Development of highly sensitive magnetic field sensing system for the purpose of cell tissue functional evaluation

• Project/Area Number: 24240080
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Nagoya University
• Principal Investigator: UCHIYAMA Tsuyoshi 名古屋大学, 工学(系)研究科(研究院), 准教授 (00203555)
• Co-Investigator(Kenkyū-buntansha): NAKAYAMA Shinsuke 名古屋大学, 医学研究科, 准教授 (30192230)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000); Fiscal Year 2014: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2013: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2012: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
• Keywords: 細胞組織 / 生体磁気 / 心磁図 / 脳磁図 / 活動電流 / 磁気センサ / 再生医療 / 高感度磁気センサ / 平滑筋 / 脳波 / 磁気計測 / 不整脈 / がん

Outline of Final Research Achievements

We developed highly sensitive magneto-impedance sensor by use of pulse current excitation method and achieved pT sensitivity, which is necessary for cell tissue magnetic field evaluation.　Magnetic fields generated by spontaneous electrical activity in the mouse and guinea pig tissue preparation were measured by use of the developed highly sensitive magneto-impedance sensor. We　confirmed that that detection magnetic signal is closely correlated with electrical signal and synchronized with electrical signal at the tissue surface. We analyzed current distribution in the cell tissue based on the experimental results. We concluded that the developed magneto-impedance sensor system is useful for cell tissue bio-magnetic measurement as well as for Magnetocardiography (MCG) and Magnetoencephalography (MEG).

