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Defence mechanism against environmental chemicals in livestock animals

Research Project

Project/Area Number 24248056
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Boundary agriculture
Research InstitutionHokkaido University

Principal Investigator

ISHIZUKA MAYUMI  北海道大学, (連合)獣医学研究科, 教授 (50332474)

Co-Investigator(Kenkyū-buntansha) IKENAKA Yoshinori  北海道大学, 大学院獣医学研究科, 准教授 (40543509)
Co-Investigator(Renkei-kenkyūsha) TSUBOTA Toshio  北海道大学, 大学院獣医学研究科, 教授 (10207441)
KONNAI Satoru  北海道大学, 大学院獣医学研究科, 准教授 (40396304)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2012: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
KeywordsシトクロムP450 / グルクロン酸抱合 / 環境汚染 / 産業動物 / グルクロン酸抱合酵素 / 獣医学 / グルクロン酸転移酵素 / 硫酸転移酵素 / グルタチオン転移酵素
Outline of Final Research Achievements

In livestock animals, we identified the enzymatic characters of cytochrome P450 as typical phase I enzyme for xenobiotics. We also analyzed glucronyltrasnferase and sulfotransferase dependent metabolites in urine samples from mammalians including livestock animals, to elucidate the ability of xenobiotic conjugating detoxification. In field surveillance at Asia and African countries, heavy metals are major accumulated environmental pollutants in cattle, and the accumulating pattern is unique in ruminants. In case of poultry species, we clarify the expressed cytochrome P450 and phase II enzymes in liver using transcriptome analyses method and in silico analyses, and we compared the structure of xenobiotic metabolizing enzymes in poultry species to those of mammals.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (112 results)

All 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (6 results) Journal Article (43 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 42 results,  Acknowledgement Compliant: 26 results,  Open Access: 12 results) Presentation (61 results) (of which Int'l Joint Research: 3 results,  Invited: 8 results) Remarks (2 results)

  • [Int'l Joint Research] ノースウェスト大学/ヨハネスブルグ大学(南アフリカ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] クワメエンクルマ大学(ガーナ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] ザガジック大学(エジプト)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] カセサート大学(タイ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] ザンビア大学(ザンビア)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] β-carotene and retinol contents in the meat of herbivorous ungulates with a special reference to their public health importance2016

    • Author(s)
      Darwish WS, Ikenaka Y, Morshdy AE, Eldesoky KI, Nakayama SMM, MizukawaH, Ishizuka M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 2 Pages: 351-354

    • DOI

      10.1292/jvms.15-0287

    • NAID

      130005131329

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Distribution and health risk assessment of organochlorine pesticides (OCP) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCP in tongue.2016

    • Author(s)
      Mahmoud AFA, IkenakaY, YohannesYB, DarwishWS, Eldaly EA, Morshdy AE, Nakayama SMM, MizukawaH, Ishizuka M.
    • Journal Title

      Chemosphere

      Volume: 144 Pages: 1365-1371

    • DOI

      10.1016/j.chemosphere.2015.10.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reliability of stable Pb isotopes to identify Pb sources and verifying biological fractionation of Pb isotopes in goats and chickens.2016

    • Author(s)
      Nakata H, Nakayama SMM, Yabe J, Liazambi A, Mizukawa H, Darwish WS, Ikenaka Y, Ishizuka M
    • Journal Title

      Environ Pollut.

      Volume: 208 Pages: 395-403

    • DOI

      10.1016/j.envpol.2015.10.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Partial cloning of CYP2C23a genes and hepatic protein expression in eight representative avian species2015

    • Author(s)
      Watanabe KP, Kawai YK, Nakayama SMM, Ikenaka Y, Mizukawa H, Takaesu N, Ito M, Ikushiro S, Sakaki T, Ishizuka M
    • Journal Title

      Journal of Veterinary Pharmacology and Therapeutics

      Volume: 38 Issue: 2 Pages: 190-195

    • DOI

      10.1111/jvp.12159

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Human health risks from metals and metalloid via consumption of food animals near Gold Mines in Tarkwa, Ghana: Estimation of the daily intakes and target hazard quotients (THQs).2015

    • Author(s)
      Bortey-Sam N, Nakayama SMM, Ikenaka Y, Akoto O, Yohannes YB, Baidoo E, Mizukawa H, Ishizuka M.
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 111 Pages: 160-167

    • DOI

      10.1016/j.ecoenv.2014.09.008

    • NAID

      120005540290

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Lead poisoning in children from townships in the vicinity of a lead-zinc mine in Kabwe, Zambia2015

    • Author(s)
      Yabe J, Nakayama SMM, Ikenaka Y, Yohannes YB, Bortey-Sam N, Oroszlany B, Muzandu K, Choongo K, Kabalo AN, Ntapisha J, Mweene A, Umemura T, Ishizuka M
    • Journal Title

      Chemosphere

      Volume: 119 Pages: 941-947

    • DOI

      10.1016/j.chemosphere.2014.09.028

    • NAID

      120005603796

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Levels, potential sources and human health risk of polycyclic aromatic hydrocarbons (PAHs) in particulate matter (PM10) in Kumasi-Ghana2015

    • Author(s)
      Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama M.M.S, Yared YB, Baidoo E, Mizukawa H, Ishizuka M
    • Journal Title

      Environ Sci Pollut Res

      Volume: 22 Issue: 13 Pages: 160-167

    • DOI

      10.1007/s11356-014-4022-1

    • NAID

      120005768774

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Are red gourami (Colisa labiosa) low xenobiotic metabolizers? Elucidation of in vivo pharmacokinetics of pyrene as a model substrate2015

