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An integrated genomic analysis on evolution of cancer cell population

Research Project

Project/Area Number 24221011
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Medical genome science
Research InstitutionThe University of Tokyo

Principal Investigator

Aburatani Hiroyuki  東京大学, 先端科学技術研究センター, 教授 (10202657)

Co-Investigator(Renkei-kenkyūsha) TSUTSUMI Shuichi  東京大学, 先端科学技術研究センター, 特任准教授 (30345152)
ISHIKAWA Shumpei  東京医科歯科大学, 難治疾患研究所, 教授 (50418638)
Project Period (FY) 2012-05-31 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥217,750,000 (Direct Cost: ¥167,500,000、Indirect Cost: ¥50,250,000)
Fiscal Year 2016: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2015: ¥44,070,000 (Direct Cost: ¥33,900,000、Indirect Cost: ¥10,170,000)
Fiscal Year 2014: ¥40,690,000 (Direct Cost: ¥31,300,000、Indirect Cost: ¥9,390,000)
Fiscal Year 2013: ¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000)
Fiscal Year 2012: ¥50,570,000 (Direct Cost: ¥38,900,000、Indirect Cost: ¥11,670,000)
Keywordsゲノム / エピゲノム / クロマチン / クローン進化 / 微小環境 / 不均一性 / 可塑性 / ドライバー変異 / ノンコーディングRNA / 腫瘍内多様性 / がん / 発現制御 / 進化 / 幹細胞 / エクソーム
Outline of Final Research Achievements

We studied genetic heterogeneity and epigenetic plasticity among the tumor cell population which promote survival and clonal evolution of resistant cell clones and adaptation to the tumor microenvironment.
We demonstrated evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment, which suggest that tumor cells may undergo positive selection during TMZ treatment in the context of mismatch repair deficiency. Adaptation to the intratumoral microenvironment is crucial for tumor cell survival. Under the low pH condition, the transcription factor SREBP2 is activated, leading to tumor cell proliferation by altering acetic acid metabolism with ACSS2 induction.
In summary, epigenomic alteration occurs in various levels, such as chromatin domains, genes, and regulatory regions during tumor development and progression.

Assessment Rating
Verification Result (Rating)

A-

Result (Rating)

A-: Progress in the research is steadily towards the initial goal. However, further efforts are necessary as a part of the research progress is delayed.

Report

(9 results)
  • 2017 Research Progress Assessment (Verification Result) ( PDF )
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(134 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research Journal Article Presentation Remarks

  • [Int'l Joint Research] University of California, San Francisco(アメリカ合衆国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine(アメリカ合衆国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Differences in genetic and epigenetic alterations between von Hippel?Lindau disease?related and sporadic hemangioblastomas of the central nervous system2017

    • Author(s)
      Takayanagi S, Mukasa A, Tanaka S, Nomura M, Omata M, Yanagisawa S, Yamamoto S, Ichimura K, Nakatomi H, Ueki K, Aburatani H, Saito N
    • Journal Title

      Neuro-Oncology

      Volume: 印刷中 Pages: 1228-1236

    • DOI

      10.1093/neuonc/nox034

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Saito N. Genetic and epigenetic stability of oligodendrogliomas at recurrence.2017

    • Author(s)
      Aihara K, Mukasa A, Nagae G, Nomura M, Yamamoto S, Ueda H, Tatsuno K, Shibahara J, Takahashi M, Momose T, Tanaka S, Takayanagi S, Yanagisawa S, Nejo T, Takahashi S, Omata M, Otani R, Saito K, Narita Y, Nagane M, Nishikawa R, Ueki K, Aburatani H, Saito N
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 5 Pages: 1-11

    • DOI

      10.1186/s40478-017-0422-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression2017

    • Author(s)
      Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H and Osawa T
    • Journal Title

      Cell Rep

      Volume: 18 Pages: 2228-2242

    • DOI

      10.1016/j.celrep.2017.02.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CellTree: an R/bioconductor package to infer the hierarchical structure of cell populations from single-cell RNA-seq data.2017

    • Author(s)
      duVerle DA, Yotsukura S, Nomura S, Aburatani H, Tsuda K
    • Journal Title

      BMC Bioinformatics

      Volume: 17 Pages: 363-363

    • DOI

      10.1186/s12859-016-1175-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CASTIN: a system for comprehensive analysis of cancer-stromal interactome.2016

    • Author(s)
      Komura D, Isagawa T, Kishi K, Suzuki R, Sato R, Tanaka M, Katoh H, Yamamoto S, Tatsuno K, Fukayama M, Aburatani H, Ishikawa S
    • Journal Title

      BMC Genomics

      Volume: 17 Pages: 899-899

    • DOI

      10.1186/s12864-016-3207-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection2016

    • Author(s)
      Namba-Fukuyo H, Funata S, Matsusaka K, Fukuyo M, Rahmutulla B, Mano Y, Fukayama M, Aburatani H, Kaneda A
    • Journal Title

      Oncotarget

      Volume: 7 Pages: 81512-26

    • DOI

      10.18632/oncotarget.13130

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Base-Resolution Analysis of 5-Hydroxymethylcytosine by One-Pot Bisulfite-Free Chemical Conversion with Peroxotungstate2016

