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Strength and Stress Characterization based on Mechanical Interaction between Mineral and Collagen Components in Bone tissue

Research Project

Project/Area Number 24240068
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHokkaido University

Principal Investigator

TADANO Shigeru  北海道大学, 工学(系)研究科(研究院), 名誉教授 (50175444)

Co-Investigator(Kenkyū-buntansha) SASAKI Naoki  北海道大学, 大学院先端生命科学研究院, 教授 (40142202)
FUJISAKI Kazuhiro  弘前大学, 大学院理工学研究科, 准教授 (90435678)
YOKOTA Hideo  理化学研究所, その他, 研究員 (00261206)
ITO Manabu  北海道大学, 大学院医学研究科, 特任教授 (00271677)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2012: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Keywordsバイオメカニクス / 生体骨組織 / 応力検出 / X線回折 / ハイドロキシアパタイト / 結晶配向性 / コラーゲン / 生物・生体工学 / 医療・福祉 / 生体分子 / 計測工学 / X線
Outline of Final Research Achievements

Bone shows a hierarchical structure from a nano scale of hydroxyapatite crystal and collagen molecular to a macro scale of cortical and cancellous bone. This work proposed a new method of detecting stress of tissue level using the information of HAp crystal deformation and collagen molecular deformation. X-ray diffraction experimental procedure and Raman spectroscopy method were developed to measure the characteristics of hierarchical structure. Some structural parameters were introduced to represent these characteristics. Also, the XRD method was applied to detect residual stress in bone, and the stress was observed at various regions in animal extremities.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (74 results)

All 2015 2014 2013 2012 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results,  Acknowledgement Compliant: 2 results) Presentation (51 results) (of which Invited: 4 results) Book (3 results)

  • [Journal Article] Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH1-34) for skeletal repair2014

    • Author(s)
      Tomohiro Shimizu, Masahiko Takahata, Yusuke Kameda, Hiroki Hamano, Teppei Ito, Hiromi Kimura-Suda, Masahiro Todoh, Shigeru Tadano, Norimasa Iwasaki
    • Journal Title

      Bone

      Volume: 64 Pages: 95-101

    • NAID

      120005457026

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Parallel LOD-FDTD Method for Debye-Dispersive Media2014

    • Author(s)
      Tadashi Hemmi, Fumie Costen, Salvador Garcia, Ryutaro Himeno, Hideo Yokota, Mehshan Mustafa
    • Journal Title

      IEEE Transactions on Antennas and Propagation

      Volume: 62 Pages: 1330-1338

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Communication Platform for Image Analysis and Sharing in Biology2014

    • Author(s)
      Masahiko Morita, Takehiro Tawara, Masaomi Nishimura, Shin Yoshizawa Yoshizawa, Bukai Chou, Ippei Kuroki, Takashi Ijiri, Yuki Tsujimura, Ryutaro Himeno, Hideo Yokota
    • Journal Title

      International Journal of Networking and Computing

      Volume: 4 Pages: 369-391

    • NAID

      130004709094

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a flow field on amyloid fibrillogenesis in a b-lactoglobulin solution2014

    • Author(s)
      Rajesh Kmar Sharma, Kazuya Furusawa, Akimasa Fukui, Naoki Sasaki
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 70 Pages: 490-497

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-ray Diffraction Technique with Imaging Plate for Detecting Surface Distribution of Residual Stress in Diaphysis of Bovine Femurs2014

    • Author(s)
      Satoshi Yamada, Shigeru Tadano, Mai Onuma
    • Journal Title

      Experimental Mechanics

      Volume: 54 Pages: 633-640

    • NAID

      120005574997

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nanostructure and elastic modulus of single trabecula in bovine cancellous bone2014

    • Author(s)
      Satoshi Yamada, Shigeru Tadano, Sakurako Fukuda
    • Journal Title

      Journal of Biomechanics

      Volume: 47 Pages: 3482-3487

    • NAID

      120005512054

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Caspase 3 Silencing Inhibits Biomechanical Overload-induced Intervertebral Disc Degeneration2014

    • Author(s)
      Katsuhisa Yamada, Hideki Sudo, Koji Iwasaki, Naoki Sasaki, Hideaki Higashi, Yusuke Kameda, Manabu Ito, Masahiko Takahata, Kuniyoshi Abumi, Akio Minami, Norimasa Iwasaki
    • Journal Title

