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Establishment and safety evaluation of carbon nanotube (CNT) bio-interface technology for developing high-function biomaterials using CNTs

Research Project

Project/Area Number 24241045
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials/Nanobioscience
Research InstitutionShinshu University

Principal Investigator

SAITO Naoto  信州大学, 学術研究院保健学系, 教授 (80283258)

Co-Investigator(Kenkyū-buntansha) 加藤 博之  信州大学, 学術研究院医学系, 教授 (40204490)
佐々木 克典  信州大学, 学術研究院医学系, 教授 (30170666)
樽田 誠一  信州大学, 学術研究院工学系, 教授 (00217209)
宇田川 信之  松本歯科大学, 歯学部, 教授 (70245801)
KIM YOONG AHM  信州大学, 工学部, 准教授 (70362100)
Co-Investigator(Renkei-kenkyūsha) ENDO Morinobu  信州大学, 先鋭領域融合研究群カーボン科学研究所, 特別特任教授 (10021015)
HANIU Hisao  信州大学, 学術研究院医学系, 准教授 (30252050)
AOKI Kaoru  信州大学, 学術研究院保健学系, 准教授 (30467170)
USUI Yuki  信州大学, 医学部附属病院, 特任研究員 (00467169)
SHIMIZU Masayuki  信州大学, 医学部附属病院, 医員 (40467171)
TAKANASHI Seiji  信州大学, 医学部附属病院, 医員 (70596783)
OKAMOTO Masanori  信州大学, 医学部附属病院, 医員 (50596781)
KOBAYASHI Shinsuke  信州大学, 医学部附属病院, 医員 (40624705)
ISHIGAKI Norio  信州大学, 医学部附属病院, 医員 (20447725)
HARA Kazuo  信州大学, 医学部附属病院, 医員 (00532045)
NOMURA Hiroki  信州大学, 医学部附属病院, 医員 (40646543)
TANAKA Manabu  信州大学, 医学部附属病院, 医員 (30723069)
AJIMA Kumiko  信州大学, 先鋭領域融合研究群バイオメディカル研究所, 研究員 (70584051)
TAKIZAWA Takashi  信州大学, 医学部附属病院, 医員 (40748109)
SOBAJIMA Atsushi  信州大学, 医学部附属病院, 医員 (00770760)
KAMANAKA Takayuki  信州大学, 医学部附属病院, 医員 (30791884)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥47,450,000 (Direct Cost: ¥36,500,000、Indirect Cost: ¥10,950,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2013: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2012: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Keywordsナノ機能材料 / ナノ粒子 / ナノチューブ / Scafford / DDS / 生体界面 / 生体安全性 / 生体材料 / scaffold / ナノ材料 / ナノ粒子ナノチューブ / ナノ粒子チューブ / カーボンナノチューブ
Outline of Final Research Achievements

To further our development of high-function biomaterials that incorporate CNTs, we have studied the biological reactions to CNTs and CNT complexes and observed the behavior and metabolism of CNTs in vivo. CNTs were analyzed by morphological, biochemical, and molecular biological methods as well. Based on these findings, we have established technologies to control the interface between organism and CNT and advance the progress of CNT-applied drug delivery system (DDS), imaging, and scaffold material for regenerative therapy and other treatments.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (87 results)

All 2017 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (2 results) Journal Article (18 results) (of which Peer Reviewed: 17 results,  Open Access: 12 results,  Acknowledgement Compliant: 4 results) Presentation (66 results) (of which Int'l Joint Research: 10 results,  Invited: 9 results) Book (1 results)

  • [Int'l Joint Research] Chonnam National University(韓国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Chonnam National University(韓国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Physico-chemical, in vitro, and in vivo evaluation of a 3d unidirectional porous hydroxyapatite scaffold for bone regeneration.2017

    • Author(s)
      Tanaka M, Haniu H, Kamanaka T, Takizawa T, Sobajima A, Yoshida K, Aoki K, Okamoto M, Kato H, Saito N.
    • Journal Title

      Materials

      Volume: 10 Issue: 1 Pages: 33-33

    • DOI

      10.3390/ma10010033

    • NAID

      120007113511

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler.2017

    • Author(s)
      Tanaka M, Sato Y, Haniu H, Nomura H, Kobayashi S, Takanashi S, Okamoto M, Takizawa T, Aoki K, Usui Y, Oishi A, Kato H, Saito N.
    • Journal Title

