| Budget Amount *help |
¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2013: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2012: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
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| Outline of Final Research Achievements |
Chemical and immunochemical analytical methods for quantification of hexanoyl- and Propanoyl-modified phospholipids have been evaluated, in particular, trials for construction of “Antibody chip” has been developed. α-Synuclein accumulates as insoluble fibrils in the Lewy bodies and protein aggregation such as amyloid β protein is considered to be an important process for the toxicity, so-called the amyloid cascade. Our research group have tried to find chemical structures of amide-modified α-synuclein and amyloid β protein and aggregation mechanism. We have also tried to find the mechanism of reguration of antioxidative food factors using astaxanthin and its stereoisomers.
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