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Design and statistical analysis in translational clinical trials

Research Project

Project/Area Number 24240042
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Statistical science
Research InstitutionNagoya University (2013-2016)
The Institute of Statistical Mathematics (2012)

Principal Investigator

Matsui Shigeyuki  名古屋大学, 医学系研究科, 教授 (80305854)

Co-Investigator(Kenkyū-buntansha) 江口 真透  統計数理研究所, 数理・推論研究系, 教授 (10168776)
手良向 聡  京都府立医科大学, 医学(系)研究科(研究院), 教授 (20359798)
松浦 正明  帝京大学, 公衆衛生学研究科, 教授 (40173794)
森田 智視  京都大学, 医学(系)研究科(研究院), 教授 (60362480)
Co-Investigator(Renkei-kenkyūsha) YAMAGUCHI Takuhiro  東北大学, 大学院医学系研究科, 教授 (50313101)
FUJISAWA Hironori  統計数理研究所, 数理・推論研究系, 教授 (00301177)
DAIMON Takashi  兵庫医科大学, 医学部, 教授 (40372156)
SOZU Takashi  東京理科大学, 工学部, 准教授 (80408723)
KAWAGUCHI Atsushi  佐賀大学, 大学院医学系研究科, 教授 (60389319)
ITO Yoichi  北海道大学, 大学院医学研究科, 准教授 (80061167)
YAMANAKA Takeharu  横浜市立大学, 大学院医学研究科, 教授 (00325466)
HIRAKAWA Akihiro  東京大学, 大学院医学系研究科, 准教授 (90609330)
NOMA Hisashi  統計数理研究所, データ科学研究系, 准教授 (70633486)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords臨床試験 / 統計的デザイン / データ解析 / 個別化医療 / 先端医療技術 / 臨床試験の計画と解析 / 先端医療技術の開発 / 診断法開発 / ゲノムデータの解析 / ゲノムデータ解析 / 統計解析 / バイオマーカー / 予測解析
Outline of Final Research Achievements

We conducted researches on the design and statistical analysis of clinical trials for developing advanced medical technologies, including those of regeneration medicine and personalized medicine. Specifically, we developed novel statistical methods for 1) the analysis of prognostic and predictive markers using omics data, 2) the design and analysis of earlier exploratory clinical trials (exploration of dose-response relationship and patient subgroups), and 3) the design and analysis of confirmative clinical trials (test and unbiased estimation of treatment effects). In particular, research outcomes related to the clinical development of personalized medicine were published as a monograph, which is one of the first attempts to provide a systematic coverage of all stages of clinical trials for the development of personalized medicine.

Report

(5 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (110 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (66 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 64 results,  Acknowledgement Compliant: 2 results,  Open Access: 5 results) Presentation (30 results) (of which Int'l Joint Research: 9 results,  Invited: 23 results) Book (11 results) Remarks (2 results) Funded Workshop (1 results)

  • [Journal Article] Long-term outcomes of living donor liver transplantation for primary biliary cirrhosis: a Japanese multicenter study2016

    • Author(s)
      Egawa H, Sakisaka S, Teramukai S, Sakabayashi S, Yamamoto M, Umeshita K, Uemoto S
    • Journal Title

      American Journal of Transplantation

      Volume: 16 Issue: 4 Pages: 1248-1257

    • DOI

      10.1111/ajt.13583

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The efficacy of adjuvant immunochemotherapy with OK-432 after curative resection of gastric cancer: an individual patient data meta-analysis of randomized controlled trials2016

    • Author(s)
      Oba M, Teramukai S, Ohashi Y, Ogawa K, Maehara Y, Sakamoto J
    • Journal Title

      Gastric Cancer

      Volume: 19 Issue: 2 Pages: 616-624

    • DOI

      10.1007/s10120-015-0489-9

    • NAID

      40020836334

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prostaglandin E-Major Urinary Metabolite as a Biomarker for Inflammation in Ulcerative Colitis2016

    • Author(s)
      Arai Y, Matsuura T, Matsuura M, Fujiwara M, Okayasu I, Ito S, Arihiro S
    • Journal Title

      Prostaglandins Revisited

      Volume: 93 Issue: 1 Pages: 32-39

    • DOI

      10.1159/000441665

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Robust Clustering Method in the Presence of Scattered Observations.2016

    • Author(s)
      A. Notsu and S. Eguchi.
    • Journal Title

      Neural Computation,

      Volume: In press Issue: 6 Pages: 1141-1162

    • DOI

      10.1162/neco_a_00833

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies2015

    • Author(s)
      Hirakawa A, Wages NA, Sato H, Matsui S
    • Journal Title

      Statistics in Medicine

      Volume: 34 Issue: 24 Pages: 3194-3213

    • DOI

      10.1002/sim.6533

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Operating characteristics of restrictions on skipping dose level for adaptive dose-finding method in two-agent phase I trials2015

