニズムの解明2014

    • Author(s)
      海部知則
    • Organizer
      第61回日本実験動物学会総会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 東京理科大学生命医科学研究所実験動物研究部門における遺伝子改変マウス供給について2014

    • Author(s)
      久保幸子
    • Organizer
      第61回日本実験動物学会総会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 関節リウマチモデルにおけるCTRP3の役割の解析2014

    • Author(s)
      村山正承
    • Organizer
      第61回日本実験動物学会総会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Rag2-/-Il1rn-/-マウスはILC3 細胞由来IL-17A が病態形成に重要な役割を果たしている2014

    • Author(s)
      秋津葵
    • Organizer
      第61回日本実験動物学会総会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dectin-1シグナルを介するマウス腸管炎症の抑制による新規な腸疾患治療法開発2014

    • Author(s)
      唐策
    • Organizer
      第61回日本実験動物学会総会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 自己免疫、及び感染防御に於けるIL-17の役割2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      第10回皮膚免疫疾患研究会
    • Place of Presentation
      ヒルトン大阪、大阪府
    • Year and Date
      2014-04-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dectin-1の腸管免疫に果たす役割2014

    • Author(s)
      岩倉洋一郎
    • Organizer
      糖鎖免疫研究会Glyco-Immunology2014
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Dcir-deficient mice as a novel model for ankylosing spondylitis2013

    • Author(s)
      岩倉洋一郎
    • Organizer
      第57回日本リウマチ学会シンポジウム3
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The roles of IL-17A and IL-17F in inflammation, tumorigenesis, and host defense against pathogens2013

    • Author(s)
      Iwakura, Y.
    • Organizer
      National Defense Medical Center, Taipei (Host: Prof. Ann Chen)
    • Place of Presentation
      Taipei
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The roles of IL-17A and IL-17F in inflammation, tumorigenesis, and host defense against pathogens2013

    • Author(s)
      Iwakura, Y.
    • Organizer
      College of Medicine, National Taiwan University, Taipei (Host: Prof. Shu-Wha Lin)
    • Place of Presentation
      Taipei
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The roles of IL-17A and IL-17F in inflammation, tumorigenesis, and host defense against pathogens2013

    • Author(s)
      Iwakura, Y.
    • Organizer
      Infection and Immunity Center, National Yang-Min University, Taipei (Host: Prof. Edmond Shie-Liang, Hsieh & Prof. Prof. Alice Chang)
    • Place of Presentation
      Taipei
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The roles of IL-17A and IL-17F in inflammation, tumorigenesis, and host defense against pathogens2013

    • Author(s)
      Iwakura, Y.
    • Organizer
      Mackay Medical College, Taipei (Host: Nan-Chi Chan)
    • Place of Presentation
      Taipei
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The roles of IL-17A and IL-17F in inflammation, tumorigenesis, and host defense against pathogens2013

    • Author(s)
      Iwakura, Y.
    • Organizer
      R & D Center for Biotech Products, National Ilan University, Ilan (Host: Wei-Jung Chen, Director & Prof., Kuo-Feng Hua)
    • Place of Presentation
      Taipei
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Novel complement regulator CTRP6 effectively treats induced arthritis2013

    • Author(s)
      Iwakura, Y.
    • Organizer
      JSICR-MMCB 2013 Joint Symposium in Tokyo, Toshi Center Hotel
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The Roles of IL-1 and IL-17 in the Development of Arthritis and Dermatitis in Animal Models2013

    • Author(s)
      Iwakura, Y.
    • Organizer
      The 8th annual meeting of the Taiwaneese Society for Investigative Dermatology. Lecture Hall, Medical College of National Taiwan University (Shiou-Hwa Jee, President)
    • Place of Presentation
      Taipei
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マウスを使った関節リウマチ治療法の研究2013

    • Author(s)
      岩倉洋一郎
    • Organizer
      免疫ふしぎ未来2013
    • Place of Presentation
      日本化学未来館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Pathways in inflammatory diseases (chair and speaker)2013

    • Author(s)
      Iwakura, Y.
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 自然免疫修飾による健康増進を目指した高機能食品開発の試み2013

    • Author(s)
      岩倉洋一郎
    • Organizer
      アグリビジネス創出フェア
    • Place of Presentation
      東京国際展示場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 腸管免疫に於ける自然免疫の役割2013

    • Author(s)
      岩倉洋一郎
    • Organizer
      北海道大学遺伝子病制御研究所講演会
    • Place of Presentation
      北海道大学遺伝子病制御研究所
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] L-17およびTh17の自己免疫疾患に於ける役割2013

