| Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2014: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2013: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
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| Outline of Final Research Achievements |
Neural stem cells actively proliferate while giving rise to many cell types. The expression of the bHLH factor Hes1 oscillates with a period of 2-3 hours, and Hes1 oscillation drives the oscillatory expression of the proneural factor Mash1/Ascl1. Mash1/Ascl1 activates the cell cycle progression when its expression oscillates but induces the cell cycle exit and neuronal differentiation when its expression is sustained. Hes1 induces astrocyte differentiation when its expression is sustained. Thus, the oscillatory versus sustained expression of Mash1/Ascl1 and Hes1 regulates the cell cycle progression of neural stem cells.
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