Ultrasound imaging and therapeutic system for minimally invasive therapy based on beam measurement and control

• Project/Area Number: 24246035
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fluid engineering
• Research Institution: The University of Tokyo
• Principal Investigator: YOICHIRO Matsumoto 東京大学, 工学(系)研究科(研究院), 教授 (60111473)
• Co-Investigator(Kenkyū-buntansha): OKITA Kouhei 日本大学, 生産工学部, 准教授 (20401135) ; UMEMURA Shinichiro 東北大学, 医工学研究科, 教授 (20402787) ; TAKAGI Shu 東京大学, 工学(系)研究科(研究院), 教授 (30272371) ; MURAGAKI Yoshihiro 東京女子医科大学, 医学部, 教授 (70210028) ; MITSUISHI Mamoru 東京大学, 工学(系)研究科(研究院), 教授 (90183110) ; YOSHINAKA Kiyoshi 独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門・研究院 (90358341) ; AZUMA Takashi 東京大学, 工学(系)研究科(研究院), 准教授 (90421932)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000); Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2013: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000); Fiscal Year 2012: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
• Keywords: 超音波治療 / 集束超音波治療 / 凝固モニタリング / 早期腫瘍検出 / 生体数値計算 / 音圧分布可視化

Outline of Final Research Achievements

Following 4 key technologies; beam measurement, beam control, monitoring and numerical calculation of wave propagation have been developed and prototype system has beem evaluated. Especially, visualization of therapeutic beam, coagulation monitoring on the basis of acoustic radiation force and wave propagation through realistic mammary structure with sufficient accuracy have been researched. Accoriding to these results, coagulated area with length of 10 mm can be detected with 10% of relative error and 1 s time interval. These results show that the proposed method can be applied to malignant tumors with compleate volume treatment.

Research Products

• [Journal Article] Real-time feedback control for high-intensity focused ultrasound (HIFU) system using localized motion imaging (2015)
  • Author(s): R. Sugiyama et al.,
  • Journal Title: Jpn. J. Appl. Phys Volume: 53
  • Peer Reviewed
• [Journal Article] A novel automatic first-arrival picking method for ultrasound sound speed tomography (2015)
  • Author(s): X. Qu et al.,
  • Journal Title: Jpn. J. Appl. Phys Volume: 53
  • Peer Reviewed
• [Journal Article] Transducer elements position compensation in a ring array USCT system (2015)
  • Author(s): S. Tamano et al.,
  • Journal Title: Jpn. J. Appl. Phys Volume: 53
  • Peer Reviewed
• [Journal Article] The role of numerical simulation for the development of an advanced HIFU system (2014)
  • Author(s): K. Okita, R. Narumi, T. Azuma, S. Takagi, Y. Matumoto
  • Journal Title: Comput. Mech. Volume: 54 Pages: 1023-1033
  • Peer Reviewed
• [Journal Article] A Novel High Intensity Focused Ultrasound Robotic System for Breast Cancer Treatment (2013)
  • Author(s): 1.T. Yonetsuji, T. Ando, J. Wang, K. Fujiwara, K. Itani, T. Azuma, K. Yoshinaka, A. Sasaki, S. Takagi, E. Kobayashi, H. Liao, Y. Matsumoto, and I. Sakuma
  • Journal Title: Medical Image Computing and Computer-Assisted Intervention Volume: 8151 Pages: 388-395
  • Peer Reviewed
• [Journal Article] Focus Control Aided by Numerical Simulation in Heterogeneous Media for High-Intensity Focused Ultrasound Treatment (2013)
  • Author(s): 2.R. Narumi, K. Matsuki, S. Mitarai, T. Azuma, K. Okita, A. Sasaki, K. Yoshinaka, S. Takagi, and Y. Matsumoto
  • Journal Title: Jpn. J. Appl. Phys. Volume: 52
  • NAID: 210000142522
  • Peer Reviewed
