| Research Collaborator |
Ihara Sayoko 東京大学, 大学院農学生命科学研究科, 助教 (80292788)
Niimura Yoshihito 東京大学, 大学院農学生命科学研究科, 特任准教授 (90396979)
Yoshikawa Keiichi 東京大学, 大学院農学生命科学研究科, 特任研究員
Horio Nao 東京大学, 大学院農学生命科学研究科, 特任研究員 (80726448)
Takai Yoshiki
Abe Takayuki
Sato Narumi
Kaneko Shoji 東京大学, 大学院農学生命科学研究科, 大学院生
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| Budget Amount *help |
¥214,630,000 (Direct Cost: ¥165,100,000、Indirect Cost: ¥49,530,000)
Fiscal Year 2016: ¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000)
Fiscal Year 2015: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2014: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2013: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2012: ¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
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| Outline of Final Research Achievements |
It has not been known what kind of odorants mice recognize via olfactory receptors in a natural environment. Olfactory receptors are expressed in non-olfactory tissues, although their endogenous ligands have not been identified. In this study, we aimed to identify natural or endogenous ligands for olfactory receptors. We developed an efficient odorant response assay that was suitable for natural ligand screening. A novel fatty acid derivative released in the preputial gland was found to be a natural ligand for an olfactory receptor. An endogenous ligand for an ovary-expressing olfactory receptor was identified. This study gives insights into areas of animal social behavior and neuroscience, ecology and environmental science, and pharmacology and drug development.
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