| Budget Amount *help |
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2014: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2013: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2012: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
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| Outline of Final Research Achievements |
In higher eukaryotes, the nucleocytoplasmic transport of proteins is fine-tuned by multiple mechanisms, including the diversification of transport pathway. Here, we examined various physiological phenomena in mammals through the point of view of the nucleocytoplasmic transport mediated by importin α family, which is comprised of multiple subtypes. Our analysis revealed that the nuclear transport mediated by importin α family plays essential roles in fundamental cellular processes such as signal transduction, cell differentiation and aging.
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