      PLos One

      Volume: 12 Issue: 2 Pages: e0172601-e0172601

    • DOI

      10.1371/journal.pone.0172601

    • NAID

      120007100159

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In vitro and in vivo evaluation of a three-dimensional porous multi-walled carbon nanotube scaffold for bone regeneration.2017

    • Author(s)
      Tanaka M, Sato Y, Zhang M, Haniu H, Okamoto M, Aoki K, Takizawa T, Yoshida K, Sobajima A, Kamanaka T, Kato H, Saito N.
    • Journal Title

      Nanomaterials-Basel

      Volume: 7 Issue: 2 Pages: 46-46

    • DOI

      10.3390/nano7020046

    • NAID

      120007113512

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity.2016

    • Author(s)
      Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N.
    • Journal Title

      Nanomaterials-Basel

      Volume: 6 Issue: 11 Pages: 219-219

    • DOI

      10.3390/nano6110219

    • NAID

      120007100160

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endocytosis of multiwalled carbon nanotubes in bronchial epithelial and mesothelial cells2015

    • Author(s)
      Maruyama K, Haniu H, Saito N, Matsuda Y, Tsukahara T, Kobayashi S, Tanaka M, Aoki K, Takanashi S, Okamoto M, Kato H
    • Journal Title

      Biomed Res Int

      Volume: 2015 Pages: 793186-793186

    • DOI

      10.1155/2015/793186

    • NAID

      120007110651

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Specific biological responses of the synovial membrane to carbon nanotubes2015

    • Author(s)
      Nomura H, Takanashi S, Tanaka M, Haniu H, Aoki K, Okamoto M, Kobayashi S, Takizawa T, Usui Y, Oishi A, Kato H, Saito N
    • Journal Title

      Sci Rep-UK

      Volume: 5 Issue: 1 Pages: 14314-14314

    • DOI

      10.1038/srep14314

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An advanced in-situ imaging method using heavy metal doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo2015

    • Author(s)
      Kobayashi S, Tsuruoka S, Usui Y, Haniu H, Aoki K, Takanashi S, Okamoto M, Nomura H, Tanaka M, Aiso S, Saito M, Kato H, Saito N
    • Journal Title

      NPG Asia Mater

      Volume: 7 Issue: 7 Pages: 203-203

    • DOI

      10.1038/am.2015.77

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of PMSA-Based Polymer on the Settling Velocity of CNT in Aqueous Media2015

    • Author(s)
      Nishimura N, Takeda S, Teranishi T, Hayashi H, Saito N, Kishimoto A
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 56 Issue: 12 Pages: 2006-2009

    • DOI

      10.2320/matertrans.Y-M2015828

    • NAID

      130005110132

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deposition of boehmite on carbon nanofibers using aluminum alkoxide and its thermal trnasformation2015

    • Author(s)
      Taruta S, Suzuki A, Arai Y, Ueda N, Yamakami T, Yamaguchi T
    • Journal Title

      Ceram Int

      Volume: 41 Issue: 10 Pages: 13171-13178

    • DOI

      10.1016/j.ceramint.2015.07.093

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pressureless sintering of SiC-coated carbon nanofiber/SiC composites and their properties2015

    • Author(s)
      Xu G, Yamakami T, Yamaguchi T, Endo M, Taruta S, Kubo I
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 123 Issue: 1439 Pages: 570-575

    • DOI

      10.2109/jcersj2.123.570

    • NAID

      130005085542

    • ISSN
      1348-6535, 1882-0743
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safe clinical use of carbon nanotubes as innovative biomaterials2014

    • Author(s)
      Saito N, Haniu H, Usui Y, Aoki K, Hara K, Takanashi S, Shimizu M, Narita N, Okamoto M, Kobayashi S, Nomura H, Kato H, Nishimura N, Taruta S, Endo M
    • Journal Title

      Chem Rev

      Volume: 114 Issue: 11 Pages: 6040-6079

    • DOI

      10.1021/cr400341h

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells2014

    • Author(s)
      Haniu H, Saito N, Matsuda N, Tsukahara T, Usui Y, Maruyama K, Takanashi S, Aoki K, Kobayashi S, Nomura H, Tanaka M, Okamoto M, Kato H
    • Journal Title