    • Author(s)
      Hayashi G, Koyama K, Shiota H, Kamio A, Umeda T, Nagae G, Aburatani H, Okamoto A.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 138 Pages: 14178-14181

    • DOI

      10.1021/jacs.6b06428

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53.2016

    • Author(s)
      Makii C, Oda K, Ikeda Y, Sone K, Hasegawa K, Uehara Y, Nishijima A, Asada K, Koso T, Fukuda T, Inaba K, Oki S, Machino H, Kojima M, Kashiyama T, Mori-Uchino M, Arimoto T, Wada-Hiraike O, Yano KK, Fujiwara K, Aburatani H, Osuga Y, Fujii T.
    • Journal Title

      Oncotarget

      Volume: 7 Pages: 75328-75338

    • DOI

      10.18632/oncotarget.12175

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis2016

    • Author(s)
      Matsusaka K, Ushiku T, Urabe M, Fukuyo M, Abe H, Ishikawa S, Seto Y, Aburatani H, Hamakubo T, Kaneda A, Fukayama M.
    • Journal Title

      Oncotarget.

      Volume: 7 Pages: 64168-64181

    • DOI

      10.18632/oncotarget.11510

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program.2016

    • Author(s)
      Vasilaki E, Morikawa M, Koinuma D, Mizutani A, Hirano Y, Ehata S, Sundqvist A, Kawasaki N, Cedervall J, Olsson AK, Aburatani H, Moustakas A, Miyazono K, Heldin CH.
    • Journal Title

      Science Signaling

      Volume: 9

    • DOI

      10.1126/scisignal.aag3232

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth.2016

    • Author(s)
      Obinata D, Takayama K, Fujiwara K, Suzuki T, Tsutsumi S, Fukuda N, Nagase H, Fujimura T, Urano T, Homma Y, Aburatani H, Takahashi S and Inoue S.
    • Journal Title

      Oncogene

      Volume: 35 Pages: 6350-6358

    • DOI

      10.1038/onc.2016.171

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Network-based analysis for identification of candidate genes for colorectal cancer progression.2016

    • Author(s)
      Tsuji S, Midorikawa Y, Seki M, Takayama T, Sugiyama Y, Aburatani H
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 476 Pages: 534-40

    • DOI

      10.1016/j.bbrc.2016.05.158

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor Content Chart-Assisted HER2/CEP17 Digital PCR Analysis of Gastric Cancer Biopsy Specimens2016

    • Author(s)
      Matsusaka K, Ishikawa S, Nakayama A, Ushiku T, Nishimoto A, Urabe M, Kaneko N, Kunita A, Kaneda A, Aburatani H, Fujishiro M, Seto Y, Fukayama M.
    • Journal Title

      PLoS One.

      Volume: 11

    • DOI

      10.1371/journal.pone.0154430

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer2016

    • Author(s)
      Fujimoto A et al.
    • Journal Title

      Nat Genet.

      Volume: 48 Pages: 500-509

    • DOI

      10.1038/ng.3547

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Meis1-mediated tranactivation of synaptotagmin like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis2016

    • Author(s)
      Yokoyama T, Nakatake M, Kuwata T, Couiznet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJ, Delwel R, Nakamura T.
    • Journal Title

      J. Clin. Invest.

      Volume: 印刷中 Pages: 1664-1678

    • DOI

      10.1172/jci81516

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells2016

    • Author(s)
      Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Kobayashi Y, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R.
    • Journal Title

      Cancer Sci

      Volume: 印刷中 Pages: 434-435

    • DOI

      10.1111/cas.12933

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence.2016

    • Author(s)
      Fujimoto M, Mano Y, Anai M, Yamamoto S, Fukuyo M, Aburatani H, Kaneda A.
    • Journal Title

      World J Biol Chem

      Volume: 7(1): Pages: 188-205

    • DOI

      10.4331/wjbc.v7.i1.188

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated multiregional analysis proposing a new model of colorectal cancer evolution2016

    • Author(s)
      R. Uchi (他40名, 山本36番目)
    • Journal Title

      PLoS Genet

      Volume: 12 Pages: 1005778-1005778

    • DOI

      10.1371/journal.pgen.1005778

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genomic landscape of esophageal squamous cell carcinoma a Japanese population2016

    • Author(s)
      Sawada G, Niida A, Uchi R, Hirata H, Shimamura T, (38 authors), Mimori K
    • Journal Title

      Gastroenterology.

