| Budget Amount *help |
¥187,590,000 (Direct Cost: ¥144,300,000、Indirect Cost: ¥43,290,000)
Fiscal Year 2016: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2015: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2014: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2013: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2012: ¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
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| Outline of Final Research Achievements |
Based on both high-resolution frequency modulation atomic force microscopy (AFM) and dual probe AFM techniques, working in liquids, we have successfully realized a novel method for the visualization of molecular-scale bio-functions in addition to structural imaging of biomolecules. The method allows us to directly investigate various biomolecules in a wide variety of aspects such as direct visualization of protein domains, molecular-scale identification of specific binding sites and quantitative force analysis of binding interactions. Furthermore, we succeeded in the visualization of hydration structures and local charge densities of biomolecules, which are directly related to biochemical activities.
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