Analysis of potential stem cells that change their fate from differentiation to self-renewal and support the regeneration of spermatogenesis

• Project/Area Number: 24247041
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: National Institute for Basic Biology
• Principal Investigator: YOSHIDA Shosei 基礎生物学研究所, 生殖細胞研究部門, 教授 (60294138)
• Project Period (FY): 2012-05-31 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000); Fiscal Year 2014: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000); Fiscal Year 2013: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000); Fiscal Year 2012: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
• Keywords: 生殖細胞 / 分化 / 脱分化 / 幹細胞 / 生殖細胞研究部門

Outline of Final Research Achievements

Using mouse spermatogenesis, his study investigated the “potential stem cells” that largely differentiate without self-renewal under a normal condition but revert back to self-renewal during regeneration after tissue damage. The discoveries made in this study include: 1) In response to retinoic acid (RA), a differentiation-inducing signal, while GFRα1+ spermatogonia (cells supporting the steady state) remain undifferentiated, while Ngn3+ cells (those acting as potential stem cells) undergo irreversible differentiation and lose the stem cell potential. 2) This differential RA responsiveness is caused by the differential expression of RARg (a RA receptor gene) only in the Ngn3+ cells. These findings suggest a novel regulatory mechanism for the robust stem cell systems.

Research Products

• [Int'l Joint Research] Cavendish Laboratory(英国)
• [Journal Article] Hierarchical differentiation competence in response to retinoic acid ensures stem cell maintenance during mouse spermatogenesis. (2015)
  • Author(s): Ikami K, Tokue M, Sugimoto R, Noda C, Kobayashi S, Hara K, Yoshida S.
  • Journal Title: Development Volume: 142 Pages: 1582-1592
  • DOI: 10.1242/dev.118695
  • Peer Reviewed / Open Access
• [Journal Article] From cyst to tubule: innovations in vertebrate spermatogenesis (2015)
  • Author(s): S. Yoshida
  • Journal Title: WIREs Developmental Biology Volume: 5 Issue: 1 Pages: 119-131
  • DOI: 10.1002/wdev.204
  • Peer Reviewed
• [Journal Article] Mouse spermatogenic stem cells continually interconvert between equipotent singly isolated and syncytial states (2014)
  • Author(s): K.Hara, T.Nakagawa, H.Enomoto, M.Suzuki, M.Yamamoto, B.D.Simons and S.Yoshida
  • Journal Title: Cell Stem Cell Volume: 14 Issue: 5 Pages: 658-672
  • DOI: 10.1016/j.stem.2014.01.019
  • URL: http://www.nibb.ac.jp/pressroom/news/2014/05/02.html
  • Peer Reviewed / Open Access
• [Journal Article] An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity (2013)
  • Author(s): Shirakawa, T., Yaman-Deveci, R., Tomizawa, S., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T., and Ohbo, K.