      Volume: 150(5) Pages: 1049-1051

    • DOI

      10.1053/j.gastro.2016.01.035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] SCFfbxo22-KDM4A targets methylated p53 for degradation and regulates senescence2016

    • Author(s)
      Johmura Y, Sun J, Kitagawa K, Nakanishi K, Kuno T, Naiki-Ito A, Sawada Y, Miyamoto T, Okabe A, Aburatani H, Li S-F, Miyoshi I, Takahashi S, Kitagawa M, Nakanishi M.
    • Journal Title

      Nature communications

      Volume: 7 Pages: 10574-10574

    • DOI

      10.1038/ncomms10574

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kruppel-like Factors2016

    • Author(s)
      Morikawa M, Koinuma D, Mizutani A, Kawasaki N, Holmborn K, Sundqvist A, Tsutsumi S, Watabe T, Aburatani H, Heldin CH, Miyazono K.
    • Journal Title

      Stem Cell Reports

      Volume: 6 Pages: 64-73

    • DOI

      10.1016/j.stemcr.2015.12.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genomic characterization of primary central nervous system lymphoma.2016

    • Author(s)
      Fukumura K, Kawazu M, Kojima S, Ueno T, Sai E, Soda M, Ueda H, Yasuda T, Yamaguchi H, Lee J, Shishido-Hara Y, Sasaki A, Shirahata M, Mishima K, Ichimura K, Mukasa A, Narita Y, Saito N, Aburatani H, Nishikawa R, Nagane M, Mano H.
    • Journal Title

      Acta Neuropathol.

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis2016

    • Author(s)
      Yoshinori Asano, Tatsuya Kawase, Atsushi Okabe, Shuichi Tsutsumi, Hitoshi Ichikawa, Satoko Tatebe, Issay Kitabayashi, Fumio Tashiro, Hideo Namiki, Tadashi Kondo, Kentaro Semba, Hiroyuki Aburatani, Yoichi Taya, Hitoshi Nakagama and Rieko Ohki
    • Journal Title

      Sci Rep.

      Volume: 6 Pages: 19174-19174

    • DOI

      10.1038/srep19174

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma2016

    • Author(s)
      Saito Y, Nagae G, Motoi N, Miyauchi E, Ninomiya H, Uehara H, Mun M, Okumura S, Ohyanagi F, Nishio M, Satoh Y, Aburatani H, Ishikawa Y.
    • Journal Title

      Cancer Sci

      Volume: 107(3) Pages: 320-325

    • DOI

      10.1111/cas.12876

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas.2016

    • Author(s)
      Ikemura M, Shibahara J, Mukasa A, Takayanagi S, Aihara K, Saito N, Aburatani H, Fukayama M.
    • Journal Title

      Histopathology.

      Volume: 印刷中

    • DOI

      10.1111/his.12927

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenomic Regulation of Smad1 Signaling During Cellular Senescence Induced by Ras Activation.2016

    • Author(s)
      Kaneda A, Nonaka A, Fujita T, Yamanaka R, Fujimoto M, Miyazono K, Aburatani H.
    • Journal Title

      Methods Mol Biol.

      Volume: 1344 Pages: 341-53

    • DOI

      10.1007/978-1-4939-2966-5_22

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway2016

    • Author(s)
      Sakai E, Fukuyo M, Ohata K, Matsusaka K, Doi N, Mano Y, Takane K, Abe H, Yagi K, Matsuhashi N, Fukushima J, Fukayama M, Akagi K, Aburatani H, Nakajima A, Kaneda A.
    • Journal Title

      International Journal of Cancer

      Volume: 138 Pages: 1634-1644

    • DOI

      10.1002/ijc.29903

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases.2016

    • Author(s)
      Ushiku T, Ishikawa S, Kakiuchi M, Tanaka A, Katoh H, Aburatani H, Lauwers GY, Fukayama M.
    • Journal Title

      Gastric Cancer

      Volume: 19 Pages: 403-11

    • DOI

      10.1007/s10120-015-0493-0

    • NAID

      40020835356

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated molecular analysis of adult T-cell leukemia/lymphoma.2015

    • Author(s)
      Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, et al.
    • Journal Title

      Nat Genet

      Volume: 47(11) Pages: 1304-1315

    • DOI

      10.1038/ng.3415

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] DNA methylation status as a biomarker of anti-EGFR treatment for metastatic colorectal cancer2015

    • Author(s)
      Ouchi K, Takahashi S, Yamada Y, Tsuji S, Tatsuno K, Takahashi H, Takahashi N, Takahashi M, Shimodaira H, Aburatani H, Ishioka C.
    • Journal Title

      Cancer Sci.

      Volume: 106 Pages: 1722-1726

    • DOI

      10.1111/cas.12827

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Comparison of chemotherapeutic agents as a myeloablative conditioning with TBI for pediatric ALL: a study from the pediatric ALL working group of the JSHCT.2015

    • Author(s)
      Seki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, Kato M, Chiba K, Tanaka H, Hoshino N, Nagae G, Shiozawa Y, Okuno Y, Hosoi H, Tanaka Y, Okita H, Miyachi M, Souzaki R, Taguchi T, Koh K, Hanada R, Kato K, Nomura Y, Akiyama M, Oka A, Igarashi T, Miyano S, Aburatani H, Hayashi Y, Ogawa S, Takita J.
    • Journal Title

      Pediatr Blood Cancer.

