| Budget Amount *help |
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2013: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2012: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
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| Outline of Final Research Achievements |
The evaluation system for measuring absolute value of ChREBPalpha/beta expression was established. ChREBPalpha/beta expression was observed in adipose tissues, liver, and small intestine, whereas only ChREBPalpha expression was detected in skeletal muscle. When ChREBPalpha/beta were overexpressed in cultured hepatocytes, lipogenic gene expression was significantly increased by ChREBPbeta. Mice overexpressing ChREBPbeta in the liver developed fatty liver. Four week feeding of a fructose-containing diet to mice resulted in a significant increase in hepatic ChREBPbeta expression and liver lipid accumulation. No alteration of hepatic SREBP-1c indicates that SREBP-1c was not involved in lipid accumulation induced by ChREBPbeta.
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