  • Journal Title: Development Volume: 140 Issue: 17 Pages: 3565-3576
  • DOI: 10.1242/dev.094045
  • Peer Reviewed / Open Access
• [Journal Article] Testis tissue explantation cures spermatogenic failure in c-Kit ligand mutant mice (2012)
  • Author(s): T.Sato, T.Yokonishi, M.Komeya, K.Katagiri, Y.Kubota, S.Matoba, N.Ogonuki, A.Ogura, S.Yoshida and T.Ogawa
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109 Issue: 42 Pages: 16934-16938
  • DOI: 10.1073/pnas.1211845109
  • Peer Reviewed
• [Presentation] Single-cell resolution analysis of mouse spermatogenic stem cell dynamics (2016)
  • Author(s): S. Yoshida
  • Organizer: Wellcome Trust Advanced Courses and Scientific Conferences “Single Cell Biology”
  • Place of Presentation: Wellcome Genome Campus, Cambridge, UK
  • Year and Date: 2016-03-08
  • Int'l Joint Research / Invited
• [Presentation] 精子幹細胞の驚異的パワー (2016)
  • Author(s): 吉田松生
  • Organizer: 生物多様性コロキウム「生殖戦略を支える細胞たち」
  • Place of Presentation: 京都府、京都市、京都大学理学研究科
  • Year and Date: 2016-02-24
  • Invited
• [Presentation] Population dynamics of the sperm stem cells and its regulation in the mouse testis (2015)
  • Author(s): S. Yoshida
  • Organizer: Commemorative Symposium for the 31st International Prize for Biology, “New horizons in life science through advances in cell biology”
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Kyoto
  • Year and Date: 2015-12-05
  • Invited
• [Presentation] Stochasticity and hierarchy of spermatogenic stem cells (2015)
  • Author(s): S. Yoshida
  • Organizer: The 38th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Kobe InternaKobe International Conference center, Kobe, Hyogo
  • Year and Date: 2015-12-01
  • Int'l Joint Research / Invited
• [Presentation] Stem cell dynamics in the mouse testis (2015)
  • Author(s): S. Yoshida
  • Organizer: The 10th CDB Lecture, Center for Developmental Biology
  • Place of Presentation: RIKEN, Kobe, Hyogo
  • Year and Date: 2015-10-19
  • Int'l Joint Research / Invited
• [Presentation] 精子幹細胞の数を一定に保つ仕組み (2015)
  • Author(s): 吉田松生
  • Organizer: 認識と形成2015
  • Place of Presentation: 沖縄県、沖縄市、沖縄科学技術大学
  • Year and Date: 2015-09-20
• [Presentation] マウス精子形成のしなやかさを支える幹細胞の集団ダイナミクス (2015)
  • Author(s): 吉田松生
  • Organizer: 第36回日本炎症･再生医学会シンポジウム8『配偶子の発生･再生･エイジング』
  • Place of Presentation: 東京都、港区、虎ノ門ヒルズフォーラム
  • Year and Date: 2015-07-22
  • Invited
• [Presentation] Dosage of FGF5 in a subset lymphatic endothelial cells controls mouse spermatogenic stem cell pool size (2015)
  • Author(s): Y. Kitadate, A. Maruyama and S. Yoshida
  • Organizer: The 48th Annual Meeting for the Japanese Society of Developmental Biologists cosponsored by the Asia-Pacific Developmental Biology Network
  • Place of Presentation: Tsukuba International Congress Center, Tsukuba, Ibaragi
  • Year and Date: 2015-06-02
  • Int'l Joint Research
• [Presentation] Spermatogenic stem cell pool control by lymphatic endothelial cells through FGF5. (2015)
  • Author(s): S. Yoshida
  • Organizer: Gordon Research Conference, Germinal Stem Cell Biology
  • Place of Presentation: The Chinese University of Hong Kong, Hong Kong, China
  • Year and Date: 2015-05-31
  • Int'l Joint Research
• [Presentation] 配偶子を作り続ける幹細胞の制御機構 (2015)
  • Author(s): 吉田松生
  • Organizer: 第60回日本生殖医学会シンポジウム 1『生殖細胞の産生制御機構』
  • Place of Presentation: 神奈川県、横浜市、パシフィコ横浜
  • Year and Date: 2015-04-27
  • Invited
• [Presentation] 精巣の研究から見出された組織幹細胞の知られざる性質 (2015)
  • Author(s): 原健士朗