    • Author(s)
      Ikenaka Y, Nakayama SMM, Oguri M, Saengtienchai A, Mizukawa H, Kobayashi J, Darwish WS, Ishizuka M
    • Journal Title

      Environ Toxicol Pharmacol

      Volume: 39 Issue: 3 Pages: 1148-1153

    • DOI

      10.1016/j.etap.2015.04.004

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization and tissue distribution of conjugated metabolites of pyrene in the rat2015

    • Author(s)
      Saengtienchai A, Ikenaka Y, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 10 Pages: 1261-1267

    • DOI

      10.1292/jvms.14-0632

    • NAID

      130005107595

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Metal extent in blood of livestock from Dandora dumping site, Kenya: source identification of Pb exposure by stable isotope analysis.2015

    • Author(s)
      Nakata H, Nakayama SMM, Ikenaka Y, Mizukawa H, Ishii C, Yohannes YB, Konnai S, Darwish WS, Ishizuka M
    • Journal Title

      Environ Pollut.

      Volume: 205 Pages: 8-15

    • DOI

      10.1016/j.envpol.2015.05.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Incidence and public health risk assessment of toxic metal residues (cadmium and lead) in Egyptian cattle and sheep meats.2015

    • Author(s)
      Darwish WS, Hussein MA, El-Desoky KI, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
    • Journal Title

      Int Food Res J,

      Volume: 22 Pages: 1719-1726

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Metabolic Activation of Heterocyclic Amines and Expression of Xenobiotic-Metabolizing Enzymes in the Gastrointestinal Tract of Rats2015

    • Author(s)
      Darwish WS, Nakayama SMM, Itotani Y, Ohno M, Ikenaka Y, Ishizuka M
    • Journal Title

      J Food Sci

      Volume: 22 Issue: 7 Pages: 1719-1726

    • DOI

      10.1111/1750-3841.12931

    • NAID

      120005768777

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Health risk assessment of heavy metals and metalloid in drinking water from communities near gold mines in Tarkwa, Ghana.2015

    • Author(s)
      Bortey-Sam N, Nakayama SMM, Ikenaka Y, Akoto O, Baidoo E, Mizukawa H, Ishizuka M
    • Journal Title

      Environ Monit Assess,

      Volume: 187 Issue: 7 Pages: 1-12

    • DOI

      10.1007/s10661-015-4630-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] UGT Xenobiotic metabolizing activity and genetic evolution in Pinniped species2015

    • Author(s)
      Kakehi M, Ikenaka Y, Nakayama M.M.S, Kawai Y.K, Watanabe K.P, Mizukawa H, Nomiyama K, Tanabe S, Ishizuka M
    • Journal Title

      Toxicological Sciences

      Volume: 147 Issue: 2 Pages: 360-369

    • DOI

      10.1093/toxsci/kfv144

    • NAID

      120005817898

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: In vitro assays in several birds and in vivo assays in chicken2015

    • Author(s)
      Watanabe KP, Kawata M, Ikenaka Y, Nakayama SMM, Ishii C, Darwish WS, Saengtienchai A, Mizukawa H, Ishizuka M
    • Journal Title

      Environ Toxicol Chem

      Volume: 34 Issue: 10 Pages: 2328-2334

    • DOI

      10.1002/etc.3062

    • NAID

      120005906927

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Accumulation of heavy metals and metalloid from agricultural soils to foodstuffs around Tarkwa area in Ghana, and associated human health risks.2015

    • Author(s)
      Bortey-Sam N, Nakayama SMM, Akoto O, Ikenaka Y, Fobil N.J., Baidoo E, Mizukawa H, Ishizuka M.
    • Journal Title

      Int J Environ Res Public Health.

      Volume: 12 Issue: 8 Pages: 8811-8827

    • DOI

      10.3390/ijerph120808811

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ecological Risk of Heavy Metals and a Metalloid in Agricultural Soils in Tarkwa, Ghana.2015

    • Author(s)
      Bortey-Sam N, Nakayama SMM, Akoto O, Ikenaka Y, Fobil N.J., Baidoo E, Mizukawa H, Ishizuka M.
    • Journal Title

      Int J Environ Res Public Health.

      Volume: 12 Issue: 9 Pages: 11448-11465

    • DOI

      10.3390/ijerph120911448

    • NAID

      120005667721

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: Association with hepatic cytochrome P4502015

    • Author(s)
      Mizukawa H, Nomiyama K, Kunisue T, Watanabe MX, Subramanian A, Iwata H, Ishizuka M, Tanabe S
    • Journal Title

      Environ Res

      Volume: 138 Pages: 255-263

    • DOI

      10.1016/j.envres.2015.02.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mercury concentrations in primary feathers reflect pollutant exposure in discrete non-breeding grounds used by Short-tailed Shearwaters2015

    • Author(s)
      Watanuki Y, Yamamoto T, Yamashita A, Ishii C, Ikenaka Y, Nakayama SMM, Ishizuka M, Suzuki Y, Niizuma Y, Meathrel CE, Phillips RA
    • Journal Title

      Journal of Ornithology

      Volume: inpress Issue: 3 Pages: 847-850

    • DOI

      10.1007/s10336-015-1205-6

    • NAID

      120005768771

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of inter-specific differences in phase II reactions: Determination of metabolites in the urine of 16 mammalian species exposed to environmental pyrene.2015