    • Author(s)
      Hirakawa A, Matsui S
    • Journal Title

      Japanese Journal of Biometrics

      Volume: 36 Pages: 1-12

    • NAID

      130005097958

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Estimation of treatment effects in all-comers randomized clinical trials with a predictive marker2015

    • Author(s)
      Choai Y, Matsui S
    • Journal Title

      Biometrics

      Volume: 71 Issue: 1 Pages: 25-32

    • DOI

      10.1111/biom.12253

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An extension of Bayesian predictive sample size selection designs for monitoring efficacy and safety.2015

    • Author(s)
      Teramukai S, Daimon T, Zohar S.
    • Journal Title

      Statistics in Medicine

      Volume: 34 Issue: 22 Pages: 3029-3039

    • DOI

      10.1002/sim.6550

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Outcomes of curative nephrectomy against renal cell carcinoma based on a central pathological review of 914 specimens from the era of cytokine treatment2015

    • Author(s)
      Ito N, Kojima S, Teramukai S, Mikami Y, Ogawa O, Kamba T
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 20 Issue: 6 Pages: 1161-1170

    • DOI

      10.1007/s10147-015-0840-5

    • NAID

      120005726175

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Incorporating historical data in Bayesian phase I trial design: The Caucasian-to-Asian toxicity tolerability problem2015

    • Author(s)
      Takeda K, Morita S
    • Journal Title

      Therapeutic Innovation & Regulatory Science

      Volume: 49 Pages: 93-99

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detecting overall survival benefit derived from survival post-progression rather than progression-free survival2015

    • Author(s)
      Morita S, Sakamaki K, Yin G
    • Journal Title

      J Natl Cancer Inst

      Volume: 107 Issue: 8 Pages: 133-133

    • DOI

      10.1093/jnci/djv133

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bayesian response adaptive randomization using longitudinal outcomes2015

    • Author(s)
      Hatayama T, Morita S, Sakamaki K
    • Journal Title

      Pharmaceutical Statistics

      Volume: 14 Issue: 5 Pages: 369-376

    • DOI

      10.1002/pst.1695

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Extensive analysis of signaling pathway molecules in breast cancer: association with clinicopathological characteristics2015

    • Author(s)
      Horii R, Matsuura M, Dan S, Ushijima M, Uehiro N, Ogiya A, Honma N, Ito Y, Iwase T, Yamori T, Akiyama F
    • Journal Title

      Int J Clin Oncol

      Volume: 20 Issue: 3 Pages: 490-498

    • DOI

      10.1007/s10147-014-0753-8

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lack of predictive power of plasma lipids or lipoproteins for gestational diabetes mellitus in Japanese women2015

    • Author(s)
      Iimura Y, Matsuura M, Yao Z, Ito S, Fujiwara M, Yoshitsugu M, Miyauchi A, Hiyoshi T
    • Journal Title

      J Diabetes Investig

      Volume: 6 Issue: 6 Pages: 640-646

    • DOI

      10.1111/jdi.12363

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Binary Classification with a Pseudo Exponential Model and Its Application for Multi-Task Learning.2015

    • Author(s)
      Takashi Takenouchi, Osamu Komori and Shinto Eguchi.
    • Journal Title

      Entropy

      Volume: 17 Issue: 8 Pages: 5673-5694

    • DOI

      10.3390/e17085673

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Generalized t-statistics for two-group classification.2015

    • Author(s)
      O. Komori, S. Eguchi and J. Copas.
    • Journal Title

      Biometrics

      Volume: 71, 2 Issue: 2 Pages: 404-416

    • DOI

      10.1111/biom.12265

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Response to Statistical comments on ‘Increased serum levels of interleukin 33 in patients with atopic dermatitis’2015

    • Author(s)
      Tamagawa-Mineoka R, Teramukai S, Katoh N
    • Journal Title

      Journal of American Academy of Dermatology

      Volume: 72 Issue: 1 Pages: 200-200

    • DOI

      10.1016/j.jaad.2014.09.026

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A simple risk scoring sysytem for predicting acute exacerbation of interstitial pneumonia after pulmonary resection in lung cancer2015

    • Author(s)
      Sato T, Kondo H, Watanabe A, Nakajima J, Niwa H, Horio H, Okami J, Okamura N, Sugio K, Teramukai S, Kishi K, Ebina M, Sugiyama Y, Kondo T, Date H
    • Journal Title

      General Thoracic and Cardiovascular Surgery

      Volume: 63 Issue: 3 Pages: 164-172

    • DOI

      10.1007/s11748-014-0487-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust estimation of location and concentration parameters for the von Mises-Fisher distribution2015

    • Author(s)
      S. Kato, S. Eguchi
    • Journal Title

      Statistical Papers

      Volume: In press Issue: 1 Pages: 205-234

    • DOI

      10.1007/s00362-014-0648-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT)2014

