Strength and Stress Characterization based on Mechanical Interaction between Mineral and Collagen Components in Bone tissue
Project/Area Number |
24240068
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Hokkaido University |
Principal Investigator |
TADANO Shigeru 北海道大学, 工学(系)研究科(研究院), 名誉教授 (50175444)
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Co-Investigator(Kenkyū-buntansha) |
SASAKI Naoki 北海道大学, 大学院先端生命科学研究院, 教授 (40142202)
FUJISAKI Kazuhiro 弘前大学, 大学院理工学研究科, 准教授 (90435678)
YOKOTA Hideo 理化学研究所, その他, 研究員 (00261206)
ITO Manabu 北海道大学, 大学院医学研究科, 特任教授 (00271677)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2012: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
|
Keywords | バイオメカニクス / 生体骨組織 / 応力検出 / X線回折 / ハイドロキシアパタイト / 結晶配向性 / コラーゲン / 生物・生体工学 / 医療・福祉 / 生体分子 / 計測工学 / X線 |
Outline of Final Research Achievements |
Bone shows a hierarchical structure from a nano scale of hydroxyapatite crystal and collagen molecular to a macro scale of cortical and cancellous bone. This work proposed a new method of detecting stress of tissue level using the information of HAp crystal deformation and collagen molecular deformation. X-ray diffraction experimental procedure and Raman spectroscopy method were developed to measure the characteristics of hierarchical structure. Some structural parameters were introduced to represent these characteristics. Also, the XRD method was applied to detect residual stress in bone, and the stress was observed at various regions in animal extremities.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] Caspase 3 Silencing Inhibits Biomechanical Overload-induced Intervertebral Disc Degeneration2014
Author(s)
Katsuhisa Yamada, Hideki Sudo, Koji Iwasaki, Naoki Sasaki, Hideaki Higashi, Yusuke Kameda, Manabu Ito, Masahiko Takahata, Kuniyoshi Abumi, Akio Minami, Norimasa Iwasaki
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Journal Title
American Journal of Pahtology
Volume: 184
Pages: 753-764
Related Report
Peer Reviewed
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[Journal Article] Expression of xSDF-1α, xCXCR4, and xCXCR7 during gastrulation in Xenopus laevis2013
Author(s)
Mishra, S.K., Nagata, T., Furusawa, K., Sasaki, N., Fukui, A
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Journal Title
Int. J. Dev. Biol
Volume: 57
Issue: 1
Pages: 95-100
DOI
Related Report
Peer Reviewed
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[Presentation] 関節リウマチでは皮質骨の骨質劣化により早期から骨脆弱性が生じる2015
Author(s)
清水智弘, 高畑雅彦, 亀田裕亮, 濱野博基, 遠藤香織, 平塚重人, 太田昌博, 岩崎倫政, 伊藤哲平, 木村-須田廣美, 東藤正浩, 但野茂
Organizer
第128回北海道整形災害外科学会
Place of Presentation
札幌医科大学(北海道・札幌市)
Year and Date
2015-01-31
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