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Elucidation of structural basis of glycoconjugate functions and its application for molecular design toward developing drugs targeting the carbohydrate recognition systems

Research Project

Project/Area Number 24249002
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionOkazaki Research Facilities, National Institutes of Natural Sciences (2013-2014)
Nagoya City University (2012)

Principal Investigator

KATO Koichi  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (20211849)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Takumi  分子科学研究所, 生命・錯体分子科学研究領域, 助教 (60522430)
YAGI Hirokazu  名古屋市立大学, 薬学研究科(研究院), 講師 (70565423)
SATOH Tadashi  名古屋市立大学, 薬学研究科(研究院), 准教授 (80532100)
矢木 真穂  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), その他部局等, 助教 (40608999)
Co-Investigator(Renkei-kenkyūsha) YAGI Maho (UTSUMI Maho)  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 特任助教 (40608999)
Project Period (FY) 2012-10-31 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2014: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2013: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2012: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Keywords構造生物学 / 糖鎖認識 / 細胞内レクチン / 免疫グロブリンG
Outline of Final Research Achievements

In this research project, we have elucidated the glycan-mediated mechanisms of biological functions through structural analyses of molecular complexes and thereby provided the groundwork for developing drugs targeting the carbohydrate recognition systems. In particular, we have revealed molecular mechanisms underlying the selective trafficking and degradation in glycoprotein-fate determination in cells. Furthermore, we have established technical basis for structural analyses of antibodies and thereby obtained solution structure information of these glycoproteins produced in various production vehicles, providing valuable insights into development of antibody drugs.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (130 results)

All 2015 2014 2013 2012 Other

All Journal Article (24 results) (of which Peer Reviewed: 24 results,  Open Access: 7 results,  Acknowledgement Compliant: 11 results) Presentation (102 results) (of which Invited: 51 results) Book (2 results) Remarks (2 results)

  • [Journal Article] 糖鎖構造学研究の新展開2015

    • Author(s)
      加藤晃一
    • Journal Title

      BIOTOVO

      Volume: 23 Pages: 2-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emerging structural insights into glycoprotein quality control coupled with N-glycan processing in the endoplasmic reticulum2015

    • Author(s)
      T.Satoh, T.Yamaguchi, and K.Kato
    • Journal Title

      Molecules

      Volume: 20 Issue: 2 Pages: 2475-2491

    • DOI

      10.3390/molecules20022475

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Depicting the Dynamic Conformations of Sugar Chains2015

    • Author(s)
      山口拓実, 加藤晃一
    • Journal Title

      Seibutsu Butsuri

      Volume: 55 Issue: 2 Pages: 081-083

    • DOI

      10.2142/biophys.55.081

    • NAID

      130005061222

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Backbone 1H, 13C, and 15N resonance assignments of the Fc fragment of human immunoglobulin G glycoprotein2015

    • Author(s)
      H.Yagi, Y.Zhang, M.Yagi-Utsumi, T.Yamaguchi, S.Iida, Y.Yamaguchi, and K.Kato
    • Journal Title

      Biomol. NMR Assign.

      Volume: - Issue: 2 Pages: 383-6

    • DOI

      10.1007/s12104-014-9586-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] NMR-based structural validation of therapeutic antibody produced in Nicotiana benthamiana2015

    • Author(s)
      H.Yagi, N.Fukuzawa, Y.Tasaka, K.Matsuo, Y.Zhang, T.Yamaguchi, S.Kondo, S.Nakazawa, N.Hashii, N.Kawasaki, T.Matsumura, and K.Kato
    • Journal Title

      Plant Cell Rep.

      Volume: - Issue: 6 Pages: 959-968

    • DOI

      10.1007/s00299-015-1757-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stable isotope labeling of glycoprotein expressed in silkworms using immunoglobulin G as a test molecule2015

    • Author(s)
      H.Yagi, M.Nakamura, J.Yokoyama, Y.Zhang, T.Yamaguchi, S.Kondo, J.Kobayashi, T.Kato, E.Y.Park, S.Nakazawa, N.Hashii, N.Kawasaki, and K.Kato
    • Journal Title

      J. Biomol. NMR

      Volume: - Issue: 2 Pages: 157-167

    • DOI

      10.1007/s10858-015-9930-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 糖鎖依存的構造異常タンパク質分解に必須な糖鎖刈り込み機構を解明2015

    • Author(s)
      蜷川 暁, 加藤晃一, 森 和俊
    • Journal Title

      化学と生物

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glycan structure and serum half-life of recombinant CTLA4Ig, an immunosuppressive agent, expressed in suspension-cultured rice cells with coexpression of human β1,4-galactosyltransferase and human CTLA4Ig2015

    • Author(s)
      S.H.Kang, H.S.Jung, S.J.Lee1, C.I.Park, S.M.Lim, H.Park, B.S.Kim, K.H.Na, G.J.Han, J.W.Bae, H.J.Park, K.C.Bang, B.T.Park, H.S.Hwang, I.-Soo .Jung, J.I.Kim, D.B.Oh, D.I.Kim, H.Yagi, K.Kato, D.K.Kim, and H.H.Kim
    • Journal Title

      Glycoconjugate J.