      Volume: 6 Pages: 1844-50

    • DOI

      10.1038/ncomms8557

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Age-Dependent Decrease of DNA Hydroxymethylation in Human T Cells2015

    • Author(s)
      Truong TP, Sakata-Yanagimoto M, Yamada M, Nagae G, Enami T, Nakamoto-Matsubara R, Aburatani H, Chiba S.
    • Journal Title

      J Clin Exp Hematopathol

      Volume: 55(1) Issue: 1 Pages: 1-6

    • DOI

      10.3960/jslrt.55.1

    • NAID

      130005083797

    • ISSN
      1346-4280, 1880-9952
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report.2015

    • Author(s)
      Ikeda Y, Oda K, Aburatani H, Kawana K, Osuga Y, Fujii T
    • Journal Title

      Gynecol Oncol Rep.

      Volume: 10 Pages: 49-52

    • DOI

      10.1016/j.gynor.2014.05.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas.2015

    • Author(s)
      Uehara Y, Oda K, Ikeda Y, Koso T, Tsuji S, Yamamoto S, Asada K, Sone K, Kurikawa R, Makii C, Hagiwara O, Tanikawa M, Maeda D, Hasegawa K, Nakagawa S, Wada-Hiraike O, Kawana K, Fukayama M, Fujiwara K, Yano T, Osuga Y, Fujii T, Aburatani H.
    • Journal Title

      PLoS One.

      Volume: 10

    • DOI

      10.1371/journal.pone.0128066

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] GATA2 and secondary mutations in familial myelodysplastic syndromes and pediatric myeloid malignancies.2015

    • Author(s)
      Huang D, Nagata Y, Grossmann V, Radivoyevitch T, Okuno Y, Nagae G, et al.
    • Journal Title

      Haematologica

      Volume: 100(8) Pages: 1051-1057

    • DOI

      10.3324/haematol.2014.111989

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.2015

    • Author(s)
      Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J.
    • Journal Title

      Nature Commun

      Volume: 6 Pages: 1-14

    • DOI

      10.1038/ncomms8052

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment2015

    • Author(s)
      van Thuijl HF, Mazor T, Johnson BE, Fouse SD, Aihara K, Hong C, Malmström A, Hallbeck M, Heimans JJ, Kloezeman JJ, Stenmark-Askmalm M, Lamfers ML, Saito N, Aburatani H, Mukasa A, Berger MS, Söderkvist P, Taylor BS, Molinaro AM, Wesseling P, Reijneveld JC, Chang SM, Ylstra B, Costello JF
    • Journal Title

      Acta Neuropathol

      Volume: 129 Pages: 597-604

    • DOI

      10.1007/s00401-015-1403-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] RUNX1, an androgen- and EZH2-regulated gene, has differential roles in AR-dependent and -independent prostate cancer.2015

    • Author(s)
      Takayama K, Suzuki T, Tsutsumi S, Fujimura T, Urano T, Takahashi S, Homma Y, Aburatani H, Inoue S
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 2263-76

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A C-terminal mutant of C/EBP (C/EBPa-Cm) down-regulates the Csf1r, a potent accelerator in the progression of AML with C/EBPa-Cm2015

    • Author(s)
      Togami, K., Kitaura, J., Uchida, T., Inoue, D., Nishimura, K., Kawabata, K.C., Nagase, R., Horikawa, S., Izawa, K., Fukuyama, T., Nakahara, F., Oki, T., Harada, Y., Harada, H., Aburatani, H. and Kitamura, T.
    • Journal Title

      Exp Hematol.

      Volume: 43 Pages: 300-308

    • DOI

      10.1016/j.exphem.2014.11.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.2015

    • Author(s)
      Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Pages: 4163-4177

    • DOI

      10.1074/jbc.m114.626929

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reduced TET2 Function Leads to T-cell Lymphoma with Follicular Helper T cell-like Features in mice.2014

    • Author(s)
      Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchida K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S
    • Journal Title

      Blood Cancer Journal

      Volume: 12

    • DOI

      10.1038/bcj.2014.83

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.2014

    • Author(s)
      Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, Tsuji S, Donehower LA, Slagle BL, Nakamura H, Yamamoto S, Shinbrot E, Hama N, Lehmkuhl M, Hosoda F, Arai Y, Walker K, Dahdouli M, Gotoh K, Nagae G, Gingras MC, Muzny DM, …, Takayama T, Fukayama M, Gibbs RA, Wheeler DA, Aburatani H, Shibata T
    • Journal Title

      Nature Genetics

      Volume: 46 Pages: 1267-1273

    • DOI

      10.1038/ng.3126

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrative analysis of FOXP1 function reveals a tumor suppressive effect in prostate cancer.2014

    • Author(s)
      Takayama K, Suzuki T, Tsutsumi S, Fujimura T, Takahashi S, Homma Y, Urano T, Aburatani H, Inoue S
    • Journal Title

      Mol Endocrinol.

      Volume: 28 Pages: 2012-2024

    • DOI

      10.1210/me.2014-1171

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells.2014

    • Author(s)
      Arase M, Horiguchi K, Ehata S, Morikawa M, Tsutsumi S, Aburatani H, Miyazono K, Koinuma D.
    • Journal Title

      Cancer Sci.