    • Author(s)
      岩倉洋一郎
    • Organizer
      ノバルティスScientific Advisory Meeting, The Prince Tower
    • Place of Presentation
      Sakura Tower Tokyo,高輪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Dectin-1 signaling synergistically enhances toll-like receptor-mediated production of interferon beta.2013

    • Author(s)
      Kadoki, M., Sasaki, Y., Tang, C., Kamiya, T., and Iwakura, Y.
    • Organizer
      2013 Inaugural Meeting of the International Cytokine and Interferon Society (ICIS)
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] CCR8 deficiency causes exacerbation of contact hypersensitivity due to enhanced dendritic cell migration.2013

    • Author(s)
      Yabe, R. Shimizu, K. Shimizu, S. Azechi, S. Choi, BI. Kubo, S. Kakuta, S. Nakae, S. and Iwakura, Y.
    • Organizer
      2013 Inaugural Meeting of the International Cytokine and Interferon Society (ICIS)
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-17-producing gamma-delta T cells are crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.2013

    • Author(s)
      Akitsu A., Ishigame H., Kakuta S., Saijo S., Iwakura Y.
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dendritic Cell ImmunoReceptor (DCIR) is a negative regulator in balancing bone metabolism.2013

    • Author(s)
      Kaifu T., Maruhashi T, Ma G, Yabe R, Seno A, Iwakura Y.
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新たな補体制御因子CTRP6の関節リウマチに対する治療効果2013

    • Author(s)
      村山正承、米沢朋、岩倉洋一郎.
    • Organizer
      第一回筑波大学・東京理科大学生命医科学研究所合同リトリート
    • Place of Presentation
      東京理科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] インターロイキン-1受容体2型欠損マウスにおけるコラーゲン誘導関節炎の増悪化.2013

    • Author(s)
      清水謙次、角田茂、溝呂木暁彦、宝来玲子、中嶋明子、岩倉洋一郎
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 炎症性大腸炎の病態形成におけるDectin-1の新規の役割解析.2013

    • Author(s)
      唐策
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] DCIR欠損マウスを用いたC型レクチン受容体による骨代謝制御機構の解明.2013

    • Author(s)
      海部知則、丸橋拓海、馬光宇、矢部力朗、妹尾彬正、岩倉洋一郎.
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 遺伝子欠損マウスを用いたIL-1の負の調節因子群の機能解析.2013

    • Author(s)
      五十嵐哲郎、清水謙次、秋津葵、久保幸子、劉陽、中嶋明子、宝来玲子、石亀晴道、松本清司、久和茂、岩倉洋一郎、角田茂.
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大、岐阜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 疾患モデルマウスを用いたIL1/IL17ファミリー遺伝子の腸管ポリープ形成における役割.2013

    • Author(s)
      角田茂、鈴木俊佐、佐々木大和、五十嵐哲郎、渋川茉莉、村山正承、秋津葵、岡江寛明、石亀晴道、松本清司、久和茂、岩倉洋一郎.
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大、岐阜
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-17産生性γδT細胞はリウマチ様関節炎発症に重要である2012

    • Author(s)
      秋津葵
    • Organizer
      第77回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      神戸商工会議所
    • Related Report
      2012 Annual Research Report
  • [Presentation] 遺伝子変異マウスを用いたIL-17A/Fの消化管における機能の解析2012

    • Author(s)
      角田茂
    • Organizer
      第21回内毒素・LPS研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Rheumatoid Arthritis Models2012

    • Author(s)
      Iwakura, Y.
    • Organizer
      Novartis IL-17 Scientific Advisory Board
    • Place of Presentation
      Frankfurt, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 腸管ポリープ形成とIL1/IL17の役割2012

    • Author(s)
      角田茂
    • Organizer
      第7回遺伝子栄養学研究会
    • Place of Presentation
      北広島クラッセホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] C-type Lectin Receptor DCIR and the Complement System as Targets for the Treatment of Rheumatoid Arthritis2012

    • Author(s)
      Iwakura, Y.
    • Organizer
      Translational Inflammation Summit, The International Association of Inflammation Societies (IAIS), “Defining the Frontiers and Translational Pathways of Inflammation Research”
    • Place of Presentation
      Bolton Landing, NY
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Dendritic immunoreceptor (DCIR) is a negative regulator in osteoclastogenesis2012

