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Construction of the database of microbial products and its application study

Research Project

Project/Area Number 24248022
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

OSADA Hiroyuki  独立行政法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836)

Co-Investigator(Renkei-kenkyūsha) MUROI Makoto  独立行政法人理化学研究所, 環境資源科学研究センター, 上級研究員 (30261168)
NOGAWA Toshihiko  独立行政法人理化学研究所, 環境資源科学研究センター, 研究員 (40462717)
Project Period (FY) 2012-05-31 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2013: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2012: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Keywords生物活性物質 / 微生物代謝産物 / プロテオーム / フラクションライブラリー / データベース / MPPlot / ChemProteoBase / NPPlot
Outline of Final Research Achievements

In order to overcome disadvantage of natural products as a source for drug screening, we established a technical platform based on chemical biology. In this study, we constructed a fraction library from microbial and plant sources based on basic chromatographic techniques, such as MPLC and HPLC, combined with a database named Natural Products Plot (NPPlot). NPPlot is a distribution map of metabolites, which are plotted as a dot in a three-dimensional area with X-, Y-, and Z-axis for retention time, m/z value, and UV absorption, respectively. Using this database, characteristic metabolites are easily found for each of strain. Furthermore, we developed a drug target identification system based on proteomic analysis by 2-D gel electrophoresis, ChemProteoBase. Isolation of novel natural compounds and prediction of their targets would be accelerated by using our systems, NPPlot and ChemProteoBase. Our research is expected to contribute to drug discovery and progress of bioscience.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (78 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 5 results) Presentation (63 results) (of which Invited: 20 results)

  • [Journal Article] A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis.2015

    • Author(s)
      Kato N, Nogawa T, Hirota H, Jang JH, Takahashi S, Ahn JS, Osada H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 460 Issue: 2 Pages: 210-215

    • DOI

      10.1016/j.bbrc.2015.03.011

    • NAID

      130007491120

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity.2015

    • Author(s)
      Hayase H, Watanabe N, Lim CL, Nogawa T, Komatsuya K, Kita K, Osada H.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 79 Issue: 4 Pages: 633-635

    • DOI

      10.1080/09168451.2014.987205

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RK-270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270.2015

    • Author(s)
      Jang JP, Nogawa T, Uramoto M, Okano A, Futamura Y, Shimizu T, Takahashi S, Jang JH, Ahn JS, Osada H.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: 68 Issue: 4 Pages: 293-295

    • DOI

      10.1038/ja.2014.141

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T2014

    • Author(s)
      Shunji Takahashi, Shingo Nagano, Toshihiko Nogawa, Naoki Kanoh, Masakazu Uramoto, Makoto Kawatani, Yoshitsugu Shiro, Hiroyuki Osada
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Issue: 47 Pages: 32446-32458

    • DOI

      10.1074/jbc.m114.598391

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A small molecule that induces reactive oxygen species via cellular glutathione depletion.2014

    • Author(s)
      Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.
    • Journal Title

      Biochem J

      Volume: 463 Issue: 1 Pages: 53-63

    • DOI

      10.1042/bj20140669

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening.2014

    • Author(s)
      Lim CL, Nogawa T, Uramoto M, Okano A, Hongo Y, Nakamura T, Koshino H, Takahashi S, Ibrahim D, Osada H.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: 67 Issue: 4 Pages: 323-329

    • DOI

      10.1038/ja.2013.144

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems.2013

    • Author(s)
      Futamura Y, Kawatani M, Muroi M, Aono H, Nogawa T, Osada H,
    • Journal Title

      ChemBioChem

      Volume: 14 Issue: 18 Pages: 2456-2463

    • DOI

      10.1002/cbic.201300499

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus.2013

    • Author(s)
      Nogawa T, Kawatani M, Uramoto M, Okano A, Aono H, Futamura Y, Koshino H, Takahashi S, Osada H.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: 66 Issue: 10 Pages: 621-623

    • DOI

      10.1038/ja.2013.55

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of new polyketide metabolites, linearolides A and B, from a Streptomyces sp. RK95-742013

