Creation of fish scale collagen material technology integrated with material engineering and cell biology
| Project/Area Number |
24241044
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
IKOMA Toshiyuki 東京工業大学, 理工学研究科, 准教授 (20370306)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Junzo 東京工業大学, 大学院理工学研究科, 教授 (10343831)
TANAKA Toshiaki 東京工業大学, 大学院生命理工学研究科, 助教 (40263446)
YOSHIOKA Tomohiko 東京工業大学, 大学院理工学研究科, 助教 (50452016)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2012: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Keywords | ナノ機能材料 |
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| Outline of Final Research Achievements |
The aim of this project is to construct the hierarchical structure of fish scale including collagen fibrils. The collagen extracted from fish scale was fibrogenesis under the flow field controlled temperature, pH and salt concentrations, and the alignment of collagen fibrils were formed. Furthermore, in situ technology about the observation of collagen production process inside cells were established. To construct the hierarchical structure similar to scale by fish cells, the substrate morphology was of great importance.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP372014
Author(s)
Tanno, H., Shigematsu, T., Nishikawa, S., Hayakawa, A., Denda, K., Tanaka, T., and Komada, M.
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Journal Title
J. Biol. Chem.
Volume: 289
Issue: 4
Pages: 2415-2423
DOI
Related Report
Peer Reviewed
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[Journal Article] ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression2013
Author(s)
Li, X., Bian, Y., Takizawa, Y., Hashimoto, T., Ikoma, T., Tanaka, J., Kitamura, N., Inagaki, Y., Komada, M., and Tanaka, T.
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Journal Title
Mol. Cancer Res.
Volume: 11
Issue: 11
Pages: 1437-1447
DOI
Related Report
Peer Reviewed
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[Journal Article] Critical role of farnesoid X receptor (FXR) for hepatocellular carcinoma cell Proliferation.2012
Author(s)
T.Fujino, A.Takeuchi, A.Maruko-Ohtake, Y.Ohtake, J.Satoh,T.Kobayashi, T.Tanaka, H.Ito, R.Sakamaki, R.Kashimura, K. Ando, T.Nishimaki-Mogami, Y.Ohkubo, R.Sato, K.Kikugawa, M.Hayakawa.
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Journal Title
Journal of Biochemistry
Volume: 152
Issue: 6
Pages: 577-586
DOI
Related Report
Peer Reviewed
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[Presentation] Analysis of the Xenopus laevis J-strain genome by BAC end sequencing, FISH, and RNA-sequence.
Author(s)
S. Takahashi, A. Toyoda, Y. Kuroki, Y. Uno, Y. Izutsu, A. Suzuki, T. Michiue, H. Ogino, H. Ochi, T. Tanaka, A. Fukui, Y. Ito, N. Ueno, M. Asashima, Y. Matsuda, M. Taira, A. Fujiyama
Organizer
The 14th International Xenopus Conference
Place of Presentation
Giens Peninsula. South of France
Related Report
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