Induction mechanism of targeted gene expression by controlling spatiotemporally plasma flow at biological interface
| Project/Area Number |
24246034
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fluid engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO Takehiko 東北大学, 流体科学研究所, 教授 (10302225)
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| Co-Investigator(Kenkyū-buntansha) |
JOHKURA Kohei 信州大学, 医学部, 准教授 (30303473)
OHARA Taku 東北大学, 流体科学研究所, 教授 (40211833)
KANAZAWA Seiji 大分大学, 工学部, 教授 (70224574)
MIYAHARA Takashi 静岡大学, 工学研究科, 教授 (70239432)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMIYA Atsuki 東北大学, 流体科学研究所, 准教授 (60371142)
OHTANI Kiyonobu 東北大学, 流体科学研究所, 助教 (80536748)
YOSHINO Daisuke 東北大学, 流体科学研究所, 助教 (80624816)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2013: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2012: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
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| Keywords | バイオ流体力学 / 自己保存プラズマ流 / 極微小時空間解析 / 細胞応答 / 遺伝子発現 |
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| Outline of Final Research Achievements |
The development of the formation and controlling method of the self-preserving plasma flow were accomplished by development of the high-speed high-voltage power supply, visualization system which had a very high spatiotemporal resolution and high accurate synchronous measurement system of the plasma characteristics. It has been shown that the self-preserving plasma flow makes a microscopic bubble cluster at the tip of the electrode several hundred nanoseconds after the voltage was applied, then starts propagation intermittently with a speed of about 2 kilometers per second from the tip of the protrusion of the bubbles synchronously with the pulsed discharge current.
As for the induction of gene cluster expression, it has been shown by the comprehensive gene analysis that the gene cluster with functions of metabolism, immunity, regeneration, etc. expressed by weak plasma stimuli, which was different from hydrogen peroxide which was a main cause of the plasma stimuli.
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Report
(4 results)
Research Products
(49 results)
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[Presentation] 水中ストリーマ放電の開始・進展機構2015
Author(s)
佐藤岳彦, 藤田英理, 金澤誠司, 大谷清伸, 小宮敦樹, 金子俊郎
Organizer
静電気学会「放電プラズマによる水処理研究委員会」キックオフ講演会
Place of Presentation
東京大学本郷キャンパス（東京都文京区）
Year and Date
2015-03-06
Related Report
Invited
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[Presentation] 大気圧水中放電の形成機構とバイオ応用2015
Author(s)
佐藤岳彦, 藤田英理, 金澤誠司, 大谷清伸, 小宮敦樹, 金子俊郎
Organizer
東北大学電気通信研究所共同プロジェクト研究会 仙台“プラズマフォーラム”
Place of Presentation
東北大学（宮城県仙台市）
Year and Date
2015-02-20
Related Report
Invited
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[Presentation] 水中１次ストリーマの高時空間分解能計測
Author(s)
藤田英理, 金澤誠司, 金子俊郎, 大谷清伸, 小宮敦樹, 佐藤岳彦
Organizer
高速度イメージングとフォトニクスに関する総合シンポジウム2013
Place of Presentation
ホテルサンルート室蘭（北海道室蘭市）
Related Report
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