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Creation of fish scale collagen material technology integrated with material engineering and cell biology

Research Project

Project/Area Number 24241044
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials/Nanobioscience
Research InstitutionTokyo Institute of Technology

Principal Investigator

IKOMA Toshiyuki  東京工業大学, 理工学研究科, 准教授 (20370306)

Co-Investigator(Kenkyū-buntansha) TANAKA Junzo  東京工業大学, 大学院理工学研究科, 教授 (10343831)
TANAKA Toshiaki  東京工業大学, 大学院生命理工学研究科, 助教 (40263446)
YOSHIOKA Tomohiko  東京工業大学, 大学院理工学研究科, 助教 (50452016)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2012: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Keywordsナノ機能材料
Outline of Final Research Achievements

The aim of this project is to construct the hierarchical structure of fish scale including collagen fibrils. The collagen extracted from fish scale was fibrogenesis under the flow field controlled temperature, pH and salt concentrations, and the alignment of collagen fibrils were formed. Furthermore, in situ technology about the observation of collagen production process inside cells were established. To construct the hierarchical structure similar to scale by fish cells, the substrate morphology was of great importance.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (32 results)

All 2015 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (21 results) (of which Invited: 2 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Photolumiescence and doping mechanism of theranostic Eu3+/Fe3+ dual-doped hydroxyapatite nanoparticles2014

    • Author(s)
      Chen MH, Yoshioka T, Ikoma T, Hanagata N, Lin FH, Tanaka J
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 15 Issue: 5 Pages: 055005-055005

    • DOI

      10.1088/1468-6996/15/5/055005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective composite preparation between graphite and iron particles by the interfacial mediation of force-activated oxygen atom2014

    • Author(s)
      Motozuka S, Tagaya M, Shiba K, Xu ZF, Nishikawa M, Yoshioka T, Ikoma T, Tanaka J
    • Journal Title

      Industrial & Engineering Chemistry Research

      Volume: 53 Pages: 1637-16753

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Porous fluorine-doped tin oxide as a promising substrate for electrochemical biosensors-demonstration in hydrogen peroxide sensing2014

    • Author(s)
      Lee KT, Liu DM, Liang YY, Matsushita N, Ikoma T, Lu SY
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 44 Pages: 7779-7784

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ynthesis of luminescent nanoporous silica spheres functionalized with folic acid for targeting to cancer cells2014

    • Author(s)
      Tagaya M, Ikoma T, Xu ZF, Tanaka J
    • Journal Title

      Inorganic Chemistry

      Volume: 53 Pages: 6817-6827

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP372014

    • Author(s)
      Tanno, H., Shigematsu, T., Nishikawa, S., Hayakawa, A., Denda, K., Tanaka, T., and Komada, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 4 Pages: 2415-2423

    • DOI

      10.1074/jbc.m113.528372

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression2013

    • Author(s)
      Li, X., Bian, Y., Takizawa, Y., Hashimoto, T., Ikoma, T., Tanaka, J., Kitamura, N., Inagaki, Y., Komada, M., and Tanaka, T.
    • Journal Title

      Mol. Cancer Res.

      Volume: 11 Issue: 11 Pages: 1437-1447

    • DOI

      10.1158/1541-7786.mcr-12-0718

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase promoting factor.2012

    • Author(s)
      Hara, M., …., Kishimoto, T.
    • Journal Title

      Nat. Commun.