      Int J Nanomed

      Volume: 9 Pages: 1979-1989

    • DOI

      10.2147/ijn.s58661

    • NAID

      120007110603

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of CNF content on microstructure and fracture toughness of CNF/alumina composites2014

    • Author(s)
      Naoki Ueda, Tomohiko Yamakami, Tomohiro Yamaguchi, Yuki Usui, Kaoru Aoki, Morinobu Endo, Naoto Saito, Seiichi Taruta
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 122 Issue: 1424 Pages: 292-299

    • DOI

      10.2109/jcersj2.122.292

    • NAID

      130003393109

    • ISSN
      1348-6535, 1882-0743
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014

    • Author(s)
      Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
    • Journal Title

      Sci. report

      Volume: 4 Issue: 1 Pages: 4493-4493

    • DOI

      10.1038/srep04493

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response2013

    • Author(s)
      Haniu H, Saito N, Matsuda Y, Tsukahara T, Maruyama K, Usui Y, Aoki K, Takanashi S, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H
    • Journal Title

      Toxicol in Vitro

      Volume: 27 Issue: 6 Pages: 1679-1685

    • DOI

      10.1016/j.tiv.2013.04.012

    • NAID

      120007110519

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カーボンナノチューブの生体材料への応用―カーボンナノチューブと骨組織の親和性―2013

    • Author(s)
      青木薫, 齋藤直人
    • Journal Title

      研究開発リーダー

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice2012

    • Author(s)
      Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K Saito N
    • Journal Title

      Sci Rep

      Volume: 2 Issue: 1 Pages: 498-498

    • DOI

      10.1038/srep00498

    • NAID

      120007110636

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microstructure development and fracture toughness of acid-treated carbon nanofibers/alumina composites2012

    • Author(s)
      Ueda N, Yamakami T, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Endo M, Saito N, Taruta S
    • Journal Title

      J Ceram Soc Jpn

      Volume: 120 Pages: 560-568

    • NAID

      130004950756

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Carbon nanotube application and safety in artificial joint2017

    • Author(s)
      Saito N.
    • Organizer
      EMN Meeting On Carbon Nanostructures
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2017-02-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 摘出リンパ管を用いた新規の生体安全性評価法の確立.2016

    • Author(s)
      安嶋久美子, 黒田千佳, 齋藤直人.
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 摘出リンパ管灌流システムを用いたナノマテリアルのリンパ管に与える影響.2016

    • Author(s)
      黒田千佳, 安嶋久美子, 青木薫, 齋藤直人.
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒトデ骨由来β-TCPの骨補填材としての評価.2016

    • Author(s)
      石田悠, 羽二生久夫, 竹内あかり, 柘植智仁, 濱野浩子, 小林亜祐美, 金子雅之, 田中学, 片上幸美, 黒田千佳, 齋藤直人.
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 配向連通多孔体ハイドロキシアパタイト担体のin vitroおよびin vivoにおける骨再生能評価.2016

    • Author(s)
      田中学, 齋藤直人, 羽二生久夫, 野村博紀, 小林伸輔, 岡本正則, 青木薫, 滝沢崇, 傍島淳, 吉田和薫, 加藤博之.
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多層カーボンナノチューブのラット膝関節内注射による他臓器への移行の検討.2016

    • Author(s)
      傍島淳, 齋藤直人, 羽二生久夫, 青木薫, 岡本正則, 田中学, 滝沢崇, 吉田和薫, 大石歩, 安嶋久美子, 黒田千佳, 加藤博之.
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] カーボンナノチューブを用いた新しい人工関節の開発(グローカリゼーション講演)2016

    • Author(s)
      齋藤直人.
    • Organizer
      第127回中部日本整形外科災害外科学会
    • Place of Presentation
      まつもと市民芸術館他、松本
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Peapod様カーボンナノチューブのバイオレスポンス評価.2016

    • Author(s)
      羽二生久夫, 小林伸輔, 鶴岡秀志, 丸山佳与, 松田佳和, 青木薫, 岡本正則, 田中学, 滝沢崇, 傍島淳, 吉田和薫, 薄井雄企, 加藤博之, 齋藤直人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、名古屋
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多層カーボンナノチューブの異なる分散条件による細胞応答性.2016

