Regulatory mechanism of cell cycle progression of neural stem cells
| Project/Area Number |
24240049
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2014: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2013: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
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| Keywords | 神経幹細胞 / 細胞周期 / Hes1 / Mash1/Ascl1 / bHLH因子 / プロニューラル因子 / 発現振動 / 光遺伝学 / Fucci / トランスジェニックマウス / 成体脳 / Mash1 / 網羅的RNAシークエンス / 神経分化決定因子 / Ascl1 / タイムラプスイメージング / ニューロン分化 / miR-9 / マイクロRNA |
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| Outline of Final Research Achievements |
Neural stem cells actively proliferate while giving rise to many cell types. The expression of the bHLH factor Hes1 oscillates with a period of 2-3 hours, and Hes1 oscillation drives the oscillatory expression of the proneural factor Mash1/Ascl1. Mash1/Ascl1 activates the cell cycle progression when its expression oscillates but induces the cell cycle exit and neuronal differentiation when its expression is sustained. Hes1 induces astrocyte differentiation when its expression is sustained. Thus, the oscillatory versus sustained expression of Mash1/Ascl1 and Hes1 regulates the cell cycle progression of neural stem cells.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Continuous postnatal neurogenesis contributes to the formation and maintenance of the functional olfactory bulb neural circuit2014
Author(s)
Sakamoto, M., Ieki, N., Miyoshi, G., Mochimaru, D., Hirano, K., Miyachi, H., Imura, T., Yamaguchi, M., Fishell, G., Mori, K., Kageyama, R., and Imayoshi, I.
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Journal Title
Journal of Neuroscience
Volume: 34
Related Report
Peer Reviewed
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[Journal Article] The adherens junction in the apical endfoot serves as a central site for active Notch signaling to control neurogenesis in vertebrates2014
Author(s)
Hatakeyama, J., Wakamatsu, Y., Nagafuchi, A., Kageyama, R., Shigemoto, R., and Shimamura, K.
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Journal Title
Development
Volume: 141
Issue: 8
Pages: 1671-1682
DOI
Related Report
Peer Reviewed
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[Journal Article] Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea2013
Author(s)
Tateya, T., Imayoshi, I., Tateya, I., Hamaguchi, K., Torii, H., Ito, J., and Kageyama, R.
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Journal Title
Development
Volume: 140
Issue: 18
Pages: 3848-3857
DOI
Related Report
Peer Reviewed
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[Journal Article] Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.2012
Author(s)
Tan, S.-L., Nishi, M., Ohtsuka, T., Matsui, T., Takemoto, K., Kamio-Miura, A., Aburatani, H., Shinkai, Y., and Kageyama, R.
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Journal Title
Development
Volume: 139
Issue: 20
Pages: 3806-3816
DOI
Related Report
Peer Reviewed
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