    • Author(s)
      Kaifu, T
    • Organizer
      Basic and Clinical Review Course, The 15th Congress of Asia Pacific League of Associations for Rheumatology (APLAR 2012)
    • Place of Presentation
      Dead Sea, Jordan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Animal Models for Rheumatoid Arthritis2012

    • Author(s)
      Iwakura, Y.
    • Organizer
      Basic and Clinical Review Course, The 15th Congress of Asia Pacific League of Associations for Rheumatology (APLAR 2012)
    • Place of Presentation
      Dead Sea, Jordan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A novel role of Dectin-1 signaling in promoting intestinal inflammation2012

    • Author(s)
      Tang, C
    • Organizer
      10th joint annual meeting of the interferon and cytokine society and the international society for interferon and cytokine research (Cytokine2012)
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-17-producing γδ T cells are crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice2012

    • Author(s)
      Akitsu, A
    • Organizer
      10th joint annual meeting of the interferon and cytokine society and the international society for interferon and cytokine research (Cytokine2012)
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Roles of IL-17A and IL-17F in Inflammation, Tumorigenesis, and Host Defense against Pathogens2012

    • Author(s)
      Iwakura, Y.
    • Organizer
      10th joint annual meeting of the interferon and cytokine society and the international society for interferon and cytokine research (Cytokine2012)
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 関節炎発症における補体の役割とC1qTNFによる制御2012

    • Author(s)
      岩倉洋一郎
    • Organizer
      第40回日本臨床免疫学会シンポジウム2「分子標的治療から見た病態へのアプローチ」
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 疾患モデルを用いた関節リウマチ発症機構の解析2012

    • Author(s)
      岩倉洋一郎
    • Organizer
      第12回臨床免疫セミナー in Kyoto
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Roles of IL-17A and IL-17F in host defense against pathogens and intestinal tumors2012

    • Author(s)
      Iwakura, Y.
    • Organizer
      The 34th Naito Conference “Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine”
    • Place of Presentation
      シャトレーゼ ガトーキングダム サッポロ、札幌
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 疾患モデルを用いた関節リウマチ発症機構の解析2012

    • Author(s)
      岩倉洋一郎
    • Organizer
      筑波大学-東京理科大学生命医科学研究所合同シンポジウム「難治性免疫疾患・アレルギー疾患の克服を目指して」
    • Place of Presentation
      学士会館、東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 関節炎発症に於ける補体系の役割2012

    • Author(s)
      岩倉洋一郎
    • Organizer
      第93回発生工学・疾患モデル研究会“終了記念講演会”
    • Place of Presentation
      ホテル東京ガーデンパレス、東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] IL-17-producing γδ T cells are crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice2012

    • Author(s)
      Akitsu, A
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] DCIR deficient mice as a novel model of ankylosing spondylitis2012

    • Author(s)
      Maruhashi, T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dendritic Cell ImmunoReceptor (DCIR) negatively regulates osteoclastogenesis2012

    • Author(s)
      Kaifu, T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dectin-1 signaling regulates the balance of intestinal microflora2012

    • Author(s)
      Kamiya, T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Book] トピックス 「自己免疫疾患に対する新たな治療標的の発見」2017

    • Author(s)
      村山正承、岩倉洋一郎
    • Total Pages
      4
    • Publisher
      理大科学フォーラム
    • Related Report
      2016 Annual Research Report
  • [Book] セミナー室「低分子βグルカン摂取により炎症性腸疾患を予防,改善する」2016

    • Author(s)
      唐策、角田茂、岩倉洋一郎
    • Total Pages
      6
    • Publisher
      日本農芸化学会
    • Related Report
      2016 Annual Research Report
  • [Book] Dendritic Cell Immunoreceptor (DCIR): An ITIM-Harboring C-Type Lectin Receptor.2016

    • Author(s)
      Tomonori Kaifu and Yoichiro Iwakura.
    • Total Pages
      12
    • Publisher
      Springer Japan
    • Related Report
      2016 Annual Research Report
  • [Book] IL-1ファミリー分子による免疫制御2016

    • Author(s)
      秋津葵、岩倉洋一郎
    • Total Pages
      7
    • Publisher
      科学評論社
    • Related Report
      2016 Annual Research Report
  • [Book] 医歯薬出版株式会社2016

    • Author(s)
      秋津葵、岩倉洋一郎
    • Total Pages
      5
    • Publisher
      自己免疫性関節炎と病原性T細胞
    • Related Report
      2016 Annual Research Report
  • [Book] Chronic inflammation2016

    • Author(s)
      Saijo S
    • Total Pages
      12
    • Publisher
      Springer Japan
    • Related Report
      2016 Annual Research Report
  • [Book] C-type lectin receptors in immunity2016