    • Author(s)
      Ueki M. et al.
    • Journal Title

      J. Antibiot.

      Volume: - Issue: 6 Pages: 333-337

    • DOI

      10.1038/ja.2013.19

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Point Mutation in <i>ftmD</i> Blocks the Fumitremorgin Biosynthetic Pathway in <i>Aspergillus fumigatus</i> Strain Af2932013

    • Author(s)
      Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 5 Pages: 1061-1067

    • DOI

      10.1271/bbb.130026

    • NAID

      10031177597

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of novel reveromycin derivatives by alcohol added fermentation2013

    • Author(s)
      Nogawa T. et al.
    • Journal Title

      J. Antibiot.

      Volume: 66 Issue: 4 Pages: 247-250

    • DOI

      10.1038/ja.2012.115

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba2012

    • Author(s)
      T. Motoyama et al
    • Journal Title

      Chem. Biol.

      Volume: 19 Issue: 12 Pages: 1611-1619

    • DOI

      10.1016/j.chembiol.2012.10.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indomethacin Induction of Metamorphosis from the Asexual Stage to Sexual Stage in the Moon Jellyfish, <i>Aurelia aurita</i>2012

    • Author(s)
      国吉 久人
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 76 Issue: 7 Pages: 1397-1400

    • DOI

      10.1271/bbb.120076

    • NAID

      130001862721

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum2012

    • Author(s)
      Francoise Hullin-Matsuda
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Issue: 29 Pages: 33706-33718

    • DOI

      10.1074/jbc.m112.344432

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.2011

    • Author(s)
      Futamura, Y., et al.
    • Journal Title

      Chem Biol.

      Volume: 19 Issue: 12 Pages: 1620-1630

    • DOI

      10.1016/j.chembiol.2012.10.014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] ChemProteoBaseのがん代謝作用薬解析に向けた応用2015

    • Author(s)
      室井 誠, 田中 美帆, 川谷 誠, 長田 裕之
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学 津島キャンパス (岡山県)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] アルコール添加による新規リベロマイシン誘導体の創製と生合成機構の考察2015

    • Author(s)
      野川 俊彦, 高橋 俊二, 高木 海, 関山 恭代, 岡野 亜紀子, 川谷 誠, 清水 猛, 長田 裕之
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学 津島キャンパス (岡山県)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Isolation of new cyclic depsipeptides from a microbial metabolites fraction library by NPPlot screening2015

    • Author(s)
      Jun-Pil Jang, Toshihiko Nogawa, Yayoi Hongo, Takeshi Shimizu, Akiko Okano, Yushi Futamura, Shunji Takahashi, Jong Seog Ahn, Hiroyuki Osada
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学 津島キャンパス (岡山県)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] マメ科植物クララSophora flavescensのLC/MSを用いたメタボロミクスによる産地比較2015

    • Author(s)
      長田 麻由佳, 野川 俊彦, 鈴木 龍一郎, 高橋 俊二, 白瀧 義明, 長田 裕之
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学 津島キャンパス (岡山県)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 化合物アレイによるソニックヘッジホッグ(Shh)結合化合物の探索とそれらとShhとの相互作用の解析2015

    • Author(s)
      近藤 恭光, 河村 達郎, 本田 香織, 関根 朋美, 長田 裕之
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学 津島キャンパス (岡山県)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] RhoGEF Ect2/極性制御因子Par6複合体による発がんシグナルを阻害する薬剤の探索:(1) Ect2及びPar6-PDZドメイン結合化合物の解析2015

    • Author(s)
      田中 弦太郎, 冨樫 英人, 三浦 悠太, 東 覚, 近藤 恭光, 長田 裕之, 三木 徹
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学 津島キャンパス (岡山県)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ハイグロマイシンB処理によるルシラクタエン生産糸状菌Fusarium sp. RK97-94における二次代謝産物生産誘導2015

    • Author(s)
      加藤 翔, 本山 高幸, 鎌倉 高志, 長田 裕之
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学 津島キャンパス (岡山県)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 遺伝子ターゲティングによる糸状菌二次代謝産物生合成経路の全容解明2015