      American Journal of Pahtology

      Volume: 184 Pages: 753-764

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Residual Stress and Structural Anisotropy of Cortical Bone2013

    • Author(s)
      Shigeru Tadano, Satoshi Yamada
    • Journal Title

      Mechanics of Biological Systems and Materials, Volume 4 - Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics

      Volume: 4 Pages: 117-122

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orientation and Deformation of HAp Crystals and Elastic Modulus of Single Trabecula in Bovine Femur2013

    • Author(s)
      Satoshi Yamada, Sakurako Fukuda, Shigeru Tadano
    • Journal Title

      IFMBE Proceedings - The 15th International Conference on Biomedical Engineering

      Volume: 43 Pages: 741-742

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-Related Residual Stresses at Diaphyseal Surface of Bovine Femur Measured by XRD-IP System2013

    • Author(s)
      Mai Onuma, Satoshi Yamada, Shigeru Tadano
    • Journal Title

      IFMBE Proceedings - The 15th International Conference on Biomedical Engineering

      Volume: 43 Pages: 743-744

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical Analysis of Mineral an Collagen Phases in Bone by Raman Spectroscopy2013

    • Author(s)
      Masahiro Todoh, Shigeru Tadano
    • Journal Title

      IFMBE Proceedings - The 15th International Conference on Biomedical Engineering

      Volume: 43 Pages: 347-348

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of growth on residual stress distribution along the radial depth of cortical cylinders from bovine femurs2013

    • Author(s)
      Satoshi Yamada, Shigeru Tadano
    • Journal Title

      Journal of Biomechanics

      Volume: 46 Issue: 13 Pages: 2130-2136

    • DOI

      10.1016/j.jbiomech.2013.07.002

    • NAID

      120005317009

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elastic properties of collagen in bone determined by measuring the Debye Waller factor.2013

    • Author(s)
      Naoki Sasaki, Hideki Shirakawa, Tsutomu Nozoe, Kazuya Furusawa
    • Journal Title

      Journal of Biomechanics

      Volume: 46 Pages: 2824-2830

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] nfluence of Osteon Area Fraction and Degree of Orientation of HAp Crystals on Mechanical Properties in Bovine Femur2013

    • Author(s)
      Satoshi Yamada
    • Journal Title

      Journal of Biomechanics

      Volume: 46(1) Issue: 1 Pages: 31-35

    • DOI

      10.1016/j.jbiomech.2012.09.020

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the viscoelastic properties of cortical bone by selective degradation of matrix protein2013

    • Author(s)
      Hideki Shirakawa
    • Journal Title

      Journal of Biomechanics

      Volume: 46 Issue: 4 Pages: 696-701

    • DOI

      10.1016/j.jbiomech.2012.11.038

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of xSDF-1α, xCXCR4, and xCXCR7 during gastrulation in Xenopus laevis2013

    • Author(s)
      Mishra, S.K., Nagata, T., Furusawa, K., Sasaki, N., Fukui, A
    • Journal Title

      Int. J. Dev. Biol

      Volume: 57 Issue: 1 Pages: 95-100

    • DOI

      10.1387/ijdb.120130af

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An automated three-dimensional internal structure observation system based on high-speed serial sectioning of steel materials2012

    • Author(s)
      Fujisaki Kazuhiro
    • Journal Title

      Precision Engineering

      Volume: 36(2) Pages: 315-321

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shape and Image Interrogation with Curvature Extremalities2012

    • Author(s)
      Shin Yoshizawa
    • Journal Title

      Journal for Geometry and Graphics

      Volume: 16(1) Pages: 81-95

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slow knot formation by suppressed self-reptation in a collapsed polymer chain2012

    • Author(s)
      Mitsuo Nakata
    • Journal Title

      Physical Review E

      Volume: 85 Issue: 2

    • DOI

      10.1103/physreve.85.021802

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies on the Formation Mechanism and the Structure of the Anisotropic Collargen Gel Prepared by Dialysis-Induced Anisotropic Gelation2012

