An integrative understanding of physiological processes based on the functional analysis of nuclear transport factors, importins
| Project/Area Number |
24247036
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | 独立行政法人医薬基盤研究所 (2014)
Osaka University (2012-2013) |
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Principal Investigator |
YONEDA Yoshihiro 独立行政法人医薬基盤研究所, その他部局等, その他 (80191667)
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| Co-Investigator(Renkei-kenkyūsha) |
OKA Masahiro 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト, プロジェクトリーダー (40432504)
YASUHARA Noriko 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト, 特任研究員 (90423152)
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| Project Period (FY) |
2012-05-31 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2014: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2013: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2012: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
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| Keywords | 核―細胞質間輸送 / 核輸送因子 / インポーティン / 細胞核 / 高次生命機能 / importin / 核輸送装置 / 細胞運命決定 / 高次脳機能 / 核－細胞質間輸送 / 核タンパク質輸送 / importin α |
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| Outline of Final Research Achievements |
In higher eukaryotes, the nucleocytoplasmic transport of proteins is fine-tuned by multiple mechanisms, including the diversification of transport pathway. Here, we examined various physiological phenomena in mammals through the point of view of the nucleocytoplasmic transport mediated by importin α family, which is comprised of multiple subtypes. Our analysis revealed that the nuclear transport mediated by importin α family plays essential roles in fundamental cellular processes such as signal transduction, cell differentiation and aging.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Proteomic identification of heterogeneous nuclear ribonucleoprotein K as a novel cold-associated autoantigen in patients with secondary Raynaud's phenomenon.2015
Author(s)
Yang L, Fujimoto M, Murota H, Serada S, Fujimoto M, Honda H, Yamada K, Suzuki K, Nishikawa A, Hosono Y, Yoneda Y, Takehara K, Imura Y, Mimori T, Takeuchi T, Katayama I, Naka T.
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Journal Title
Rheumatology (Oxford).
Volume: 54
Issue: 2
Pages: 349-58
DOI
Related Report
Peer Reviewed
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[Journal Article] Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β.2014
Author(s)
Choi S., Yamashita E., Yasuhara N., Song J., Son S.Y., Won Y.H., Hong H.R., Shin Y.S., Sekimoto T., Park I.Y., Yoneda Y., Lee S.J.
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Journal Title
Acta Crystallogr D Biol Crystallogr.
Volume: 70
Issue: 4
Pages: 1050-1060
DOI
Related Report
Peer Reviewed
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[Journal Article] Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance2013
Author(s)
Yasuhara N, Yamagishi R, Arai Y, Mehmood R, Kimoto C, Fujita T, Touma K, Kaneko A, Kamikawa Y, Moriyama T, Yanagida T, Kaneko H, Yoneda Y.
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Journal Title
Dev. Cell
Volume: 26
Issue: 2
Pages: 123-135
DOI
Related Report
Peer Reviewed
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[Journal Article] The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza2013
Author(s)
Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanebe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M, Imai Y.
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Journal Title
Cell
Volume: 153
Issue: 1
Pages: 112-125
DOI
Related Report
Peer Reviewed
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