    • Author(s)
      Sugimoto T, Matsumoto T, Hosoi T, Miki T, Gorai I, Yoshikawa H, Tanaka Y, Tanaka S, Fukunaga M, Sone T, Nakano T, Ito M, Matsui S, Yoneda T, Takami H, Watanabe K, Osakabe T, Okubo N, Shiraki M, Nakamura T
    • Journal Title

      Osteoporos Int

      Volume: 26 Issue: 2 Pages: 765-774

    • DOI

      10.1007/s00198-014-2964-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of statistical analysis plans in randomize-all phase III trials with a predictive biomarker2014

    • Author(s)
      Matsui S, Choai Y, Nonaka T
    • Journal Title

      Clinical Cancer Research

      Volume: 20 Issue: 11 Pages: 2820-2830

    • DOI

      10.1158/1078-0432.ccr-13-2698

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response to letter to the editor by Dr Wages et al2014

    • Author(s)
      Hirakawa A, Matsui S
    • Journal Title

      Stat Med

      Volume: 33 Issue: 12 Pages: 2159-2160

    • DOI

      10.1002/sim.5972

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An exploratory clinical study on the safety and efficacy of an autologous fibroblast-seeded artificial skin cultured with animal product-free medium in patients with diabetic foot ulcers2014

    • Author(s)
      Morimoto N, Ito T, Takemoto S, Katakami M, Kanda N, Tada H, Tanaka S, Teramukai S, Kawai K, Nakamura Y, Kasai Y, Yokode M, Maekawa T, Shimizu A, Suzuki S
    • Journal Title

      International Wound Journal

      Volume: 11 Issue: 2 Pages: 183-189

    • DOI

      10.1111/j.1742-481x.2012.01064.x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for primary prevention of cardiovascular disease and risk reduction by lipid control: The OMEGA study risk factor sub-analysis2014

    • Author(s)
      Teramoto T, Kawamori R, Miyazaki S, Teramukai S, Mori Y, Okuda Y, Hiramatsu K, OMEGA Study Group
    • Journal Title

      Clinical and Experimental Hypertension

      Volume: 36 Issue: 4 Pages: 236

    • DOI

      10.3109/10641963.2013.810226

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of prognosis in patients with metastatic renal cell carcinoma and Memorial Sloan-Kettering Cancer Center intermediate risk features by modern strategy including molecular-targeted therapy in clinical practice2014

    • Author(s)
      Kamba T, Yamasaki T, Teramukai S, Shibasaki N, Arakaki R, Sakamoto H, Matsui Y, Okubo K, Yoshimura K, Ogawa O
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 19 Issue: 3 Pages: 505-515

    • DOI

      10.1007/s10147-013-0581-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A exploratory clinical trial for idiopathic osteonecrosis of femoral head by cultured autologous multipotent mesenchymal stromal cells augmented with vascularized bone grafts2014

    • Author(s)
      Aoyama T, Goto K, Kakinoki R, Ikeguchi R, Ueda M, Kasai Y, Maekawa T, Tada H, Teramukai S, Nakamura T, Toguchida J
    • Journal Title

      Tissue Engineering Part B

      Volume: 20 Issue: 4 Pages: 233-242

    • DOI

      10.1089/ten.teb.2014.0090

    • NAID

      120005468373

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of zoledronic acid and the association between its efficacy and \gamma\delta T cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol2014

    • Author(s)
      Sumi E, Sugie T, Yoshimura K, Tada H, Ikeda T, Suzuki E, Tanaka Y, Teramukai S, Shimizu A, Toi M, Minato N
    • Journal Title

      Journal of Translational Medicine

      Volume: 12 Issue: 1 Pages: 310-310

    • DOI

      10.1186/s12967-014-0310-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer.2014

    • Author(s)
      Ono, H., Motoi, N., Nagano, H et al.
    • Journal Title

      Cancer Medicine

      Volume: 3 MAR Issue: 3 Pages: 1-11

    • DOI

      10.1002/cam4.220

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A subset of small cell lung cancer with low neuroendocrine expression and good prognosis: a comparison study of surgical and inoperable cases with biopsy.2014

    • Author(s)
      Hamanaka, W, Motoi, N, Ishikawa, S., et al.
    • Journal Title

      Human Pathology

      Volume: 45 Issue: 5 Pages: 1045-1056

    • DOI

      10.1016/j.humpath.2014.01.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence and prediction of invasive disease and nodal metastasis in preoperatively diagnosed ductal carcinoma in situ2014

    • Author(s)
      Osako T, Iwase T, Ushijima M, Horii R, Fukami Y, Kimura K, Matsuura M, Akiyama F
    • Journal Title

      Cancer Sci

      Volume: 105 Issue: 5 Pages: 576-582

    • DOI

      10.1111/cas.12381

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomarker-based Bayesian randomized phase II clinical trial design to identify a sensitive patient subpopulation2014