    • Author(s)
      黒田千佳, 羽二生久夫, 傍島淳, 野村博紀, 生田太郎, 青木薫, 安嶋久美子, 岡本正則,田中学, 滝沢崇, 吉田和薫, 齋藤直人.
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、名古屋
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Anti-tumor effects for osteosarcoma by carbon nanotubes.2016

    • Author(s)
      Aoki K, Okamoto M, Tanaka M, Takizawa T, Yoshida K, Sobajima A, Kato H, Haniu H, Saito N.
    • Organizer
      10th World Biomaterials Congress
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2016-05-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多孔質に成型した多層カーボンナノチューブブロック体の骨形成への影響2016

    • Author(s)
      田中学, 齋藤直人, Mei Zhang, 佐藤義倫, 羽二生久夫, 滝沢崇, 野村博紀, 小林伸輔, 岡本正則, 高梨誠司, 青木薫, 薄井雄企, 加藤博之
    • Organizer
      第117回信州整形外科懇談会
    • Place of Presentation
      信州大学、長野県松本市
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Antitumor effects for osteosarcoma by multi-walled carbon nanotubes2016

    • Author(s)
      Aoki K, Okamoto M, Tanaka M, Takizawa T, Yoshida K, Sobajima A, Kato H, Haniu H, Saito N
    • Organizer
      10th AACR-JCA Joint Conference
    • Place of Presentation
      Maui, USA
    • Year and Date
      2016-02-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カーボンナノチューブ含有人工関節開発事例2016

    • Author(s)
      齋藤直人
    • Organizer
      長野県地域イベーション戦略推進地域総合報告会
    • Place of Presentation
      ホテルブエナビスタ、長野県松本市
    • Year and Date
      2016-02-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ナノカーボンの生体材料への応用2015

    • Author(s)
      齋藤直人
    • Organizer
      日本材料学会第41 回生体・医療材料部門委員会
    • Place of Presentation
      石川県文教会館、石川県金沢市
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Carbon nanotube toxicity: in-situ imaging method using peapods to evaluate the biokinetics of carbon nanotubes2015

    • Author(s)
      Saito N.
    • Organizer
      5th International Conference on Nanotek & Expo
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨肉腫モデルマウスに対するカーボンナノチューブの効果2015

    • Author(s)
      青木薫, 高梨誠司, 岡本正則, 小林伸輔, 野村博紀, 田中学, 滝沢崇, 大石歩, 加藤博之, 薄井雄企, 羽二生久夫, 齋藤直人
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山国際会議場、富山県富山市
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Porous multi-walled carbon nanotube block (p-MWCNT block)の骨形成への影響2015

    • Author(s)
      田中学, 齋藤直人, Zhang Mei, 佐藤義倫, 滝沢崇, 野村博紀, 小林伸輔, 岡本正則, 青木薫, 薄井雄企, 羽二生久夫, 加藤博之
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山国際会議場、富山県富山市
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ジルコニアコーティングカーボンナノチューブ複合アルミナセラミックスの微構造変化2015

    • Author(s)
      鈴木彩香,山上朋彦,山口朋浩,齋藤直人,樽田誠一
    • Organizer
      日本セラミックス協会第28回秋季シンポジウム
    • Place of Presentation
      富山大学、富山県富山市
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ジルコニアコーティングしたカーボンナノチューブの作製とその加熱変化2015

    • Author(s)
      鈴木彩香,山上朋彦,山口朋浩,樽田誠一
    • Organizer
      第31回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      信州松代ロイヤルホテル、長野県長野市
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] γ-アルミナ粉末を用いて作製したアルミナセラミックスおよびCNFs/アルミナ複合体の微構造変化2015

    • Author(s)
      西尾翔多, 山上朋彦,山口朋浩, 齋藤直人, 樽田誠一
    • Organizer
      第31回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      信州松代ロイヤルホテル、長野県長野市
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 単層カーボンナノチューブの分散とアルミナとの複合化2015

    • Author(s)
      本宮優希,山口朋浩,樽田誠一
    • Organizer
      第31回日本セラミックス協会関東支部研究発表会
    • Place of Presentation
      信州松代ロイヤルホテル、長野県長野市
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新しい人工関節の開発2015

    • Author(s)
      齋藤直人
    • Organizer
      第17回臨床研究支援センター公開セミナー: 医療機器開発研究者発掘セミナー
    • Place of Presentation
      信州大学医学部松医会講堂第2臨床講堂、長野県松本市
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Antitumor effects for osteosarcoma cells by carbon nanotubes2015

