| Budget Amount *help |
¥207,610,000 (Direct Cost: ¥159,700,000、Indirect Cost: ¥47,910,000)
Fiscal Year 2016: ¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000)
Fiscal Year 2015: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2014: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2013: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2012: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
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| Outline of Final Research Achievements |
In this study, we found that lysine biosynthesis via a carrier protein (AmCP) that binds to the amino group we have previously found is widely distributed in the thermophilic archaea with evolutionarily old origins, and that it is also utilized as arginine biosynthesis system, suggesting that the system is the key to clarifying the biosynthesis evolution. We also succeeded in elucidating the crystal structures of complexes of various biosynthetic enzymes and AmCP, revealing that they recognize each other by electrostatic interaction for efficient reaction. Furthermore, we discovered that biosynthesis diverted from this system is also used for secondary metabolism of actinomycetes. All these results also clarified that the system plays an important role as a biosynthesis system.
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