    • Author(s)
      Morita S. Yamamoto H, Sugitani Y
    • Journal Title

      Stat Med

      Volume: 33 Issue: 23 Pages: 4008-4018

    • DOI

      10.1002/sim.6209

    • NAID

      120005669352

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploring ethnic differences in toxicity in early phase clinical trials for oncology drugs2014

    • Author(s)
      Ogura T, Morita S, Yonemori K, Nonaka T, Urano T
    • Journal Title

      Therapeutic Innovation & Regulatory Science

      Volume: 48 Issue: 5 Pages: 644-650

    • DOI

      10.1177/2168479014524582

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A continual reassessment method with cohort size adaptation based on Bayesian posterior probabilities in phase I dose-finding studies2014

    • Author(s)
      Kakizume T, Morita S
    • Journal Title

      Therapeutic Innovation & Regulatory Science

      Volume: 48 Issue: 2 Pages: 213-219

    • DOI

      10.1177/2168479013500970

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Individualized prostate-specific antigen threshold values to avoid overdiagnosis of prostate cancer and reduce unnecessary biopsy in elderly men2014

    • Author(s)
      Kanao K., Komori O., Nakashima J., Ohigashi T., Kikuchi E., Miyajima A., Nakagawa K., Eguchi S. and Oya M
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 44 Issue: 9 Pages: 852-859

    • DOI

      10.1093/jjco/hyu133

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Duality of Maximum Entropy and Minimum Divergence2014

    • Author(s)
      Shinto Eguchi, Osamu Komori and Atsumi Ohara
    • Journal Title

      Entropy

      Volume: 16 Issue: 7 Pages: 3552-3572

    • DOI

      10.3390/e16073552

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overview of Model-Based Dose-Finding Methods for Combinations of Two Agents in Phase I Oncology Trials2014

    • Author(s)
      平川晃弘,松井茂之
    • Journal Title

      Japanese Journal of Biometrics

      Volume: 34 Issue: 2 Pages: 81-97

    • DOI

      10.5691/jjb.34.81

    • NAID

      130004721700

    • ISSN
      0918-4430, 2185-6494
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Date H for the Japanese Association for Chest Surgery. Impact and predictors of acute exacerbation of interstitial lung diseases after pulmonary resection for lung cancer2014

    • Author(s)
      Sato T, Teramukai S, Kondo H, Watanabe A, Ebina M, Kishi K, Fujii Y, Mitsudomi T, Yoshimura M, Maniwa T, Suzuki K, Kataoka K, Sugiyama Y, Kondo T
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery

      Volume: 147 Issue: 5 Pages: 1604-1611

    • DOI

      10.1016/j.jtcvs.2013.09.050

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Impact of rituximab desensitization on blood-type-incompatible adult living donor liver transplantation: A Japanese multicenter study2014

    • Author(s)
      Egawa H, Teramukai S, Haga H, Tanabe M, Mori A, Ikegami T, Kawagishi N, Ohdan H, Kasahara M, Umeshita K
    • Journal Title

      American Journal of Transplantation

      Volume: 14 Issue: 1 Pages: 102-114

    • DOI

      10.1111/ajt.12520

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for alcohol relapse after liver transplantation for alcoholic cirrhosis in Japan2014

    • Author(s)
      Egawa H, Nishimura K. Teramukai S, Yamamoto M, Umeshita K, Furukawa H, Uemoto S
    • Journal Title

      Liver Transplantation

      Volume: 20 Issue: 3 Pages: 298-310

    • DOI

      10.1002/lt.23797

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous clustering via minimum gamma-divergence2014

    • Author(s)
      Notsu A, Komori O, Eguchi S
    • Journal Title

      Neural Computation

      Volume: 26 Issue: 2 Pages: 421-448

    • DOI

      10.1162/neco_a_00547

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Empirical Bayes ranking and selection methods via semiparametric hierarchical mixture models in microarray studies2013

    • Author(s)
      Noma H, Matsui S
    • Journal Title

      Statistics in Medicine

      Volume: 32 Issue: 11 Pages: 1904-1916

    • DOI

      10.1002/sim.5718

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A dose-finding approach based on shrunken predictive probability for combinations of two agents in phase I trials2013

    • Author(s)
      Hirakawa A, Hamada C, Matsui S
    • Journal Title

      Statistics in Medicine

      Volume: 32 Issue: 26 Pages: 4515-4525

    • DOI

      10.1002/sim.5843

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of oro-cecal transit time in fasting subjects2013

    • Author(s)
      Kokubo T, Matsui S, Ishiguro M
    • Journal Title

      Pharmaceutical Research

      Volume: 30 Issue: 2 Pages: 402-411

    • DOI

      10.1007/s11095-012-0882-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nested case control study of proteomic biomarkers for interstitial lung disease in Japanese patients with non-small-cell lung cancer treated with erlotinib: a multicenter phase IV study (JO21661)2013

