| Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2014: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2013: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2012: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
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| Outline of Final Research Achievements |
Beta-1,6-glucan is an essential component of yeast cell wall, but the molecular mechanism of its biosynthesis still remains unclear. We found that most important proteins among many participants in beta-1,6-glucan synthesis are Keg1 and Kre6, which are the ER-residents, Kre6 and Kre9 and their homologs Skn1 and Knh1, respectively, which are delivered from the ER to the cell surface. We showed that delivery of Kre6 to the cell membrane with the aid of proper interaction among these proteins is essntial for beta-1,6-glucan synthesis and present a new model of the biosynthetic molecular process.
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