    • Author(s)
      Aoki K, Okamoto M, Takanashi S, Kobayashi S, Nomura H, Tanaka M, Takizawa T, Kato H, Usui Y, Haniu H, Saito N
    • Organizer
      27th European Conference on Biomaterials
    • Place of Presentation
      Krakow, Poland
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A capacity of porous carbon nanotube blocks as scaffold of bone regeneration2015

    • Author(s)
      Tanaka M, Saito N, Zhang M, Sato Y, Haniu H, Takizawa T, Nomura H, Kobayashi S, Okamoto M, Takanashi S, Aoki K, Usui Y, Kato H
    • Organizer
      12th Bone Biology Forum
    • Place of Presentation
      Cross Wave Makuhari, Chiba, Chiba, Japan
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳関連細胞種での多層カーボンナノチューブによる生物学的応答2015

    • Author(s)
      羽二生久夫, 齋藤直人, 丸山佳与, 松田佳和, 青木薫, 高梨誠司, 岡本正則, 小林伸輔, 野村博紀, 田中学, 滝沢崇, 大石歩, 薄井雄企, 加藤博之
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他、石川県金沢市
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] in vitroでのPeapod-CNTのバイオレスポンス2015

    • Author(s)
      丸山佳与, 羽二生久夫, 小林伸輔, 鶴岡秀志, 松田佳和, 青木薫, 岡本正則, 高梨誠司, 野村博紀, 田中学, 滝沢崇, 大石歩, 薄井雄企, 齋藤直人
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県立音楽堂他、石川県金沢市
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] The effect of carbon nanotube blocks on bone regeneration2015

    • Author(s)
      Tanaka M, Saito N, Zhang M, Sato Y, Haniu H, Takizawa T, Nomura H, Kobayashi S, Okamoto M, Takanashi S, Aoki K, Usui Y, Kato H
    • Organizer
      6th Symposium on Carbon Nanomaterials Biology, Medicine & Toxicology
    • Place of Presentation
      Nagoya University, Nagoya, Aichi, Japan
    • Year and Date
      2015-06-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biomaterial applications and safety of carbon nanotubes2015

    • Author(s)
      Saito N
    • Organizer
      6th Symposium on Carbon Nanomaterials Biology, Medicine & Toxicology
    • Place of Presentation
      Nagoya University, Nagoya, Aichi, Japan
    • Year and Date
      2015-06-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of multi-walled carbon nanotubes using the MC3T3-E1 cell line2015

    • Author(s)
      Haniu H, Saito N, Maruyama K, Matsuda N, Tanaka M, Aoki K, Okamoto M, Kobayashi S, Nomura H, Takizawa T, Ohishi A, Usui Y, Kato H
    • Organizer
      TechConnect World Innovation Conference & Expo-2015
    • Place of Presentation
      Washinton DC, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An advanced in-situ imaging method using heavy metal doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo2015

    • Author(s)
      Saito N, Kobayashi S, Tsuruoka S, Usui Y, Haniu H
    • Organizer
      TechConnect World Innovation Conference & Expo-2015
    • Place of Presentation
      Washinton DC, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CNT redox potential in chemical reactions.2014

    • Author(s)
      Tsuruoka S, Matsumoto H, Koyama K, Akiba E, Yanagisawa T, Cassee FR, Saito N, Usui Y, Kobayashi S, Porterg DW, Castranovag V, Endo M.
    • Organizer
      International Conference on Safe production and use of nanomaterials
    • Place of Presentation
      Grenoble, France
    • Year and Date
      2014-11-18 – 2014-11-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects for osteosarcoma cells by carbon nanotubes.2014

    • Author(s)
      Aoki K, Okamoto M, Kobayashi S, Nomura H, Tanaka M, Kato H, Usui U, Haniu H, Saito N.
    • Organizer
      ANZBMS Annual Scientific Meeting
    • Place of Presentation
      Queenstown, New Zealand
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Noncanonical Wnt5a enhances Wnt/b-catenin signaling through the up-regulation of Lrp5/6 during osteoblastogenesis.2014