      Volume: - Issue: 3-4 Pages: 161-172

    • DOI

      10.1007/s10719-015-9590-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.2014

    • Author(s)
      Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K
    • Journal Title

      J Cell Biol.

      Volume: 206 Issue: 3 Pages: 347-356

    • DOI

      10.1083/jcb.201404075

    • NAID

      120005468381

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Site-specific classification of N-linked oligosaccharides of the extracellular regions of Fcγ receptor IIIb expressed in baby hamster kidney cells2014

    • Author(s)
      N.Kawasaki, T.Okumoto, Y.Yamaguchi, N.Takahashi, W.H.Fridman, C.Sautes-Fridman, H.Yagi, and K.Kato
    • Journal Title

      J. Glycomics Lipidomics

      Volume: 4 Issue: 02 Pages: 116-116

    • DOI

      10.4172/2153-0637.1000116

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exploration of conformational spaces of high-mannose-type oligosaccharides by an NMR-validated simulation2014

    • Author(s)
      T.Yamaguchi, Y.Sakae, Y.Zhang, S.Yamamoto, Y.Okamoto, and K.Kato
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 53 Issue: 41 Pages: 10941-10944

    • DOI

      10.1002/ange.201406145

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural insight into substrate recognition by the endoplasmic reticulum folding-sensor enzyme: crystal structure of third thioredoxin-like domain of UDP-glucose:glycoprotein glucosyltransferase2014

    • Author(s)
      T.Zhu, T.Satoh, and K.Kato
    • Journal Title

      Sci. Rep.

      Volume: 4 Issue: 1 Pages: 7322-7322

    • DOI

      10.1038/srep07322

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recent advances in glycoprotein production for structural biology: toward tailored design of glycoforms2014

    • Author(s)
      Y.Kamiya, T.Satoh, and K.Kato
    • Journal Title

      Curr. Opin. Struct. Biol.

      Volume: 26 Pages: 44-53

    • DOI

      10.1016/j.sbi.2014.03.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 糖鎖構造生物学の最前線2014

    • Author(s)
      矢木宏和, 矢木-内海真穂, 加藤晃一
    • Journal Title

      ファルマシア

      Volume: 50 Pages: 746-750

    • NAID

      130005246009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for disparate sugar-binding specificities in the homologous cargo receptors ERGIC-53 and VIP362014

    • Author(s)
      Tadashi Satoh, Kousuke Suzuki, Takumi Yamaguchi, and Koichi Kato
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 2 Pages: e87963-e87963

    • DOI

      10.1371/journal.pone.0087963

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erol-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases2013

    • Author(s)
      Kazutaka Araki, Shun-ichiro Iemura, Yukiko Kamiya, David Ron, Koichi Kato, Tohru Natsume, and Kazuhiro Nagata
    • Journal Title

      The Journal of Cell Biology

      Volume: 6 Issue: 6 Pages: 861-874

    • DOI

      10.1083/jcb.201303027

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein.2013

    • Author(s)
      Horimoto S, Ninagawa S, Okada T, Koba H, Sugimoto T, Kamiya Y, Kato K, Takeda S, Mori K
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 44 Pages: 31517-31527

    • DOI

      10.1074/jbc.m113.476010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.2013

    • Author(s)
      Yagi H, Nakagawa N, Saito T, Kiyonari H, Abe T, Toda T, Wu SW, Khoo KH, Oka S, Kato K.
    • Journal Title

      Sci Rep

      Volume: 3 Issue: 1 Pages: 3288-3288

    • DOI

      10.1038/srep03288

    • NAID

      120005353504

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New NMR tools for characterizing the dynamic conformations and interactions of oligosaccharides2013

    • Author(s)
      Ying Zhang, Takumi Yamaguchi, and Koichi Kato
    • Journal Title

      Chem. Lett.

      Volume: 42 Issue: 12 Pages: 1455-1462

    • DOI

      10.1246/cl.130789

    • NAID

      130004867848

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経幹細胞の幹細胞性維持における複合糖質の役割2013

    • Author(s)
      矢木宏和,加藤晃一
    • Journal Title

      生化学

      Volume: 85 Pages: 1012-1016

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IgG-FcとFc受容体の複合体形成における糖鎖の役割2013

    • Author(s)
      矢木宏和,加藤晃一
    • Journal Title

      実験医学

      Volume: 31 Pages: 1602-1606

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of metabolic ^<13>C labeling in conjunction with high-field nuclear magnetic resonance spectroscopy for comparative conformational analysis of high mannose-type oligosaccharides.2013

    • Author(s)
      Y.Kamiya, K.Yanagi, T.Kitajima, T.Yamaguchi, Y.Chiba, and K.Kato
    • Journal Title

      Biomolecules

      Volume: 3 Issue: 1 Pages: 108-123

    • DOI

      10.3390/biom3010108

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant2013

    • Author(s)
      Fujimori T, Kamiya Y, Nagata K, Kato K, Hosokawa N*
    • Journal Title

      FEBS J

      Volume: Vol. 280 Issue: 6 Pages: 1563-1575

    • DOI

      10.1111/febs.12157

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Terminal spin labeling of a high-mannose-type oligosaccharide for quantitative NMR analysis of its dynamic conformation2013

    • Author(s)
      Takumi Yamaguchi
    • Journal Title

      Chem. Lett.

