Study on hepatic liver accumulation and SREBP-1 activation, and function of food factors
| Project/Area Number |
24248023
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATO Ryuichiro 東京大学, 農学生命科学研究科, 教授 (50187259)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Makoto 東京大学, 大学院農学生命科学研究科, 助教 (40409008)
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| Project Period (FY) |
2012-05-31 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2013: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2012: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
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| Keywords | SREBP-1 / ChREBP / 脂肪肝 / スプライシング / 果糖 / 転写因子 / 脂肪酸合成 / メチル化 / トリグリセリド / 脂肪滴形成 / SREBP / Perilipin / コレステロール |
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| Outline of Final Research Achievements |
The evaluation system for measuring absolute value of ChREBPalpha/beta expression was established. ChREBPalpha/beta expression was observed in adipose tissues, liver, and small intestine, whereas only ChREBPalpha expression was detected in skeletal muscle. When ChREBPalpha/beta were overexpressed in cultured hepatocytes, lipogenic gene expression was significantly increased by ChREBPbeta. Mice overexpressing ChREBPbeta in the liver developed fatty liver. Four week feeding of a fructose-containing diet to mice resulted in a significant increase in hepatic ChREBPbeta expression and liver lipid accumulation. No alteration of hepatic SREBP-1c indicates that SREBP-1c was not involved in lipid accumulation induced by ChREBPbeta.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] The role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle.2014
Author(s)
Sasaki, T., Nakata, R., Inoue, H., Shimizu, M., Inoue, J., and Sato, R.
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Journal Title
Am. J. Physiol. Endocrinol. Metab.
Volume: 306
Issue: 9
Pages: 1085-1092
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Peyer’s patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy．2014
Author(s)
Haruyo Nakajima-Adachi, Akira Kikuchi, Yoko Fujimura, Kyoko Shibahara, Tsuyoshi Makino, Masae Goseki-Sone, Miran Kihara-Fujioka, Tomonori Nochi, Yosuke Kurashima, Osamu Igarashi, Masafumi Yamamoto, Jun Kunisawa, Masako Toda, Shuichi Kaminogawa, Ryuichiro Sato, Hiroshi Kiyono, Satoshi Hachimura
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Journal Title
ＰＬｏＳ Ｏｎｅ
Volume: 9
Issue: 10
Pages: e107492-e107492
DOI
Related Report
Peer Reviewed / Open Access
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