    • Author(s)
      Saengtienchai A, Ikenaka Y, Nakayama SMM, Mizukawa H, Kakehi M, Bortey-Sam N, Darwish W, Tsubota T, Terasaki M, Poapolathep A, Ishizuka M
    • Journal Title

      Environmental Toxicology and Chemistry

      Volume: 33 Issue: 9 Pages: 2062-2069

    • DOI

      10.1002/etc.2656

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Contamination status and accumulation characteristics of metals and a metalloid in birds on Teuri Island, Hokkaido, Japan2014

    • Author(s)
      Ishii C, Ikenaka Y, Nakayama SMM, Suzuki Y, Watanuki Y, Watanabe Y, Yohannes YB, Mizukawa H, Ishizuka M
    • Journal Title

      Japanese Journal of Veterinary Research

      Volume: 62 Issue: 3 Pages: 143-149

    • DOI

      10.14943/jjvr.62.3.143

    • NAID

      120005469243

    • ISSN
      0047-1917
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS3982014

    • Author(s)
      Fujisawa N, Nakayama SMM, Ikenaka Y, Ishizuka M
    • Journal Title

      Arch. Toxicol

      Volume: 88 Issue: 9 Pages: 1739-1748

    • DOI

      10.1007/s00204-014-1225-7

    • NAID

      120005649117

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Contamination status and possibility of toxic effects of co-planar polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and dichlorodiphenyltrichloroethane in large Japanese field mouse (Apodemus speciosus) collected from Hokkaido and Aomori2014

    • Author(s)
      Mizukawa H, Ikenaka Y, Nakayama SMM, Sakamoto KQ, Fujita S, Ishizuka M
    • Journal Title

      Japanese Journal of Veterinary Research

      Volume: 62 Issue: 3 Pages: 107-115

    • DOI

      10.14943/jjvr.62.3.107

    • NAID

      120005469239

    • ISSN
      0047-1917
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Concentrations and human health risk assessment of organochlorine pesticides in edible fish species from a Rift Valley Lake-Lake Ziway, Ethiopia2014

    • Author(s)
      Yohannes YB, Ikenaka Y, Saengtienchai A, Watanabe KP, Nakamyama SMM, Ishizuka M
    • Journal Title

      Ecotoxicol. Environ. Saf.

      Volume: 106 Pages: 121-128

    • DOI

      10.1016/j.ecoenv.2014.04.014

    • NAID

      120005468140

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organochlorine pesticides in bird species and their prey (fish) from the Ethiopian Rift Valley region, Ethiopia.2014

    • Author(s)
      Yohannes YB, Ikenaka Y, Nakamyama SMM, Ishizuka M
    • Journal Title

      Environmental Pollution

      Volume: 192 Pages: 121-128

    • DOI

      10.1016/j.envpol.2014.05.007

    • NAID

      120005476098

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles.2014

    • Author(s)
      Yasui H, Takeuchi R, Nagane M, Meike S, Nakamura Y, Yamamori T, Ikenaka Y, Kon Y, Murotani H, Oishi M, Nagasaki Y, Inanami O
    • Journal Title

      Cancer Letters

      Volume: 347 Issue: 1 Pages: 151-158

    • DOI

      10.1016/j.canlet.2014.02.005

    • NAID

      120005425361

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distribution of heavy metals in organs of sheep and goat reared in Obuasi: A gold mining town in Ghana2014

    • Author(s)
      Akoto O, Bortey-Sam N, Nakayama SMM, Ikenaka Y, Baidoo E, Yohannes YB, Mizukawa H, Ishizuka M
    • Journal Title

      Int. J. Environ. Sci. Toxic

      Volume: 2 Pages: 81-89

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] The effect of copper on the mRNA expression profile of xenobiotic-metabolizing enzymes in cultured rat H4-II-E cells.2014

    • Author(s)
      Darwish WS, Ikenaka Y, Nakayama SMM, Ishizuka M.
    • Journal Title

      Biol Trace Elem Res

      Volume: (印刷中) Issue: 2 Pages: 51-58

    • DOI

      10.1007/s12011-014-9915-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Overview on Mycotoxin Contamination of Foods in Africa2014

    • Author(s)
      Darwish WS, Ikenaka Y, Nakayama SMM, Ishizuka M
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 76 Issue: 6 Pages: 789-797

    • DOI

      10.1292/jvms.13-0563

    • NAID

      130003391291

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toxicokinetics and tissue depletion of Fusarenon-X and its metabolite nivalenol in piglets2014

    • Author(s)
      Saengtienchai T, Poapolathep S, Isariyodom S, Ikenaka Y, Ishizuka M, Poapolathep A
    • Journal Title

      Food Chem Toxicol

      Volume: 66C Pages: 307-312

    • DOI

      10.1016/j.fct.2014.01.053

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Metal distribution in tissues of free-range chickens near a lead-zinc mine in Kabwe, Zambia.2013

    • Author(s)
      Yabe, J., Nakayama, S.M.M., Ikenaka, Y., Muzandu, K., Choongo, K., Mainda, G., Kabeta, N., Ishizuka, M. and Umemura, T
    • Journal Title

      Environ. Toxicol. Chem.

      Volume: 32 Pages: 189-192

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Phase-II conjugation reaction of polycyclic aromatic hydrocarbons in fish species: unique pyrene metabolism and species specificity observed in fish species2013

    • Author(s)
      Ikenaka, Y., Oguri, M., Saengtienchai, A., Nakayama, S.M.M., Ijiri, S. and Ishizuka, M. 2013.
    • Journal Title

      Environ. Toxicol. Pharmacol.