      Volume: 42 Issue: 5 Pages: 544-546

    • DOI

      10.1246/cl.130040

    • NAID

      10031167819

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] NMR解析に基づく分子シミュレーションによる高マンノース型糖鎖の動的立体構造の解明2015

    • Author(s)
      山口拓実, 榮 慶丈, 岡本祐幸, 加藤晃一
    • Organizer
      日本化学会 第95春季年会
    • Place of Presentation
      日本大学(千葉県船橋市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 複合糖質の構造生物学と創薬2015

    • Author(s)
      加藤晃一
    • Organizer
      第4回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
    • Place of Presentation
      岐阜薬科大学(岐阜県岐阜市)
    • Year and Date
      2015-03-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Conformational dynamics and interactions of oligosaccharides and glycoconjugate2015

    • Author(s)
      Koichi Kato
    • Organizer
      第4回よこはまNMR研究会
    • Place of Presentation
      理化学研究所・横浜研究所交流棟ホール(神奈川県横浜市)
    • Year and Date
      2015-02-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structural basis for sugar trimming reactions by glucosidase II involved glycoprotein quality control system2015

    • Author(s)
      T. Satoh, T. Toshimori, T. Zhu, G. Yan, T. Yamaguchi, and K. Kato
    • Organizer
      The 5th Yonsei-IMS Joint Workshop: “Multilateral approaches for investigating biomolecular structures and functions”
    • Place of Presentation
      箱根高原ホテル(神奈川県足柄郡)
    • Year and Date
      2015-01-30 – 2015-02-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural aspects of glycoprotein folding sensor enzyme (UGGT): A combined X-ray crystallography and small angle X-ray scattering study2015

    • Author(s)
      T. Zhu, T. Satoh, H. Kamikubo, and K. Kato
    • Organizer
      The 5th Yonsei-IMS Joint Workshop: “Multilateral approaches for investigating biomolecular structures and functions
    • Place of Presentation
      箱根高原ホテル(神奈川県足柄郡)
    • Year and Date
      2015-01-30 – 2015-02-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Elucidation of conformational dynamics of oligosaccharides by NMR spectroscopy and molecular dynamics simulation2015

    • Author(s)
      T. Yamaguchi, Y. Zhang, and K. Kato
    • Organizer
      The 5th Yonsei-IMS Joint Workshop: “Multilateral approaches for investigating biomolecular structures and functions
    • Place of Presentation
      箱根高原ホテル(神奈川県足柄郡)
    • Year and Date
      2015-01-30 – 2015-02-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural views of glycans in physiological and pathological contexts2015

    • Author(s)
      Koichi Kato
    • Organizer
      CU-IMS workshop
    • Place of Presentation
      Bangkok、Thailand
    • Year and Date
      2015-01-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NMRを利用した抗体の高次構造解析2015

    • Author(s)
      加藤晃一
    • Organizer
      平成26年度先駆的医薬品・医療機器研究発掘支援事業成果発表会-彩都産学官連携フォーラム2015-
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Year and Date
      2015-01-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structural insight into the ER folding sensor enzyme UDP-glucose: glycoprotein glucosyltransferase (UGGT)2015

    • Author(s)
      T. Zhu, T. Satoh, H. Kamikubo, and K. Kato
    • Organizer
      The 3rd International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
    • Place of Presentation
      合歓の里(三重県志摩市)
    • Year and Date
      2015-01-10 – 2015-01-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Elucidation of the molecular basis of oligosaccharide functions by NMR spectroscopy and molecular dynamics simulation2015

    • Author(s)
      T. Yamaguchi, Y. Sakae, M. Yagi-Utsumi, Y. Zhang, S. Yamamoto, Y. Okamoto, and K. Kato
    • Organizer
      The 3rd International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
    • Place of Presentation
      合歓の里(三重県志摩市)
    • Year and Date
      2015-01-10 – 2015-01-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural basis for recognition of the terminal glucose tag of N-glycans as fate-determinant of glycoproteins in cells2014

    • Author(s)
      T. Satoh, T. Toshimori, K. Suzuki, T. Yamaguchi, G. Yan, T. Zhu and K. Kato
    • Organizer
      The 7th Korea-Japan Seminars on Biomolecular Sciences: Experiments and Simulations
    • Place of Presentation
      Seoul、Korea
    • Year and Date
      2014-11-26 – 2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] EDEM1/2/3 areα1,2-mannosidases essential for endoplasmic reticulum-associated degradation of glycoproteins2014

    • Author(s)
      Satoshi Ninagawa, Tetsuya Okada, Yoshiki Sumitomo, Yukiko Kamiya, Satoshi Horimoto, Tokiro Ishikawa, Shunichi Takeda, Tetsushi Sakuma, Takashi Yamamoto, Koichi Kato and Kazutoshi Mori
    • Organizer
      Sarellite Symposium II “Glycans in Neuroscience”
    • Place of Presentation
      Honolulu、U.S.A.
    • Year and Date
      2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] NMRを利用した抗体の高次構造バリデーション2014

    • Author(s)
      矢木宏和
    • Organizer
      第5回グライコバイオロジクス研究会
    • Place of Presentation
      臨床研究情報センター(兵庫県神戸市)
    • Year and Date
      2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] X線とNMRによる抗体の構造解析2014

