|Budget Amount *help
¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2014: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2013: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2012: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
|Outline of Final Research Achievements
Most of the cancer patients still show bad prognosis, in spite of the tremendous progress of Molecular Biology. Therefore, new molecular targeting drugs are awaited. Functions of cancer suppressor genes should urgently be studied, because they will become the nice targets for the cancer treatment. Among the cancer suppressor genes, p53, PTEN, and Hippo signaling pathways are the most important for the onset of cancers, because these genes are frequently altered in a variety of cancers, and they can cause various cancers by single gene alteration, as oncogenic drivers. We clarified the functions of these cancer suppressor genes by making full use of these gene-altered mice, the tumor spectrum by Hippo pathway alteration, and Hippo pathway-targeted anti-cancer drugs.