      Volume: 36 Issue: 2 Pages: 567-578

    • DOI

      10.1016/j.etap.2013.05.018

    • NAID

      120005341794

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo sequence analysis of cytochrome P450 1–3 genes expressed in ostrich liver with highest expression of CYP2G19.2013

    • Author(s)
      Kawai, Y.K., Watanabe, K.P., Ishii, A., Onuma, A., Sawa, H., Ikenaka, Y. and Ishizuka, M.
    • Journal Title

      Comp. Biochem. Physiol. D

      Volume: 8 Issue: 3 Pages: 201-208

    • DOI

      10.1016/j.cbd.2013.05.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evaluation of a new highly sensitive aryl hydrocarbon receptor in ostriches.2013

    • Author(s)
      Fujisawa N, Darwish WS, Ikenaka Y, Kim E, Lee J, Iwata H, Nakayama SMM, Ishizuka M.
    • Journal Title

      Poultry Science

      Volume: 92 Issue: 7 Pages: 1921-1929

    • DOI

      10.3382/ps.2013-03090

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Avian Cytochrome P450 (CYP) 1-3 Family Genes : Isoforms, Evolutionary Relationships, and mRNA Expression in Chicken Liver2013

    • Author(s)
      Kensuke P WATANABE, et al.
    • Journal Title

      PLoS ONE

      Volume: 8(9) Issue: 9 Pages: e75689-e75689

    • DOI

      10.1371/journal.pone.0075689

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but Not in Rat Liver2013

    • Author(s)
      5.Sasaki N, Matumoto T, Ikenaka Y, Nakayama SMM, Ishizuka M, Kazusaka A, Fujita S.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 75 Issue: 11 Pages: 1497-1502

    • DOI

      10.1292/jvms.12-0531

    • NAID

      130003362235

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metal distribution in tissues of free-range chickens near a lead-zinc mine in Kabwe, Zambia2013

    • Author(s)
      Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Choongo K, Mainda G, Kabeta N, Ishizuka M, Umemura T
    • Journal Title

      Environ Toxicol Chem.

      Volume: 32 Issue: 1 Pages: 189-92

    • DOI

      10.1002/etc.2029

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts.2012

    • Author(s)
      Dominic MUREITHI, Wageh Sobhy DARWISH, Yoshinori IKENAKA, Laetitia KANJA, Mayumi ISHIZUKA.
    • Journal Title

      Jpn. J. Vet. Res.

      Volume: 60 Pages: 205-210

    • NAID

      120005008268

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The nucleotide sequence of metallothioneins (MT) in liver of the Kafue lechwe (Kobus leche kafuensis) and their potential as biomarkers of heavy metal pollution of the Kafue River.2012

    • Author(s)
      M’kandawire E, Syakalima M, Muzandu K, Pandey G, Simuunza M, Nakayama SM, Kawai YK, Ikenaka Y, Ishizuka M.
    • Journal Title

      Gene

      Volume: 506 Issue: 2 Pages: 310-6

    • DOI

      10.1016/j.gene.2012.07.002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of environmental lead contamination on cattle in a lead/zinc mining area : changes in cattle immune systems on exposure to lead in vivo and in vitro.2012

    • Author(s)
      Ikenaka Y, Nakayama SMM, Muroya T, Yabe J, Konnai S, Darwish WS, Muzandu K, Choongo K, Mainda G, Teraoka H, Umemura T, Ishizuka M.
    • Journal Title

      Environ Toxicol Chem.

      Volume: 31 Issue: 10 Pages: 2300-2305

    • DOI

      10.1002/etc.1951

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional profiling of inflammatory cytokine genes in Theileria parva-infected African buffalo (Syncerus caffer).2012

    • Author(s)
      Okagawa, T., Konnai, S., Mekata, H., Githaka, N., Suzuki, S., Kariuki, E., Gakuya, F., Kanduma, E., Shirai, T., Ikebuchi, R., Ikenaka, Y., Ishizuka, M., Murata, S., Ohashi.
    • Journal Title

      Vet Immunol Immunopathol.

      Volume: 148 Issue: 3-4 Pages: 373-9

    • DOI

      10.1016/j.vetimm.2012.06.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metal and metalloid levels and bio-accumulation characteristics in soil, sediment, land plants and hippopotami (Hippopotamus amphibius L) from the South Luangwa National Park, Zambia2012

    • Author(s)
      中山翔太
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: (印刷中) Pages: 333-338

    • DOI

      10.1016/j.ecoenv.2012.04.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer)2012

    • Author(s)
      Suzuki S, Konnai S, Okagawa T, Githaka N W, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K
    • Journal Title

      Int J Immunogenet

      Volume: 39 Issue: 2 Pages: 170-182

    • DOI

      10.1111/j.1744-313x.2011.01062.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 非実験動物における化学物質代謝能の特徴と種差2016

    • Author(s)
      池中良徳、筧麻友、水川葉月、中山翔太、石塚真由美
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Metabolism and biotransformation of organohalogen compounds in the liver microsomes of cats and dogs.2015

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Nozomu, Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama,Misaki Maehara, Shinsuke Tanabe, Mayumi Ishizuka.
    • Organizer
      SETAC North America 36th Annual Meeting,
    • Place of Presentation
      Salt Palace Convention Center, Salt Lake City, USA
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 鳥類で起こっているケミカルハザードとそのメカニズム2015