    • Author(s)
      Okamoto M, Udagawa N, Yamashita T, Uehara S, Aoki K, Haniu H, Kato H, Saito N, Takahashi N, Kobayashi Y.
    • Organizer
      ANZBMS Annual Scientific Meeting
    • Place of Presentation
      Queenstown, New Zealand
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of intraarticular reactions to Multi Walled Carbon Nanotubes (MWCNTs) by injection at once with three divided times.2014

    • Author(s)
      Nomura H, Haniu H, Takanashi S, Kobayashi S, Okamoto M, Aoki K, Maruyama K, Usui Y, Kato H, Saito N.
    • Organizer
      22th Annual Meeting of the European Orthopaedic Research Society
    • Place of Presentation
      Nantes, France
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Wnt5a up-regulated the expression of Lrp5/6 during osteoblastogenesis.2014

    • Author(s)
      Okamoto M, Udagawa N, Yamashita T, Uehara S, Kato H, Saito N, Takahashi N, Kobayashi Y.
    • Organizer
      5th International Conference on Osteoimmunology
    • Place of Presentation
      Kos, Greece
    • Year and Date
      2014-06-15 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ROS evaluation for series of cnts using the esr method and the effects of cnt mophology.2013

    • Author(s)
      Tsuruoka S, Takeuchi K, Koyama K, Endo M, Fujisawa K, Matsumoto H, Saito N, Usui Y, Porter DW, Castranova V.
    • Organizer
      TechConnect World Conference and Expo 2013.
    • Place of Presentation
      Washington DC, USA.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Wnt5a enhances Wnt/ß-catenin signaling through the up-regulation of Lrp5/6 during osteogenesis.(President’s Poster Competition Award)2013

    • Author(s)
      Okamoto M, Udagawa N, Yamashita T, Uehara S, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y.
    • Organizer
      ASBMR 2013 Annual Meeting.
    • Place of Presentation
      Baltimore, Maryland, USA.
    • Related Report
      2013 Annual Research Report
  • [Presentation] An innovative method to evaluate biodistribution and kinetics of carbon nanotubes using CNT peapods.2013

    • Author(s)
      Kobayashi S, Tsuruoka S, Usui Y, Haniu H, Aoki K, Shimizu M, Takanashi S, Okamoto M, Kato H, Saito N.
    • Organizer
      6th International Symposium on Nanotechnology, Occupational and Environmental Health.
    • Place of Presentation
      Nagoya, Japan.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Strength improvement and tissue compatibility of multi-walled carbon nanotubes-polyethylene complex for prosthetic joint.2013

    • Author(s)
      Aoki K, Takanashi S, Shimizu M, Haniu H, Kato H, Usui Y, Nishi K, Noguchi T, Nishimura N, Saito N.
    • Organizer
      25th European Conference on Biomaterials.
    • Place of Presentation
      Madrid, Spain.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Drug delivery system by carbon nanotubes for sarcoma cells.2013

    • Author(s)
      Aoki K, Haniu H, Shimizu M, Takanashi S, Okamoto M, Kobayashi S, Nomura H, Usui Y, Kato H, Saito N.
    • Organizer
      6th International Symposium on Nanotechnology, Occupational and Environmental Health.
    • Place of Presentation
      Nagoya, Japan.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Carcinogenicity evaluation of carbon nanotubes in rasH2 mice.2013

    • Author(s)
      Takanashi S, Haniu H, Usui U, Aoki K, Okamoto M, Kobayashi S, Nomura H, Tanaka M, Kato H, Saito N.
    • Organizer
      The 6th International Symposium on Nanotechnology, Occupational and Environmental Health.
    • Place of Presentation
      Nagoya, Japan.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Endocytosis of MWCNT in BEAS-2B cells are affected by the culture medium type.2013

    • Author(s)
      Haniu H, Saito N, Matsuda N, Maruyama K, Tsukahara T, Usui Y, Takanashi S, Aoki K, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H.
    • Organizer
      The 6th International Symposium on Nanotechnology, Occupational and Environmental Health.
    • Place of Presentation
      Nagoya, Japan.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intraarticular reaction and secretion of inflammatory chemokines to Multi wall carbon nanotubes.2013

    • Author(s)
      Nomura H, Haniu H, Takanashi S, Kobayashi S, Okamoto M, Aoki K, Maruyama K, Usui Y, Kato H, Saito N.
    • Organizer
      8th Combined Meeting of Orthopaedic Research Societies
    • Place of Presentation
      Venice, Italy.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intraarticular reaction and secretion of inflammatory chemokines to Multi wall carbon nanotubes.2013