• [Journal Article] Focal spot imaging by means of acoustic radiation force: novel method to predict thermo coagulation spot of high-intensity focused ultrasound (2013)
  • Author(s): 3.O. Arai，T. Aazuma，K. Kawabata, Y. Muragagi，and H. Iseki
  • Journal Title: Jpn J Med Ultrasonics Volume: 40 Pages: 495-506
  • Peer Reviewed
• [Journal Article] "Focus Control Aided by Numerical Simulation in Heterogeneous Media for High-Intensity Focused Ultrasound Treatment (2013)
  • Author(s): R. Narumi
  • Journal Title: Jpn. J. Appl. Phys Volume: 未確定
  • Peer Reviewed
• [Presentation] REAL‐TIME COAGULATION SIZE CONTROL SYSTEM BASED ON SIZE ESTIMSTION WITH LOCALIZED MOTION IMAGING AND MULTIPLE MODULATION FREQUENCIES TO ACHIEVE HIGHER SPATIAL RESOLUTION (2015)
  • Author(s): T.Azuma et al.,
  • Organizer: The 15th International Symposium on Therapeutic Ultrasound
  • Place of Presentation: Utrecht, Netherland
  • Year and Date: 2015-04-15 – 2015-04-18
• [Presentation] INFLUENCE OF BREAST STRUCTURE ON HIFU FOCAL ERROR (2015)
  • Author(s): K. Okita et al.,
  • Organizer: The 15th International Symposium on Therapeutic Ultrasound
  • Place of Presentation: Utrecht, Netherland
  • Year and Date: 2015-04-15 – 2015-04-18
• [Presentation] HIFU BEAM IMAGING ENHANCEMENT TECHNIQUE BASED ON THE REFLECTED ECHO OF MICROSECOND PULSES OF HIFU (2015)
  • Author(s): K. Matsui et al.,
  • Organizer: The 15th International Symposium on Therapeutic Ultrasound
  • Place of Presentation: Utrecht, Netherland
  • Year and Date: 2015-04-15 – 2015-04-18
• [Presentation] Bent ray ultrasound tomography reconstruction using virtual receivers for reducing time cost (2015)
  • Author(s): X. Qu et al.,
  • Organizer: SPIE medical imaging symposium 2015
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-02-21 – 2015-02-26
• [Presentation] 凝固サイズの推定結果に基づいた加熱凝固領域制御手法 (2014)
  • Author(s): 金沢憲吾他
  • Organizer: 第13回日本超音波治療研究会
  • Place of Presentation: 仙台情報・産業プラザ, 宮城県仙台市
  • Year and Date: 2014-12-15
• [Presentation] HIFU Beam Visualization using Beam Profile Extraction from Tissue Speckle Pattern (2014)
  • Author(s): R. Sugiyama et al.,
  • Organizer: The 35th Symposium on Ultrasonic Electronics
  • Place of Presentation: Meiji University, Tokyo
  • Year and Date: 2014-12-03 – 2014-12-05
• [Presentation] Optimization of Transmitted Pulse Length of HIFU Beam Imaging (2014)
  • Author(s): K. Matusi et al.,
  • Organizer: The 35th Symposium on Ultrasonic Electronics
  • Place of Presentation: Meiji University, Tokyo
  • Year and Date: 2014-12-03 – 2014-12-05
• [Presentation] A novel automatic first-arrival picking method for ultrasound sound speed tomography (2014)
  • Author(s): X. Qu et al.,
  • Organizer: The 35th Symposium on Ultrasonic Electronics
  • Place of Presentation: Meiji University, Tokyo
  • Year and Date: 2014-12-03 – 2014-12-05
• [Presentation] 超音波CTにおける振動子位置補正の検討 (2014)
  • Author(s): 玉野聡他
  • Organizer: 第35回超音波エレクトロニクスの基礎と応用に関するシンポジウム
  • Place of Presentation: 明治大学, 東京都
  • Year and Date: 2014-12-03 – 2014-12-05
• [Presentation] Preclinical Ultrasound Image-guided High Intensity Focused Ultrasound Robot System for Breast Cancer Therapy (2014)
  • Author(s): T. Azuma et al.,
  • Organizer: 4th International Symposium of Focued Ultrasound
  • Place of Presentation: Washingtom DC, USA
  • Year and Date: 2014-10-12 – 2014-10-16
• [Presentation] Integrated transducer and system for therapeutic ultrasound with ultrasound image guide (2014)
  • Author(s): T. Azuma
  • Organizer: 1st international conference on ultrasonic-based Applications: from analysis to synthesis
