| Research Collaborator |
KOJIMA Daisuke 東京大学, 大学院理学系研究科, 講師 (60376530)
SHIMIZU Kimiko 東京大学, 大学院理学系研究科, 助教 (50451828)
YOSHITANE Hikari 東京大学, 大学院理学系研究科, 助教 (70569920)
SHIRAKI Tomoya 東京大学, 大学院理学系研究科, 特任助教 (40632352)
TORII Masaki 東京大学, 大学院理学系研究科, 特任研究員 (10586407)
TERAJIMA Hideki 東京大学, 大学院理学系研究科, 特任研究員
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| Budget Amount *help |
¥217,360,000 (Direct Cost: ¥167,200,000、Indirect Cost: ¥50,160,000)
Fiscal Year 2016: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2015: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2014: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2013: ¥60,190,000 (Direct Cost: ¥46,300,000、Indirect Cost: ¥13,890,000)
Fiscal Year 2012: ¥74,100,000 (Direct Cost: ¥57,000,000、Indirect Cost: ¥17,100,000)
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| Outline of Final Research Achievements |
Most living organisms show a variety of rhythms by virtue of having an intrinsic time-measuring system. This system is called circadian clock entrainable to daily changes in the internal and environmental conditions such as light-dark cycle. In mammals, the central clock resides in the hypothalamic suprachismatic nucleus (SCN), and its output signal play significant roles in maintenance of brain functions. This research project aimed to understand the molecular mechanisms underlying the circadian clock oscillation together with its input and output regulation. The major outcomes follow: 1) We identified several key molecules in the input pathway. 2) We found that the SCN clock governs brain peripheral clocks that regulate long-term memory formation and anxiety-like behaviors via SCOP, and 3) we found essential roles of new clock components such as FBXL3/21 and ADAR2 that are important for post-translational and post-transcriptional regulation.
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