| Project/Area Number |
24240066
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University |
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Principal Investigator |
OKABE Masaru 大阪大学, 微生物病研究所, 特任研究員(常勤) (30089875)
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| Co-Investigator(Kenkyū-buntansha) |
ISOTNI Ayako 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (20444523)
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| Co-Investigator(Renkei-kenkyūsha) |
IKAWA Masahito 大阪大学, 微生物病研究所, 教授 (20304066)
YAMAGATA Kazuo 大阪大学, 微生物病研究所, 特任准教授(常勤) (10361312)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2014: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2012: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Keywords | 免疫 / マウス・ラットキメラ / 自己・非自己 / マウス / ラット / 異種キメラ / 発生工学 / 着床 / 受精能 |
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| Outline of Final Research Achievements |
A special interaction is said to be established during pregnancy between the maternal immune system and fetal cells to allow the survival and the normal growth of the fetus. A local immunosuppression is considered to be an important feature of a pregnancy. However, when we used heavily immunodeficiency mice for the recipient of rat embryos, the duration until the miscarriage was the same with wild-type mice. This was also true when the mouse-rat chimera was used for the recipient mothers. Moreover, producing embryos with mouse placenta and rat fetus also revealed that the immunity was not the first cause of a zenogenetic abortion.
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