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Ultrasound imaging and therapeutic system for minimally invasive therapy based on beam measurement and control

Research Project

Project/Area Number 24246035
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Fluid engineering
Research InstitutionThe University of Tokyo

Principal Investigator

YOICHIRO Matsumoto  東京大学, 工学(系)研究科(研究院), 教授 (60111473)

Co-Investigator(Kenkyū-buntansha) OKITA Kouhei  日本大学, 生産工学部, 准教授 (20401135)
UMEMURA Shinichiro  東北大学, 医工学研究科, 教授 (20402787)
TAKAGI Shu  東京大学, 工学(系)研究科(研究院), 教授 (30272371)
MURAGAKI Yoshihiro  東京女子医科大学, 医学部, 教授 (70210028)
MITSUISHI Mamoru  東京大学, 工学(系)研究科(研究院), 教授 (90183110)
YOSHINAKA Kiyoshi  独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門・研究院 (90358341)
AZUMA Takashi  東京大学, 工学(系)研究科(研究院), 准教授 (90421932)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2012: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Keywords超音波治療 / 集束超音波治療 / 凝固モニタリング / 早期腫瘍検出 / 生体数値計算 / 音圧分布可視化
Outline of Final Research Achievements

Following 4 key technologies; beam measurement, beam control, monitoring and numerical calculation of wave propagation have been developed and prototype system has beem evaluated. Especially, visualization of therapeutic beam, coagulation monitoring on the basis of acoustic radiation force and wave propagation through realistic mammary structure with sufficient accuracy have been researched. Accoriding to these results, coagulated area with length of 10 mm can be detected with 10% of relative error and 1 s time interval. These results show that the proposed method can be applied to malignant tumors with compleate volume treatment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (45 results)

All 2015 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (34 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Real-time feedback control for high-intensity focused ultrasound (HIFU) system using localized motion imaging2015

    • Author(s)
      R. Sugiyama et al.,
    • Journal Title

      Jpn. J. Appl. Phys

      Volume: 53

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel automatic first-arrival picking method for ultrasound sound speed tomography2015

    • Author(s)
      X. Qu et al.,
    • Journal Title

      Jpn. J. Appl. Phys

      Volume: 53

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transducer elements position compensation in a ring array USCT system2015

    • Author(s)
      S. Tamano et al.,
    • Journal Title

      Jpn. J. Appl. Phys

      Volume: 53

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of numerical simulation for the development of an advanced HIFU system2014

    • Author(s)
      K. Okita, R. Narumi, T. Azuma, S. Takagi, Y. Matumoto
    • Journal Title

      Comput. Mech.

      Volume: 54 Pages: 1023-1033

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Novel High Intensity Focused Ultrasound Robotic System for Breast Cancer Treatment2013

    • Author(s)
      1.T. Yonetsuji, T. Ando, J. Wang, K. Fujiwara, K. Itani, T. Azuma, K. Yoshinaka, A. Sasaki, S. Takagi, E. Kobayashi, H. Liao, Y. Matsumoto, and I. Sakuma
    • Journal Title

      Medical Image Computing and Computer-Assisted Intervention

      Volume: 8151 Pages: 388-395

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Focus Control Aided by Numerical Simulation in Heterogeneous Media for High-Intensity Focused Ultrasound Treatment2013

    • Author(s)
      2.R. Narumi, K. Matsuki, S. Mitarai, T. Azuma, K. Okita, A. Sasaki, K. Yoshinaka, S. Takagi, and Y. Matsumoto
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 52

    • NAID

      210000142522

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Focal spot imaging by means of acoustic radiation force: novel method to predict thermo coagulation spot of high-intensity focused ultrasound2013

    • Author(s)
      3.O. Arai,T. Aazuma,K. Kawabata, Y. Muragagi,and H. Iseki
    • Journal Title

