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The mechanisms for deterioration of thermoregulatory responses in older people and the counter measure against their heat illness

Research Project

Project/Area Number 24240089
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionShinshu University

Principal Investigator

NOSE Hiroshi  信州大学, 学術研究院医学系, 教授 (40128715)

Co-Investigator(Kenkyū-buntansha) KAMIJO Yoshi-ichiro  信州大学, 学術研究院医学系, 講師 (40372510)
OKAZAKI Kazunobu  大阪市立大学, 都市健康・スポーツ研究センター, 准教授 (70447754)
HIGUCHI Keiichi  信州大学, 学術研究院医学系, 教授 (20173156)
TANIGUCHI Shun'ichiro  信州大学, 学術研究院医学系, 教授 (60117166)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2014: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2013: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2012: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Keywordsスポーツ生理学 / 運動生理学 / 体温調節能 / 血液量 / インシュリン / 中高年者 / 暑熱耐性 / 熱中症予防 / 生活習慣病 / 遺伝子修飾 / 運動トレーニング / 糖質・乳蛋白質 / 糖質・乳タンパク質
Outline of Final Research Achievements

We examined any merits of the supplementation of a mixture of carbohydrate and protein during exercise training. First, we divided older men into 2 groups; carbohydrate + protein (Pro-CHO) and carbohydrate (CHO) supplementation groups. After 2-mo training, we found that thermoregulatory responses more improved with more increases in plasma volume and albumin content in Pro-CHO than CHO but arterial blood pressure decreased in both groups. Second, we divided older women into 3 groups; control (CNT), low (L-Pro-CHO), and high carbohydrate + protein (H-Pro-CHO) supplementation during interval walking training. After 5-mo training, we found that muscle strength, plasma volume, and inflammatory genes methylation increased more in H-Pro-CHO than CNT. In addition, the inter-individual variation of renal Na+ reabsorption rate in response to plasma insulin concentration during OGTT was smaller in H-Pro-CHO than in CNT. Thus, the supplementation might enhance the benefits of exercise training.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (43 results)

All 2015 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (27 results) (of which Invited: 15 results) Book (6 results)

  • [Journal Article] NFkB2 gene as anoble candidate epidemiologically responding to interval walking training.2015

    • Author(s)
      Zhang Y, Hashimoto S, Fujii C, Hida S, Ito K, Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H, Higuchi K, Nakajima K, Taniguchi S
    • Journal Title

      Int. J. Sports. Med.

      Volume: in press Issue: 09 Pages: 769-775

    • DOI

      10.1055/s-0035-1547221

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The factors affecting adherence to a long-term interval walking training program in middle-aged and older people2015

    • Author(s)
      Masuki S, Mori M, Tabara Y, Sakurai A, Hashimoto S, Morikawa M, Miyagawa K, Sumiyoshi E, Miki T, Higuchi K, and Nose H
    • Journal Title

      J. Appl. Physiol.

      Volume: 118 Issue: 5 Pages: 595-603

    • DOI

      10.1152/japplphysiol.00819.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 大規模科学的エビデンスにもとづく遠隔型個別運動処方2015

    • Author(s)
      能勢 博、森川真悠子、増木静江、上條義一郎
    • Journal Title

      保健の科学

      Volume: 57 Pages: 22-25

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of home-based interval walking training on thigh muscle strength and aerobic capacity in female top hip arthroplasty patients: a randomized, controlled pilot study2014

    • Author(s)
      Morishima Y, Mizushima T, Yamauchi K, Morikawa M, Masuki S, and Nose H
    • Journal Title

      PLOS ONE

      Volume: 9 Pages: 1-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interval Walking Training for Middle-Aged and Older People: Methods and Evidence2014

    • Author(s)
      Nose H
    • Journal Title

      IEICE Transactions on Communications

      Volume: E97.B Issue: 3 Pages: 534-539

    • DOI

      10.1587/transcom.E97.B.534

    • NAID

      130003394646

    • ISSN
      0916-8516, 1745-1345
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of macronutrient intake on thigh muscle mass during home-based walking training in middle-aged and older women.2013

    • Author(s)
      Okazaki K, Yazawa D, Goto M, Kamijo YI, Furihata M, Gen-no H, Hamada K, Nose H.
    • Journal Title

      Scand J Med Sci Sports.

      Volume: 23 Issue: 5

    • DOI

      10.1111/sms.12076

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free moving mice2013

    • Author(s)
      Masuki S, Sumiyoshi E, Koshimizu T, Qian J, Higuchi K, Tsujimoto G, and Nose H
    • Journal Title

      Journal of Physiology (Lond.)