  • Organizer: 日本畜産学会第119回 大会第14回若手企画シンポジウム
  • Place of Presentation: 栃木県、宇都宮市、宇都宮大学
  • Year and Date: 2015-03-27
  • Invited
• [Presentation] Reconsidering the stem cell niche. (2014)
  • Author(s): S. Yoshida
  • Organizer: Division of Germ Cell Biology, 性差若手研究会
  • Place of Presentation: 静岡県、静岡市、ハートピア熱海
  • Year and Date: 2014-12-09
  • Invited
• [Presentation] ライブイメージングを基盤としたマウス精子幹細胞ダイナミクスの解明（Live imaging-based investigation of mouse spermatogenic stem cell dynamics） (2014)
  • Author(s): 吉田松生
  • Organizer: 公開シンポジウム「The Frontire of the Reproductive Biology」
  • Place of Presentation: 岡山県、岡山市、岡山大学創立五十周年記念館
  • Year and Date: 2014-11-28
  • Invited
• [Presentation] Dynamics of mouse sperm stem cells: How is the tissue homeostasis maintained? (2014)
  • Author(s): S. Yoshida
  • Organizer: The 37th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Pacifico Yokohama, Yokohama, Kanagawa
  • Year and Date: 2014-11-25
  • Int'l Joint Research / Invited
• [Presentation] Mouse spermatogenic stem cells: their in vivo identity and dynamics. (2014)
  • Author(s): S. Yoshida
  • Organizer: EMBL Conference on Stem Cells in Cancer and Regenerative Medicine 2014
  • Place of Presentation: EMBL, Heidelberg, Germany
  • Year and Date: 2014-10-09
  • Int'l Joint Research / Invited
• [Presentation] FGF5 is expressed in the vasculature-associated peritubular cells and controls the size of spermatogenic stem cell pool in the mouse testis. (2014)
  • Author(s): Y. Kitadate, A. Maruyama, and S. Yoshida
  • Organizer: Cold Spring Harbor Laboratory Meeting on Germ Cells
  • Place of Presentation: Cold Spring Harbor, New York, USA
  • Year and Date: 2014-10-07
  • Int'l Joint Research
• [Presentation] マウス精子幹細胞集団を支えるニッチの実体と機能の究明 (2014)
  • Author(s): 吉田松生
  • Organizer: 認識と形成2014
  • Place of Presentation: 熊本県、熊本市、同仁堂4Fホール
  • Year and Date: 2014-09-14
• [Presentation] Mouse spermatogenic stem cells: their identity and dynamics. (2014)
  • Author(s): S. Yoshida
  • Organizer: KEY Forum: From Stem Cells to Organs
  • Place of Presentation: Kumamoto City Medical Association Hall, Kumamoto
  • Year and Date: 2014-09-04
  • Int'l Joint Research / Invited
• [Presentation] A single-cell-resolution analysis of the sperm stem cell dynamics in the mouse testis. (2014)
  • Author(s): S. Yoshida
  • Organizer: The World Congress of Reproductive Biology 2014
  • Place of Presentation: Edinburgh International Conference Centre, Edinburgh, UK
  • Year and Date: 2014-09-02
  • Int'l Joint Research / Invited
• [Presentation] マウス精子幹細胞の動態とニッチの実体解明への挑戦 (2014)
  • Author(s): 吉田松生
  • Organizer: 新学術領域高濱班･小林班合同シンポジウム「ニッチの謎を議論する：免疫器官と生殖器官から見た微小環境の実体、制御、生理的意義」
  • Place of Presentation: 京都府、京都市、国際高等研究所
  • Year and Date: 2014-06-18
  • Invited
• [Presentation] Peritubular cells expressing CXCL12/FGF5 sustain spermatogonial stem cells in mice. (2014)
  • Author(s): Y. Kitadate, A. Maruyama, R. Ichikawa, M. Ema, F. Sugiyama, S. Takahashi, T. Nagasawa and S. Yoshida
  • Organizer: The 47th annual meeting for the Japanese Society of Developmental Biologists cosponsored by the Asia-Pacific Developmental Biology Network
  • Place of Presentation: Winc Aichi, Nagoya, Aichi
  • Year and Date: 2014-05-28
  • Int'l Joint Research
• [Presentation] 精子幹細胞を制御する微小環境ニッチの解明 (2013)
  • Author(s): 北舘祐、丸山亜裕美、市川理恵、吉田松生
  • Organizer: 日本発生生物学会 秋季シンポジウム2013
  • Place of Presentation: 兵庫、しあわせの村
• [Presentation] ニッチ微小環境による精子幹細胞の解析 (2013)