      Jpn J Med Ultrasonics

      Volume: 40 Pages: 495-506

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Focus Control Aided by Numerical Simulation in Heterogeneous Media for High-Intensity Focused Ultrasound Treatment2013

    • Author(s)
      R. Narumi
    • Journal Title

      Jpn. J. Appl. Phys

      Volume: 未確定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] REAL‐TIME COAGULATION SIZE CONTROL SYSTEM BASED ON SIZE ESTIMSTION WITH LOCALIZED MOTION IMAGING AND MULTIPLE MODULATION FREQUENCIES TO ACHIEVE HIGHER SPATIAL RESOLUTION2015

    • Author(s)
      T.Azuma et al.,
    • Organizer
      The 15th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Utrecht, Netherland
    • Year and Date
      2015-04-15 – 2015-04-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] INFLUENCE OF BREAST STRUCTURE ON HIFU FOCAL ERROR2015

    • Author(s)
      K. Okita et al.,
    • Organizer
      The 15th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Utrecht, Netherland
    • Year and Date
      2015-04-15 – 2015-04-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] HIFU BEAM IMAGING ENHANCEMENT TECHNIQUE BASED ON THE REFLECTED ECHO OF MICROSECOND PULSES OF HIFU2015

    • Author(s)
      K. Matsui et al.,
    • Organizer
      The 15th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Utrecht, Netherland
    • Year and Date
      2015-04-15 – 2015-04-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Bent ray ultrasound tomography reconstruction using virtual receivers for reducing time cost2015

    • Author(s)
      X. Qu et al.,
    • Organizer
      SPIE medical imaging symposium 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-02-21 – 2015-02-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 凝固サイズの推定結果に基づいた加熱凝固領域制御手法2014

    • Author(s)
      金沢憲吾他
    • Organizer
      第13回日本超音波治療研究会
    • Place of Presentation
      仙台情報・産業プラザ, 宮城県仙台市
    • Year and Date
      2014-12-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] HIFU Beam Visualization using Beam Profile Extraction from Tissue Speckle Pattern2014

    • Author(s)
      R. Sugiyama et al.,
    • Organizer
      The 35th Symposium on Ultrasonic Electronics
    • Place of Presentation
      Meiji University, Tokyo
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optimization of Transmitted Pulse Length of HIFU Beam Imaging2014

    • Author(s)
      K. Matusi et al.,
    • Organizer
      The 35th Symposium on Ultrasonic Electronics
    • Place of Presentation
      Meiji University, Tokyo
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] A novel automatic first-arrival picking method for ultrasound sound speed tomography2014

    • Author(s)
      X. Qu et al.,
    • Organizer
      The 35th Symposium on Ultrasonic Electronics
    • Place of Presentation
      Meiji University, Tokyo
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 超音波CTにおける振動子位置補正の検討2014

    • Author(s)
      玉野聡他
    • Organizer
      第35回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      明治大学, 東京都
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Preclinical Ultrasound Image-guided High Intensity Focused Ultrasound Robot System for Breast Cancer Therapy2014

    • Author(s)
      T. Azuma et al.,
    • Organizer
      4th International Symposium of Focued Ultrasound
    • Place of Presentation
      Washingtom DC, USA
    • Year and Date
      2014-10-12 – 2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Integrated transducer and system for therapeutic ultrasound with ultrasound image guide2014

    • Author(s)
      T. Azuma
    • Organizer
      1st international conference on ultrasonic-based Applications: from analysis to synthesis
    • Place of Presentation
      Costa da Caparica, Portugal
    • Year and Date
      2014-09-15 – 2014-09-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Real-time Localized Motion Imaging for Coagulation Monitoring using Acoustic Radiation Force2014

    • Author(s)
      R. Sugiyama et al.,
    • Organizer
      2014 IEEE International Ultrasonics Symposium
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-09-06 – 2014-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Algebraic reconstruction considering Curved Ray for ultrasound tomography with ring array to Integrate HIFU therapeutic system2014