    • Author(s)
      Nomura H, Haniu H, Takanashi S, Kobayashi S, Okamoto M, Aoki K, Maruyama K, Usui Y, Kato H, Saito N.
    • Organizer
      6th International Symposium on Nanotechnology, Occupational and Environmental Health.
    • Place of Presentation
      Nagoya, Japan.
    • Related Report
      2013 Annual Research Report
  • [Presentation] ROS evaluation for series of cnts using esr method and its cnt concentration effects2013

    • Author(s)
      Tsuruoka S, Takeuchi K, Koyama K, Endo M, Fujisawa K, Tristan F, Terrones M, Matsumoto H, Saito N, Usui Y, Porter DW, Castranova V
    • Organizer
      The 52nd Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Texas
    • Related Report
      2012 Annual Research Report
  • [Presentation] ROS evaluation for series of cnts using the esr method and the effects of cnt mophology2013

    • Author(s)
      Tsuruoka S, Takeuchi K, Koyama K, Endo M, Fujisawa K, Tristan F, Terrones M, Matsumoto H, Saito N, Usui Y, Porter DW, Castranova V
    • Organizer
      TechConnect World Conference and Expo 2013
    • Place of Presentation
      Washington DC
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノファイバー/アルミナ複合体の微細構造および破壊靱性に与えるカーボンナノファイバー添加量の影響2013

    • Author(s)
      植田直樹, 山上朋彦, 山口朋浩, 遠藤守信, 齋藤直人, 樽田誠一
    • Organizer
      日本セラミックス協会2013年年会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ROS evaluation for a series of cnts and their derivatives using esr method with dmpo. International Conference on Safe production and use of nanomaterials2012

    • Author(s)
      Tsuruoka S, Takeuchi K, Koyama K, Endo M, Matsumoto H, Saito N, Usui Y, Porter DW, Castranova V
    • Organizer
      Nanosafe 2012
    • Place of Presentation
      Grenoble
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanical property and bone tissue compatibility of MWCNT (multi-walled carbon nanotube)-polyethylene complex2012

    • Author(s)
      Aoki K, Ogihara N, Ishigaki N, Nakamura K, Shimizu M, Haniu H, Kato H, Usui Y, Nishi K, Noguchi T, Nishimura N, Saito N
    • Organizer
      6th International Conference on Nanotoxicology
    • Place of Presentation
      Beijing
    • Related Report
      2012 Annual Research Report
  • [Presentation] Estimation of microstructure development of CNTs/alumina composites by electrical conductivity measurement2012

    • Author(s)
      Ueda N, Yamakami T, Yamaguchi T, Endo M, Saito N, Taruta S
    • Organizer
      4th International Congress on Cwramics
    • Place of Presentation
      Chicago
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノチューブを複合した新規アルミナセラミックスの開発2012

    • Author(s)
      齋藤直人, 荻原伸英, 樽田誠一,薄井雄企, 加藤博之, 西村直之
    • Organizer
      第118回中部日本整形外科災害外科学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノチューブ複合超高分子量ポリエチレンの機械的特性と骨組織親和性2012

    • Author(s)
      青木薫, 荻原伸英, 石垣範雄, 中村恒一, 清水政幸, 薄井雄企, 加藤博之, 齋藤直人
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] Peapod-CNTによるカーボンナノチューブの体内動態評価方法の開発2012

    • Author(s)
      小林伸輔, 高梨誠司, 羽二生久夫, 岡本正則, 清水政幸, 荻原伸英, 石垣範雄, 中村恒一,  加藤博之, 薄井雄企, 齋藤直人
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノチューブは骨芽細胞との双方向性の相互作用により骨の石灰化を促進する2012

    • Author(s)
      清水政幸, 青木薫, 成田伸代, 原一生, 羽二生久夫, 岡本正則, 高梨誠司, 加藤博之, 小林泰浩, 中村浩彰, 川原一郎, 宇田川信之, 高橋直之, 小澤英浩, 薄井雄企, 齋藤直人
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノチューブに対する細胞反応の定量的評価法の開発: ONE TO ONE法2012