  • Author(s): 北舘祐、丸山亜裕美、市川理恵、吉田松生
  • Organizer: 生殖エピゲノム若手勉強会2013
  • Place of Presentation: 大阪、大阪大学
• [Presentation] Maintenance of spermatogenic stem cells follows from dynamic heterogeneity in mouse testis. (2013)
  • Author(s): K. Hara and S. Yoshida
  • Organizer: Cold Spring Harbor Laboratory Meeting on Stem Cell Biology
  • Place of Presentation: Cold Spring Harbor Laboratory, New York, USA
• [Presentation] Peritubular cells expressing CXCL12/FGF5 sustain spermatogonial stem cells in mice. (2013)
  • Author(s): Y. Kitadate and S. Yoshida
  • Organizer: Cold Spring Harbor Laboratory Meeting on Stem Cell Biology
  • Place of Presentation: Cold Spring Harbor Laboratory, New York, USA
• [Presentation] レチノイン酸応答性の不均一を幹細胞集団がマウス精子形成を持続させる (2013)
  • Author(s): 伊神香菜子、杉本亮、吉田松生
  • Organizer: 日本動物学会第84回大会
  • Place of Presentation: 岡山、岡山大学
• [Presentation] マウスの精子形成“潜在的幹細胞”の制御機構 (2013)
  • Author(s): 徳江萌、吉田松生
  • Organizer: 日本動物学会第84回大会
  • Place of Presentation: 岡山、岡山大学
• [Presentation] マウス精子幹細胞の多様な細胞運命 (2013)
  • Author(s): 原健士朗、吉田松生
  • Organizer: 第106回日本繁殖生物学会大会
  • Place of Presentation: 東京、東京農工大学
• [Presentation] Polarized distribution of niche microenvironment in seminiferous tubules. (2013)
  • Author(s): Y. Kitadate, A. Maruyama and S. Yoshida
  • Organizer: 新学術領域研究「上皮管腔組織形成」第1回国際シンポジウム
  • Place of Presentation: 北海道、北海道大学
• [Presentation] Characterization of mammalian spermatogenic stem cell niche. (2013)
  • Author(s): Y. Kitadate and S. Yoshida
  • Organizer: The 46th annual meeting for JSDB cosponsored byAPDBN
  • Place of Presentation: 島根、くにびきメッセ
• [Presentation] Differential response to Retinoic acid achieves balances self-renewal and differentiation of the stem cell compartment in mouse spermatogenesis. (2013)
  • Author(s): K. Ikami, R. Sugimoto and S. Yoshida
  • Organizer: The 46th annual meeting for JSDB cosponsored by APDBN
  • Place of Presentation: 島根、くにびきメッセ
• [Presentation] Niche microenvironment for the mouse spermatogenic stem cells. (2013)
  • Author(s): S. Yoshida
  • Organizer: The XXII North American Testis workshop “The Foundations of Male Fertility”
  • Place of Presentation: Hyatt Regency San Antonio, San Antonio, Texas, USA
  • Invited
• [Presentation] Characterization of mammalian spermatogenic stem cell niche. (2013)
  • Author(s): Y. Kitadate and S. Yoshida
  • Organizer: The 46th annual meeting for JSDB cosponsored by APDBN
  • Place of Presentation: 島根、くにびきメッセ
• [Presentation] マウス精巣における幹細胞のふるまい (2013)
  • Author(s): 原健士朗、吉田松生
  • Organizer: 第155回日本獣医学会学術集会
  • Place of Presentation: 東京、東京大学駒場キャンパス
  • Invited
• [Presentation] マウス精子幹細胞の集団動態に見る競合と協調 (2013)
  • Author(s): 吉田松生
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 高松、サンポートホール高松・かがわ国際会議場
  • Invited
• [Presentation] Stem cell dynamics of mouse spermatogenesis at a single-cell resolution based on live-imaging, clonal-fate, and theoretical analyses (2013)
  • Author(s): 吉田松生
  • Organizer: The 10th NIBB-EMBL Symposium 2013 Quantitative Bioimaging
  • Place of Presentation: 愛知、岡崎コンファレンスセンター
  • Invited
• [Presentation] 幹細胞制御機構：ニッチはどこまで解明されたか？ (2012)
  • Author(s): 吉田松生
  • Organizer: 第35回日本分子生物学会 シンポジウム･ワークショップ1W9II
  • Place of Presentation: 福岡、福岡国際会議場・マリンメッセ福岡
  • Invited
• [Presentation] 哺乳類の精子形成を支える幹細胞の究明 (2012)
  • Author(s): 吉田松生
  • Organizer: 第7回 認識と形成研究会
  • Place of Presentation: 栃木、宇都宮大学
• [Presentation] Mouse sperm stem cells: their behavior and functionality. (2012)
  • Author(s): S. Yoshida
