| Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2014: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2013: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
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| Outline of Final Research Achievements |
Suprachiasmatic nucleus (SCN) is a center of biological rhythm. SCN emits a powerful circadian rhythm signals to other brain regions and various peripheral organs, and synchronizes systemic clocks in order of the central clock. We started SCN-Gene Project, in which genes expressed in SCN were identified histochemically, and were characterized in rhythms by making their knockout mice. By the SCN-Gene Project, we so far identified animals with longer period length, or with stronger reaction to light pulse in the night. Moreover, we isolated mice without jet lag: they abruptly change their behavioral rhythms when they are exposed to new light-dark cycles. Many of these genes, were not directly related to circadian transcription, but directly linked to intercellular or intracellular signal transductions. These findings suggest that posttranscriptional processes are strongly involved to characterize the nature of the clock.
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