    • Author(s)
      中山翔太、水川葉月、池中良徳、石塚真由美
    • Organizer
      第21回日本野生動物医学会大会
    • Place of Presentation
      酪農学園大学、北海道
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Vector-control pesticides disseminating via international waterways to accumulate in free-ranging freshwater and marine fish species2015

    • Author(s)
      Lesa A Thompson, Yoshinori Ikenaka, Johannes J van Vuren, Victor, Wepener, Nico Smit, Wynand Vlok, Yared B. Yohannes, Hazuki Mizukawa, Shouta M.M. Nakayama, Mayumi Ishizuka.
    • Organizer
      Vth International Wildlife Management Congress
    • Place of Presentation
      Sapporo Convention Center, Sapporo, Japan
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lead poisoning and source identification in raptors from Japan.2015

    • Author(s)
      Chihiro Ishii, Shouta M.M. Nakayama, Yoshinori Ikenaka, Hazuki Mizukawa, Yared B. Yohannes, Hokuto Nakata, Keisuke Saito, Yukiko Watanabe, Shinsuke Tanabe, Kei Nomiyama, Terutake Hayashi, Yasushi Masuda, Kentaro Q. Sakamoto, Mayumi Ishizuka
    • Organizer
      Vth International Wildlife Management Congress
    • Place of Presentation
      Sapporo Convention Center, Sapporo, Japan
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 外来化学物質の代謝の種差2015

    • Author(s)
      石塚真由美、中山翔太、水川葉月、池中良徳
    • Organizer
      第31回日本毒性病理学シンポジウム
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2015-01-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 食肉目におけるグルクロン酸抱合酵素の遺伝子解析2014

    • Author(s)
      筧麻友、池中良徳、中山翔太、水川葉月、渡邉研右、坂本健太郎、和田 昭彦、服部薫、田辺信介、野見山桂、石塚真由美
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Distribution of toxic metals in free-range chicken, goat and sheep in Ghana and other African countries; and assessment of potential risks to human health through consumption2014

    • Author(s)
      Nesta Bortey-Sam, Shouta M.M. Nakayama, Yoshinori Ikenaka, Yared Beyene Yohannes, Elvis Baidoo, Hazuki Mizukawa, Osei Akoto, Mayumi Ishizuka
    • Organizer
      SETAC North America 35th Annual Meeting
    • Place of Presentation
      Vancouver Convention Centre, Vancouver, Canada
    • Year and Date
      2014-11-09 – 2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Contamination status and biotransformation of organohalogen compounds in cats and dogs2014

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Susumu Nakatsu, Akira Kubota, Hisato Iwata, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      12th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
    • Place of Presentation
      Conference Hall of the Kyoto International Foundation, Kyoto, Japan
    • Year and Date
      2014-09-24 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mammalian interspecies differences in xenobiotic phase II reaction2014

    • Author(s)
      Yoshinori Ikenaka, Saengtienchai Aksorn, Mayu Kakehi, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      12th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
    • Place of Presentation
      Conference Hall of the Kyoto International Foundation, Kyoto, Japan
    • Year and Date
      2014-09-24 – 2014-09-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Species differences of UDP-glucuronosyltransferases (UGTs) in Carnivores2014

    • Author(s)
      Mayu Kakehi, Yoshinori Ikenaka, Shouta MM Nakayama, Hazuki Mizukawa,Kensuke P Watanabe, Kentaro Sakamoto, Akihiko Wada, Kaoru Hattori,Shinsuke Tanabe, Kei Nomiyama, Mayumi Ishizuka
    • Organizer
      12th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
    • Place of Presentation
      Conference Hall of the Kyoto International Foundation, Kyoto, Japan
    • Year and Date
      2014-09-24 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 鰭脚類においてグルクロン酸抱合酵素が担う異物代謝2014

    • Author(s)
      筧麻友、池中良徳、中山翔太、水川葉月、渡邉研右、坂本健太郎、和田 昭彦、服部薫、田辺信介、野見山桂、石塚真由美
    • Organizer
      第20回日本野生動物医学会つくば大会
    • Place of Presentation
      つくば国際会議場、茨城
    • Year and Date
      2014-09-16 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] アフリカのゴミ集積場における化学物質の汚染実態と生体への健康影響の評価:ナイロビのダンドラ地域における家畜の重金属汚染の例2014

    • Author(s)
      中田北斗、中山翔太、水川葉月、池中良徳、石井千尋、ヨハンネス ヤレド ベイヤネ、ヤベジョン、今内覚、石塚真由美
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学 高等教育推進機構、北海道
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本における猛禽類の鉛中毒被害状況と中毒原因、鉛体内分布の解明2014

    • Author(s)
      石井千尋、中山翔太、池中良徳、水川葉月、中田北斗、齊藤慶輔、渡邊有希子、田辺信介、野見山桂、林光武、増田泰、坂本健太郎、石塚真由美
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学 高等教育推進機構、北海道
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ニワトリにおけるDDTの汚染状況と臓器蓄積性の解析2014

    • Author(s)
      伊藤玄悟、池中良徳、Beyene Yared、中山翔太、水川葉月、Vuren Johannes、Wepener Victor、Smit Nico、Wynand Vlok、石塚真由美
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学 高等教育推進機構、北海道
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Preliminary survey of lead poisoning in raptors from Japan2014