  • Organizer: Swiss Japanese Developmental Biology Meeting
  • Place of Presentation: 京都、京都ガーデンパレス
  • Invited
• [Presentation] Behaviors and dynamics of the male germline stem cells in the mouse testis. (2012)
  • Author(s): S. Yoshida
  • Organizer: Mammalian meiosis network, 2012 meeting
  • Place of Presentation: La Maison du Seminaire, Nice, France
  • Invited
• [Presentation] A theory for mouse spermatogenic stem cell maintenance based on single cell fate analyses and live imaging (2012)
  • Author(s): K. Hara, B. Simons and S. Yoshida
  • Organizer: Cold Spring Harbor Laboratory Meeting on Germ Cells
  • Place of Presentation: Cold Spring Harbor Laboratory, New York, USA
  • Invited
• [Presentation] Spermatogonia support the stem sell maintenance. (2012)
  • Author(s): K. Ikami, R. Sugimoto and S. Yoshida
  • Organizer: Cold Spring Harbor Laboratory Meeting on Germ Cells
  • Place of Presentation: Cold Spring Harbor Laboratory, New York, USA
• [Presentation] Continuous observation of donor germ cells after spermatogonial transplantation in mice. (2012)
  • Author(s): Y. Nakamura and S. Yoshida
  • Organizer: Cold Spring Harbor Laboratory Meeting on Germ Cells
  • Place of Presentation: Cold Spring Harbor Laboratory, New York, USA
• [Presentation] Population asymmetric self-renewal of GFRα1-expressing stem cells supports steady-state spermatogenesis in mouse testis. (2012)
  • Author(s): K. Hara, B. D. Simons and S. Yoshida
  • Organizer: Cold Spring Harbor Laboratory Meeting on Germ Cells
  • Place of Presentation: Cold Spring Harbor Laboratory, New York, USA
• [Presentation] Vasculature-associated cxcl12 positive peritubular cells are important cell types associated with the distribution of spermatogenic stem cells. (2012)
  • Author(s): Y. Kitadate, A. Maruyama and S. Yoshida
  • Organizer: Cold Spring Harbor Laboratory Meeting on Germ Cells
  • Place of Presentation: Cold Spring Harbor Laboratory, New York, USA
• [Presentation] マウス精子幹細胞を支えるニッチ細胞の探索 (2012)
  • Author(s): 北舘祐、丸山亜裕美、市川理恵、吉田松生
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 福岡、九州大学
  • Invited
• [Presentation] マウス精細管内移植後における精子形成幹細胞の挙動解析 (2012)
  • Author(s): 中村隼明、吉田松生
  • Organizer: 第105回日本繁殖生物学会大会
  • Place of Presentation: 茨城、筑波大学
  • Invited
• [Presentation] マウス精子形成を支える幹細胞の実体とその動態 (2012)
  • Author(s): 吉田松生
  • Organizer: 第30回日本受精着床学会総会・学術講演会
  • Place of Presentation: 大阪、大阪府立国際会議場
  • Invited
• [Presentation] Spermatogenic stem cell functionality in the mouse testis (2012)
  • Author(s): S. Yoshida
  • Organizer: Scandinavian Physiological Society Annual Meeting
  • Place of Presentation: Helsingin yliopisto, Helsinki, Finland
  • Invited
• [Presentation] 数理統計的にみたマウス精子幹細胞システム (2012)
  • Author(s): 吉田松生
  • Organizer: 第5回 生殖研究若手の会
  • Place of Presentation: 神奈川、東京大学三崎臨海実験所
• [Presentation] How are the Self-renewal and Differentiation of Mouse Spermatogenic Stem Cells Balanced? (2012)
  • Author(s): S. Yoshida
  • Organizer: The 58/60th NIBB Conference “Germline”
  • Place of Presentation: 愛知、岡崎コンファレンスセンター
  • Invited
• [Presentation] Characterization of mouse male germline stem cell niche by gene expression profiling using laser capture microdissection. (2012)
  • Author(s): Y. Kitadate, R. Ichikawa, A, Maruyama and S. Yoshida
  • Organizer: 10th Annual Meeting of the International Society for Stem Cell Research
  • Place of Presentation: 神奈川、パシフィコ横浜
• [Presentation] Sperm stem cell behavior in mouse testis.
