Mechanism of signal transduction regulating axon regeneration
| Project/Area Number |
24247025
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HISAMOTO Naoki 名古屋大学, 大学院理学研究科, 准教授 (80283456)
HANAFUSA Hiroshi 名古屋大学, 大学院理学研究科, 准教授 (00345844)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2014: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2013: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2012: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
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| Keywords | 遺伝学 / シグナル伝達 / 神経科学 / 脳・神経 / 軸索再生 / 再生医学 |
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| Outline of Final Research Achievements |
The ability of neurons to regenerate their axons after injury is determined by a balance between signaling pathways that promote and inhibit regeneration. In Caenorhabditis elegans, JNK MAP kinase pathway is important for axon regeneration. We demonstrated that the SVH-1 growth factor and its receptor SVH-2 regulate axon regeneration via the JNK MAPK. We also found that the endocannabinoid anandamide (AEA) inhibits axon regeneration via the Goα; subunit GOA-1, which antagonizes the JNK pathway. In this study, we showed that a signaling network consisting of multiple pathways regulates axon regeneration via the JNK pathway.
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Report
(4 results)
Research Products
(14 results)