    • Author(s)
      Yabe R. and Saijo S.
    • Total Pages
      12
    • Publisher
      Springer Japan
    • Related Report
      2016 Annual Research Report
  • [Book] C-type Lectin Receptors in Immunity2016

    • Author(s)
      Yabe, R. and Saijo, S
    • Total Pages
      215
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 第1章 インターロイキン「IL-1」 サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      清水謙次、岩倉洋一郎
    • Total Pages
      3
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 第1章 インターロイキン「IL-18/33/36/37」 サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      海部知則、岩倉洋一郎
    • Total Pages
      3
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 第1章 インターロイキン「IL-12」 サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      矢部力朗、岩倉洋一郎
    • Total Pages
      2
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 第1章 インターロイキン「IL-23/35」 サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      唐策、岩倉洋一郎
    • Total Pages
      3
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 第1章 インターロイキン「IL-10」 サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      鄭琇絢、岩倉洋一郎
    • Total Pages
      3
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 第1章 インターロイキン「IL-19/20/22/24/26」 サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      神谷知憲、岩倉洋一郎
    • Total Pages
      3
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 第1章 インターロイキン「IL-17A/17B/17C/17D/17E/17F」 サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      秋津葵、岩倉洋一郎
    • Total Pages
      3
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 第1章 インターロイキン「IL-14」「IL-16」「IL-32」サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      村山正承、岩倉洋一郎
    • Total Pages
      3
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 第1章 インターロイキン「成長ホルモン」「プロラクチン」サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      米沢朋、丸田大貴、岩倉洋一郎
    • Total Pages
      5
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 第2章 インターフェロン「概論」「IFN-α/β」「IFN-γ」「IFN-λファミリー(IL-28, IL-29)」サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      角田茂、岩倉洋一郎
    • Total Pages
      10
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 【大学発 日本 人と技術】日本を支える研究活動と技術開発 関節リウマチの新たな治療薬開発2015

    • Author(s)
      村山正承、岩倉洋一郎
    • Total Pages
      1
    • Publisher
      フジサンケイビジネスアイ
    • Related Report
      2015 Annual Research Report
  • [Book] Current Topics. デクチン1シグナルの阻害は、腸内乳酸桿菌を増殖させ、制御性T細胞を増加させることによって、大腸炎を抑制する」実験医学20162015

    • Author(s)
      唐策、岩倉洋一郎
    • Total Pages
      4
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] 実験医学増刊、炎症―全体像を知り慢性炎症を制御するー2014

    • Author(s)
      矢部力朗、岩倉洋一郎、西城忍
    • Total Pages
      219
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] サイトカインと自己免疫疾患.EXPERT膠原病・リウマチ 改訂第3版(住田孝之編)2013

    • Author(s)
      角田茂、岩倉洋一郎
    • Publisher
      診断と治療社
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京理科大学生命医科学研究所実験動物学研究部門

    • URL

      http://www.rs.tus.ac.jp/iwakuralab/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 東京理科大学生命医科学研究所ヒト疾患モデル研究センター

    • URL

      http://www.ribs.tus.ac.jp/index.php/cadm/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 千葉大学真菌医学研究センター感染免疫分野

    • URL

      http://cytokine.pf.chiba-u.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京理科大学 生命医科学研究所 実験動物学研究部門 岩倉研究室

    • URL

      http://www.rs.tus.ac.jp/iwakuralab/

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 樹状細胞免疫受容体活性化剤、樹状細胞免疫受容体活性化方法、破骨細胞形成抑制剤、破骨細胞形成抑制方法、樹状細胞分化・増殖阻害剤、樹状細胞分化・増殖阻害方法2014

    • Inventor(s)
      岩倉洋一郎、海部知則、矢部力朗
    • Industrial Property Rights Holder
      岩倉洋一郎、海部知則、矢部力朗
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] CTRP3 plays an important role in the development of collagen-induced arthritis in mice.2013

    • Inventor(s)
      岩倉洋一郎,村山正承
    • Industrial Property Rights Holder
      東京理科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-15
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 自己免疫疾患治療及び予防薬としてのCTRP62012

    • Inventor(s)
      岩倉洋一郎,村山正承,石亀晴道,角田茂 (東京大学)
    • Industrial Property Rights Holder
      岩倉洋一郎,村山正承,石亀晴道,角田茂 (東京大学)
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-11-22
    • Related Report
      2012 Annual Research Report
    • Overseas

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

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