    • Author(s)
      K. Furusawa, S.Sato, J. Masumoto, Y. Hanazaki, Y. Maki, T. Dobashi, T. Yamamoto, A. Fukui and N. Sasaki
    • Journal Title

      Biomacromolecules

      Volume: Vol.13 Issue: 1 Pages: 29-39

    • DOI

      10.1021/bm200869p

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] tructural Strength of Bovine Cancellous Cubic Specimens Under Cyclic Compression2015

    • Author(s)
      Kaori Endo, Satoshi Yamada, Masahiro Todoh, Shigeru Tadano, Masahiko Takahata, Norimasa Iwasaki
    • Organizer
      ORS2015 (Orthopaedic Research Society 2015 Annual Meeting)
    • Place of Presentation
      Las Vegas (US)
    • Year and Date
      2015-03-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] MRI T2 mappingによる移植骨の骨強度評価の可能性2015

    • Author(s)
      遠藤香織, 杉森博行, 高畑雅彦, 高橋大介, Jeffery Kuo-Chen Wang, 山田悟史, 東藤正浩, 但野茂, 岩崎倫政
    • Organizer
      第27回代用臓器・再生医学研究会総会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 逐次断面切削-観察技術に基づいた工業材料の内部構造観察・組成分析システムの開発2015

    • Author(s)
      藤崎和弘,古城直道,中土裕樹,山下典理男,横田秀夫
    • Organizer
      理研シンポジウム「3次元内部構造顕微鏡による3次元計測の生物・材料分野への挑戦と展開」
    • Place of Presentation
      理化学研究所(埼玉県・和光市)
    • Year and Date
      2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 関節リウマチでは皮質骨の骨質劣化により早期から骨脆弱性が生じる2015

    • Author(s)
      清水智弘, 高畑雅彦, 亀田裕亮, 濱野博基, 遠藤香織, 平塚重人, 太田昌博, 岩崎倫政, 伊藤哲平, 木村-須田廣美, 東藤正浩, 但野茂
    • Organizer
      第128回北海道整形災害外科学会
    • Place of Presentation
      札幌医科大学(北海道・札幌市)
    • Year and Date
      2015-01-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 年齢によるウシ大腿骨表層残留応力と微視構造特性の変化2015

    • Author(s)
      山田悟史, 大沼舞, 東藤正浩, 但野茂
    • Organizer
      日本機械学会第27回バイオエンジニアリング講演会
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター(新潟県・新潟市)
    • Year and Date
      2015-01-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨組織の構造、骨形成に及ぼす物理刺激効果2014

    • Author(s)
      佐々木直樹
    • Organizer
      第3回日本MRS講演会
    • Place of Presentation
      横浜市開講記念館(神奈川県・横浜市)
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 異方性DNAゲルの薬剤徐放挙動について2014

    • Author(s)
      安井憲、佐々木直樹、古澤和也
    • Organizer
      第62回レオロジー討論会
    • Place of Presentation
      福井市地域交流プラザ(福井県・福井市)
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA-CTAグロビュラー高分子固体の応力緩和特性に及ぼす吸着水の効果2014

    • Author(s)
      岡田昂樹、Ossai, C. Emmanuel, 古澤和也、福井彰雅、佐々木直樹
    • Organizer
      第62回レオロジー討論会
    • Place of Presentation
      福井市地域交流プラザ(福井県・福井市)
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 海綿骨の粘弾性特性―材料特性と構造特性2014

    • Author(s)
      上田和貴、佐々木直樹、古澤和也
    • Organizer
      第62回レオロジー討論会
    • Place of Presentation
      福井市地域交流プラザ(福井県・福井市)
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] マルチチャネルコラーゲンゲルを用いた再生肝組織の構築と細胞の浸潤2014

    • Author(s)
      古澤和也、福井空彰雅、佐々木直樹
    • Organizer
      第62回レオロジー討論会
    • Place of Presentation
      福井市地域交流プラザ(福井県・福井市)
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA分子-陽イオン界面活性剤相互作用に及ぼす塩濃度の効果2014

    • Author(s)
      大木翔太、佐々木直樹、古澤和也
    • Organizer
      第62回レオロジー討論会
    • Place of Presentation
      福井市地域交流プラザ(福井県・福井市)
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウシ大腿骨表層残留応力の年齢による変化2014

