Effects of stresses via CNS on fish energy metabolisms and immunological systems
| Project/Area Number |
24248037
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
USHIO Hideki 東京大学, 農学生命科学研究科, 教授 (50251682)
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| Co-Investigator(Kenkyū-buntansha) |
HIRONO Ikuo 東京海洋大学, 大学院 (00270926)
KONDO Hidehiro 東京海洋大学, 大学院 (20314635)
NAGASAKA Reiko 東京海洋大学, 大学院 (90444132)
KANEKO Gen 東京大学, 大学院 (30466809)
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| Project Period (FY) |
2012-10-31 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2014: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2013: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2012: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Keywords | 水産業 / シグナル伝達 / 発現制御 / ストレス / 細胞・組織 / 脳・神経 |
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| Outline of Final Research Achievements |
Evaluation methods of fish stress responses via central nervous system including visual stress, overcrowding stress, etc. were developed. Proteofragmentome analysis using NanoLC-MS/MS developed in this research suggested that proteolyses related to autophagy, proteasome system, and apoptosis occur in normal fish muscle tissue, and that the proteolyses are upregulated by the stresses. Immunological responses against the stresses were partly different among fish species. gamma Oryzanol is a stress-suppressor.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] DNA microarray analysis on gene candidates possibly related to tetrodotoxin accumulation in pufferfish2014
Author(s)
Holger Feroudj, Takuya Matsumoto, Yohei Kurosu, Gen Kaneko, Hideki Ushio, Katsuaki Suzuki, Hidehiro Kondo, Ikuo Hirono, Yuji Nagashima, Seiji Akimoto, Kazushige Usui, Shigeharu Kinoshita, Shuichi Asakawa, Masaaki Kodama, Shugo Watabe
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Journal Title
Toxicon
Volume: 77
Pages: 68-72
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] DNA microarray analysis on the genes differentially expressed in the liver of the pufferfish Takifugu rubripes following an intramuscular administration of tetrodotoxin.2014
Author(s)
Matsumoto T, Feroudj H, Kikuchi R, Kawana Y, Kondo H, Hirono I, Aki S, Mochizuki T, Nagashima Y, Kaneko G, Ushio H, Kodama M, Watabe S.
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Journal Title
Microarrays
Volume: 3
Issue: 4
Pages: 226-244
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Differences in lipid distribution and expression of peroxisome proliferator-activated receptor gamma and lipoprotein lipase genes in torafugu and red seabream2013
Author(s)
Kaneko G, Yamada T, Han Y, Hirano Y, Khieokhajonkhet A, Shirakami H, Nagasaka R, Kondo H, Hirono I, Ushio H, Watabe S
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Journal Title
Gen Comp Endocrinol
Volume: 184
Pages: 51-60
DOI
Related Report
Peer Reviewed
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[Presentation] Biotechnology in food science.2013
Author(s)
Kaneko G and Ushio H
Organizer
The First Turkish-International Circle's Workshop on Global Food Science and Technology
Place of Presentation
Erciyes University, Kayseri, Turkey
Related Report
Invited
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