Research Products

• [Journal Article] Real-time Measurement of Biomagnetic Vector Fields in Functional Syncytium Using Amorphous Metal (2015)
  • Author(s): Nakayama S, Uchiyama T
  • Journal Title: Scientific report Volume: 5 Issue: 1 Pages: 1-9
  • DOI: 10.1038/srep08837
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Detection of P300 brain waves using a Magneto-Impedance sensor (2014)
  • Author(s): Wang K, Tajima S, Asano Y, Okuda Y, Hamada N, Cai C, Uchiyama T
  • Journal Title: Sensing Technology (ICST), 2014, 8th International Conference on Publication Volume: 8 Pages: 547-550
  • Peer Reviewed
• [Journal Article] Highly Sensitive CMOS Magneto-Impedance Sensor Using Miniature Multi-core Head Based on Amorphous Wire (2014)
  • Author(s): Uchiyama T, Hamada N, Cai C.
  • Journal Title: IEEE Transactions on Magnetics Volume: 50 Issue: 11 Pages: 4005404-4005404
  • DOI: 10.1109/tmag.2014.2326658
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High Resolution Magneto-impedance Sensor with TAD for Low Noise Signal Processing (2014)
  • Author(s): Tajima S, Okuda Y, Watanabe T, Aoyama H, Yamamoto M, Uchiyama T
  • Journal Title: IEEE Transactions on Magnetics Volume: 50 Issue: 11 Pages: 4005504-4005504
  • DOI: 10.1109/tmag.2014.2332178
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MIセンサを用いた非破壊検査 (2014)
  • Author(s): 内山 剛
  • Journal Title: 非破壊検査 Volume: 63 Pages: 562-566
  • Peer Reviewed
• [Journal Article] Development of multicore magneto-impedance sensor for stable pico-Tesla resolution (2013)
  • Author(s): T. Uchiyama, N. Hamada, C.M. Cai
  • Journal Title: ICST'13, 2013 Seventh International Conference on Volume: 7 Pages: 573-577
  • DOI: 10.1109/icsenst.2013.6727718
  • Peer Reviewed
• [Journal Article] マルチコアヘッドによるコイル検出型磁気インピーダンスセンサの開発 (2013)
  • Author(s): 内山 剛，濱田典彦、蔡 長梅
  • Journal Title: 電気学会マグネティックス研究会 Volume: MAG-13-12 Pages: 67-70
  • NAID: 10031182587
• [Journal Article] Human biomagnetic field measurement using pico-Tesla sensitive amorphous wire magnetoimpedance sensor (2013)
  • Author(s): T. Uchiyama, K. Mohri, S. Nakayama
  • Journal Title: Sensor Letters Volume: 11 Pages: 191-194
  • Peer Reviewed
• [Journal Article] Magnetic sensors using amorphous metal materials: Detection of premature ventricular magnetic waves (2013)
  • Author(s): T. Uchiyama, S. Nakayama
  • Journal Title: Physiological Reports Volume: 1
  • Peer Reviewed
• [Journal Article] MI素子を利用した高精度グラジオメーターによる摘出細胞組織の活動磁気計測 (2013)
  • Author(s): 内山 剛
  • Journal Title: 電気学会マグネティックス研究会資料 Volume: MAG-13-12 Pages: 49-53
  • NAID: 10031155262
• [Journal Article] 医療技術における磁気応用研究の動向ー生体機能計測に於ける磁気応用技術ー (2013)
  • Author(s): 伊良皆啓二
  • Journal Title: 電気学会マグネティックス研究会資料 Volume: MAG-13-12 Pages: 5-12
• [Journal Article] Recent advances of pico-Tesla Resolution Micro Magnetic Sensors Based on Amorphous Wire and CMOS IC MI sensor (2012)
  • Author(s): T.Uchiyama
  • Journal Title: IEEE Trans. Magn. Volume: 48 Pages: 3833-3839
  • Peer Reviewed
• [Journal Article] Physiological Magnetic Stimulation for Arousal of Elder Car Driver Evaluated with Electro-encephalogram and Spine Magnetic Field (2012)
  • Author(s): K. Mohri
  • Journal Title: IEEE Trans. Magn. Volume: 48 Pages: 3505-3508
  • Peer Reviewed
• [Journal Article] MI素子による高性能グラジメーターの開発と細胞組織磁気計測への応用 (2012)
  • Author(s): 内山 剛
  • Journal Title: 電気学会マグネティックス研究会資料 Volume: MAG-12-13 Pages: 43-47
• [Presentation] Development of highly sensitive magneto-impedance sensor and its application to P300 brainwaves measurement (2014)
  • Author(s): Uchiyama T, Nakayama S
  • Organizer: 8TH INTERNATIONAL CONFERENCE ONENERGY - MATERIALS - NANOTECHNOLOGY
  • Place of Presentation: Orlando USA
  • Year and Date: 2014-11-22 – 2015-11-22
  • Invited
• [Presentation] Biomagnetic Field Detection of Cellular Organizations Using Improved Gradio-type MI Magneto Sensor (2014)
  • Author(s): Nakayama S, Uchiyama T
  • Organizer: PIERS 2014
  • Place of Presentation: Guangzhou China
  • Year and Date: 2014-08-25 – 2014-08-28
  • Invited
• [Presentation] Detection of Back Magneto-cardiogram for Heart Disease Using Pico-Tesla Resolution Amorphous Wire Magneto-Impedance Sensor (2014)
  • Author(s): Mohri Y, Uchiyama T, Yamada, K. Mohri
  • Organizer: PIERS 2014
  • Place of Presentation: Guangzhou China
  • Year and Date: 2014-08-25 – 2014-08-28
• [Presentation] Arousal Effect of ELF Magnetic Stimulus on Car Driver’s Spine Evaluated with Occipital Electroencephalogram and Back Magneto-cardiogram (2014)
  • Author(s): Mohri Y, Yamada M, Kato W, Uchiyama T, Mohri K
  • Organizer: PIERS 2014
  • Place of Presentation: Guangzhou China
  • Year and Date: 2014-08-25 – 2014-08-28
• [Presentation] 磁気インピーダンスセンサによる脳波P３００信号の検出と脳磁計測の可能性 (2014)
  • Author(s): 内山 剛、田島 真吾、王 可望
  • Organizer: 日本生体磁気学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-29 – 2014-05-30
  • Invited
• [Presentation] High Resolution Magneto-impedance Sensor with TAD for Low Noise Signal Processing (2014)
  • Author(s): Tajima S, Okuda Y, Watanabe T, Aoyama H, Yamamoto M, Uchiyama T