    • Author(s)
      Atagi S, Katakami N, Yoshioka H, Fukuoka M, Kudoh S, Ogiwara A, Imai M, Ueda M, Matsui S
    • Journal Title

      Clinical Lung Cancer

      Volume: 14 Issue: 4 Pages: 407-417

    • DOI

      10.1016/j.cllc.2012.12.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High expressions of ATP-binding cassette transporter ABCC11 in the breast tumors are associated with aggressive subtypes and worse disease-free survival2013

    • Author(s)
      Yamada A, Ishikawa T, Ota I et al.
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: 137 Issue: 3 Pages: 773-782

    • DOI

      10.1007/s10549-012-2398-5

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of heterogeneous structures on the Gaussian copula model using predictive power entropy2013

    • Author(s)
      Notsu, A., Kawasaki, Y. and Eguchi, S.
    • Journal Title

      ISRN Probability and Statistics

      Volume: 2013 Pages: 1-10

    • DOI

      10.1155/2013/787141

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust independent component analysis via minimum gamma-divergence estimation2013

    • Author(s)
      Chen PW, Hung H, Komori O, Huang SY, Eguchi S
    • Journal Title

      IEEE Journal of Selected Topics in Signal Processing

      Volume: 7 Issue: 4 Pages: 614-624

    • DOI

      10.1109/jstsp.2013.2247024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Group Invariance of Information Geometry on q-Gaussian Distributions Induced by Beta-Divergence2013

    • Author(s)
      Atsumi Ohara and Shinto Eguchi
    • Journal Title

      Entrtopy

      Volume: 15 Issue: 11 Pages: 4732-4747

    • DOI

      10.3390/e15114732

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Editorial note on special issue "Statistical Analysis of Biomarkers for Personalized Medicine," by Computational and Mathematical Methods in Medicine2013

    • Author(s)
      Eguchi S. Matsui S, Huang SY, Hsiao CK
    • Journal Title

      (総説・会議録)

      Volume: - Pages: 2-2

    • DOI

      10.1155/2013/467420

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.2013

    • Author(s)
      Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M.
    • Journal Title

      Cancer Sci.

      Volume: 104(3) Issue: 3 Pages: 360-368

    • DOI

      10.1111/cas.12071

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer Outlier Analysis Based on Mixture Modeling of Gene Expression Data2013

    • Author(s)
      Mori K, Oura T, Noma H, Matsui S
    • Journal Title

      Computational and Mathematical Methods in Medicine

      Volume: Article ID 693901 Pages: 1-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic Biomarkers for Personalized Medicine: Development and Validation in Clinical Studies2013

    • Author(s)
      Matsui S
    • Journal Title

      Computational and Mathematical Methods in Medicine

      Volume: Article ID 865980 Pages: 1-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Suboptimal Solutions for Prediction Rules in Gene Expression Data2013

    • Author(s)
      Komori O, Prichard M, Eguchi S
    • Journal Title

      Computational and Mathematical Methods in Medicine

      Volume: Article ID 798189 Pages: 1-14

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Updated Overall Survival Results from A Randomized Phase III Trial Comparing Gefitinib with Carboplatin-Paclitaxel for Chemo-Naive Non-Small Cell Lung Cancer with Sensitive EGFR Gene Mutations (NEJ002)2013

    • Author(s)
      Inoue A, Kobayashi K, Maemondo M, et al
    • Journal Title

      Ann Oncol

      Volume: 24 Issue: 1 Pages: 54-9

    • DOI

      10.1093/annonc/mds214

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of IL-28B gene polymorphism on response to peginterferon plus ribavirin combination therapy for genotype 2 chronic hepatitis C.2012

    • Author(s)
      Shimoyama Y, Nozaki A*, Morimoto M, Moriya S, Kondo M, Fukuda H, Numata K, Miyajima E, Oba MS, Taguri M, Morita S, Maeda S, Tanaka K.(*corresponding author)
    • Journal Title

      Hepatol. Res. published online doi

      Volume: - Issue: 9 Pages: 919-924

    • DOI

      10.1111/hepr.12037

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developing and validating continuous genomic signatures in randomized clinical trials for predictive medicine2012

    • Author(s)
      Matsui S, Simon R, Qu P et al.
    • Journal Title

      Clinical Cancer Research

      Volume: 18 Issue: 21 Pages: 6065-6073

    • DOI

      10.1158/1078-0432.ccr-12-1206

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An extension of the Receiver Operating Characteristic curve and AUC-optimal classification2012

    • Author(s)
      Takenouchi T, Komori O, Eguchi S
    • Journal Title

      Neural Computation

      Volume: 24 Issue: 10 Pages: 2789-2824

    • DOI

      10.1162/neco_a_00336

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Bayesian predictive sample size selection design for single-arm exploratory clinical trials2012