    • Author(s)
      H. Imoto et al.,
    • Organizer
      2014 IEEE International Ultrasonics Symposium
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-09-06 – 2014-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 検出精度の向上に向けた放射圧によるリアルタイム加熱凝固モニタリング手法の開発2014

    • Author(s)
      杉山隆介他
    • Organizer
      第87回日本超音波医学会
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-05-10 – 2014-05-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 超音波CTをベースとした治療診断統合システムの開発2014

    • Author(s)
      中村弘文他
    • Organizer
      第87回日本超音波医学会
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-05-10 – 2014-05-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] HIFU治療評価に向けた3次元リアルタイム温度計測ファントムの開発2014

    • Author(s)
      岩橋利英他
    • Organizer
      第87回日本超音波医学会
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-05-10 – 2014-05-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Real-time monitoring system for coagulated area using Localized motion imaging2014

    • Author(s)
      R. Sugiyama et al.,
    • Organizer
      The 14th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2014-04-02 – 2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Algebraic reconstruction considering curved ray for sound-speed tomography with ring-array transducer to integrate HIFU therapeutic system2014

    • Author(s)
      H. Nakamura et al.,
    • Organizer
      The 14th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2014-04-02 – 2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] High Accuracy position control of HIFU transducer for breast cancer treatment using 5DOF parallel-link robot2014

    • Author(s)
      T. Iwahashi et al.,
    • Organizer
      The 14th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2014-04-02 – 2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Algebraic reconstruction technique considering curved ray for sound-speed tomography with ring-array transducer2013

    • Author(s)
      H. Nakamura et al.,
    • Organizer
      the 166th Meeting of the Acoustical Society of America
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2013-12-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] リング型トランスデューサを用いた超音波CT における屈折を考慮した音速再構成法の検討2013

    • Author(s)
      H. Nakamura et al.,
    • Organizer
      第 34 回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      同志社大学寒梅館、京都府京都市
    • Year and Date
      2013-11-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] Monitoring System for Coagulated Area using Optimal Modulation Frequency of Acoustic Radiation Force2013

    • Author(s)
      R.Sugiyama et al.,
    • Organizer
      The 34th Symposium on Ultrasonic Electronics
    • Place of Presentation
      Doushisya University, Kyoto, Japan
    • Year and Date
      2013-11-21
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超音波 CT をベースとした超音波診断治療統合システムの開発2013

    • Author(s)
      H. Nakamura et al.,
    • Organizer
      第 12 回日本超音波治療研究会
    • Place of Presentation
      帝京大学板橋キャンパス、東京都板橋区
    • Year and Date
      2013-11-10
    • Related Report
      2013 Annual Research Report
  • [Presentation] Numerical Estimation of HIFU Focal Error to Breast Cancer Treatment2013

    • Author(s)
      R. Narumi, K. Matsuki, T. Azuma, K. Okita, A. Sasaki, K. Yoshinaka, J. Shidooka, H. Furusawa, S. Takagi, Y. Matsumoto
    • Organizer
      2013 IEEE International Ultrasonics Symposium
    • Place of Presentation
      Prague, Czech
    • Year and Date
      2013-07-21 – 2013-07-25
    • Related Report
      2013 Annual Research Report
  • [Presentation] Localized Motion Imaging for Coagulation Monitoring using Acoustic Radiation Force2013

    • Author(s)
      R. Aoyagi, T. Azuma, H. Nakamura, K. Fujiwara, H. Takeuchi, K. Itani, K. Yoshinaka, A. Sasaki, S. Takagi, Y. Matsumoto
    • Organizer
      2013 IEEE International Ultrasonics Symposium
    • Place of Presentation
      Prague, Czech
    • Year and Date
      2013-07-21 – 2013-07-25
    • Related Report
      2013 Annual Research Report
  • [Presentation] TEMPERATURE DISTRIBUTION MEASUREMENT OF HIGH INTENSITY FOCUSED ULTRASOUND USING A THIN-FILM THERMOCOUPLE ARRAY AND ESTIMATION OF THERMAL ERROR CAUSED BY VISCOUS HEATING2013