  • Organizer: INTERMAG 2014
  • Place of Presentation: Dresden Germany
  • Year and Date: 2014-05-04 – 2015-05-08
• [Presentation] Detection of P300 brain waves in the parietal region using a Magneto-Impedance sensor (2014)
  • Author(s): Wang K, Tajima S, Asano Y, Okuda Y, Hamada N, Cai C, Uchiyama T
  • Organizer: INTERMAG 2014
  • Place of Presentation: Dresden Germany
  • Year and Date: 2014-05-04 – 2015-05-08
• [Presentation] Highly Sensitive CMOS Magneto-Impedance Sensor Using Miniature Multi-core Head Based on Amorphous Wire (2014)
  • Author(s): Uchiyama T, Hamada N, Cai C
  • Organizer: INTERMAG 2014
  • Place of Presentation: Dresden Germany
  • Year and Date: 2014-05-04 – 2014-05-08
• [Presentation] 磁気直線的MIグラジオセンサーによる疑似リアルタイムの生体磁界計測 (2014)
  • Author(s): 中山晋介、近藤正夫、熱田諭志、内山剛
  • Organizer: 日本生理学会（第９１回)
  • Place of Presentation: 鹿児島
• [Presentation] Stable pico-Tesla Resolution Multi Amorphous Wire GMI Sensor and Its Application to Cardiac Magnetic Field Measurement (2013)
  • Author(s): T. Uchiyama, N. Hamada, K.Mohri
  • Organizer: The 34th PIERS
  • Place of Presentation: Stockholm, Sweden
  • Invited
• [Presentation] Stable pico-Tesla Resolution Multi Amorphous Wire MI Sensor and Its Application to Biomagnetic Field Measurement (2013)
  • Author(s): T. Uchiyama, N. Hamada, C.M. Cai
  • Organizer: International US-French Workshop
  • Place of Presentation: La Jolla California, US
• [Presentation] Development of Multicore Magneto-Impedance Sensor for Stable Pico-Tesla Resolution (2013)
  • Author(s): T. Uchiyama, N. Hamada, C.M. Cai
  • Organizer: The 7th International Conference on Sensing Technology (ICST’13)
  • Place of Presentation: Wellington, NZ
• [Presentation] Brain activity measurement at the occipital region of the head using magneto-impedance sensor (2013)
  • Author(s): S. Tajima, T. Uchiyama, Y. Okuda, and K. Wang.
  • Organizer: The 7th International Conference on Sensing Technology (ICST’13)
  • Place of Presentation: Wellington, NZ
• [Presentation] Applications of pulse-driven magnetoimpedance sensors to biological magnetic fields (2013)
  • Author(s): S. Nakayama, S. Atsuta, M> Kondo, T. Uchiyama
  • Organizer: UPS (International Union of Physiological Society) 37th World Congress
  • Place of Presentation: Birmingham, UK
• [Presentation] Highly sensitive amorphous wire CMOS magneto-impedance sensor with coplanar line filter for (2013)
  • Author(s): S. Kawahara
  • Organizer: 12th Joint MMM Intermag Conference
  • Place of Presentation: Chicago,USA
• [Presentation] Multi Amorphous Wire assembly GMI Sensor for Stable pico-Tesla Resolution (2013)
  • Author(s): T.Uchiyama
  • Organizer: 12th Joint MMM Intermag Conference
  • Place of Presentation: Chicago,USA
• [Presentation] Make biomagnetic field realistic: Application of pulse-driven magneto-impedance sensor to physiology (2013)
  • Author(s): 中山晋介
  • Organizer: 日本生理学会
  • Place of Presentation: 東京
• [Presentation] 高感度MIセンサ回路の小型化に関する研究 (2013)
  • Author(s): 奥田有記浩
  • Organizer: 電気学会全国大会
  • Place of Presentation: 名古屋
• [Presentation] 高感度MIセンサを用いた脳波計測の基礎検討 (2013)
  • Author(s): 藤波駿一朗
  • Organizer: 電気学会全国大会
  • Place of Presentation: 名古屋
• [Presentation] Recent advances of pico-Tesla Resolution Micro Magnetic Sensors Based on Amorphous Wire and CMOS IC MI sensor (2012)
  • Author(s): T.Uchiyama
  • Organizer: Intermag
  • Place of Presentation: Vancouver, Canada
  • Invited
• [Presentation] A MEG measurement using pico-Tesla sensitivity amorphous wire magneto-impedance sensor for brain activity measurement (2012)
  • Author(s): T.Uchiyama
  • Organizer: PIERS
  • Place of Presentation: Moscow,Russia
  • Invited
• [Presentation] Recent advances of Amorphous Wire & CMOS IC Magneto-Impedance Sensor for Super MI Sensor (2012)
  • Author(s): K.Mohri
  • Organizer: RTNSA
  • Place of Presentation: Ordizia,Spain
  • Invited
• [Presentation] A MEG measurement using pico-Tesla sensitivity amorphous wire magneto-impedance sensor with simultaneously recorded EEG (2012)
  • Author(s): S. Tajima
  • Organizer: ICAUM
  • Place of Presentation: Nara,Japan
• [Presentation] Development of highly precise gradiometer using amorphous wire magneto-impedance element for cell tissue evaluation (2012)
  • Author(s): T.Uciyama
  • Organizer: ICAUM
  • Place of Presentation: Nara,Japan
• [Presentation] 山田斉哉 (2012)
  • Author(s): アモルファスワイアMI素子の高周波特性と磁気センサ応用
  • Organizer: 電気学会マグネティックス研究会
  • Place of Presentation: 仙台
• [Presentation] 河原信二 (2012)
  • Author(s): コプレーナラインフィクタを用いた高感度・広帯域なパルス駆動型MIセンサの開発
  • Organizer: 電気学会A部門大会
  • Place of Presentation: 秋田
• [Presentation] 山本俊也 (2012)
  • Author(s): コルピッツ発信回路を利用した高感度MIセンサの開発
  • Organizer: 電気学会A部門大会
  • Place of Presentation: 秋田
• [Presentation] 磁気インピーダンスセンサーによる平滑筋細胞組織計測と最近の高精度化 (2012)
  • Author(s): 中山晋介
  • Organizer: 日本平滑筋学会
  • Place of Presentation: 東京
• [Book] 新しい磁気センサとその応用 (2013)
  • Author(s): 毛利佳年雄、安藤康夫、本蔵義信、大兼幹彦、内山剛、野々村 裕
  • Total Pages: 197
  • Publisher: トリケップス
• [Remarks] 名古屋大学 電子情報システム専攻 電子工学部分野 知能デバイスグループ
  • URL: http://www.nuee.nagoya-u.ac.jp/labs/uchiyamalab/