    • Author(s)
      大沼舞, 山田悟史, 但野茂
    • Organizer
      第94回北海道医学大会生体医工学分科会・第53回日本生体医工学会北海道支部大会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨幹皮質骨表層と内部の弾性率とHAp結晶配向性2014

    • Author(s)
      近久晃一郎, 山田悟史, 但野茂
    • Organizer
      第94回北海道医学大会生体医工学分科会・第53回日本生体医工学会北海道支部大会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 広範囲X線回折プロファイルによる皮質骨のナノスケール変形計測2014

    • Author(s)
      箕輪政伸, 東藤正浩, 但野茂
    • Organizer
      第53回日本生体医工学会北海道支部大会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウシ大腿骨海綿骨の異方性弾性率とハイドロキシアパタイト(HAp)結晶構造の関係2014

    • Author(s)
      遠藤香織, 山田悟史, 東藤正浩, 但野茂, 高畑雅彦, 岩崎倫政
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      城山観光ホテル(鹿児島県・鹿児島市)
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラマン分光法による骨コラーゲン/アパタイト複合構造に基づく力学機能評価2014

    • Author(s)
      東藤正浩, 但野茂
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      城山観光ホテル(鹿児島県・鹿児島市)
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウシ海綿骨立方体試験片の繰返し圧縮時における強度特性2014

    • Author(s)
      遠藤香織, 山田悟史, 東藤正浩, 但野茂, 高畑雅彦, 岩崎倫政
    • Organizer
      生活生命支援医療福祉工学系学会連合大会2014(LIFE2014)
    • Place of Presentation
      ルスツリゾート (北海道・虻田郡)
    • Year and Date
      2014-09-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nanostructure of single trabecula in cancellous bone2014

    • Author(s)
      Satoshi Yamada, Shigeru Tadano
    • Organizer
      JSB2014 (4th Japan-Switzerland Workshop on Biomechanics)
    • Place of Presentation
      Shima Kanko Hotel The Classic (Shima, Mie)
    • Year and Date
      2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] elationship between micro-nano structure and macroscopic strength of bovine cotrical bone2014

    • Author(s)
      Shigeru Tadano, Satoshi Yamada, Masahiro Todoh, Kazuhiro Fujisaki
    • Organizer
      JSB2014 (4th Japan-Switzerland Workshop on Biomechanics)
    • Place of Presentation
      Shima Kanko Hotel The Classic (Shima, Mie)
    • Year and Date
      2014-09-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] HAp Crystal Strain and Elastic Modulus of Single Trabecula of Bovine Cancellous Bone2014

    • Author(s)
      Satoshi Yamada, Sakurako Fukuda, Shigeru Tadano
    • Organizer
      WCB2014 (7th World Congress of Biomechanics)
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2014-07-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] How is structural hierarchy in bone tissue reflected on its mechanical properties?2014

    • Author(s)
      Naoki Sasaki
    • Organizer
      How is structural hierarchy in bone tissue reflected on its mechanical properties?
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2014-07-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] How is structural hierarchy in bone tissue reflected on its mechanical properties?2014

    • Author(s)
      Naoki Sasaki
    • Organizer
      7th World Congress of Biomechanics
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2014-07-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] マルチチャネルコラーゲンゲルを用いた上皮管腔組織の構築2014

    • Author(s)
      古澤和也、町野ひろみ、福井彰雅、佐々木直樹
    • Organizer
      第37回日本バイオレオロジー学会
    • Place of Presentation
      さいたま市大宮ソニックシティ(埼玉県・さいたま市)
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 異方性DNAゲルの形成動力学と構造制御2014

    • Author(s)
      古澤和也、福井空彰雅、佐々木直樹
    • Organizer
      第37回日本バイオレオロジー学会
    • Place of Presentation
      さいたま市大宮ソニックシティ(埼玉県・さいたま市)
    • Year and Date
      2014-06-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] b-lactoglobulinアミロイド・ナノ粒子とゲル化2014

    • Author(s)
      佐々木直樹、山下聡一、古澤和也
    • Organizer
      第37回日本バイオレオロジー学会
    • Place of Presentation
      さいたま市大宮ソニックシティ(埼玉県・さいたま市)
    • Year and Date
      2014-06-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 皮質骨組織の破壊特性に及ぼす脱アパタイトの影響2014