      Volume: 105 Pages: 974-82

    • DOI

      10.1111/cas.12454

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients.2014

    • Author(s)
      Takane K, Midorikawa Y, Yagi K, Sakai A, Aburatani H, Takayama T, Kaneda A
    • Journal Title

      Cancer Med

      Volume: 3 Pages: 1235-45

    • DOI

      10.1002/cam4.273

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP9 up-regulation in leukemic cells.2014

    • Author(s)
      Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T.
    • Journal Title

      blood

      Volume: 123(25) Pages: 3932-3942

    • DOI

      10.1182/blood-2013-01-476747

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma2014

    • Author(s)
      Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, Ichimura T, Ushiku T, Funahashi S, Tateishi K, Wada I, Shimizu N, Nomura S, Koike K, Seto Y, Fukayama M, Aburatani H, Ishikawa S
    • Journal Title

      Nat Genet

      Volume: 46(6) Pages: 583-587

    • DOI

      10.1038/ng.2984

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial mesenchymal transition.2014

    • Author(s)
      Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y
    • Journal Title

      Hum Pathol

      Volume: 45 Pages: 1397-1405

    • DOI

      10.1016/j.humpath.2014.02.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A subset of small cell lung cancer with low neuroendocrine expression and good prognosis: a comparison study of surgical and inoperable cases with biopsy2014

    • Author(s)
      Hamanaka, W, Motoi, N, Ishikawa, S., et al.
    • Journal Title

      Hum Pathol

      Volume: 45 Pages: 1045-1056

    • DOI

      10.1016/j.humpath.2014.01.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concurrent activation of acetylation and tri-methylation of H3K27 in a subset of hepatocellular carcinoma with aggressive behavior.2014

    • Author(s)
      Hayashi A, Yamauchi N, Shibahara J, Kimura H, Morikawa T, Ishikawa S, Nagae G, Nishi A, Sakamoto Y, Kokudo N, Aburatani H, Fukayama M.
    • Journal Title

      PLoS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0091330

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylation epigenotypes and genetic features in colorectal laterally spreading tumors.2014

    • Author(s)
      Sakai E, Ohata K, Chiba H, Matsuhashi N, Doi N, Fukushima J, Endo H, Takahashi H, Tsuji S, Yagi K, Matsusaka K, Aburatani H, Nakajima A, Kaneda A.
    • Journal Title

      International Journal of Cancer

      Volume: in press Pages: 1586-1595

    • DOI

      10.1002/ijc.28814

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome2014

    • Author(s)
      Arai E, Sakamoto H, Ichikawa H, Totsuka H, Chiku S, Gotoh M, Mori T, Nakatani T, Ohnami S, Nakagawa T, Fujimoto H, Wang L, Aburatani H, Yoshida T, Kanai Y.
    • Journal Title

      Int J Cancer.

      Volume: 135 Pages: 1330-1342

    • DOI

      10.1002/ijc.28768

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.2014

    • Author(s)
      Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana, Jalbert, Nelson, Bollen, Gustafson, Charron, Weiss, Smirnov, Song, Olshen, Cha, Zhao, Moore, Mungall, Jones SJ, Hirst M, Marra MA, Saito N, Aburatani H, Mukasa A, Berger S, Chang SM, Taylor BS, Costello JF
    • Journal Title

      Science

      Volume: 343 Pages: 189-193

    • DOI

      10.1126/science.1239947

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] H3F3A K27M mutations in thalamic gliomas from young adult patients.2014

    • Author(s)
      Aihara K, Mukasa A, Gotoh K, Saito K, Nagae G, Tsuji S, Tatsuno K, Yamamoto S, Takayanagi S, Narita Y, Shibui S, Aburatani H, Saito N
    • Journal Title

      Neuro Oncology

      Volume: 16 Pages: 140-146

    • DOI

      10.1093/neuonc/not144

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Landscape of genetic lesions in 944 patients with myelodysplastic syndromes.2014

    • Author(s)
      Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G, Schnittger S, Sanada M, Kon A, Alpermann T, Yoshida K, Roller A, Nadarajah N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Kohlmann A, Miyano S, Haferlach C, Kern W, Ogawa S.
    • Journal Title

      Leukemia

      Volume: 28(2) Pages: 4241-247

    • DOI

      10.1038/leu.2013.336

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated molecular analysis of clear-cell renalcell carcinoma2014

    • Author(s)
      Sato Y, Yoshida K
    • Journal Title

      Nat Genet

      Volume: 45 Pages: 860-7

    • DOI

      10.1038/ng.2699

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploration of liver cancer genomes.2014

    • Author(s)
      Shibata T, Aburatani H.
    • Journal Title

      Nat Rev Gastroenterol Hepatol.

      Volume: in press

    • DOI

      10.1038/nrgastro.2014.6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus Latent membrane protein 2A for non-transformed cells.2014

    • Author(s)
      Nakaya T, Kikuchi Y, Kunita A, Ishikawa S, Matsusaka K, Hino R,Aburatani H
    • Journal Title

      Virus Res.

