| Budget Amount *help |
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2012: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
|
|---|
| Outline of Final Research Achievements |
Increasing attention has recently been directed toward the new methodology of asymmetric photochemistry using various supramolecules as chiral reaction medias. In this project, we have discussed about the novel strategy and recent results of supramolecular asymmetric photochirogenesis (SMAP) with tailor-made biopolymers as chiral reaction medias. We have reported the enantiodifferentiating photocyclodimerization of 2-antharcenecarboxylate (AC) mediated by bovine and human serum albumin (BSA & HSA) as a chiral reaction media to give the [4+4]-cyclodimers with high enantioselectivities of up to 90 % ee. In this project, effects of polyethylene glycol (PEG) modification of BSA and HSA upon in the ground state and in the excited state interaction with AC were discussed. Additionally supramolecular photochirogenesis of AC dimerization with PEG modified BSA and HSA as chiral reaction medias were also discussed.
|