      Volume: 3 Issue: 1 Pages: 1059-1059

    • DOI

      10.1038/ncomms2062

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of farnesoid X receptor (FXR) for hepatocellular carcinoma cell Proliferation.2012

    • Author(s)
      T.Fujino, A.Takeuchi, A.Maruko-Ohtake, Y.Ohtake, J.Satoh,T.Kobayashi, T.Tanaka, H.Ito, R.Sakamaki, R.Kashimura, K. Ando, T.Nishimaki-Mogami, Y.Ohkubo, R.Sato, K.Kikugawa, M.Hayakawa.
    • Journal Title

      Journal of Biochemistry

      Volume: 152 Issue: 6 Pages: 577-586

    • DOI

      10.1093/jb/mvs101

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 水酸アパタイト/コラーゲン複合体とポリエチレングリコールとのγ線照射による架橋2015

    • Author(s)
      峯元誠也、杉山友明、生駒俊之、田中順三
    • Organizer
      日本セラミックス協会 2015年年会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fabrication of Functionally Gradient Porous Artificial Bone of Hydroxyapatite and Tilapia Scale Collagen Nanocomposites2014

    • Author(s)
      Yamaoka N, Ikoma T, Tanaka J
    • Organizer
      The 14th Asian BioCeramc Symposium
    • Place of Presentation
      Shanghai
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effective Composite of Polyphosphate for Regeneration Material2014

    • Author(s)
      Watanabe R, Xu Z, Yoshioka T, Ikoma T, Kashiwazaki H, Tanaka J
    • Organizer
      The 14th Asian BioCeramc Symposium
    • Place of Presentation
      Shanghai
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Type A carbonatepatite; its structure predicts biomedical applications2014

    • Author(s)
      Ikoma T, Tanaka J
    • Organizer
      The 14th Asian BioCeramc Symposium
    • Place of Presentation
      Shanghai
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 水酸アパタイト/コラーゲン複合体へのポリエチレングリコールジアクリレートによる架橋2014

    • Author(s)
      峯元誠也、吉岡朋彦、生駒俊之、田中順三
    • Organizer
      日本セラミックス協会 第27回秋季シンポジウム
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Alignement of Tilapia Fish-Scale Collagen Fibers with Flowing Fluid on Glass Substrate and Silicon Wafe2014

    • Author(s)
      Hirosawa S, Yoshioka T, Ikoma T, Tanaka J
    • Organizer
      The 8th International Conference on the Science and Technology for Advanced Ceramics
    • Place of Presentation
      Mielparque-Yokohama
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Formation Mechanism of Polyphosphate/Collagen/Hydroxyapatite2014

    • Author(s)
      Watanabe R, Yoshioka T, Ikoma T, Tanaka J
    • Organizer
      The 8th International Conference on the Science and Technology for Advanced Ceramics
    • Place of Presentation
      Mielparque-Yokohama
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Preparation Method of Porous Composites of Hydroxyapatite and Tilapia Scale Collagen for Artificial Bone2014

    • Author(s)
      Yamaoka N, Ikoma T, Yoshioka T, Tanaka J
    • Organizer
      The 8th International Conference on the Science and Technology for Advanced Ceramics
    • Place of Presentation
      Mielparque-Yokohama
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Influence of Poly(Ethylene Glycol) and gamma-ray Irradiation toMechanical Property of Apatite-Collagen Composite2014

    • Author(s)
      Minemoto M, Yoshioka T, Ikoma T, Tanaka J
    • Organizer
      The 8th International Conference on the Science and Technology for Advanced Ceramics
    • Place of Presentation
      Mielparque-Yokohama
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fabrication of Oriented Tilapia Fish-Scale Collagen Fibers under Flowing Fluid2013

    • Author(s)
      Hirosawa S, Tanakaa J, Ikoma T, Yoshioka T
    • Organizer
      Seventh International Conference on Science and Technology of Advanced Ceramics
    • Place of Presentation
      Mielparque-Yokohama
    • Related Report
      2013 Annual Research Report
  • [Presentation] Deposition of Calcium Phosphate Crystals onto Fibrous Membranes of Polyphosphate/Fish Scale Collagen2013

    • Author(s)
      Watanabe R, Xu Z, Yoshioka T, Ikoma T, Tanaka J
    • Organizer
      Seventh International Conference on Science and Technology of Advanced Ceramics
    • Place of Presentation
      Mielparque-Yokohama
    • Related Report
      2013 Annual Research Report
  • [Presentation] Preparation of Tilapia Scale Collagen/Chondroitin Sulfate Fibrous Membranes for Tissue Engineering2013