  • Place of Presentation: Costa da Caparica, Portugal
  • Year and Date: 2014-09-15 – 2014-09-17
  • Invited
• [Presentation] Real-time Localized Motion Imaging for Coagulation Monitoring using Acoustic Radiation Force (2014)
  • Author(s): R. Sugiyama et al.,
  • Organizer: 2014 IEEE International Ultrasonics Symposium
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-09-06 – 2014-09-08
• [Presentation] Algebraic reconstruction considering Curved Ray for ultrasound tomography with ring array to Integrate HIFU therapeutic system (2014)
  • Author(s): H. Imoto et al.,
  • Organizer: 2014 IEEE International Ultrasonics Symposium
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-09-06 – 2014-09-08
• [Presentation] 検出精度の向上に向けた放射圧によるリアルタイム加熱凝固モニタリング手法の開発 (2014)
  • Author(s): 杉山隆介他
  • Organizer: 第87回日本超音波医学会
  • Place of Presentation: パシフィコ横浜, 神奈川県横浜市
  • Year and Date: 2014-05-10 – 2014-05-12
• [Presentation] 超音波CTをベースとした治療診断統合システムの開発 (2014)
  • Author(s): 中村弘文他
  • Organizer: 第87回日本超音波医学会
  • Place of Presentation: パシフィコ横浜, 神奈川県横浜市
  • Year and Date: 2014-05-10 – 2014-05-12
• [Presentation] HIFU治療評価に向けた3次元リアルタイム温度計測ファントムの開発 (2014)
  • Author(s): 岩橋利英他
  • Organizer: 第87回日本超音波医学会
  • Place of Presentation: パシフィコ横浜, 神奈川県横浜市
  • Year and Date: 2014-05-10 – 2014-05-12
• [Presentation] Real-time monitoring system for coagulated area using Localized motion imaging (2014)
  • Author(s): R. Sugiyama et al.,
  • Organizer: The 14th International Symposium on Therapeutic Ultrasound
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2014-04-02 – 2014-04-05
• [Presentation] Algebraic reconstruction considering curved ray for sound-speed tomography with ring-array transducer to integrate HIFU therapeutic system (2014)
  • Author(s): H. Nakamura et al.,
  • Organizer: The 14th International Symposium on Therapeutic Ultrasound
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2014-04-02 – 2014-04-05
• [Presentation] High Accuracy position control of HIFU transducer for breast cancer treatment using 5DOF parallel-link robot (2014)
  • Author(s): T. Iwahashi et al.,
  • Organizer: The 14th International Symposium on Therapeutic Ultrasound
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2014-04-02 – 2014-04-05
• [Presentation] Algebraic reconstruction technique considering curved ray for sound-speed tomography with ring-array transducer (2013)
  • Author(s): H. Nakamura et al.,
  • Organizer: the 166th Meeting of the Acoustical Society of America
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2013-12-05
• [Presentation] リング型トランスデューサを用いた超音波CT における屈折を考慮した音速再構成法の検討 (2013)
  • Author(s): H. Nakamura et al.,
  • Organizer: 第 34 回超音波エレクトロニクスの基礎と応用に関するシンポジウム
  • Place of Presentation: 同志社大学寒梅館、京都府京都市
  • Year and Date: 2013-11-22
• [Presentation] Monitoring System for Coagulated Area using Optimal Modulation Frequency of Acoustic Radiation Force (2013)
  • Author(s): R.Sugiyama et al.,
  • Organizer: The 34th Symposium on Ultrasonic Electronics
  • Place of Presentation: Doushisya University, Kyoto, Japan
  • Year and Date: 2013-11-21
• [Presentation] 超音波 CT をベースとした超音波診断治療統合システムの開発 (2013)
  • Author(s): H. Nakamura et al.,
  • Organizer: 第 12 回日本超音波治療研究会
  • Place of Presentation: 帝京大学板橋キャンパス、東京都板橋区
  • Year and Date: 2013-11-10
• [Presentation] Numerical Estimation of HIFU Focal Error to Breast Cancer Treatment (2013)
  • Author(s): R. Narumi, K. Matsuki, T. Azuma, K. Okita, A. Sasaki, K. Yoshinaka, J. Shidooka, H. Furusawa, S. Takagi, Y. Matsumoto