    • Author(s)
      加藤 直樹, 高橋 俊二, 長田 裕之
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学 津島キャンパス (岡山県)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Multidimensional approach for drug discovery and target identification2015

    • Author(s)
      Hiroyuki Osada
    • Organizer
      Drug Screening and Discovery Technologies Asian Forum 2015
    • Place of Presentation
      InterContinental Shanghai Pudong Hotel (Shanghai, China)
    • Year and Date
      2015-01-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Biosynthesis study of reveromycin: Aiming at a therapeutic agent to osteoclast related diseases2015

    • Author(s)
      Hiroyuki Osada, Shunji Takahashi, Makoto Kawatani
    • Organizer
      Natural product discovery & development in the post genomic era
    • Place of Presentation
      Westin San Diego Gaslamp Quarter Hotel (San Diego, USA)
    • Year and Date
      2015-01-11 – 2015-01-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Construction of a microbial metabolite fraction library with NPPlot for discovery of novel metabolites2015

    • Author(s)
      Toshihiko Nogawa, Akiko Okano, Chung Liang Lim, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      Natural product discovery & development in the post genomic era
    • Place of Presentation
      Westin San Diego Gaslamp Quarter Hotel (San Diego, USA)
    • Year and Date
      2015-01-11 – 2015-01-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characterization of a-ketoglutarate-dependent dioxygenase FtmF catalyzing endoperoxide bond formation in fumitremorgin pathway2015

    • Author(s)
      Naoki Kato, Hideo Okumura, Shunji Takahashi, Hiroyuki Osada
    • Organizer
      Natural product discovery & development in the post genomic era
    • Place of Presentation
      Westin San Diego Gaslamp Quarter Hotel (San Diego, USA)
    • Year and Date
      2015-01-11 – 2015-01-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] キノマイシン誘導体はDNA挿入活性で抗マラリア効果を示す2014

    • Author(s)
      渡邉 信元, 早瀬 大貴, Lim Chung Liang, 野川 俊彦, 小松谷 啓介, 北 潔, 長田 裕之
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cell cycle inhibitors targeting Achilles heels of cells2014

    • Author(s)
      Hiroyuki Osada
    • Organizer
      Asian Biological Medicine Summit Forum in Hangzhou: The International Symposium on Natural Products Chemistry and Chemical Biology 2014 & ACBI 2014 Hangzhou Meeting
    • Place of Presentation
      Hangzhou Shujian Hotel (Hangzhou, China)
    • Year and Date
      2014-11-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] エキセチンからフサリセチンAへの変換に関わる酵素遺伝子の探索2014

    • Author(s)
      加藤 直樹, Jae-Hyuk JANG, 高橋 俊二, Jong Seog AHN, 長田 裕之
    • Organizer
      第14回糸状菌分子生物学コンファレンス(2014)
    • Place of Presentation
      東北大学 川内北キャンパス (宮城県)
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 化合物アレイを用いたメラニン生合成阻害剤探索2014

    • Author(s)
      本山 高幸, 田中 陽子, 長田 裕之
    • Organizer
      第14回糸状菌分子生物学コンファレンス(2014)
    • Place of Presentation
      東北大学 川内北キャンパス (宮城県)
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] ハイグロマイシンB処理によるルシラクタエン生産糸状菌Fusarium sp. RK97-94における二次代謝産物生産誘導2014

    • Author(s)
      加藤 翔, 本山 高幸, 鎌倉 高志, 長田 裕之
    • Organizer
      第14回糸状菌分子生物学コンファレンス(2014)
    • Place of Presentation
      東北大学 川内北キャンパス (宮城県)
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] in vitro Reconstitution of Biosynthetic Machinery for Reveromycin2014

    • Author(s)
      Hiroyuki Osada, Shunji Takahashi
    • Organizer
      XVII. International Symposium on the Biology of Actinomycetes
    • Place of Presentation
      Pine Bay Holiday Resort (Izmir, Turkey)
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Isolation and target identification of pyrrolizilactone2014