    • Author(s)
      高梨誠司, 羽二生久夫, 石垣範雄, 荻原伸英, 青木薫, 清水政幸, 岡本正則, 小林伸輔, 野村博紀, 加藤博之, 薄井雄企, 齋藤直人
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノカーボン複合 UHMWPEの機械的性質2012

    • Author(s)
      貞森和馬, 桜本逸男, 綱嶋義貴, 西村直之, 蔵本孝一, 齋藤直人
    • Organizer
      日本実験力学会2012
    • Place of Presentation
      豊橋
    • Related Report
      2012 Annual Research Report
  • [Presentation] MWCNTを用いた人工関節部材の開発: 高耐久性部材を中心として2012

    • Author(s)
      西村直之, 綱島義貴, 井上俊之, 薄井雄企, 齋藤直人
    • Organizer
      ナノメディシンフォーラム
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Study of the manufacturing process of multi-walled carbon nanotubes for improving biocompatibility

    • Author(s)
      Haniu H, Saito N, Matsuda Y, Usui Y, Takanashi S, Kobayashi S, Okamoto M, Shimizu M, Ogihara N, Ishigaki N, Nakamura K, Kato H.
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Sendai
    • Related Report
      2012 Annual Research Report
  • [Presentation] CNT’s physicochemical properties & safety for applications

    • Author(s)
      Tsuruoka S, Saito N, Usui Y, Koyama K, Takeuchi K
    • Organizer
      The 2nd Symposium on Carbon Nanoforms, jointed with the 6th Annual Meeting of Nano Biomedical Soc
    • Place of Presentation
      Tsukuba
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] カーボンナノチューブの細胞毒性:形とタイプの影響

    • Author(s)
      羽二生久夫, 齋藤直人, 松田佳和, 薄井雄企, 高梨誠司, 小林伸輔, 岡本正則, 清水政幸, 荻原伸英, 石垣範雄, 中村恒一, 加藤博之
    • Organizer
      第39回日本毒性学会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロテオミクスを使ったカーボンナノチューブの物性評価

    • Author(s)
      羽二生久夫, 齋藤直人, 松田佳和, 石川えり, 薄井雄企, 青木薫, 高梨誠司, 小林伸輔, 岡本正則, 加藤博之
    • Organizer
      日本プロテオーム学会2012年大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノチューブをモデルにした個の安全性評価の検討

    • Author(s)
      羽二生久夫, 齋藤直人, 松田佳和, 石川えり, 薄井雄企, 青木薫, 高梨誠司, 小林伸輔, 岡本正則, 加藤博之
    • Organizer
      第2回日本レギュラトリーサイエンス学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノチューブ複合ポリエチレンを人工関節の摺動部に用いるための生体安全性評価

    • Author(s)
      齋藤直人, 西村直之, 薄井雄企, 羽二生久夫, 青木薫, 岡本正則, 高梨誠司, 小林伸輔, 野村博紀, 加藤博之
    • Organizer
      第5回医療機器に関するレギュラトリーサイエンス研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノチューブを用いた医療用コンポジット材料の開発

    • Author(s)
      西村直之, 網島義貴, 浦部匡史, 日笠茂樹, 西勝志, 齋藤直人
    • Organizer
      第20回フィラーシンポジウム
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] カーボンナノチューブに対する細胞反応の定量的評価法の開発: ONE TO ONE法

    • Author(s)
      高梨誠司, 羽二生久夫, 石垣範雄,青木薫, 清水政幸, 岡本正則, 小林伸輔, 野村博紀, 加藤博之, 薄井雄企, 齋藤直人
    • Organizer
      第111回 信州整形外科懇談会
    • Place of Presentation
      松本
    • Related Report
      2012 Annual Research Report
  • [Presentation] 医療機器材料の生体適合性・安全性: 世界で初めてカーボンナノチューブを生体材料に応用するために

    • Author(s)
      齋藤直人
    • Organizer
      第2回医工連携セミナー
    • Place of Presentation
      松本
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] カーボンナノチューブ・グラフェンの応用研究最前線-製造・分離・分散・評価から半導体デバイス・複合材料の開発、リスク管理まで2016

    • Author(s)
      青木薫, 齋藤直人, 樽田誠一, 荻原伸英, 西村直之
    • Total Pages
      480
    • Publisher
      株式会社エヌ・ティー・エス
    • Related Report
      2016 Annual Research Report

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Published: 2013-05-15   Modified: 2022-02-07  

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