      Volume: Vol.174 Pages: 108-115

    • DOI

      10.1016/j.virusres.2013.03.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung Cancer with Loss of BRG1/BRM, shows Epithelial Mesenchymal Transition Phenotype and2014

    • Author(s)
      Matsubara D, Murakami Y, Niki T et al.
    • Journal Title

      Thorax,

      Volume: 104 Pages: 266-273

    • DOI

      10.1111/cas.12065

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrantly methylated genes in human papillary thyroid cancer and their association with BRAF/RAS mutation2013

    • Author(s)
      Kikuchi Y, Tsuji E, Yagi K, Matsusaka K, Tsuji S, Kurebayashi J, Ogawa T, Aburatani H, Kaneda
    • Journal Title

      Front Genet

      Volume: 5 Pages: 271-271

    • DOI

      10.3389/fgene.2013.00271

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations2013

    • Author(s)
      Inoue, D
    • Journal Title

      J Clin Invest.

      Volume: 123 Pages: 4627-40

    • DOI

      10.1172/jci70739

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrent mutations in multiple components of the cohesin complex inmyeloid neoplasms2013

    • Author(s)
      Kon A, Yoshida K
    • Journal Title

      Nature Genetics

      Volume: 45 Pages: 1232-1237

    • DOI

      10.1038/ng.2731

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders2013

    • Author(s)
      Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y, Sanada M, Miyagi S, Saraya A, Kamio A, Nagae G, Nakaseko C, Yokote K, Shimoda K, Koseki H, Suzuki Y, Sugano S, Aburatani H, Ogawa S, Iwama A.
    • Journal Title

      J Exp Med.

      Volume: 210(12) Pages: 2627-2639

    • DOI

      10.1084/jem.20131144

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer.2013

    • Author(s)
      Sato T, Kaneda A, Tsuji S, Isagawa T, Yamamoto S, Fujita T, Yamanaka R, Tanaka Y, Nukiwa T, Marquez VE, Ishikawa Y, Ichinose M, Aburatani H.
    • Journal Title

      Sci Rep.

      Volume: 3 Pages: 1911-1911

    • DOI

      10.1038/srep01911

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci.2013

    • Author(s)
      Hiratsuka S, Ishibashi S, Tomita T, Watanabe A, Tamura SA, Murakami M, Kijima H, Miyake K, Aburatani H, Maru Y
    • Journal Title

      Nat Commun.

      Volume: 4 Pages: 1-10

    • DOI

      10.1038/ncomms2856

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Androgen-responsive non-coding RNA CTBP1-AS promotes prostate cancer growth by epigenetic regulation2013

    • Author(s)
      Takayama K, Horie-Inoue K, Katayama S, Suzuki T, Tsutsumi S, Ikeda K, Urano T, Fujimura T, Takagi K, Takahashi S, Homma Y, Ouchi Y, Aburatani H, Hayashizaki Y, Inoue S
    • Journal Title

      EMBO J.

      Volume: 32 Pages: 1665-1680

    • DOI

      10.1038/emboj.2013.99

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages2013

    • Author(s)
      Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M
    • Journal Title

      Cancer Research

      Volume: 73 Pages: 3019-28

    • DOI

      10.1158/0008-5472.can-12-3231

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of cyclin D2 in cell cycle progression and tumorigenicity of glioblastoma stem cells.2013

    • Author(s)
      R Koyama-Nasu, Y Nasu-Nishimura, T Todo, Y Ino, N Saito, H Aburatani, K Funato, K Echizen, H Sugano, R Haruta, M Matsui, R Takahashi, E Manabe, T Oda and T Akiyama
    • Journal Title

      Oncogene

      Volume: 32 Pages: 3840-3845

    • DOI

      10.1038/onc.2012.399

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: Morphological significance of calponin h1.2013

    • Author(s)
      Hayashi T,Horiuchi A,Sano K,Hiraoka N,Kasai M,Ichimura T,Sudo T,Nishimura R,Ishiko O,Shiozawa T,Kanai Y,Yaegashi N,Aburatani H,Konishi I.
    • Journal Title

      FEBS Letters

      Volume: 586 Pages: 1824-1831

    • DOI

      10.1016/j.febslet.2012.05.029

    • NAID

      120005440157

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Sendai virus vectors and their potential applications in gene therapy and regenerative medicine.2013

    • Author(s)
      Keiki Kumano
    • Journal Title

      Curr Gene Ther.

      Volume: 119 Pages: 6234-42

    • DOI

      10.1182/blood-2011-07-367441

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of CCDC6-RET Fusion in the Human Lung Adenocarcinoma Cell Line, LC-2/ad.2012

    • Author(s)
      Matsubara D, Murakami Y, Niki T et al.
    • Journal Title

      J Thorac Oncol.

      Volume: 7 Pages: 1872-1876

    • DOI

      10.1097/jto.0b013e3182721ed1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.2012

    • Author(s)
      Fujii, Y.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Pages: 20584-20589

    • DOI

      10.1073/pnas.1208651109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML-ETO-positive leukemia in mice.2012

    • Author(s)
      Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T.
    • Journal Title

      Int J Hematol

      Volume: 96(5) Pages: 638-48

    • DOI

      10.1007/s12185-012-1207-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A simple knowledge-based mining method for exploring hidden key molecules in a human biomolecular network.2012

    • Author(s)
      Tsuji S
    • Journal Title

      BMC Syst Biol.