    • Author(s)
      Chihiro Ishii, Shouta M.M. Nakayama, Yoshinori Ikenaka, Hazuki Mizukawa, Yared B. Yohannes, Hokuto Nakata, Keisuke Saito, Yukiko Watanabe, Shinsuke Tanabe, Kei Nomiyama, Terutake Hayashi, Yasushi Masuda, Kentaro Q. Sakamoto, Mayumi Ishizuka
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Investigation of heavy metal contamination and assessment of impact on health in Dandora dumping site, Nairobi2014

    • Author(s)
      Hokuto Nakata, Shouta M.M. Nakayama, Hazuki Mizukawa, Yoshinori Ikenaka, Chihiro Ishii, Yared Beyene Yohannes, John Yabe, Satoru Konnai, Mayumi Ishizuka
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Contamination status of organohalogen compounds and their metabolites in the blood of pet dogs and cats2014

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Miyuki Yamamoto, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Human and ecological health risk assessment of pesticides used for vector control: Current situation and problems of DDT use in Africa2014

    • Author(s)
      Yoshinori Ikenaka, Yared Beyene Yohannes, Lesa Thompson, Shouta M.M. Nakayama, Hazuki Mizukawa, Johannes J. van Vuren, Victor Wepener, Nico J. Smit, Volk Wynand, Mayumi Ishizuka
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of international land-based use of vector-control pesticides on a marine ecosystem: organochlorine analysis of fish from Maputo Bay, Mozambique2014

    • Author(s)
      Lesa Thompson, Yoshinori Ikenaka, Yared Beyene Yohannes, Shouta M.M. Nakayama, Hazuki Mizukawa, Johannes J. van Vuren, Victor Wepener, Nico J. Smit, Volk Wynand, Mayumi Ishizuka
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pb excretion in feces and urine of exposed children from polluted townships in Kabwe, Zambia2014

    • Author(s)
      John Yabe, Shouta M.M. Nakayama, Yoshinori Ikenaka, Yared B Yohannes, Nesta Bortey-Sam, Balazs Oroszlany, Kaampwe Muzandu, Kennedy Choongo, Abel Nketani Kabalo, John Ntapisha, Aaron Mweene, Takashi Umemura, Mayumi Ishizuka
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Health Risk Assessment of Heavy Metal Residues in Tissues of Cattle and Goats in Benin City, Nigeria2014

    • Author(s)
      Emmanuel Temiotan Ogbomida, Isioma Tongo, Alex Ajeh Enuneku, Martins Oshioriamhe Ainerua, Shouta M.M. Nakayama, Nesta Bortey-Sam, Balazs Oroszlany, Lawrence Ikechukwu Ezemonye, Mayumi Ishizuka
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Distribution of heavy metals in organs of sheep and goat reared in Obuasi, a gold mining town in Ghana2014

    • Author(s)
      Osei Akoto, Nesta Bortey-Sam, Shouta M.M. Nakayama, Yoshinori Ikenaka, Elvis Baidoo, Yared Beyene Yohannes, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Baseline levels and trophic transfer of organochlorine pesticidesic in biota from a sub tropical floodplain in Africa2014

    • Author(s)
      Nico J. Smit, Johan J van Vuren, Claire Edwards, Jonathan Caramin, Lieven Bervoets, Mayumi Ishizuka, Yoshinori Ikenaka, Victor Wepener
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of the Olifants and Luvuvhu river aquatic food webs, potential food web disturbances and dietary patterns of Hydrocynus vittatus as revealed by stable isotope analyses2014

    • Author(s)
      Ruan Gerber, Victor Wepener, Johan J van Vuren, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Nico Smit
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Aquatic toxicology of gold nanoparticles (nAu) in Danio rerio2014

    • Author(s)
      Tarryn Lee Botha, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka, Victor Wepener
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] DDT in amphibians from the lower Phongola floodplain2014

    • Author(s)
      Nico Wolmarans, Victor Wepener, Louis Du Preez, Mayumi Ishizuka, Yoshinori Ikenaka, Nico Smit
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Biomarkers of pollution in Synodontis zambesensis and Hydrocynus vittatus in the lower Pongola river and floodplain2014

    • Author(s)
      Claire Michelle Edwards, Yoshinori Ikenaka, Yared Beyene Yohannes, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka, Victor Wepener, Johan J van Vuren
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Antibiotics residues in different poultry meats marketed in Egypt2014

    • Author(s)
      Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Mayumi Ishizuka, Eldaly Elsaid, El-Abbasy Mohamed, El-Ghareeb Walid, Tharwat Ahmed, El-Desoky Kamal, Elged Mohamed
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] The impact of environmental stressors on biomarkers in Clarias gariepinus and Oreochromis mossambicus in Ndumo game reserve2014

    • Author(s)
      Mary Tsono Mkhonto, Johan J van Vuren, Nico Smit, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Yared Beyene Yohannes, Mayumi Ishizuka
    • Organizer
      6th International Toxicology Symposium in Africa
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Environmental Pollution in African countries -Focus on metal and organochlorine pesticide-, International symposium on environmental pollution and food safety2014

    • Author(s)
      Mayumi Ishizuka
    • Organizer
      International symposium on environmental pollution and food safety, Zagazig University
    • Place of Presentation
      Zagazig, Egypt
    • Year and Date
      2014-08-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ペット動物における有機ハロゲン化合物の汚染実態解明と水酸化代謝物の動態解析2014