  • Organizer: 2013 IEEE International Ultrasonics Symposium
  • Place of Presentation: Prague, Czech
  • Year and Date: 2013-07-21 – 2013-07-25
• [Presentation] Localized Motion Imaging for Coagulation Monitoring using Acoustic Radiation Force (2013)
  • Author(s): R. Aoyagi, T. Azuma, H. Nakamura, K. Fujiwara, H. Takeuchi, K. Itani, K. Yoshinaka, A. Sasaki, S. Takagi, Y. Matsumoto
  • Organizer: 2013 IEEE International Ultrasonics Symposium
  • Place of Presentation: Prague, Czech
  • Year and Date: 2013-07-21 – 2013-07-25
• [Presentation] TEMPERATURE DISTRIBUTION MEASUREMENT OF HIGH INTENSITY FOCUSED ULTRASOUND USING A THIN-FILM THERMOCOUPLE ARRAY AND ESTIMATION OF THERMAL ERROR CAUSED BY VISCOUS HEATING (2013)
  • Author(s): K. Matsuki et al.,
  • Organizer: he 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Osaka International Convention center, Osaka, Japan
  • Year and Date: 2013-07-05
• [Presentation] Size Effect of Complexed Plasmid DNA to Gene Transfection Efficiency of Microbubble-mediated Sonoporation (2013)
  • Author(s): Y. Matsumoto, Y. Zhang, R. Tachibana, A. Okamoto, T. Azuma, A. Sasaki, K. Yoshinaka, K. Osada, K. Kataoka, and S. Takagi,
  • Organizer: ICA 2013
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2013-06-01
  • Invited
• [Presentation] Optimization of HIFU Treatment on the Basis of Temperature Distributions Measured by a Thin-film Thermocouple Array (2012)
  • Author(s): K. Matsuki
  • Organizer: 2012 IEEE Ultrasonics Symposium
  • Place of Presentation: Dresden, Germany
• [Presentation] Optimization of Amplitude Modulation Frequency for Harmonic Motion Imaging (2012)
  • Author(s): R. Aoyagi
  • Organizer: 2012 IEEE Ultrasonics Symposium
  • Place of Presentation: Dresden, Germany
• [Presentation] Development of Focus Control Method Aided by Numerical Simulation In Multi-Structural Media for HIFU Treatment (2012)
  • Author(s): R. Narumi
  • Organizer: 12th International Symposium for Therapeutic Ultrasound
  • Place of Presentation: Heidelberg, Germany
• [Presentation] Focus Control Method Aided by Numerical Simulation in Heterogeneous Media for HIFU Treatment (2012)
  • Author(s): R. Narumi
  • Organizer: 33rd Symposium on Ultrasonic Electronics
  • Place of Presentation: 千葉大学、千葉, 日本
• [Presentation] ハーモニックモーションイメージングを用いた加熱凝固領域の評価 (2012)
  • Author(s): 青柳良佑
  • Organizer: 第11回日本超音波治療研究会
  • Place of Presentation: KITENコンベンションホール、宮崎、日本
• [Presentation] 超音波CTを用いた超音波診断治療の基礎研究 (2012)
  • Author(s): 中村弘文
  • Organizer: 第11回日本超音波治療研究会
  • Place of Presentation: KITENコンベンションホール、宮崎、日本
• [Presentation] 集束超音波治療におけるシミュレーションを援用した多媒質中の焦点位置制御手法の開発 (2012)
  • Author(s): 鳴見竜太
  • Organizer: 第11回日本超音波治療研究会
  • Place of Presentation: KITENコンベンションホール、宮崎、日本
• [Patent(Industrial Property Rights)] 超音波医用装置 (2013)
  • Inventor(s): 東隆, 佐々木明, 青柳良佑, 高木周, 射谷和徳, 藤原圭祐他
  • Industrial Property Rights Holder: 東隆, 佐々木明, 青柳良佑, 高木周, 射谷和徳, 藤原圭祐他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-05-30
  • Acquisition Date: 2014-08-08
• [Patent(Industrial Property Rights)] 超音波治療装置 (2013)
  • Inventor(s): 東隆, 高木周, 佐々木明, 射谷和徳, 藤原圭祐
  • Industrial Property Rights Holder: 東隆, 高木周, 佐々木明, 射谷和徳, 藤原圭祐
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-114504
  • Filing Date: 2013-05-30
• [Patent(Industrial Property Rights)] 超音波医用装置 (2013)
  • Inventor(s): 東隆, 高木周, 佐々木明, 青柳良佑, 射谷和徳他
  • Industrial Property Rights Holder: 東隆, 高木周, 佐々木明, 青柳良佑, 射谷和徳他
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-113609
  • Filing Date: 2013-05-30