      Volume: 6 Pages: 124-124

    • DOI

      10.1186/1752-0509-6-124

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased Expression and Aberrant Localization of Mucin 13 in Metastatic Colon Cancer.2012

    • Author(s)
      Gupta BK
    • Journal Title

      J Histochem Cytochem

      Volume: 60 Pages: 822-31

    • DOI

      10.1369/0022155412460678

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming2012

    • Author(s)
      Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M*, and Motohashi H*.
    • Journal Title

      Cancer Cell

      Volume: 22 Pages: 66-79

    • DOI

      10.1016/j.ccr.2012.05.016

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-barr virus infection as an epigenetic driver of tumorigenesis.2012

    • Author(s)
      Kaneda A, Matsusaka K, Aburatani H, Fukayama M
    • Journal Title

      Cancer Res.

      Volume: Vol.72 Pages: 3445-3450

    • DOI

      10.1158/0008-5472.can-11-3919

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell2012

    • Author(s)
      Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T,Mogushi K, Tanaka H, Osawa T, Kanki Y, et al
    • Journal Title

      Nat Commun

      Volume: 6;3 Pages: 883-883

    • DOI

      10.1038/ncomms1892

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotype-Dependent Efficacy of a Dual PI3K/mTOR Inhibitor, NVP-BEZ235, and an mTOR Inhibitor, RAD001, in Endometrial Carcinomas.2012

    • Author(s)
      Shoji K, Oda K, Nakagawa S,-Hiraike O, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y.
    • Journal Title

      PloS one

      Volume: 7(5):

    • DOI

      10.1371/journal.pone.0037431

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer2012

    • Author(s)
      Ikeda Y, Oda K, Nakagawa S
    • Journal Title

      Int J Gynecol Cancer.

      Volume: 22(5) Pages: 725-31

    • DOI

      10.1097/igc.0b013e31824c6ea6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Nucleome analysis: transcriptional regulation by chromatin interaction2016

    • Author(s)
      油谷浩幸
    • Organizer
      39th Annual Meeting of Molecular Biology Society Japan
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ゲノム研究と医療の融合2016

    • Author(s)
      油谷浩幸
    • Organizer
      日本オミックス医療学会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Progression of hepatocellular carcinoma: Interplay of genome and epigenome2016

    • Author(s)
      油谷浩幸
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Interplay of genome and epigenome in progression of hepatocellular carcinoma2016

    • Author(s)
      油谷浩幸
    • Organizer
      12th Scientific Workshop, International Cancer Genome Consortium
    • Place of Presentation
      ボストン、アメリカ
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Progression of hepatocellular carcinoma: interplay of genome and epigenome2016

    • Author(s)
      油谷浩幸
    • Organizer
      The 41st Naito Conference on Tumor Heterogeneity and Plasticity
    • Place of Presentation
      札幌
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Methylation profiling of hepatocellular carcinoma2016

    • Author(s)
      油谷浩幸
    • Organizer
      The 35th Sapporo International Cancer Symposium 2016
    • Place of Presentation
      札幌
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高悪性度漿液性卵巣がんのゲノム変異と化学療法感受性2016

    • Author(s)
      油谷浩幸
    • Organizer
      第20回日本がん分子標的治療学会
    • Place of Presentation
      別府
    • Year and Date
      2016-05-31
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Early hepatocellular carcinoma2016

    • Author(s)
      油谷浩幸
    • Organizer
      The 102nd General Meeting of the Japanese Society of Gastroenterology The 5th International Forum
    • Place of Presentation
      東京
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Integrated genomic analysis of liver cancer progression2016

    • Author(s)
      油谷浩幸
    • Organizer
      The 13th International Congress of Human Genetics
    • Place of Presentation
      京都
    • Year and Date
      2016-04-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞運命制御とエピジェネティクス2016

    • Author(s)
      油谷浩幸
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Molecular spectra of hepatocellular carcinoma2016

    • Author(s)
      油谷浩幸
    • Organizer
      第25回アジア太平洋肝臓病学会議年次総会
    • Place of Presentation
      東京
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Genomic dissection of high grade serous ovarian cancer2016

    • Author(s)
      油谷浩幸
    • Organizer
      Advances in Genome Biology and Technology
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Year and Date
      2016-02-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エピゲノム創薬標的探索2016

    • Author(s)
      油谷浩幸
    • Organizer
      日本がん分子標的治療学会 第11回TRワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2016-01-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] がん進展とエピゲノム転換2015

    • Author(s)
      油谷浩幸
    • Organizer
      第26回日本消化器癌発生学会サテライトシンポジウム
    • Place of Presentation
      米子
    • Year and Date
      2015-12-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細胞分化におけるクロマチン動態2015

    • Author(s)
      油谷浩幸
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Genomic dissection of high grade serous ovarian cancer2015

    • Author(s)
      油谷浩幸
    • Organizer
      22nd International Symposium Yonsei Song-Dang Institute for Cancer Research
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 血漿遊離DNA 解析による「リキッドバイオプシー」2015

    • Author(s)
      油谷浩幸
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Comprehensive genomic characterization of gastric cancer2015