      Volume: 591 Pages: 3651-3665

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of macronutrient intake on thigh muscle mass during home-based walking training in middle-aged and older women2013

    • Author(s)
      Okazaki K, Yazawa D, Goto M, Kmaijo Y, Furuhata M, Gen-no H, Hamada K, and Nose H
    • Journal Title

      Scandinavian Journal of Medicine Science in Sports

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men2012

    • Author(s)
      Kamijo Y, Ikegawa S, Okada Y, Masuki S, Okazaki K, Uchida K, Sakurai M, and Nose H
    • Journal Title

      Am. J. Physiol.

      Volume: 301

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メリハリをつけて歩くインターバル速歩-その方法と効果のエビデンス-2012

    • Author(s)
      能勢 博
    • Journal Title

      顎機能誌, J. Jpn. Soc. Stomatognath. Funct.

      Volume: 19 Pages: 1-9

    • NAID

      130004547544

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 運動+乳製品の生活習慣病予防効果:筋力と慢性炎症反応への影響2015

    • Author(s)
      増木静江、谷口俊一郎、能勢 博
    • Organizer
      第92回日本生理学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 生活習慣病予防に適した運動プログラムの開発・評価-高強度インターバル速歩トレーニング理論-2015

    • Author(s)
      能勢 博
    • Organizer
      身体活動の科学の再構築に関するシンポジウム
    • Place of Presentation
      東京工業大学
    • Year and Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「インターバル速歩」で元気に富士登山2014

    • Author(s)
      能勢 博
    • Organizer
      山梨県富士山科学研究所国際シンポジウム
    • Place of Presentation
      富士山科学研究所
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「歩き方を変える」だけで10歳若返る!-生活習慣病・介護予防のための新しい運動処方システム-2014

    • Author(s)
      能勢 博
    • Organizer
      第42回日本歯科麻酔学会
    • Place of Presentation
      日本歯科大学(新潟校)
    • Year and Date
      2014-10-11 – 2014-10-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「インターバル速歩」のアンチエイジング効果2014

    • Author(s)
      能勢 博
    • Organizer
      第14回日本抗加齢医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-06-06 – 2014-06-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] メリハリをつけて歩く「インターバル速歩」-生活習慣病・介護予防のための遠隔型個別運動処方システム-2014

    • Author(s)
      能勢 博
    • Organizer
      ITヘルスケア学会 第8回年次学術大会
    • Place of Presentation
      東京医療保健大学
    • Year and Date
      2014-05-24 – 2014-05-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Interval walking training for middle-aged and older people: methods and evidence.2013

    • Author(s)
      Hiroshi Nose
    • Organizer
      7th International Symposium on Medical Information and Communication Technology (ISMICT2013), key note lecture
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 10歳若返る!「インターバル速歩」-生活習慣病・介護予防のための新しい運動処方-2013

    • Author(s)
      能勢 博
    • Organizer
      第3回日本腎臓リハビリテーション学会学術集会
    • Place of Presentation
      宇都宮市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ヒト暑熱馴化と圧反射性皮膚血流調節:シンポジウム「運動による暑熱耐性の獲得メカニズム-末梢と中枢の役割-」2013

    • Author(s)
      上條義一郎、小川 雄、能勢 博
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Vasopressin V1a受容体遺伝子と動機づけ行動-動物とヒトの双方向性研究:シンポジウム「腎尿細管の膜機能タンパク:分子から疾患まで」2013

    • Author(s)
      増木静江、住吉愛里、能勢 博
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Vasopressin V1a receptor and pressor responses for food-seeking behavior in fasting mice.2013

    • Author(s)
      Sumiyoshi E, Masuki S, and Nose H
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston
    • Related Report
      2012 Annual Research Report
  • [Presentation] Vasopressin V1a receptor and voluntary locomotion linked with cerebral activation in free-miving mice.2013

    • Author(s)
      Masuki S, Sumiyoshi E, Koshimizu T, Tsujimoto G, and Nose H
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston
    • Related Report
      2012 Annual Research Report
  • [Presentation] Head-up tilt suppressed sympathetic nerve activity synchronized with cardiac cycle to skin but increased that to muscle in passively warmed men.2013