  • Author(s): S. Yoshida
  • Organizer: Workshop “Animal diversity and Developmental Biology II” International Mini-Symposium, “Eco-Devo-Evo”
  • Place of Presentation: 京都、京都大学
  • Invited
• [Presentation] マウス精子形成を支える幹細胞の自己複製・分化と挙動におけるケモカインの寄与
  • Author(s): 吉田松生
  • Organizer: 京都大学再生医科学研究所「再生医学・再生医療の先端融合的共同研究拠点」平成25年度 共同研究報告会
  • Place of Presentation: 京都、京都大学再生医科学研究所
• [Presentation] マウス精子形成を支える幹細胞の正体とその動態
  • Author(s): 吉田松生
  • Organizer: 京都大学再生医科学研究所「再生医学・再生医療の先端融合的共同研究拠点」平成25年度 学術講演会
  • Place of Presentation: 京都、京都大学再生医科学研究所
  • Invited
• [Presentation] In vivo behavior of mouse spermatogenic stem cells in testicular microenvironment.
  • Author(s): S. Yoshida
  • Organizer: Mini-curso “Spermatogonial stem cells physiology, niche and biotechnological potential of these cells in vertebrates” Institute of Biological Sciences at Federal University of Minas Gerais
  • Place of Presentation: Institute of Biological Sciences at Federal University of Minas Gerais, Belo Horizonte, Brazil
  • Invited
• [Presentation] Useful tools to investigate spermatogonial stem cells.
  • Author(s): S. Yoshida
  • Organizer: Mini-curso “Spermatogonial stem cells physiology, niche and biotechnological potential of these cells in vertebrates” Institute of Biological Sciences at Federal University of Minas Gerais
  • Place of Presentation: Institute of Biological Sciences at Federal University of Minas Gerais, Belo Horizonte, Brazil
  • Invited
• [Presentation] Towards the understanding of the sperm stem cell niche in the mouse testis.
  • Author(s): S. Yoshida
  • Organizer: IV Workshop on Male Reproductive Biology
  • Place of Presentation: Hotel Travel-Inn Ibirapuera, Sao Paulo, Brazil
  • Invited
• [Presentation] Dynamics of the mouse spermatogenic stem cells in seminiferous tubules.
  • Author(s): S. Yoshida
  • Organizer: IV Workshop on Male Reproductive Biology
  • Place of Presentation: Hotel Travel-Inn Ibirapuera, Sao Paulo, Brazil
  • Invited
• [Presentation] Investigation of the in vivo dynamics of mouse spermatogenic stem cells.
  • Author(s): S. Yoshida
  • Organizer: Friedrich Miescher Institute for Biomedical Research
  • Place of Presentation: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
• [Presentation] Dynamics of the mouse sperm stem cells and their competition.
  • Author(s): S. Yoshida
  • Organizer: Universitat Basel, Zoologisches Institut
  • Place of Presentation: Universitat Basel, Zoologisches Institut, Basel, Switzerland
• [Presentation] Spermatogenic stem cell dynamics in the mouse testis.