    • Author(s)
      油谷浩幸
    • Organizer
      第74回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Chromatin dynamics in cell fate determination2015

    • Author(s)
      油谷浩幸
    • Organizer
      Japanese German Epigenomic Medicine meeting
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Genomic dissection of high grade serous ovarian carcinoma2015

    • Author(s)
      油谷浩幸
    • Organizer
      第13回日本臨床腫瘍学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-07-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] がんゲノムデータから探る変異プロセス2015

    • Author(s)
      油谷浩幸
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-07-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Progression of Hepatocellular Carcinoma2015

    • Author(s)
      油谷浩幸
    • Organizer
      The 34th Sapporo International Cancer Symposium
    • Place of Presentation
      札幌
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] がんゲノム解析の最新動向2015

    • Author(s)
      油谷浩幸
    • Organizer
      第11回北関東小児がんセミナー
    • Place of Presentation
      高崎
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Epigenetic Regulation in Cardiac Differentiation and Disease2015

    • Author(s)
      油谷浩幸
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大規模ゲノム解析データの医療への利活用2015

    • Author(s)
      油谷浩幸
    • Organizer
      第52回日本臨床分子医学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] がんゲノム情報にもとづく精密医療2015

    • Author(s)
      油谷浩幸
    • Organizer
      第21回神経芽腫研究会
    • Place of Presentation
      埼玉県立がんセンター(埼玉県、北足立郡)
    • Year and Date
      2015-03-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Chromatin remodeling complex gene mutations in cancer2014

    • Author(s)
      油谷浩幸
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 大規模がんゲノム解析2014

    • Author(s)
      油谷浩幸
    • Organizer
      第59回人類遺伝学会
    • Place of Presentation
      タワーホール船堀(東京都、江戸川区)
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Chromatin remodeling complex gene mutations in cancer2014

    • Author(s)
      油谷浩幸
    • Organizer
      The 4th Japan-France Cancer Workshop
    • Place of Presentation
      関西セミナーハウス(京都府、京都市)
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 血中遊離DNAを用いた腫瘍ゲノム解析2014

    • Author(s)
      油谷浩幸
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府、京都市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Mutation in chromatin remodeling complex genes and cancer2014

    • Author(s)
      油谷浩幸
    • Organizer
      第73回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Integrated genomic analysis of hepatocellular carcinoma2013

    • Author(s)
      油谷浩幸
    • Organizer
      International Scientific Coordination Network (ISCN)
    • Place of Presentation
      Toulouse, France
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ゲノム科学とがん研究

    • Author(s)
      油谷浩幸
    • Organizer
      第53回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] がんゲノム解析と分子標的治療

    • Author(s)
      油谷浩幸
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 大規模がんゲノム解析がもたらすインパクト

    • Author(s)
      油谷浩幸
    • Organizer
      金沢大学十全医学会総会・学術集会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] がんゲノム情報から癌を理解する

    • Author(s)
      油谷浩幸
    • Organizer
      第4回富山ライフサイエンスシンポジウム
    • Place of Presentation
      富山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Tumor profiling in clinical practice

    • Author(s)
      油谷浩幸
    • Organizer
      第11回日本臨床腫瘍学会学術集会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] DNA demethylation and Cancer

    • Author(s)
      油谷浩幸
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] がんゲノム解析の現状と医療応用へ向けての課題

    • Author(s)
      油谷浩幸
    • Organizer
      第13回東北がん分子標的治療研究会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ゲノムデータから読み解く環境応答メカニズム

    • Author(s)
      油谷浩幸
    • Organizer
      分子予防環境医学研究会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] パーソナルオンコロジーへ向けてのゲノム情報解析

    • Author(s)
      油谷浩幸
    • Organizer
      第327回CBI学会研究講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 第48回日本肝癌研究会

    • Author(s)
      油谷浩幸
    • Organizer
      肝細胞癌の統合的ゲノム解析
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Genomics of Cancer Progression

    • Author(s)
      油谷浩幸
    • Organizer
      71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Genomic Medicine towards personal oncology

    • Author(s)
      油谷浩幸
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 肝細胞癌の統合的ゲノム解析

    • Author(s)
      油谷浩幸
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 次世代シーケンサーによるがん診断

    • Author(s)
      油谷浩幸
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      新宿
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Genomics of cancer progression

    • Author(s)
      油谷浩幸
    • Organizer
      NSFC-JST Workshop on Genomics for Clinical Studies
    • Place of Presentation
      Shanghai (China)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Integrated genomics of hepatocellular carcinoma genome

    • Author(s)
      油谷浩幸
    • Organizer
      AGBT 2013
    • Place of Presentation
      Marco Island, FL USA
    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センター ゲノムサイエンス分野

    • URL

      http://www.genome.rcast.u-tokyo.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センターゲノムサイエンス分野

    • URL

      http://www.genome.rcast.u-tokyo.ac.jp/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センター ゲノムサイエンス分野

    • URL

      http://www.genome.rcast.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センターゲノムサイエンス分野

    • URL

      http://www.genome.rcast.u-tokyo.ac.jp/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

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