    • Author(s)
      K. Matsuki et al.,
    • Organizer
      he 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Osaka International Convention center, Osaka, Japan
    • Year and Date
      2013-07-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] Size Effect of Complexed Plasmid DNA to Gene Transfection Efficiency of Microbubble-mediated Sonoporation2013

    • Author(s)
      Y. Matsumoto, Y. Zhang, R. Tachibana, A. Okamoto, T. Azuma, A. Sasaki, K. Yoshinaka, K. Osada, K. Kataoka, and S. Takagi,
    • Organizer
      ICA 2013
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2013-06-01
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optimization of HIFU Treatment on the Basis of Temperature Distributions Measured by a Thin-film Thermocouple Array2012

    • Author(s)
      K. Matsuki
    • Organizer
      2012 IEEE Ultrasonics Symposium
    • Place of Presentation
      Dresden, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] Optimization of Amplitude Modulation Frequency for Harmonic Motion Imaging2012

    • Author(s)
      R. Aoyagi
    • Organizer
      2012 IEEE Ultrasonics Symposium
    • Place of Presentation
      Dresden, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of Focus Control Method Aided by Numerical Simulation In Multi-Structural Media for HIFU Treatment2012

    • Author(s)
      R. Narumi
    • Organizer
      12th International Symposium for Therapeutic Ultrasound
    • Place of Presentation
      Heidelberg, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] Focus Control Method Aided by Numerical Simulation in Heterogeneous Media for HIFU Treatment2012

    • Author(s)
      R. Narumi
    • Organizer
      33rd Symposium on Ultrasonic Electronics
    • Place of Presentation
      千葉大学、千葉, 日本
    • Related Report
      2012 Annual Research Report
  • [Presentation] ハーモニックモーションイメージングを用いた加熱凝固領域の評価2012

    • Author(s)
      青柳良佑
    • Organizer
      第11回日本超音波治療研究会
    • Place of Presentation
      KITENコンベンションホール、宮崎、日本
    • Related Report
      2012 Annual Research Report
  • [Presentation] 超音波CTを用いた超音波診断治療の基礎研究2012

    • Author(s)
      中村弘文
    • Organizer
      第11回日本超音波治療研究会
    • Place of Presentation
      KITENコンベンションホール、宮崎、日本
    • Related Report
      2012 Annual Research Report
  • [Presentation] 集束超音波治療におけるシミュレーションを援用した多媒質中の焦点位置制御手法の開発2012

    • Author(s)
      鳴見竜太
    • Organizer
      第11回日本超音波治療研究会
    • Place of Presentation
      KITENコンベンションホール、宮崎、日本
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 超音波医用装置2013

    • Inventor(s)
      東隆, 佐々木明, 青柳良佑, 高木周, 射谷和徳, 藤原圭祐他
    • Industrial Property Rights Holder
      東隆, 佐々木明, 青柳良佑, 高木周, 射谷和徳, 藤原圭祐他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-30
    • Acquisition Date
      2014-08-08
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 超音波治療装置2013

    • Inventor(s)
      東隆, 高木周, 佐々木明, 射谷和徳, 藤原圭祐
    • Industrial Property Rights Holder
      東隆, 高木周, 佐々木明, 射谷和徳, 藤原圭祐
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-114504
    • Filing Date
      2013-05-30
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 超音波医用装置2013

    • Inventor(s)
      東隆, 高木周, 佐々木明, 青柳良佑, 射谷和徳他
    • Industrial Property Rights Holder
      東隆, 高木周, 佐々木明, 青柳良佑, 射谷和徳他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-113609
    • Filing Date
      2013-05-30
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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