    • Author(s)
      Hiroyuki Osada
    • Organizer
      2014 Osong International Bio Industry Exposition
    • Place of Presentation
      Osong Bio Valley (Osong, Korea)
    • Year and Date
      2014-10-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ケミカルバイオロジーによる創農薬の可能性2014

    • Author(s)
      長田 裕之
    • Organizer
      東京農業大学総合研究所 農薬部会 (第95回セミナー)
    • Place of Presentation
      東京農業大学 総合研究所 (東京都)
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 天然物創薬を目指して2014

    • Author(s)
      長田 裕之
    • Organizer
      静岡大学農学部公開講演会(第214回 静岡ライフサイエンスセミナー)
    • Place of Presentation
      静岡大学農学部 (静岡県)
    • Year and Date
      2014-09-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Characterization of BR-1 activity on LAL family regulator in reveromycin biosynthesis2014

    • Author(s)
      Suresh Panthee, Shunji Takahashi, Seiji Matsuoka, Tetsuo Onuki, Minoru Yoshida, Hiroyuki Osada
    • Organizer
      2014年度(第29回)日本放線菌学会大会
    • Place of Presentation
      つくばカピオ (茨城県)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Butylmalonyl-CoAの選択的生産に関与するRevRの機能解析2014

    • Author(s)
      宮澤 岳, 高橋 俊二, 鈴木 健裕, 堂前 直, 長田 裕之
    • Organizer
      2014年度(第29回)日本放線菌学会大会
    • Place of Presentation
      つくばカピオ (茨城県)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 異種発現によるtautomycin生合成遺伝子クラスターの解析2014

    • Author(s)
      寺井 敦高, 高橋 俊二, 橋本 絢子, 新家 一男, 池田 治生, 川崎 寿, 長田 裕之
    • Organizer
      2014年度(第29回)日本放線菌学会大会
    • Place of Presentation
      つくばカピオ (茨城県)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 破骨細胞を標的とする薬剤のケミカルバイオロジー2014

    • Author(s)
      長田 裕之
    • Organizer
      公益社団法人 日本薬剤学会第29年会
    • Place of Presentation
      大宮ソニックシティビル (埼玉県)
    • Year and Date
      2014-05-20 – 2014-05-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] High-throughput screening of cell cycle inhibitors from NPDepo library2014

    • Author(s)
      Hiroyuki Osada
    • Organizer
      Korean Society for Biochemistry and Molecular Biology (KSBMB): Annual International Conference 2014
    • Place of Presentation
      COEX Center (Seoul, Korea)
    • Year and Date
      2014-05-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 世界における天然物創薬の現状2014

    • Author(s)
      長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス(神奈川県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 放線菌由来抗がん性物質 collismycin A の作用標的同定2014

    • Author(s)
      井上 尭, 川谷 誠, 室井 誠, 二村 友史, 青野 晴美, 浦本 昌和, 本郷 やよい, 越野 広雪, 五十嵐 康弘, 安藤 直子, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ChemProteoBaseによるcollismycin Aの作用機作解析2014

    • Author(s)
      室井 誠, 近藤 久恵, 平田 泰子, 井上 尭, 川谷 誠, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糸状菌Fusarium sp. RK97-94のルシラクタエン生合成遺伝子クラスターの解析2014

    • Author(s)
      加藤 翔, 本山 高幸, 林 敏明, 廣田 洋, 鎌倉 高志, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 微生物培養ブロスからの抗マラリア活性化合物の探索2014

    • Author(s)
      早瀬 大貴, 宇賀田 久美子, LIM Chung Liang, 二村 友史, 野川 俊彦, 渡邉 信元, 北 潔, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] NPPlot(Natural Products Plot)を用いた新規微生物代謝産物の探索と単離2014

    • Author(s)
      野川 俊彦, リム チュン・リャン, 浦本 昌和, 岡野 亜紀子, 本郷 やよい, 中村 健道, 越野 広雪, 高橋 俊二, イブラヒム ダーラ, 長田 裕之
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学 生田キャンパス(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intenational Collaboration on Chemical Biology: How to Pass a Baton to the Future2014

