Analysis of behavior and neural circuits with optogenetics
Project/Area Number |
24247001
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Genetics/Genome dynamics
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Research Institution | Nagoya University |
Principal Investigator |
MORI Ikue 名古屋大学, 理学(系)研究科(研究院), 教授 (90219999)
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Co-Investigator(Renkei-kenkyūsha) |
TSUKADA Yuki 名古屋大学, 大学院理学研究科, 助教 (80580000)
NAKANO Shunji 名古屋大学, 大学院理学研究科, 助教 (60608529)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2014: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2013: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2012: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
|
Keywords | 感覚神経細胞 / 記憶・学習 / 温度走性 / Cエレガンス / 神経回路 |
Outline of Final Research Achievements |
Using thermotaxis behavior of C. elegans as a model system, we analyzed the relationship between behavioral regulation and neural activities in the neural circuit responsible for thermotaxis. We introduced and evaluated newly developed optogenetic tools to elucidate the mechanism through which a behavior is regulated in the circuit. We constructed reliable assay systems that enable to monitor neural activity and behavior. Our results show the relationship between AFD thermosensory neural activity and behavior, and shed light onto the function of stochastic activity of interneurons AIY and RIA.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans.2016
Author(s)
Fujiwara, M., Hino, T., Miyamoto, R., Inada, H., Mori, I., Koga, M., Miyahara, K., Ohshima, Y., Ishihara, T.
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Journal Title
Genetics
Volume: 201
Issue: 4
Pages: 1497-1510
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Single-Cell memory regulates a neural circuit for sensory behavior.2016
Author(s)
Kobayashi, K., Nakano,S., Amano, M., Tsuboi, D., Nishioka, T., Ikeda, S., Yokoyama, G., Kaibuchi, K., Mori,I.
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Journal Title
Cell Rep.
Volume: 14
Issue: 1
Pages: 11-21
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reconstruction of spatial thermal gradient encoded in thermosensory neuron AFD in Caenorhabditis elegans.2016
Author(s)
Tsukada, Y., Yamao, M., Honda, N., Shimowada, T., Ohnishi, N., Kuhara, A., Ishii, S., Mori, I.
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Journal Title
J Neurosci.
Volume: 36
Issue: 9
Pages: 2571-2581
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Optically Detected Magnetic Resonance of Nanodiamonds In Vivo; Implementation of Selective Imaging and Fast Sampling.2015
Author(s)
Yoshinari, Y., Mori, S., Igarashi, R., Sugi, T., Yokota, H., Ikeda, K., Sumiya, H., Mori, I, Tochio, H., *Harada, Y. and Shirakawa, M.
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Journal Title
J Nanosci Nanotechnol.
Volume: 15
Issue: 2
Pages: 1014-1021
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A glial K+/Cl- cotransporter modifies temperature-evoked dynamics in Caenorhabditis elegans sensory neurons.2015
Author(s)
Yoshida, A., Nakano, S., Suzuki, T., Ihara, K., Higashiyama, T., Mori, I.
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Journal Title
Genes Brain Behav.
Volume: 15
Issue: 4
Pages: 429-440
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes.2013
Author(s)
Ohnishi, T., Tanizawa, Y., Watanabe, A., Nakamura, T., Ohba, H., Hirata, H., Kaneda, C., Iwayama, Y., Arimoto, T., Watanabe, K., Mori, I., Yoshikawa, T.
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Journal Title
J Neurochem.
Volume: 124
Issue: 5
Pages: 685-694
DOI
Related Report
Peer Reviewed
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[Journal Article] Real-time background-free selective imaging of fluorescent nanodiamond in vivn2012
Author(s)
Ryuji Igarashi, Yohsake Yoshinari, Riroaki Yokoia, Takuma Sugi, Fuminori Sugihara, Kazuhiro Ikeda, Hiroshi Sumiya, Shigenori Tsuji, Ikme Mori, Hidehito Tochio, Yoshie Rarada, Masahiro Shirakawa.
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Journal Title
Nano Letters
Volume: 12
Issue: 11
Pages: 5726-5732
DOI
Related Report
Peer Reviewed
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[Journal Article] Synaptic Polarity Depends on Phosphatidylinositol Signaling Regulated by Myo-inositol Monophosphatase in Caenorhabditis elegans2012
Author(s)
Kimata, T., Tanizawa, Y., Can, Y., Ikeda, S., Kuhara, A., Mori, I.
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Journal Title
Genetics
Volume: (印刷中)(未定)
Issue: 2
Pages: 509-521
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans.2012
Author(s)
Nishio, N., Mohri-Shiomi, A., Nishida, Y., Hiramatsu, N., Kodama-Namba, E., Kimura, K.D., Kuhara, A., and Mori, I.
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Journal Title
Genes Cells
Volume: 17
Issue: 5
Pages: 365-386
DOI
Related Report
Peer Reviewed
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[Presentation] 感覚情報の時間統合を担う分子神経基盤2015
Author(s)
中野俊詩, Giles C. Andrew, 鈴木孝征, 佐野文菜, 東山哲也, 森 郁恵
Organizer
第38回日本神経科学大会
Place of Presentation
神戸国際会議場および神戸国際展示場, 神戸市
Year and Date
2015-07-28
Related Report
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[Presentation] Thermal memory and behavioral regulation revealed by calcium imaging of the cultured neurons and neural circuits.2015
Author(s)
Kobayashi K, Nakano S, Amano M, Tsuboi D, Nishioka T, Ikeda S, Yokoyama G, Kaibuchi K, Mori I.
Organizer
C.elegans 20th International Meeting2015
Place of Presentation
University of California, LA, アメリカ合衆国
Year and Date
2015-06-24
Related Report
Int'l Joint Research
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[Presentation] Design of the microchip device to dissect the neural circuits based on thermotactic behavior in C. elegans.2013
Author(s)
Nishida, Y., Nakajima, M., Jaehoon, J., Takeuchi, M., Kobayashi, K., Fukuda, T. & Mori, I.
Organizer
19th International C. elegans Meeting
Place of Presentation
Los Angels, USA
Related Report
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[Presentation] High-speed, high-magnification tracking system for calcium imaging of neurite during free moving.2013
Author(s)
Tsukada, Y., Min, C., Fei, X., Hashimito, K., & Mori, I.
Organizer
19th International C. elegans Meeting
Place of Presentation
Los Angels, USA
Related Report
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[Presentation] System identification for thermosensory neuron encoding thermal environment.2013
Author(s)
Tsukada, Y., Honda, N., Murase, A., Shimowada, T., Onishi, N., Kuhara, A., Ishii, S. & Mori, I.
Organizer
19th International C. elegans Meeting
Place of Presentation
Los Angels, USA
Related Report
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[Presentation] Memory Circuits
Author(s)
Ikue Mori
Organizer
Mittwochskolloquium, Max Planck Institute for Developmental Biology
Place of Presentation
Max Planck Institute(テュービンゲン市 ドイツ)
Related Report
Invited
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