    • Author(s)
      Teramukai S, DaimonT, ZoharS
    • Journal Title

      Statistics in Medicine

      Volume: 31 Issue: 30 Pages: 4243-4254

    • DOI

      10.1002/sim.5505

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 代替エンドポイントの統計学的評価2012

    • Author(s)
      手良向聡
    • Journal Title

      臨床評価

      Volume: 40 Suppl XXXI Pages: 191-195

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Prior effective sample size in conditionally independent hierarchical models.2012

    • Author(s)
      Morita S, Thall PF, Mueller P
    • Journal Title

      Bayesian Analysis

      Volume: 7 Issue: 3 Pages: 591-614

    • DOI

      10.1214/12-ba720

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homozygous c. 14576G> A Variant of<I> RNF213</I> Predicts Early-Onset and Severe Form of Moyamoya Disease2012

    • Author(s)
      Miyatake S, Miyake N, Touho H, Nishimura-T, A, Kondo Y, Okada ; I, Tsurusaki ; Y, Doi H, Sakai H, Saitsu ; H, Shimojima K, Yamamoto T, Higurashi M, Kawahara, N, Kawauchi, H, Nagasaka, K, Okamoto N, Mori, T, Koyano S, Kuroiwa Y, Taguri M, Morita S, Matsuba S, Kure S, Matsumoto N
    • Journal Title

      Neurology

      Volume: 78(11) Issue: 11 Pages: 803-10

    • DOI

      10.1212/wnl.0b013e318249f71f

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impacts and predictors of cytotoxic anticancer agents in different breast cancer subtypes2012

    • Author(s)
      Ishikawa T, Shimizu D, Yamada A et al.
    • Journal Title

      Oncol Res.

      Volume: 20 Pages: 71-79

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome2012

    • Author(s)
      Goto M, Sugimoto K, Hayashi S et al.
    • Journal Title

      Exp Gerontol.

      Volume: 47 Issue: 12 Pages: 936-939

    • DOI

      10.1016/j.exger.2012.08.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detailed features of palisade vessels as a marker of the esophageal mucosa revealed by magnifying endoscopy with narrow band imaging.2012

    • Author(s)
      Kumagai Y, Yagi M, Aida J et al.
    • Journal Title

      Dis Esophagus.

      Volume: 25 Issue: 6 Pages: 484-490

    • DOI

      10.1111/j.1442-2050.2011.01283.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-in duced cyto toxicity during glucose deprivation2012

    • Author(s)
      Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T, Tomida A
    • Journal Title

      Mol Cancer Ther

      Volume: 11(5) Issue: 5 Pages: 1082-1091

    • DOI

      10.1158/1535-7163.mct-11-0871

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis2011

    • Author(s)
      Fujiwara T, Aburatani H, et al.
    • Journal Title

      Lung Cancer

      Volume: 75 Issue: 1 Pages: 119-25

    • DOI

      10.1016/j.lungcan.2011.05.028

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Point and interval estimation of subgroup treatment effects in randomized clinical trials with a significant treatment-by-subgroup interaction2015

    • Author(s)
      Toyoizumi K,Matsui S
    • Organizer
      East Asia Regional Biometric Conference 2015
    • Place of Presentation
      Kyushu University(Fukuoka)
    • Year and Date
      2015-12-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Power and sample size in randomized clinical trials with over-dispersed count data: an approach based on a quasi-likelihood test with sandwich-type robust variance estimator2015

    • Author(s)
      Igeta M,Matsui S
    • Organizer
      East Asia Regional Biometric Conference 2015
    • Place of Presentation
      Kyushu University(Fukuoka)
    • Year and Date
      2015-12-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Information geometry and spontaneous data learning2015

    • Author(s)
      Eguchi S
    • Organizer
      Workshop on High-Dimensional Statistical Analysis
    • Place of Presentation
      Taipei,Taiwan
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hierarchical Mixture Modelling and Empirical Bayes Estimation in Biomedical Studies with High-dimensional Data2015

    • Author(s)
      Matsui S
    • Organizer
      Frontiers in Data-Driven Science and Technology: Recent Advances in Machine Learning and Applications
    • Place of Presentation
      Nagoya Institute of Technology(Aichi,Nagoya)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Spontaneous learning for data distributions via minimum divergence2015

    • Author(s)
      Eguchi S
    • Organizer
      ICMS Workshop on Computational information geometry for image and signal processing
    • Place of Presentation
      Edinburgh,United Kingdom
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分布の異質性を考慮したt統計量とAUCの一般化2015

    • Author(s)
      小森理,江口真透
    • Organizer
      統計関連学会連合大会2015
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] クラスタリングのためのロバストなK-平均法について2015

    • Author(s)
      野津昭文,江口真透
    • Organizer
      統計関連学会連合大会2015
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 異質性が内在する2標本検定問題におけるロバストな統計量2015

