| Project/Area Number |
24223004
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental psychology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大原 慎也 東北大学, 生命科学研究科, 助教 (10570038)
渡辺 正孝 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 特任研究員 (50092383)
櫻井 芳雄 同志社大学, 脳科学研究科, 教授 (60153962)
飯島 敏夫 東北大学, 生命科学研究科, 名誉教授 (90333830)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIWARA Juri 福島県立医科大学, 医学部, 助教 (30569322)
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| Project Period (FY) |
2012-05-31 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥188,110,000 (Direct Cost: ¥144,700,000、Indirect Cost: ¥43,410,000)
Fiscal Year 2016: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2014: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2013: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2012: ¥62,790,000 (Direct Cost: ¥48,300,000、Indirect Cost: ¥14,490,000)
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| Keywords | 高次脳機能 / 単一ニューロン電気穿孔法 / 経頭蓋磁気刺激 / 脳・神経 / 実験心理学 / 生理学 / 実験系心理学 / 短期記憶 / 傍細胞記録 / 遅延ニューロン / 神経科学 / 認知科学 |
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| Outline of Final Research Achievements |
Using in-vivo single neuron electroporation technique that has been developed in our lab, we for the first time identified working-memory neurons histologically. As many of them project to striatum, it was suggested that the cortico-basal ganglia circuit may be playing an important role in the maintenance of working memory. By the world’s first transcranial magnetic stimulation (TMS) experiment using behaving monkeys, it was suggested that the prefrontal, parietal, and premotor cortices are forming different components of the working memory function, i.e., sensory, motor, and sensorimotor. Furthermore, by the detailed analysis of neural activity driven by computational models, it was suggested that there may be some specific circuits, such as integral and XOR logic, within the prefrontal cortex, which are dedicated for neural computations for decision making and logical thinking.
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| Assessment Rating |
Verification Result (Rating)
A
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Assessment Rating |
Result (Rating)
A: Progress in the research is steadily towards the initial goal. Expected research results are expected.
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