    • Author(s)
      Hiroyuki Osada
    • Organizer
      The 7th Japan-Korea Chemial Biology Symposium
    • Place of Presentation
      Ramada Hotel (Jeju, Korea)
    • Related Report
      2013 Annual Research Report
  • [Presentation] New OxindoleDerivatives Isolated from the Microbial Metabolite Fraction Library of Streptomyces sp. RK85-2702014

    • Author(s)
      Jun-Pil Jang, Toshihiko Nogawa, Masakazu Uramoto, Akiko Okano, Yushi Futamura, Takeshi Shimizu, Shunji Takahashi, Jae-Hyuk Jang, Jong Seog Ahn, Hiroyuki Osada
    • Organizer
      The 7th Japan-Korea Chemial Biology Symposium
    • Place of Presentation
      Ramada Hotel (Jeju, Korea)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗マラリア原虫薬の開発2013

    • Author(s)
      早瀬 大貴, 渡邉 信元, ヴィエジバ コンスタンティ, 川谷 誠, 北 潔, 長田 裕之
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chemical biology study of anti-osteoporosis agent isolated from a soil actinomycete2013

    • Author(s)
      Hiroyuki Osada, Makoto Kawatani, Shunji Takahashi
    • Organizer
      International Symposium on Natural Products Chemistry and Chemical Biology 2013
    • Place of Presentation
      Hotel Rubura Ohzan (Nagoya, Japan)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 糸状菌 Fusarium sp. RK97-94 のルシラクタエン生合成遺伝子クラスター中のメチル基転移酵素遺伝子 luc1 とトランスポーター遺伝子 luc4 の機能解析2013

    • Author(s)
      加藤 翔, 本山 高幸, 廣田 洋, 鎌倉 高志, 長田 裕之
    • Organizer
      第13回糸状菌分子生物学コンファレンス
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of a target for collismycin A, a cytotoxic microbial product, by proteomic profiling2013

    • Author(s)
      Makoto Kawatani, Gyo Inoue, Makoto Muroi, Yushi Futamura, Harumi Aono, Masakazu Uramoto, Yayoi Hongo, Hiroyuki Koshino, Yasuhiro Igarashi, Naoko Takahashi Ando, Hiroyuki Osada
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Hynes Convention Center (Boston, MA, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development and utilization of a cell morphology database, MorphoBase, for drug target identification2013

    • Author(s)
      Yushi Futamura, Makoto Kawatani, Makoto Muroi, Harumi Aono, Hiroyuki Osada
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Hynes Convention Center (Boston, MA, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Isolation of New Microbial Metabolites for Natural Product Depository (NPDepo)2013

    • Author(s)
      Hiroyuki Osada
    • Organizer
      2nd Annual Conference - ICBS2013
    • Place of Presentation
      Shirankaikan (Kyoto, Japan)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 抗がん剤のケミカルバイオロジー2013

    • Author(s)
      長田 裕之
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Isolation of novel bioactive compounds from fraction library of Microorganisms based on NPPlot screening2013

    • Author(s)
      Lim Chung Liang, Nogawa Toshihiko, Uramoto Masakazu, Okano Akiko, Hongo Yayoi, Nakamura Takemichi, Koshino Hiroyuki, Takahashi Shunji, Ibrahim Darah and Osada Hiroyuki
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      同志社大学 寒梅館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Biosynthesis of fungal secondary metabolites2013

    • Author(s)
      Hiroyuki Osada
    • Organizer
      International Symposium on The Miraculous Power of Fermentation Microorganisms
    • Place of Presentation
      The Portland Paramount Hotel (Portland, OR, USA)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 細胞形態とプロテオーム変化を指標にした新規抗がん剤の分子標的予測2013

    • Author(s)
      長田 裕之, 二村 友史, 室井 誠
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 糸状菌由来新規抗がん活性物質pyrrolizilactoneの標的同定2013

    • Author(s)
      川谷 誠, 青野 晴美, 野川 俊彦, 二村 友史, 室井 誠, 渡辺 信元, 長田 裕之
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 化合物からタンパク質機能の解明に挑む2013