    • Author(s)
      大前勝弘,小森理,江口真透
    • Organizer
      統計関連学会連合大会2015
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Biomarker-based all-comers phase III trials: design issues and solutions.2015

    • Author(s)
      Matsui S
    • Organizer
      Pacific Rim Cancer Biostatistics Conference
    • Place of Presentation
      Seattle,USA
    • Year and Date
      2015-08-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bayesian phase II designs2015

    • Author(s)
      Teramukai S
    • Organizer
      Pacific Rim Cancer Biostatistics Workshop
    • Place of Presentation
      Seattle,USA
    • Year and Date
      2015-08-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bias-corrected estimation of treatment effects in biomarker-based randomized clinical trials2015

    • Author(s)
      Toyoizumi K, Matsui S
    • Organizer
      Joint Statistical Meetings 2015
    • Place of Presentation
      Seattle,USA
    • Year and Date
      2015-08-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Estimating bias in population mean pharmacokinetic parameters caused by limited sampling design2015

    • Author(s)
      Nemoto A, Matsuura M, Yamaoka K
    • Organizer
      The 28th International Biometrics Conference
    • Place of Presentation
      Utrecht,The Netherlands
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ベイズ流標本サイズ設定2015

    • Author(s)
      手良向聡
    • Organizer
      医学統計研究会特定主題シンポジウム2015「臨床評価におけるBayes流接近法」
    • Place of Presentation
      東京都,中央区日本橋本町,アステラス製薬
    • Year and Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 群判別のための多重マーカーの一般化 t-統計量について:セミパラメトリックスとラッソ2015

    • Author(s)
      江口 真透、小森 理
    • Organizer
      バイオ統計学の挑戦と貢献
    • Place of Presentation
      福岡県,福岡市南区塩原,九州大学
    • Year and Date
      2015-02-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] リスク・予後因子解析の方法と限界2015

    • Author(s)
      手良向聡
    • Organizer
      みやこリウマチ研究会
    • Place of Presentation
      京都府,京都市東山区,ウェスティン都ホテル京都
    • Year and Date
      2015-01-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 臨床試験の統計的デザイン2014

    • Author(s)
      手良向聡
    • Organizer
      京都運動器疾患フォーラム
    • Place of Presentation
      京都府,京都市中京区河原町御池,京都ホテルオークラ
    • Year and Date
      2014-12-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Correlation between DNA copy number and clinicopathological features2014

    • Author(s)
      Ishikawa T, Uetake H, Murotani K, Kobunai T, Ishiguro M, Matsui S, Sugihara K, , ACTS-CC study group
    • Organizer
      Biomarker search using genome-wide analysis of DNA copy number alterations in a phase III study of postoperative adjuvant chemotherapy for stage III colon cancer (ACTS-CC trial) ESMO 2014 Congress
    • Place of Presentation
      Madrid,Spain
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Duality in a maximum generalized entropy model2014

    • Author(s)
      Eguchi S., Komori, O. Ohara, A
    • Organizer
      34th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering Amboirs France 2014
    • Place of Presentation
      Amboirs,France
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] A novel boosting algorithm for multi-task learning based on the Itakuda-Saito divergence2014

    • Author(s)
      Takenouchi T. Komori O, Eguchi S.
    • Organizer
      34th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering Amboirs France 2014
    • Place of Presentation
      Amboirs,France
    • Year and Date
      2014-09-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロアレイデータによるロバストな遺伝子ランキングを用いた表現型予測2014

    • Author(s)
      大前 勝弘、小森 理、江口 真透
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      東京都,文京区本郷,東京大学本郷キャンパス
    • Year and Date
      2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Statistical analysis plans in phase III all-comers clinical trials with predictive biomarkers2014

    • Author(s)
      Matsui S
    • Organizer
      27th International Biometric Conference
    • Place of Presentation
      Florence,Italy
    • Year and Date
      2014-07-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Robust ranking method via repeated random partition for gene expressions data2014

    • Author(s)
      Omae, K., Komori, O., Eguchi, S
    • Organizer
      The 3rd Institute of Mathematical Statistics Asia Pacific Rim Meeting Taipei Taiwan 2014
    • Place of Presentation
      Taipei,China
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Generalized entropy and divergence in statistical learning2014

    • Author(s)
      Eguchi, S., Komori, O
    • Organizer
      The 3rd Institute of Mathematical Statistics Area Pasific Rim Meeting Taipei Taiwan 2014
    • Place of Presentation
      Taipei,China
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Pattern Recognition for Marine Ecological Assessments2013

    • Author(s)
      Eguchi S
    • Organizer
      The Ninth ICSA International Conference: Challenges of Statistical Methods for Interdisciplinary Research and Big Data
    • Place of Presentation
      Hong Kong,china
    • Year and Date
      2013-10-20 – 2013-10-23
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] An extension of Bayesian predictive sample size selection design for monitoring efficacy and safety in single-arm clinical trials2013