    • Author(s)
      水川葉月、野見山桂、中津賞、池中良徳、中山翔太、田辺信介、石塚真由美
    • Organizer
      第28回北海道薬物作用談話会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 食肉目におけるグルクロン酸抱合酵素の解析および種差2014

    • Author(s)
      筧麻友、池中良徳、中山翔太、水川葉月、渡邉研右、坂本健太郎、和田昭彦、服部薫、田辺信介、野見山桂、石塚真由美
    • Organizer
      第28回北海道薬物作用談話会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本に生息する猛禽類の鉛汚染状況と鉛安定同位体比を指標とした汚染源の解明2014

    • Author(s)
      石井千尋、中山翔太、池中良徳、水川葉月、中田北斗、齊藤慶輔、渡邊有希子、田辺信介、野見山桂、林光武、増田泰、坂本健太郎、石塚真由美
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター、兵庫
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] ケニアの大規模ゴミ集積場・ダンドラ地域における家畜の化学物質汚染の実態と住民の健康影響評価2014

    • Author(s)
      中田北斗、中山翔太、水川葉月、池中良徳、石井千尋、ヨハンネス ヤレド ベイヤネ、今内覚、石塚真由美
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター、兵庫
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 鰭脚類を中心とした食肉目において異物代謝を担うグルクロン酸抱合酵素の特徴2014

    • Author(s)
      筧麻友、中山翔太、水川葉月、池中良徳、渡邊研右、坂本健太郎、和田昭彦、服部薫、田辺信介、野見山桂、石塚真由美
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター、兵庫
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 鰭脚類におけるグルクロン酸抱合酵素の解析2014

    • Author(s)
      筧麻友、池中良徳、中山翔太、水川葉月、渡邊研右、坂本健太郎、和田昭彦、服部薫、田辺信介、野見山桂、石塚真由美
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター、兵庫
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] アフリカのゴミ集積場における化学物質の汚染実態と生体への健康影響の評価:ナイロビのダンドラ地域における重金属汚染の例2014

    • Author(s)
      中田北斗、中山翔太、水川葉月、池中良徳、石井千尋、ヨハンネス ヤレド ベイヤネ、今内覚、石塚真由美
    • Organizer
      第23回環境化学討論会
    • Place of Presentation
      京都大学
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本に生息する猛禽類における鉛汚染状況の解析2014

    • Author(s)
      石井千尋、池中良徳、中山翔太、水川葉月、齊藤慶輔、渡邊有希子、田辺信介、野見山桂、林光武、増田泰、坂本健太郎、石塚真由美
    • Organizer
      第23回環境化学討論会
    • Place of Presentation
      京都大学
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Quantification of Neonicotinoids in human urine using liquid chromatography/tandem mass spectrometry2014

    • Author(s)
      Jemima Tiwaa Marfo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Hazuki Mizukawa, Kumiko Taira, Kazutoshi Fujioka, Yoshiko Aoyama, Osei Akoto, Mayumi Ishizuka
    • Organizer
      23rd Symposium on Environmental Chemistry
    • Place of Presentation
      Kyoto University
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Residue levels and health risk assessment of organochlorine pesticides (OCPs) in domesticated animals from Egypt2014

    • Author(s)
      Abdallah Fikry A. Mahmoud, Elsaid A. Eldaly, Alaa Eldin M.A. Morshdy, Yoshinori Ikenaka, Shouta Nakayama, Hazuki Mizukawa, Yared B. Yohannes, Waleed R. El-Ghareeb, Mohamed Tharwat El-Abbasy, Mayumi Ishizuka
    • Organizer
      23rd Symposium on Environmental Chemistry
    • Place of Presentation
      Kyoto University
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lead pollution in the children in Kabwe mining area, Republic of Zambia2014

    • Author(s)
      Shouta M.M. Nakayama,John Yabe,Yoshinori Ikenaka,Yared Beyene, Balazs Oroszlany, Nesta Bortey-Sam, Kaampwe Muzandu, Kennedy Choongo, Abel Kabalo, John Ntapisha, Aaron Mweene, Takashi Umemura, Mayumi Ishizuka
    • Organizer
      23rd Symposium on Environmental Chemistry
    • Place of Presentation
      Kyoto University
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lead pollution in soil, domestic animals and children from townships near a lead-zinc mine in Kabwe, Zambia.2014

    • Author(s)
      Shouta M.M. Nakayama, John Yabe, Yoshinori Ikenaka, Yared B. Yohannes, Balazs Oroszlany, Nesta Bortey-Sam, Kaampwe Muzandu, Kennedy Choongo, Abel Nketani Kabalo, John Ntapisha, Aaron Mweene, Takashi Umemura, Mayumi Ishizuka
    • Organizer
      SOT 53rd Annual Meeting
    • Place of Presentation
      Phoenix Convention Center, Phoenix, Arizona, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of Interspecies Differences in Phase II Reaction in Nonexperimental Mammalian Species.2014

    • Author(s)
      Yoshinori Ikenaka, Aksorn Saengtienchai, Mayumi Ishizuka
    • Organizer
      SOT 53rd Annual Meeting
    • Place of Presentation
      Phoenix Convention Center, Phoenix, Arizona, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Species difference of warfarin sensitivity among birds can be explained by the two enzymes, cytochrome P450 and vitamin K epoxide reductase.2013

    • Author(s)
      Kensuke P. Watanabe, Yusuke K. Kawai, Minami Kawata, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka,
    • Organizer
      10th International ISSX
    • Place of Presentation
      Westin Harbour Castle Hotel, Toronto, Ontario, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vitroにおけるウマのジアゼパム代謝2013