  • Author(s): S. Yoshida
  • Organizer: EMBL Monterotondo
  • Place of Presentation: EMBL, Monterotondo, Italy
  • Invited
• [Presentation] Toward the fuller understanding of identity and behavior of the mouse spermatogenic stem cells.
  • Author(s): S. Yoshida
  • Organizer: Sapienza University of Rome
  • Place of Presentation: Sapienza University of Rome, Rome, Italy
• [Presentation] Stem Cell Dynamics in Mouse Spermatogenesis: a combination of live-imaging, pulse-labeling, and in silico modeling studies
  • Author(s): 吉田松生
  • Organizer: 発生・細胞生物学・システム生物学ジョイントコース 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点
  • Place of Presentation: 京都、京都大学
  • Invited
• [Presentation] マウス精子形成幹細胞の正体とふるまい
  • Author(s): 吉田松生
  • Organizer: 京都大学ウイルス研究所 ウイルス研究の潮流 シリーズ講義（共同利用・共同研究拠点セミナー 再生医科学研究所セミナー）
  • Place of Presentation: 京都、京都大学ウイルス研究所
  • Invited
• [Presentation] Stem Cell Dynamics in Mouse Spermatogenesis: a combination of live-imaging, pulse-labeling, and in silico modeling studies.
  • Author(s): 吉田松生
  • Organizer: 発生・細胞生物学・システム生物学ジョイントコース 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点
  • Place of Presentation: 京都、京都大学
  • Invited
• [Presentation] マウス精子形成を支える幹細胞の自己複製・分化と挙動におけるケモカインの寄与
  • Author(s): 吉田松生
  • Organizer: 京都大学再生医科学研究所「再生医学・再生医療の先端融合的共同研究拠点」平成24年度 共同研究報告会
  • Place of Presentation: 京都、京都大学再生医科学研究所
  • Invited
• [Presentation] Spermatogenic stem cell functionality in the mouse testis.
  • Author(s): S. Yoshida
  • Organizer: Gurdon Institute, University of Cambridge
  • Place of Presentation: Gurdon Institute, University of Cambridge, Cambridge, UK
• [Presentation] マウス精子形成幹細胞の自己複製と分化の集団動態
  • Author(s): 吉田松生
  • Organizer: 久留米大学分子生命科学研究所セミナー
  • Place of Presentation: 福岡、久留米大学
• [Presentation] 継続するマウス精子形成を支える幹細胞の実体と動態
  • Author(s): 吉田松生
  • Organizer: 岡山大学大学院自然科学研究科第377回生物科学セミナー
  • Place of Presentation: 岡山、岡山大学
• [Presentation] マウスにおける雄性配偶子幹細胞の実体と動態を求めて
  • Author(s): 吉田松生
  • Organizer: 弘前大学農学部セミナー
  • Place of Presentation: 青森、弘前大学
  • Invited
• [Presentation] マウス精子形成を支える幹細胞の実体と動態を探る
  • Author(s): 吉田松生
  • Organizer: 名古屋大学リーディング大学院リトリート
  • Place of Presentation: 愛知、岡崎コンファレンスセンター
  • Invited
• [Presentation] Dynamics of spermatogenic stem cell population in the mouse testis.
  • Author(s): S. Yoshida
  • Organizer: University of Turku, Finland
  • Place of Presentation: University of Turku, Turku, Finland
  • Invited
• [Presentation] 精子形成幹細胞研究の現状と展望
  • Author(s): 吉田松生
  • Organizer: 第31回日本アンドロロジー学会シンポジウム1
  • Place of Presentation: 神戸、神戸ポートピアホテル
  • Invited
• [Remarks] 基礎生物学研究所 吉田研究室
  • URL: http://www.nibb.ac.jp/germcell/
• [Remarks] 基礎生物学研究所 吉田研究室
  • URL: http://www.nibb.ac.jp/germcell/
• [Remarks] 基礎生物学研究所 吉田研究室
  • URL: http://www.nibb.ac.jp/germcell/