    • Author(s)
      加藤晃一
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] タンパク質機能の制御に関わるN型糖鎖構造の多様性と多型性2014

    • Author(s)
      加藤晃一
    • Organizer
      第87回 日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 古くて新しい小胞体の糖鎖生物学2014

    • Author(s)
      佐藤匡史
    • Organizer
      第87回 日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 小胞体糖タンパク質品質管理に関わるグルコシダーゼIIの基質認識機構2014

    • Author(s)
      年森隆泰,佐藤匡史,Gengwei Yan,山口拓実,Tong Zhu,加藤晃一
    • Organizer
      第1回「動的秩序と機能」若手研究会
    • Place of Presentation
      ラフォーレ蔵王(宮城県刈田郡)
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Crystal structure of third thioredoxin-like domain of ER folding sensor glucosyltransferase2014

    • Author(s)
      Tong Zhu, Tadashi Satoh, Koichi Kato
    • Organizer
      第1回「動的秩序と機能」若手研究会
    • Place of Presentation
      ラフォーレ蔵王(宮城県刈田郡)
    • Year and Date
      2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖タンパク質品質管理システムにおける糖鎖修飾メカニズムの構造基盤Structural basis for the glycan-processing mechanisms in glycoprotein quality control system2014

    • Author(s)
      佐藤匡史,加藤晃一
    • Organizer
      第52回 日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NMR exploration of dynamic conformations and interactions of oligosaccharides and glycoconjugates2014

    • Author(s)
      Koichi Kato
    • Organizer
      The 6th Iberoamerican NMR meeting // IV Iberian NMR meeting //VII Reunion Bienal del GERMN
    • Place of Presentation
      Alcala de Henares、Spain
    • Year and Date
      2014-09-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structural basis for fate determination and functional regulation of proteins mediated by sugar chains2014

    • Author(s)
      Koichi Kato
    • Organizer
      The Cordeliers Research Center Seminar
    • Place of Presentation
      Paris、France
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structural views of physiological and pathological roles of glycans2014

    • Author(s)
      K. Kato
    • Organizer
      Academia Sinica Institutional Lecture
    • Place of Presentation
      Taipei 、Taiwan
    • Year and Date
      2014-09-10 – 2014-09-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Exploration of conformational dynamics of oligosaccharides by stable isotope- and lanthanide- assisted NMR approaches2014

    • Author(s)
      Takumi Yamaguchi, Ying Zhang, Yukiko Kamiya, Sayoko Yamamoto, and Koichi Kato
    • Organizer
      XXVIth International Council on Magnetic Resonance in Biological Systems (ICMRBS)
    • Place of Presentation
      Dallas、U.S.A.
    • Year and Date
      2014-08-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小胞体で新生タンパク質に付加されたN型糖鎖からのマンノーストリミングはEDEM2によって開始される2014

    • Author(s)
      蜷川 暁,岡田徹也,住友嘉樹,神谷由紀子,堀本 賢,石川時郎,武田俊一,佐久間哲史,山本 卓,加藤晃一,森 和俊
    • Organizer
      第33回 日本糖質学会年会
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2014-08-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小胞体グルコシダーゼIIの基質認識メカニズムの構造基盤2014

    • Author(s)
      年森隆泰,佐藤匡史,Gengwei Yan,山口拓実,Tong Zhu,加藤晃一
    • Organizer
      第33回 日本糖質学会年会
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2014-08-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural basis for substrate recognition mechanism of ER glucosidase II2014

    • Author(s)
      Tadashi Satoh, Takayasu Toshimori, Takumi Yamaguchi, Zhu Tong, and Koichi Kato
    • Organizer
      23rd Congress and General Assembly of the International Union of Crystallography
    • Place of Presentation
      Montreal、Canada
    • Year and Date
      2014-08-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖タンパク質の細胞内プロセッシングに関わるグルコシダーゼⅡの基質認識メカニズム2014

    • Author(s)
      年森隆泰,佐藤匡史,Gengwei Yan,山口拓実,Tong Zhu,加藤晃一
    • Organizer
      第12回 次世代を担う若手のためのフィジカル・ファーマフォーラム
    • Place of Presentation
      箱根高原ホテル(神奈川県足柄郡)
    • Year and Date
      2014-07-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小胞体品質管理システムに関わるグルコシダーゼIIの基質認識機構Substrate recognition mechanism of glucosidase II involved in ER quality control system2014

    • Author(s)
      佐藤 匡史,年森 隆泰,山口 拓実,Zhu Tong,加藤 晃一
    • Organizer
      第14回 日本蛋白質科学会年会
    • Place of Presentation
      ワークピア横浜(神奈川県横浜市)
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 揺らめく糖鎖のかたちとはたらき2014

    • Author(s)
      山口拓実
    • Organizer
      「宇宙・生命・脳・物質・エネルギー」若手研究者による Rising SunⅢ自然科学研究機構若手研究者賞記念講演
    • Place of Presentation
      日本科学未来館(東京都江東区)
    • Year and Date
      2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小胞体でのN型糖鎖マンノースのトリミングはEDEM2によって開始される2014

