| Budget Amount *help |
¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2014: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2013: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2012: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
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| Outline of Final Research Achievements |
The ability of neurons to regenerate their axons after injury is determined by a balance between signaling pathways that promote and inhibit regeneration. In Caenorhabditis elegans, JNK MAP kinase pathway is important for axon regeneration. We demonstrated that the SVH-1 growth factor and its receptor SVH-2 regulate axon regeneration via the JNK MAPK. We also found that the endocannabinoid anandamide (AEA) inhibits axon regeneration via the Goα; subunit GOA-1, which antagonizes the JNK pathway. In this study, we showed that a signaling network consisting of multiple pathways regulates axon regeneration via the JNK pathway.
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