    • Author(s)
      Kawamura K, Yoshioka T, Ikoma T, Uemura T, Tanaka J
    • Organizer
      Seventh International Conference on Science and Technology of Advanced Ceramics
    • Place of Presentation
      Mielparque-Yokohama
    • Related Report
      2013 Annual Research Report
  • [Presentation] Physicochemical Property of Collagen Extracted from Fish Scales2013

    • Author(s)
      Ikoma T
    • Organizer
      The 3rd International Symposium on Human Resource Development towards Global Initiative
    • Place of Presentation
      Krabi, Thailand
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Tissue engineering approach using hydroxyapatite/fish scale collagen composites2013

    • Author(s)
      Ikoma T, Xu Z, Yoshioka T, Tanaka J
    • Organizer
      Termis Asia
    • Place of Presentation
      Wuzhen, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分子細胞生物学的手法に関する研究:魚鱗コラーゲン高次構造構築の試み

    • Author(s)
      田中利明
    • Organizer
      第29回魚コラーゲン研究会
    • Place of Presentation
      倉敷市倉敷物語館 会議室
    • Related Report
      2013 Annual Research Report
  • [Presentation] 流れ場を用いて配向させたテラピア鱗コラーゲン線維膜の作製

    • Author(s)
      廣澤聡太、吉岡朋彦、生駒俊之、田中順三
    • Organizer
      2013年日本セラミックス協会年会
    • Place of Presentation
      東京工業大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hepatocyte growth factor (HGF) による細胞増殖制御機構の解明

    • Author(s)
      瀧澤友里、辺頴、小山遼、楊宇、駒田雅之、福光寛、中尾祥絵、皆川香織、山岡華児、住吉秀明、稲垣豊、喜多村直実、 田中利明
    • Organizer
      第19回 肝細胞研究会
    • Place of Presentation
      札幌医科大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 哺乳類由来不死化遺伝子の導入による金魚うろこ細胞の株化について

    • Author(s)
      田中利明
    • Organizer
      第25回コラーゲン研究会
    • Place of Presentation
      北海道大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of the Xenopus laevis J-strain genome by BAC end sequencing, FISH, and RNA-sequence.

    • Author(s)
      S. Takahashi, A. Toyoda, Y. Kuroki, Y. Uno, Y. Izutsu, A. Suzuki, T. Michiue, H. Ogino, H. Ochi, T. Tanaka, A. Fukui, Y. Ito, N. Ueno, M. Asashima, Y. Matsuda, M. Taira, A. Fujiyama
    • Organizer
      The 14th International Xenopus Conference
    • Place of Presentation
      Giens Peninsula. South of France
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肝細胞増殖因子HGFによる肝癌細胞株HepG2の不可逆的な増殖停止誘導におけるヒストンH3K9のメチル化局在変化の解析

    • Author(s)
      辺穎、瀧澤有里、李暁然、駒田雅之、喜多村直実、田中利明
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議長、マリンメッセ福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規 Cdk インヒビター Ink4X によるツメガエル初期発生関連 mRNA の翻訳制御

    • Author(s)
      田中利明
    • Organizer
      第7回長野ミーティング
    • Place of Presentation
      ラフォーレ倶楽部白馬八方
    • Related Report
      2012 Annual Research Report
  • [Book] アンチエイジングシリーズ3 骨研究最前線2013

    • Author(s)
      生駒俊之、杉浦弘明、吉岡朋彦、近藤英司、安田和則、田中順三
    • Total Pages
      10
    • Publisher
      株式会社エヌ・ティーエス
    • Related Report
      2013 Annual Research Report
  • [Remarks] http://www.bio.ceram.titech.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 田中・生駒研究室

    • URL

      http://www.bio.ceram.titech.ac.jp/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2019-07-29  

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