    • Author(s)
      蜷川 暁
    • Organizer
      平成26年度 比較グライコーム研究会
    • Place of Presentation
      名古屋市立大学(愛知県名古屋市)
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] カーゴレセプターERGIC-53/MCFD2複合体による糖タンパク質認識メカニズムの構造基盤2014

    • Author(s)
      鈴木康介,佐藤匡史,山口拓実,西尾美穂,神谷由紀子,矢木真穂,加藤晃一
    • Organizer
      第78回 日本生化学会中部支部例会
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖タンパク質品質管理に関わるグルコシダーゼIIの基質認識メカニズムの構造基盤2014

    • Author(s)
      年森隆泰,佐藤匡史,Genwei Yan,山口拓実,Zhu Tong,加藤晃一
    • Organizer
      第78回 日本生化学会中部支部例会
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural views of glycosylation as potential drug target2014

    • Author(s)
      Koichi Kato
    • Organizer
      The 4th Asia Pacific Protein Association (APPA) Conference
    • Place of Presentation
      Jeju、Korea
    • Year and Date
      2014-05-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structural insights into substrate recognition mechanism of glycoprotein processing enzyme ER glucosidase II2014

    • Author(s)
      Tadashi Satoh, Takayasu Toshimori, Takumi Yamaguchi, Tong Zhu, and Koichi Kato
    • Organizer
      The 4th Asia Pacific Protein Association (APPA) Conference
    • Place of Presentation
      Jeju、Korea
    • Year and Date
      2014-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 創薬と生命分子構造学2014

    • Author(s)
      加藤晃一
    • Organizer
      名古屋市立大学見学模擬授業
    • Place of Presentation
      名古屋市立大学(愛知県名古屋市)
    • Year and Date
      2014-05-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NMR spectroscopic approaches to the conformational dynamics of oligosaccharides by paramagnetic tagging2012

    • Author(s)
      Takumi Yamaguchi
    • Organizer
      ISBC2012
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] NMRを用いた生体分子のダイナミクスの解析

    • Author(s)
      加藤晃一
    • Organizer
      大阪市立大学分子ナノ情報解析センターユーザーズミーティング
    • Place of Presentation
      大阪市立大学学術情報総合センター(大阪府)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生命分子のダイナミクスと自己組織化

    • Author(s)
      加藤晃一
    • Organizer
      国際高等研究所研究プロジェクト 「分子基盤に基づく生体機能への揺らぎとダイナミックネットワークの解明」第1回研究会
    • Place of Presentation
      国際高等研究所(京都府)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Structural glycobiology for biophysical decoding sweet messages

    • Author(s)
      Koichi Kato
    • Organizer
      8th Asian Biophysics Association Symposium (ABA Jeju 2013)
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Paramagnetic NMR approaches for revealing conformational dynamics of oligosaccharides

    • Author(s)
      Takumi Yamaguchi, Ying Zhang, and Koichi Kato
    • Organizer
      8th Asian Biophysics Association Symposium (ABA Jeju 2013)
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Recombinant expression of an ER folding sensor UDP-glucose:glycoprotein glucosyltransferase

    • Author(s)
      Tong Zhu, Maho Yagi-Utsumi, Hirokazu Yagi, Tadashi Satoh, and Koichi Kato
    • Organizer
      Korea and Japan joint symposium (Structural and functional studies on biomolecules)
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] 異なる生物基材で発現させた抗体の糖鎖プロファイリング

    • Author(s)
      矢木宏和
    • Organizer
      平成25年度 比較グライコーム研究会
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] NMR analyses of conformational dynamics and interactions of oligosaccharides by employing paramagnetic probes

    • Author(s)
      Ying Zhang, Takumi Yamaguchi, Sayoko Yamamoto, Yoshinori Uekusa, Maho Yagi-Utsumi, and Koichi Kato
    • Organizer
      The 22nd International Glycoconjugate Symposium (GLYCO 22)
    • Place of Presentation
      Dalian, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] ERGIC-53/MCFD2 複合体による糖鎖認識の構造基盤

    • Author(s)
      佐藤匡史,鈴木康介,西尾美穂,神谷由紀子,矢木真穂,水島恒裕,加藤晃一
    • Organizer
      第59回 日本薬学会東海支部会
    • Place of Presentation
      名城大学(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 安定同位体標識と常磁性プローブ導入による高マンノース型糖鎖のNMR動的構造解析

    • Author(s)
      山口拓実,Zhang Ying,王 進政,喜多島敏彦,千葉靖典,戸谷希一郎,神谷由紀子,加藤晃一
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター(大阪府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 積荷受容体ERGIC-53/MCFD2による糖鎖認識の構造基盤

    • Author(s)
      佐藤匡史,鈴木康介,西尾美穂,神谷由紀子,矢木真穂,水島恒裕,加藤晃一
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター(大阪府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 立体構造からみた糖鎖の不均一性

    • Author(s)
      加藤晃一
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪国際交流センター(大阪府)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NMRを用いた糖鎖のコンフォメーション揺らぎとクラスター特性の解析

    • Author(s)
      山口拓実,加藤晃一
    • Organizer
      国際高等研研究プロジェクト「分子基盤に基づく生体機能ネットワークと ダイナミクスの解明」第2回研究会
    • Place of Presentation
      国際高等研究所(京都府)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NMRを用いた生命分子のダイナミクス解析