    • Author(s)
      Ogawa Y, Kamijo Y, Ikegawa S, Masuki S, Morita A, and Nose H
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston
    • Related Report
      2012 Annual Research Report
  • [Presentation] Rapid plasma volume restoration increased skin sympathetic nerve activity component synchronized with cardiac cycle and cutaneous vasodilation in hypovolemic and passively warmed men.2013

    • Author(s)
      Kamijo Y, Okazaki K, Ikegawa S, Okada Y, and Nose H
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston
    • Related Report
      2012 Annual Research Report
  • [Presentation] Anti-aging medicine and high intensity interval walking training in aging society,” Symposium on Exercise Makes Perfect!”2012

    • Author(s)
      Hiroshi Nose
    • Organizer
      The 2nd International Conference on Anti-Aging Medicine
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生活習慣病・介護予防のための新しい運動処方:シンポジウム「生活習慣病とライフスタイルイノベーション」2012

    • Author(s)
      能勢 博
    • Organizer
      第164回日本農芸化学会中部支部
    • Place of Presentation
      伊那市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 10歳若返る!「インターバル速歩」-生活習慣病・介護予防のための新しい運動処方-2012

    • Author(s)
      能勢 博
    • Organizer
      第23回日本スポーツ歯科医学会・総会・学術大会、教育講演
    • Place of Presentation
      長野市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 熱中症と生活習慣病にならない体づくり2012

    • Author(s)
      能勢 博
    • Organizer
      第51回日本生気象学会大会、ランチオンセミナー
    • Place of Presentation
      松本市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 水中歩行時の有酸素性運動能に及ぼす免荷率の影響2012

    • Author(s)
      大塩琢也、半田秀一、上條義一郎、能勢 博
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 餌の探索行動におけるバゾプレッシンV1a受容体の役割2012

    • Author(s)
      住吉愛里、増木静江、輿水崇鏡、辻本豪三、能勢 博
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高体温時ヘッドアップティルト時の右心房容量変化が皮膚血管コンダクタンスに及ぼす影響2012

    • Author(s)
      小川 雄、上條義一郎、池川茂樹、増木静江、森田淳美、能勢 博
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 5-アミノレブリン酸 (ALA) 摂取が運動時の呼吸循環応答とトレーニング量に与える影響2012

    • Author(s)
      森田淳美、池川茂樹、上條義一郎、片岡由布子、能勢 博
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Vasopressin V1a receptor and pressor responses for food-seeking behavior in fasting mice.

    • Author(s)
      Sumiyoshi E, Masuki S, and Nose H
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      ボストン(アメリカ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Vasopressin Via receptor and voluntary locomotion linked with cerebral activation in free-moving mice

    • Author(s)
      Masuki S, Sumiyoshi E, Koshimizu T, Tsujimoto G, and Nose H
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      ボストン(アメリカ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Head-up tilt suppressed sympathetic nerve activity synchronized cardiac cycle to skin but increased that to muscle in passively warmed men

    • Author(s)
      Ogawa Y, Kamijo Y, Ikegawa S, Masuki S, Morita A, and Nose H
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      ボストン(アメリカ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Rapid plasma volume restoration increased skin sympathetic nerve activity component synchronized with cardiac cycle and cutaneous vasodilation in hypovolemic and passively warmed men

    • Author(s)
      Kamijo Y, Okazaki K, Ikegawa S, Okada Y, and Nose H
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      ボストン(アメリカ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Impact of milk intake durinf exercise training on thermoregulatoty and musclr adaptation

    • Author(s)
      Nose H
    • Organizer
      IDF World Dairy Summit
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 山に登る前の読む本2014

    • Author(s)
      能勢 博
    • Total Pages
      190
    • Publisher
      講談社ブルーバックス
    • Related Report
      2014 Annual Research Report
  • [Book] 浮腫2014

    • Author(s)
      能勢 博
    • Total Pages
      315
    • Publisher
      医薬ジャーナル社
    • Related Report
      2014 Annual Research Report
  • [Book] 運動と乳製品の摂取効果 in 「乳の機能」2014

    • Author(s)
      能勢 博、上條義一郎
    • Publisher
      朝倉書店
    • Related Report
      2013 Annual Research Report
  • [Book] 「歩き方を変える」だけで10歳若返る2013

    • Author(s)
      能勢 博
    • Publisher
      主婦と生活社
    • Related Report
      2013 Annual Research Report
  • [Book] 運動体力の生理 in 「新訂生理学実習書」2013

    • Author(s)
      能勢 博
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] 熱中症 Review2012

    • Author(s)
      能勢 博(分担)
    • Publisher
      中外医学社
    • Related Report
      2012 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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