    • Author(s)
      長谷川歩, 藤崎和弘, 笹川和彦
    • Organizer
      日本非破壊協会 平成26年度東北支部講演会
    • Place of Presentation
      青年文化センター(宮城県・仙台市)
    • Year and Date
      2014-04-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Residual Stresses for Bone Axial Direction in Bovine Femoral Diaphysis - Growing Effect -2013

    • Author(s)
      Satoshi Yamada
    • Organizer
      ORS2013 (Orthopaedic Research Society 2013 Annual Meeting)
    • Place of Presentation
      Henry B. Gonzalez Convention Center (San Antonio, Texas, US)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanical Analysis of Mineral Phase in Bone by Raman Sectroscopy and Effects of Aging and Its Anisotropy2013

    • Author(s)
      Masahiro Todoh
    • Organizer
      ORS2013 (Orthopaedic Research Society 2013 Annual Meeting)
    • Place of Presentation
      Henry B. Gonzalez Convention Center (San Antonio, Texas, US)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Anteior Surgical Treatment of Kyphotic Deformity with Compression Fracture2012

    • Author(s)
      Manabu Ito
    • Organizer
      SPINE ACROSS THE SEA SYMPOSIUM
    • Place of Presentation
      Kauai Marriott (Hawaii USA)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Anterior reconstruction2012

    • Author(s)
      Manabu Ito
    • Organizer
      AOSpine Advances Course Sapporo 2012
    • Place of Presentation
      札幌プリンスホテル (札幌市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ラマン分光法による骨微視力学挙動観察2012

    • Author(s)
      東藤正浩
    • Organizer
      第39回日本臨床バイオメカニクス学会
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] 海綿骨の力学特性: 材料特性と構造特性

    • Author(s)
      上田和貴, 佐々木直樹, 福井彰雅, 古澤和也
    • Organizer
      第48回高分子学会北海道支部研究発表会
    • Place of Presentation
      北海道大学、札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 皮質骨と海綿骨のHAp結晶配向およびEDS成分分析

    • Author(s)
      福田桜子, 山田悟史, 東藤正浩, 但野茂
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      東北大学、仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] マルチチャネルコラーゲンゲルの階層構造の制御

    • Author(s)
      古澤和也, 増元淳一, 花崎洋平, 福井彰雅, 佐々木直樹
    • Organizer
      第23回日本MRS年次大会
    • Place of Presentation
      横浜市開港記念会館、横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Age-Related Residual Stresses at Diaphyseal Surface of Bovine Femur Measured by XRD-IP System

    • Author(s)
      Mai Onuma, Satoshi Yamada, Shigeru Tadano
    • Organizer
      ICBME2013 (15th International Conference on Biomedical Engineering)
    • Place of Presentation
      National University of Singapore, Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] Orientation and Deformation of HAp Crystals and Elastic Modulus of Single Trabecula in Bovine Femur

    • Author(s)
      Satoshi Yamada, Sakurako Fukuda, Shigeru Tadano
    • Organizer
      ICBME2013 (15th International Conference on Biomedical Engineering)
    • Place of Presentation
      National University of Singapore, Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanical Analysis of Mineral an Collagen Phases in Bone by Raman Spectroscopy

    • Author(s)
      Masahiro Todoh, Shigeru Tadano
    • Organizer
      ICBME2013 (15th International Conference on Biomedical Engineering)
    • Place of Presentation
      National University of Singapore, Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウシ大腿骨海綿骨骨梁の弾性率と微視構造特性

    • Author(s)
      福田桜子, 山田悟史, 東藤正浩, 但野茂
    • Organizer
      第93回北海道医学大会生体医工学分科会・第52回日本生体医工学会北海道支部大会
    • Place of Presentation
      北海道大学、札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] マルチチャネルコラーゲンゲルの構造とレオロジー特性が骨芽細胞の振る舞いに与える影響

    • Author(s)
      古澤和也, 福井彰雅, 佐々木直樹
    • Organizer
      第61回レオロジー討論会
    • Place of Presentation
      山形大学、米澤市
    • Related Report
      2013 Annual Research Report
  • [Presentation] XRD-IP System for Residual Stress Measurement of Diaphyseal Surface