    • Author(s)
      加藤晃一
    • Organizer
      第2回 立命館大学BKC生体分子ネットワークセミナー
    • Place of Presentation
      立命館大学(滋賀県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Atomic anatomy of antibody as glycoprotein

    • Author(s)
      Koichi Kato
    • Organizer
      World Biopharma Week China Focus 2013
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Paramagnetism-assisted NMR for atomic description of dynamic oligosaccharides

    • Author(s)
      Ying Zhang, Takumi Yamaguchi, Sayoko Yamamoto, and Koichi Kato
    • Organizer
      糖鎖科学中部拠点 第11回若手の力フォーラム
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bacterial expression and EM analysis of UDP-glucose glycosyltransferase from a thermophilic fungus

    • Author(s)
      Tong Zhu, Kazuyoshi Murata, Takahasu Toshimori, Maho Yagi-Utsumi, Tadashi Sato, and Koichi Kato
    • Organizer
      糖鎖科学中部拠点 第11回若手の力フォーラム
    • Place of Presentation
      名古屋市立大学(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] バイオ医薬品の構造をみる

    • Author(s)
      加藤晃一
    • Organizer
      第22回日本バイオイメージング学会学術集会
    • Place of Presentation
      東京大学薬学部講堂(東京都文京区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 糖鎖が担う タンパク質社会の秩序維持

    • Author(s)
      加藤晃一
    • Organizer
      市民公開講座・第99回分子科学フォーラム
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ランタニドイオンを活用した常磁性NMR法による糖鎖の動的構造解析

    • Author(s)
      山口拓実,Zhang Ying,王 進政,戸谷希一郎,榮 慶丈,岡本祐幸,神谷由紀子,加藤 晃一
    • Organizer
      第7回バイオ関連化学シンポジウム
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 常磁性効果を活用した糖鎖の立体構造解析-NMRと分子動力学計算によるコンフォメーション空間の探査-

    • Author(s)
      山口拓実
    • Organizer
      日本分光学会NMR分光部会
    • Place of Presentation
      名古屋大学理学研究科付属構造生物学研究センター(愛知県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 多次元HPLC法およびNMR法による糖鎖解析技術

    • Author(s)
      加藤晃一
    • Organizer
      抗体バイオ分析セミナー-抗体/バイオ医薬品における各種分析手法および解析手法-
    • Place of Presentation
      ゆうぽうと(東京都品川区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NMR characterization of dynamic conformational ensembles of oligosaccharides and intermolecular interactions in glycolipid clusters

    • Author(s)
      Koichi Kato
    • Organizer
      5th Asia-Pacific NMR Symposium in conjunction with ANZMAG 2013
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 糖鎖の機能解明を目指したNMRアプローチ

    • Author(s)
      加藤晃一
    • Organizer
      第52回NMR討論会
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] EM tomography analysis of ER folding sensor enzyme UDP-glucose: glycoprotein glucosyltransferase

    • Author(s)
      Tong Zhu, Kazuyoshi Murata, Takayasu Toshimori, Takumi Yamaguchi, Maho Yagi-Utsumi, Tadashi Satoh, and Koichi Kato
    • Organizer
      平成25年度 生理学研究所研究会「電子顕微鏡機能イメージングの医学・生物学への応用」
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖鎖を見る:分子模型からムービーへ

    • Author(s)
      加藤晃一
    • Organizer
      平成25年度 生理学研究所研究会「構造の多様性に立脚した糖鎖機能の解明に向けて」
    • Place of Presentation
      生理学研究所(愛知県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Overall structure of ER folding sensor UDP-glucose: glycoprotein glucosyltransferase revealed by EM tomography

    • Author(s)
      Tong Zhu, Kazuyoshi Murata, Takayasu Toshimori, Takumi Yamaguchi, Maho Yagi-Utsumi, Tadashi Satoh, and Koichi Kato
    • Organizer
      山田研究会・統合バイオサイエンスシンポジウム
    • Place of Presentation
      伊良湖ビューホテル(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] タンパク質社会の秩序維持における糖鎖の役割

    • Author(s)
      加藤晃一
    • Organizer
      お茶の水女子大学 糖鎖科学教育研究センター 第6回 公開シンポジウム
    • Place of Presentation
      お茶の水女子大学(東京都文京区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Paramagnetism-assisted NMR evaluation of molecular dynamics simulations for conformational characterization of oligosaccharides

    • Author(s)
      Takumi Yamaguchi, Ying Zhang, Yukiko Kamiya, Yoshitake Sakae, Yuko Okamoto, and Koichi Kato
    • Organizer
      6th Japan-Korea Seminars on Biomolecular Science : Experiments and Simulation
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Position selective 13C labeling of multi-antennary oligosaccharides for NMR analysis

    • Author(s)
      Panuwat Padungros, Takumi Yamaguchi, and Koichi Kato
    • Organizer
      SOKENDAI Asian Winter School "Innovations and Challenges in Molecular Science: From Basics to Cutting-edge Researches”
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 核磁気共鳴法による糖鎖の3次元構造ダイナミクスの解明

