| Project/Area Number |
24229005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
CHIBA Tsutomu 京都大学, 医学(系)研究科(研究院), 教授 (30188487)
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| Co-Investigator(Kenkyū-buntansha) |
MARUSAWA Hiroyuki 京都大学, 医学研究科, 講師 (80324630)
WATANABE Tomohiro 京都大学, 医学研究科, 准教授 (40444468)
USHIJIMA Toshikazu 独立行政法人国立がん研究センター, 研究所 (90232818)
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| Project Period (FY) |
2012-05-31 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥171,730,000 (Direct Cost: ¥132,100,000、Indirect Cost: ¥39,630,000)
Fiscal Year 2014: ¥53,040,000 (Direct Cost: ¥40,800,000、Indirect Cost: ¥12,240,000)
Fiscal Year 2013: ¥53,560,000 (Direct Cost: ¥41,200,000、Indirect Cost: ¥12,360,000)
Fiscal Year 2012: ¥65,130,000 (Direct Cost: ¥50,100,000、Indirect Cost: ¥15,030,000)
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| Keywords | AID / 炎症発癌 / 癌幹細胞 / 組織幹細胞 / エピゲノム / 遺伝子変異 / ゲノム異常 / エピゲノム異常 / H.Pylori / HCV |
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| Outline of Final Research Achievements |
Infection and/or inflammation play important roles in the development of various cancers in digestive organs. We have previously demonstrated that activation-induced cytidine deaminase (AID), a DNA editing enzyme, is involved in inflammation-associated carcinogenesis through induction of various mutations. In the present study, by using ultra-deep sequencer we serially analyzed genetic and epigenetic changes during cancer development with the background of inflammation in both human and mice. As a result, we demonstrated that AID has crucial roles in the induction of not only genetic but also epigenetic changes during inflammation-induced carcinogenesis.
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| Assessment Rating |
Verification Result (Rating)
A-
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Assessment Rating |
Result (Rating)
A-: Progress in the research is steadily towards the initial goal. However, further efforts are necessary as a part of the research progress is delayed.
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