    • Author(s)
      速水秋、Wageh Sobhy Darwish、池中良徳、中山翔太、石塚真由美
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学、岐阜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lead and cadmium pollution in soil and edible tissues of cattle and chickens from townships near a lead-zinc mine in Kabwe, Zambia2013

    • Author(s)
      Shouta M.M. Nakayama, John Yabe, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, Takashi Umemura, Mayumi Ishizuka,
    • Organizer
      5th International Toxicology Symposium in Africa
    • Place of Presentation
      Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Regulatory effects of carotenoids on Aryl hydrocarbon receptor (AhR) gene battery,2013

    • Author(s)
      Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Mayumi Ishizuka,
    • Organizer
      The 40th Annual Meeting of the Japanese Society of Toxicology
    • Place of Presentation
      akuhari Messe International Convention Complex, Chiba, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] ガーナの金鉱山周辺(オブアシ自治区)におけるヒ素汚染と陸生哺乳類への毒性影響評価2013

    • Author(s)
      大谷豪、池中良徳、中山翔太、Osei Akoto、Joseph Apau、Elvis Baidoo、石塚真由美
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京農工大学、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 鳥類CYP遺伝子の網羅的同定・分類と、ニワトリの異物代謝で重要なシトクロムP450分子種の特定2013

    • Author(s)
      渡邉研右、川合佑典、河田みなみ、池中良徳、石塚真由美
    • Organizer
      P450とUGT/SULT研究会
    • Place of Presentation
      フェニックス・シーガイア・リゾート、宮崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characteristics of phase II metabolism reaction in pig: Clear sulfation and sulfotransferase activity observed in pyrene2013

    • Author(s)
      Aksorn Saengtienchai, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yusuke Kawai, Mayumi Ishizuka
    • Organizer
      The 155th Meeting of the Japanese Society of Veterinary Science
    • Place of Presentation
      東京大学、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] アフリカ諸国の環境汚染の現状と共同研究の取り組み2013

    • Author(s)
      石塚真由美
    • Organizer
      日本学術会議北海道地区会議主催学術講演会
    • Place of Presentation
      北海道大学、札幌
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Predicting toxicological effects on Ostrich using high-throughput sequencing data,2012

    • Author(s)
      Yusuke Kawai, Kensuke Watanabe, Akihiro Ishii, Minami Kawata, Hirofumi Sawa, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      SETAC Asia/Pacific Annual Meeting
    • Place of Presentation
      ANA New Sky Hotel, Kumamoto
    • Related Report
      2012 Annual Research Report
  • [Presentation] Interspecies difference of phase II reaction in mammals; determination of pyrene metabolites from the urine of various mammalian species2012

    • Author(s)
      Aksorn Saengtienchai, Yoshinori Ikenaka, Yusuke Kawai, Toshio Tsubota, Mayumi Ishizuka
    • Organizer
      SETAC Asia/Pacific Annual Meeting
    • Place of Presentation
      ANA New Sky Hotel, Kumamoto
    • Related Report
      2012 Annual Research Report
  • [Presentation] 鳥類における薬物代謝の特徴:ピレンをモデル化合物として2012

    • Author(s)
      河田みなみ、池中良徳、渡邉研右、Aksorn Saengtienchai、大野円実、石塚真由美
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学、盛岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] アフリカ諸国における化学物質汚染:金属およびメタロイド汚染を中心に2012

    • Author(s)
      石塚真由美
    • Organizer
      第59回トキシンシンポジウム
    • Place of Presentation
      とかちプラザ,帯広市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ダチョウ肝臓に発現する異物代謝酵素の配列解析2012

    • Author(s)
      18.川合佑典, 渡邉研右, 石井秋宏,  大沼愛子, 澤洋文, 池中良徳, 石塚真由美
    • Organizer
      日本進化学会
    • Place of Presentation
      首都大学、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] The identification of the important CYP isoforms in avian xenobiotics metabolism and its species difference among bird species2012

    • Author(s)
      Kensuke WATANABE, Minami KAWATA, Yusuke KAWAI, Yoshinori IKENAKA, Mayumi ISIZUKA
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      Sendai International center, Sendai
    • Related Report
      2012 Annual Research Report
  • [Presentation] 鳥類における薬物代謝の特徴:ピレンをモデル化合物として2012

    • Author(s)
      池中良徳、Aksorn Saengtienchai、川合佑典、石塚真由美
    • Organizer
      第21回環境化学討論会
    • Place of Presentation
      愛媛県県民文化会館、松山市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of Chicken CYP1-4: mRNA Expressions and Genomic Analysis2012

    • Author(s)
      Kensuke P. Watanabe, Minami KAWATA, Yusuke KAWAI, Yoshinori IKENAKA, Mayumi ISHIZUKA
    • Organizer
      11th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
    • Place of Presentation
      University of Torino, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] 鳥類異物代謝における重要なCYP分子種の特定とその種差の解明2012

    • Author(s)
      渡邉研右、河田みなみ、川合佑典、池中良徳、石塚真由美
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台国際センター、仙台市
    • Related Report
      2012 Annual Research Report
  • [Remarks] 北海道大学大学院獣医学研究科毒性学教室

    • URL

      http://tox.vetmed.hokudai.ac.jp/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 毒性学教室

    • URL

      http://tox.vetmed.hokudai.ac.jp/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2019-07-29  

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