    • Author(s)
      山口拓実
    • Organizer
      第 2 回 NINS Colloquium
    • Place of Presentation
      ヤマハリゾートつま恋(静岡県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structural biology of glycoconjugates: sugar chains as therapeutic targets

    • Author(s)
      Koichi Kato
    • Organizer
      Yonsei-IMS Seminars on Biomolecular Sciences : Protein Structure and Diseases
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Structural basis for disparate sugar-binding specificities in the homologous cargo receptors ERGIC-53 and VIP36

    • Author(s)
      Tadashi Satoh, Kosuke Suzuki, Takumi Yamaguchi, and Koichi Kato
    • Organizer
      Yonsei-IMS Seminars on Biomolecular Sciences : Protein Structure and Diseases
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Elucidation of the conformational dynamics of oligosaccharides by using paramagnetism-assisted NMR spectroscopy

    • Author(s)
      Ying Zhang, Takumi Yamaguchi, Sayoko Yamamoto, and Koichi Kato
    • Organizer
      Yonsei-IMS Seminars on Biomolecular Sciences : Protein Structure and Diseases
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] The structural biology study on ER folding sensor UDP-glucose:glycoprotein glucosyltransferase (UGGT)

    • Author(s)
      Tong Zhu, Kazuyoshi Murata, Takayasu Toshimori, Takumi Yamaguchi, Maho Yagi-Utsumi, Tadashi Satoh, and Koichi Kato
    • Organizer
      Yonsei-IMS Seminars on Biomolecular Sciences : Protein Structure and Diseases
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Conformational dynamics of oligosaccharides characterized by paramagnetism-assisted NMR spectroscopy in conjunction with molecular dynamics simulation

    • Author(s)
      Koichi Kato
    • Organizer
      The 10th International Symposium on Biochemical roles of Eukaryotic Cell Surface Macromolecules
    • Place of Presentation
      Kolkata, India
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NMR approaches for elucidating the functional roles of carbohydrate chains

    • Author(s)
      Koichi Kato
    • Organizer
      20th Symposium of National Magnetic Resonance Society (NMRS-2014)
    • Place of Presentation
      Assam, India
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生命分子の揺らぎと秩序形成

    • Author(s)
      加藤晃一
    • Organizer
      日本学術振興会 分子系の複合電子機能第181委員会
    • Place of Presentation
      国際高等研究所(京都府)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 超高磁場NMR分光法を中心としたタンパク質の高次構造・相互作用解析

    • Author(s)
      加藤晃一
    • Organizer
      第2回 ISITナノ・バイオフォーラム
    • Place of Presentation
      福岡市産学連携交流センター(福岡県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小胞体品質管理に関わるグルコシダーゼIIの基質認識機構の構造基盤

    • Author(s)
      年森隆泰,佐藤匡史,Zhu Tong,加藤晃一
    • Organizer
      2013年度 生物物理中部支部会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structural-architecture of the ER glycoprotein folding sensor UDP-glucose:glycoprotein glucosyltransferase (UGGT)

    • Author(s)
      Tong Zhu, Tadashi Satoh, Kazuyoshi Murata, Hironari Kamikubo, Takayasu Toshimori, Takumi Yamaguchi, Maho Yagi-Utsumi, and Koichi Kato
    • Organizer
      2013年度 生物物理中部支部会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] NMRを応用した糖鎖の動的構造解析

    • Author(s)
      加藤晃一
    • Organizer
      よこはまNMR構造生物学研究会 第49回ワークショップ
    • Place of Presentation
      理化学研究所横浜研究所交流棟ホール(神奈川県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小胞体糖タンパク質フォールディング装置を構成するタンパク質群の構造生物学研究

    • Author(s)
      佐藤匡史,年森隆泰,Tong Zhu,村田和義,山口拓実,矢木真穂,加藤晃一
    • Organizer
      日本薬学会134年会
    • Place of Presentation
      熊本大学(熊本県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Elucidation of the conformational dynamics of oligosaccharides by paramagnetism-assisted NMR approach

    • Author(s)
      Ying Zhang, Takumi Yamaguchi, Sayoko Yamamoto, Yoshitake Sakae, Yuko Okamoto, and Koichi Kato
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 常磁性効果を応用した糖鎖の動的立体構造解析

    • Author(s)
      山口拓実
    • Organizer
      第51回NMR討論会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] Conformational dynamics and interactions of glycoconjugates of therapeutic interest

    • Author(s)
      Koichi Kato
    • Organizer
      Commemorative Symposium on the 20th Anniversary of the Mizutani Foundation for Glycoscience
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 複合糖質の構造生物学: 創薬標的としての糖鎖

    • Author(s)
      加藤晃一
    • Organizer
      第40回構造活性相関シンポジウム
    • Place of Presentation
      岡崎
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] HPLCによる糖鎖の構造解析およびバリデーションの方法

    • Author(s)
      矢木宏和
    • Organizer
      技術情報協会セミナー「バイオ/抗体医薬品の各種分析手法とバリデーション」
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] High resolution analysis of protein glycosylation

    • Author(s)
      Koichi Kato
    • Organizer
      CASSS CMC Strategy Forum Japan 2012
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 糖タンパク質の運命を決める細胞内レクチンの糖鎖認識メカニズムを“見る”

