Establishment and application of evaluation system of brain aging using alkyl-amide adducts as probe
| Project/Area Number |
24248024
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Wakako 独立行政法人国立長寿医療研究センター, 加齢健康脳科学研究部, 部長 (20333396)
KATO Yoji 兵庫県立大学, 環境人間学部, 教授 (30305693)
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| Co-Investigator(Renkei-kenkyūsha) |
HISAKA Shinsuke 名城大学, 薬学部, 助教 (60583838)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2013: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2012: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
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| Keywords | アルキルアミド型付加体 / プロパノイル型付加体 / ヘキサノイル型付加体 / リポソーム / 脳内神経細胞 / アルツハイマー症 / 抗酸化食品因子 / アスタキサンチン / 脳内老化 / 酸化ストレスバイオマーカー / 抗炎症反応 / アミノリン脂質修飾 |
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| Outline of Final Research Achievements |
Chemical and immunochemical analytical methods for quantification of hexanoyl- and Propanoyl-modified phospholipids have been evaluated, in particular, trials for construction of “Antibody chip” has been developed. α-Synuclein accumulates as insoluble fibrils in the Lewy bodies and protein aggregation such as amyloid β protein is considered to be an important process for the toxicity, so-called the amyloid cascade. Our research group have tried to find chemical structures of amide-modified α-synuclein and amyloid β protein and aggregation mechanism. We have also tried to find the mechanism of reguration of antioxidative food factors using astaxanthin and its stereoisomers.
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Report
(4 results)
Research Products
(116 results)
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[Journal Article] Stereochemical determination of O-desmethylangolensin produced from daizein2015
Author(s)
Niwa, T., Yokoyama, S., Matsugasaki, N., Inomata, E., Taira, A., Osawa, T.
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Journal Title
Food Chemistry
Volume: 171
Pages: 153-156
Related Report
Peer Reviewed
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[Journal Article] Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats2013
Author(s)
Mochizuki, M., Takayanagi,H., Yamada, S., Osawa, T., Kitaura, Y. and Shimomura, Y.
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Journal Title
The Journal of Physical Fitness and Sports Medicine
Volume: 2
Issue: 4
Pages: 509-513
DOI
NAID
ISSN
2186-8123, 2186-8131
Related Report
Peer Reviewed
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