    • Author(s)
      Teramukai S, Daimon T, Zohar S
    • Organizer
      34th Annual Conference of the International Society for Clinical Biostatistics
    • Place of Presentation
      Munich,Germany
    • Year and Date
      2013-08-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] A new design for phase II single-arm clinical trials: Bayesian predictive sample size selection design2013

    • Author(s)
      Teramukai S, Daimon T, Zohar S
    • Organizer
      American Society of Clinical Oncology Annual Meeting
    • Place of Presentation
      Chicago,U.S.A
    • Year and Date
      2013-06-03
    • Related Report
      2013 Annual Research Report
  • [Presentation] Developing and validating continuous genomic signatures in randomized clinical trials2012

    • Author(s)
      Matsui S
    • Organizer
      XXVIth International Biometric Conference, Invited Session, Design and Analysis of Clinical Trials for Predictive Medicine: New Paradigm and Challenges
    • Place of Presentation
      Kobe
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Networking clinical biostatisticians in Japan2012

    • Author(s)
      Matsui S
    • Organizer
      XXVIth International Biometric Conference, Invited Session, International Collaborations and Networking of the Biometricians to Develop Statistical Methodologies and to Solve Global Statistical Issues
    • Place of Presentation
      Kobe
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Information geometry in statistics2012

    • Author(s)
      Eguchi S
    • Organizer
      The 2nd Institute of Mathematical Statistics Asia Pacific Rim Meeting
    • Place of Presentation
      Tsukuba
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 臨床試験における統計的デザイン2012

    • Author(s)
      手良向聡
    • Organizer
      日本外科学会第9回臨床研究セミナー
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Spontaneous learning for data distributions via minimum divergence.2016

    • Author(s)
      Eguchi S, Notsu A, Komori O
    • Total Pages
      299
    • Publisher
      Springer International Publishing
    • Related Report
      2015 Annual Research Report
  • [Book] Design and Analysis of Clinical Trials for Predictive Medicine2015

    • Author(s)
      Matsui S, Buyse M, Simon R
    • Total Pages
      400
    • Publisher
      Chapman & Hall/CRC Press 2015
    • Related Report
      2015 Annual Research Report
  • [Book] Statistical and machine-learning methods for class prediction in high dimension2015

    • Author(s)
      Komori O, Eguchi S
    • Total Pages
      381
    • Publisher
      Chapman & Hall/CRC Press 2015
    • Related Report
      2015 Annual Research Report
  • [Book] Path connectedness on a space of probability density functions2015

    • Author(s)
      Eguchi S, Komori O
    • Total Pages
      790
    • Publisher
      Springer International Publishing
    • Related Report
      2015 Annual Research Report
  • [Book] Design and Analysis of Clinical Trials for Predictive Medicine2015

    • Author(s)
      Matsui S, Buyse M, Simon R
    • Publisher
      CRC Press
    • Related Report
      2014 Annual Research Report
  • [Book] Developments in Statistical Evaluation of Clinical Trials2014

    • Author(s)
      Matsui S, Nonaka T, Choai Y
    • Total Pages
      361
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Developments in Statistical Evaluation of Clinical Trials2014

    • Author(s)
      Hirakawa A, Matsui S
    • Total Pages
      361
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] 臨床試験デザイン-ベイズ流・頻度流の適応的方法2014

    • Author(s)
      手良向聡、大門貴志
    • Publisher
      ディカル・パブリケーションズ
    • Related Report
      2014 Annual Research Report
  • [Book] Bayesian Inference and Mximum Eentropy Mmethods in Science and Engineering2014

    • Author(s)
      T Takenouchi, O Komori, S Eguchi
    • Total Pages
      1641
    • Publisher
      AIP Publishing
    • Related Report
      2014 Annual Research Report
  • [Book] Bayesian Inference and Mximum Eentropy Mmethods in Science and Engineering2014

    • Author(s)
      S Eguchi, O Komori, A Ohara
    • Total Pages
      1641
    • Publisher
      AIP Publishing
    • Related Report
      2014 Annual Research Report
  • [Book] Crowley J.J. and Hoering A. (ed.) Handbook of Statistics in Clinical Oncology, 3rd edition. Chapman & Hall/CRC Press, Boca Raton2012

    • Author(s)
      Matsui S, Noma H.
    • Publisher
      Analysis of DNA microarrays
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.nagoya-biostat.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] ホーム | 先端医療技術の開発における臨床試験の計画と統計解析に関する研究

    • URL

      http://www.nagoya-biostat.jp/kaken/index.html

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Funded Workshop] Pacific Rim Cancer Biostatistics Conference2015

    • Place of Presentation
      Seattle,USA
    • Year and Date
      2015-08-14
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2023-03-16  

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