    • Author(s)
      佐藤匡史
    • Organizer
      糖鎖科学中部拠点「糖鎖科学講義」
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NMR characterization of conformational fluctuations of oligosaccharides and glycoconjugates

    • Author(s)
      Koichi Kato
    • Organizer
      The 6th International Symposium, Molecular Science of Fluctuations toward Biological Functions
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Conformations, dynamics, and interactions of sugar chains as studied by NMR spectroscopy

    • Author(s)
      Yoshinori Uekusa
    • Organizer
      The 6th International Symposium, Molecular Science of Fluctuations toward Biological Functions
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization of conformational dynamics of branched oligosaccharides by using paramagnetic NMR techniques

    • Author(s)
      Ying Zhang
    • Organizer
      9th SOKENDAI Student Seminar (Life Science Retreat 2012)
    • Place of Presentation
      静岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 複合糖質の立体構造・ダイナミクス・相互作用

    • Author(s)
      加藤晃一
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Comparative conformational analysis of high-mannose-type oligosaccharides using high-field NMR spectroscopy combined with 13C-labeling technique

    • Author(s)
      Kotaro Yanagi
    • Organizer
      Sokendai Asian Winter School "Frontiers in Photo-Molecular Science"
    • Place of Presentation
      岡崎
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structural views of carbohydrate-protein interaction systems as potential therapeutic targets

    • Author(s)
      Koichi Kato
    • Organizer
      Kasetsart University Special Seminar
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Paramagnetic lanthanide-tagging for NMR conformational characterization of glycolipids

    • Author(s)
      Takumi Yamaguchi
    • Organizer
      Pure and Applied Chemistry International Conference 2013 (PACCON 2013)
    • Place of Presentation
      Chon Buri, Thailand
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structural views of carbohydrate-protein interaction systems as potential therapeutic targets

    • Author(s)
      Koichi Kato
    • Organizer
      Pure and Applied Chemistry International Conference 2013 (PACCON 2013)
    • Place of Presentation
      Chon Buri, Thailand
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NMR approaches to the molecular basis of oligosaccharide functions

    • Author(s)
      Takumi Yamaguchi
    • Organizer
      2013 Asian Core Winter School
    • Place of Presentation
      Busan, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生命分子複合体の動態解明への実験的アプローチ

    • Author(s)
      加藤晃一
    • Organizer
      京都大学原子炉実験所 粒子線基礎物性研究特別講演会
    • Place of Presentation
      熊取
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Paramagnetic NMR approaches for characterization of conformational dynamics and interactions of oligosaccharides

    • Author(s)
      Zhang Ying
    • Organizer
      日本生物物理学会中部支部講演会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] Conformational dynamics and interactions of oligosaccharides in physiological and pathological contexts

    • Author(s)
      Koichi Kato
    • Organizer
      Fifth Korea-Japan Seminars on Biomolecular Sciences: Experiments and Simulations
    • Place of Presentation
      Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular and structural basis for N-glycan-dependent determination of glycoprotein fates in cells

    • Author(s)
      Koichi Kato
    • Organizer
      Glycobiology Gordon Research Conference
    • Place of Presentation
      Ventura, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NMRとSANSによるタンパク質の動的構造解析

    • Author(s)
      加藤晃一
    • Organizer
      中性子連携研究会
    • Place of Presentation
      品川
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NMRによる糖鎖クラスターのダイナミクスと相互作用の解析

    • Author(s)
      加藤晃一
    • Organizer
      糖鎖集合状態の変化による幹細胞近接場制御についての討論会
    • Place of Presentation
      岡崎
    • Related Report
      2012 Annual Research Report
  • [Presentation] NMRを用いた生体分子のダイナミクスの解析

    • Author(s)
      加藤晃一
    • Organizer
      大阪市立大学分子ナノ情報解析センターユーザーズミーティング
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生命分子のダイナミクスと自己組織化

    • Author(s)
      加藤晃一
    • Organizer
      国際高等研究所研究プロジェクト 「分子基盤に基づく生体機能への揺らぎとダイナミックネットワークの解明」第1回研究会
    • Place of Presentation
      奈良
    • Related Report
      2012 Annual Research Report
  • [Book] Advances in Neurobiology2014

    • Author(s)
      Y.Yamaguchi, T.Yamaguchi, and K.Kato
    • Total Pages
      584
    • Publisher
      Springer (New York)
    • Related Report
      2014 Annual Research Report
  • [Book] Advances in Experimental Medicine and Biology2014

    • Author(s)
      Y.Zhang, T.Yamaguchi, T.Satoh, M.Yagi-Utsumi, Y.Kamiya, Y.Sakae, Y.Okamoto, and K.Kato
    • Total Pages
      411
    • Publisher
      Springer (Switzerland)
    • Related Report
      2014 Annual Research Report
  • [Remarks] 構造異常糖タンパク質の分解に必須な糖鎖刈り込み機構を解明

    • URL

      http://www.kyoto-u.ac.jp/ja/research/research_results/2014/140902_1.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 水中で絶え間なく揺らいでいる糖鎖の立体構造を描き出す

    • URL

      https://www.ims.ac.jp/news/2014/09/05_2994.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

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