    • Author(s)
      長田 裕之
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館(鳥取県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Isolation of novel compounds from fraction library based on NPPlot screening2013

    • Author(s)
      Lim Chung Liang, Toshihiko Nogawa, Akiko Okano, Masakazu Uramoto, Hiroyuki Osada
    • Organizer
      KRIBB-RIKEN Chemical Biology Joint Symposium
    • Place of Presentation
      KRIBB (Ochang, Korea)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Exploration of novel antimalarial compounds2013

    • Author(s)
      Kumiko Ugata, Yushi Futamura, Hiroki Hayase, Nobumoto Watanabe, Hiroyuki Osada
    • Organizer
      KRIBB-RIKEN Chemical Biology Joint Symposium
    • Place of Presentation
      KRIBB (Ochang, Korea)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糸状菌の二成分情報伝達系攪乱により生産誘導されるポリケタイド化合物の生合成遺伝子クラスターの同定2013

    • Author(s)
      本山 高幸、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Proteobaseを用いた新規プロテアソーム阻害剤ピロリジラクトンの標的同定2013

    • Author(s)
      室井 誠、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 化学の力で生命現象の解明に挑む2013

    • Author(s)
      長田 裕之
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multidimentional approach to target identification of new antitumor compounds2013

    • Author(s)
      Futamura Y. et al.
    • Organizer
      9th AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Hawaii (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 天然物創薬の難しさ、面白さ2012

    • Author(s)
      長田 裕之
    • Organizer
      第19回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      大阪大学会館(大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規リベロマイシン誘導体の創製と活性評価2012

    • Author(s)
      野川 俊彦、他
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京農業大学(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multi-dimensional profiling for the target identification of bioactive small molecules2012

    • Author(s)
      Osada H.
    • Organizer
      Queenstown Molecular Biology Meeting (QMB) Chemical Biology and Drug Discovery
    • Place of Presentation
      Queenstown (New Zealand)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Systems chemical biology for drug discovery from microbial metabolites2012

    • Author(s)
      Osada H.
    • Organizer
      13th International Conference on Systems Biology (ICSB 2012)
    • Place of Presentation
      University of Toronto, Toronto (Canada)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A point mutation in ftmD inactivates the fumitremorgin biosynthetic pathway in Aspergillus fumigatus Af2932012

    • Author(s)
      Kato N. et al.
    • Organizer
      International Conference of Natural Products Biosynthesis (ICNPB)
    • Place of Presentation
      Awaji Yumebutai, Hyogo (Japan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel compound which up-regulates secondary metabolite gene cluster2012

    • Author(s)
      Takahashi S. et al.
    • Organizer
      International Conference of Natural Products Biosynthesis (ICNPB)
    • Place of Presentation
      Awaji Yumebutai, Hyogo (Japan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Comprehensive analyses of biosynthesis and biological activity of reveromycin A2012

    • Author(s)
      Osada H.
    • Organizer
      International Conference of Natural Products Biosynthesis (ICNPB)
    • Place of Presentation
      Awaji Yumebutai, Hyogo (Japan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 微生物から薬を探す難しさ、面白さ

    • Author(s)
      長田 裕之
    • Organizer
      メディカル・サイエンス セミナー
    • Place of Presentation
      学士会館(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 新規抗がん剤候補物質の標的分子同定法

    • Author(s)
      長田 裕之
    • Organizer
      アカデミア発のがん創薬・個別化医療への挑戦
    • Place of Presentation
      がん研究会 吉田講堂(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 抗真菌剤のスクリーニングと生理活性小分子の標的同定

    • Author(s)
      長田 裕之
    • Organizer
      アステラス製薬株式会社所内セミナー
    • Place of Presentation
      アステラス製薬 つくば研究センター(茨城県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Profiling for target identification of bioactive small molecules

    • Author(s)
      Hiroyuki Osada
    • Organizer
      Centre for Biodiscovery Symposium 2013
    • Place of Presentation
      Victoria University of Wellington (Wellington, New Zealand)
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2012-11-27   Modified: 2019-07-29  

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