| Budget Amount *help |
¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2012: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
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| Outline of Final Research Achievements |
Reactive oxygen species (ROS) and electrophiles, known to exert stress on organisms, are emerging as mediators of cellular signals. Transient Receptor Potential (TRP) Ca2+-permeable cation channels are activated by various triggers from outside and inside the cell. We and others have revealed that multiple redox-sensitive TRPs sense ROS to induce diverse physiological/pathological responses, such as cell death, chemotaxis, and pain transduction. TRPs sense ROS/electrophiles either indirectly through second messengers or directly via oxidative modification of cysteine residues. In this project, I clarified roles of redox-sensitive TRPs in inflammation. In particular, TRPM2 turned out to be a key signal regulator for diverse inflammatory cellular responses. Also, TRPA1 showed a unique, high sensitivity to oxidants including O2. Understanding the physiological significance of redox-sensitive TRPs will lead us to consider these TRP channels as viable therapeutic targets.
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