Supramolecular Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate with Proteins and Protein-Polymer Hybrids as Chiral Reaction Medias
| Project/Area Number |
24245044
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Tohoku University |
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Principal Investigator |
WADA Takehiko 東北大学, 多元物質科学研究所, 教授 (20220957)
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| Co-Investigator(Kenkyū-buntansha) |
YASUYUKI Araki 東北大学, 多元物質科学研究所, 准教授 (80361179)
SAKAMOTO Seiji 東北大学, 多元物質科学研究所, 助教 (30335228)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2012: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
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| Keywords | 生体高分子 / 血清アルブミン / キラル反応場 / 不斉合成 / 光反応 / 超分子 / 超分子不斉光反応 / PEG / 合成坑体 / 不斉光反応 / 超分子不斉光化学 / 人工坑体 / 2-アントラセンカルボン酸 / ファージディスプレイ法 / キラルソフト界面 |
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| Outline of Final Research Achievements |
Increasing attention has recently been directed toward the new methodology of asymmetric photochemistry using various supramolecules as chiral reaction medias. In this project, we have discussed about the novel strategy and recent results of supramolecular asymmetric photochirogenesis (SMAP) with tailor-made biopolymers as chiral reaction medias. We have reported the enantiodifferentiating photocyclodimerization of 2-antharcenecarboxylate (AC) mediated by bovine and human serum albumin (BSA & HSA) as a chiral reaction media to give the [4+4]-cyclodimers with high enantioselectivities of up to 90 % ee. In this project, effects of polyethylene glycol (PEG) modification of BSA and HSA upon in the ground state and in the excited state interaction with AC were discussed. Additionally supramolecular photochirogenesis of AC dimerization with PEG modified BSA and HSA as chiral reaction medias were also discussed.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Double Helices of a Pyridine-Appended Zinc Chlorophyll Derivative2013
Author(s)
Y. Shinozaki, G. Richards, K. Ogawa, A. Yamano, K. Ohara, K. Yamaguchi, S. Kawano, K. Tanaka, Y. Araki, T. Wada, and J. Otsuki
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Journal Title
J. Am. Chem. Soc.
Volume: 135
Issue: 14
Pages: 5262-5265
DOI
Related Report
Peer Reviewed
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[Presentation] DEVELOPMENT OF HIGH SENSITIVE AND HIGH TIME-RESOLVED CIRCULAR DICHROISM DETECTION METHOD ? TOWARD THE ANALYSES OF SUPRAMOLECULAR CHIRALITY AND DYNAMICS2014
Author(s)
Takehiko Wada, Makoto Murakami, Yutaka Sano, Yasuyuki Araki, Makoto Kuronuma, Tadashi Mori, Tomoo Miyahara, Katsuji Hasegawa, Hiroshi Nakatsuji, Yoshihisa Inoue
Organizer
XXV IUPAC Symposium on Photochemistry
Place of Presentation
Bordeaux, France
Year and Date
2014-07-13 – 2014-07-18
Related Report
Invited
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[Presentation] Remarkable Enhancements of Cellular Membrane Uptake Ability and RNase H Activities of Arg Introduced Peptide Ribonucleic Acids (PRNA) and PRNA-DNA Chimera for Cancer Cell Specific Oligonucleotide Therapeutics2013
Author(s)
T. WADA, R. UEMATSU, T. MIZUTANI, J. ARIYOSHI, Y. ARAKI, S. SAKAMOTO, A. YAMAYOSHI, S. Futaki, A. MURAKAMI, Y. INOUE
Organizer
40th Annual Meeting & Exposition of the Controlled Release Society
Place of Presentation
Honolulu, USA
Year and Date
2013-07-21 – 2013-07-24
Related Report
Invited
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[Presentation] New strategy of supramolecular asymmetric photochirogenesis with biomolecular soft-interfaces as chiral reaction medias2012
Author(s)
Takehiko Wada, Sakie Minato, Yui Sugawara, Masaki Nishijima, Mihoko Ui, Kazushi Kinbara, Kohei Tsumoto, Yasuyuki Araki, Seiji Sakamoto, and Yoshihisa Inoue
Organizer
International Association of Colloid and Interface Scientists2012 (IACIS2012) Conference
Place of Presentation
Sendai, JAPAN
Related Report
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