    • Author(s)
      Satoshi Yamada, Mai Onuma, Shigeru Tadano
    • Organizer
      AP Biomech2013 (7th Asian Pacific Conference on Biomechanics)
    • Place of Presentation
      KIST International Cooperation Building, Seoul, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] マルチチャネルコラーゲンゲルの階層構造に与える温度の影響

    • Author(s)
      古澤和也, 花崎洋平, 増元淳一 福井彰雅, 佐々木直樹
    • Organizer
      第36回日本バイオレオロジー学会年会
    • Place of Presentation
      九州大学西新プラザ、博多市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Residual Stress and Structural Anisotropy of Cortical Bone

    • Author(s)
      Shigeru Tadano, Satoshi Yamada
    • Organizer
      SEM2013 (2013 SEM Annual Conference & Exposition on Experimental & Applied Mechanics)
    • Place of Presentation
      The Westin Lombard Yorktown Center, Lombard, IL, US
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of Apatite Crystal Alignments on Anisotropic Fracture Characteristics of Cortical Bone

    • Author(s)
      Kazuhiro Fujisaki, Hiroya Yokoyama, Masahiro Todoh, Shigeru Tadano
    • Organizer
      Korea-Japan Joint Session/ KSME 2013 Bioengineering Division Spring Conference
    • Place of Presentation
      The Ocean Resort, Yeosu, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨粗鬆症性椎体骨折に対する治療ー特に椎体圧潰による麻痺症例に対する治療方針―.前方固定術の立場から

    • Author(s)
      伊東 学
    • Organizer
      第2回Debate on the Ring
    • Place of Presentation
      神戸ベイシェラトンホテル&タワーズ(神戸市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Residual Stress in One-Month and Two-Year Old Bovine Femurs

    • Author(s)
      Satoshi Yamada
    • Organizer
      WC2012 (World Congress 2012 on Medical Physics and Biomedical Engineering)
    • Place of Presentation
      Beijing International Convention Center,(Beijing, China)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウシ大腿骨海綿骨骨梁のHAp結晶配向性と弾性率

    • Author(s)
      山田悟史
    • Organizer
      日本機械学会2012年度年次大会
    • Place of Presentation
      金沢大学角間キャンパス(石川県金沢市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] X線IPによる骨表層残留応力計測

    • Author(s)
      山田悟史
    • Organizer
      日本機械学会第23回バイオフロンティア講演会
    • Place of Presentation
      弘前文化センター(青森県弘前市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 3次元内部構造顕微鏡を用いた家兎胸大動脈壁内微細構造の観察

    • Author(s)
      横田秀夫
    • Organizer
      日本機械学会第23回バイオフロンティア講演会
    • Place of Presentation
      弘前文化センター(青森県弘前市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 前駆骨芽細胞様細胞による異方性コラーゲンゲルリモデリング

    • Author(s)
      佐々木直樹
    • Organizer
      第60回レオロジー討論会
    • Place of Presentation
      名古屋大学 (愛知県名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨芽細胞によるマトリックスのリモデリングの解析

    • Author(s)
      佐々木直樹
    • Organizer
      第35回日本バイオレオロジー学会年会
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター(新潟県新潟市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of viscoelastic properties of bone on the analogy to polymeric network gels

    • Author(s)
      Naoki Sasaki
    • Organizer
      The XVIth International Congress on Rheology
    • Place of Presentation
      Centro Cultural de Belem(Lisbon Portugal)
    • Related Report
      2012 Annual Research Report
  • [Book] 骨研究最前線ーアンチエイジングシリーズ3- 第5章第2節「非侵襲骨応力計測の測定原理」2013

    • Author(s)
      但野 茂
    • Total Pages
      430
    • Publisher
      エヌティーエス
    • Related Report
      2013 Annual Research Report
  • [Book] 力学刺激に対する細胞応答 In 「生体電気・物理刺激による骨・軟部組織修復法」2013

    • Author(s)
      佐々木直樹
    • Publisher
      金芳堂
    • Related Report
      2012 Annual Research Report
  • [Book] Viscoelastic Properties of biological materials in Viscoelasticity2012

    • Author(s)
      Naoki Sasaki
    • Publisher
      InTec
    • Related Report
      2012 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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