| Budget Amount *help |
¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2014: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2013: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2012: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Outline of Final Research Achievements |
Principles of eukaryotic gene expression were studied theoretically by developing statistical mechanical and computational models of gene expression. By using a statistical mechanical model, stochastic behavior of genes was analyzed with the "eddy" current representation of probability flow, and importance of multiple stages of non-adiabatic fluctuations, i.e., super-non-adiabatic fluctuations, was shown. Methods of genome-scale simulation of chromosome structure and movement (genome-MD) were developed and applied to budding yeast and human nuclei. Genome-MD revealed correlatin between spatial distribution and transcriptional activity of genes in budding yeast nucleus. Fluctuations and transitions in expression dynamics of embryonic stem cells were examined theoretically and effects of super-non-adiabatic fluctuations were analyzed.
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