Immunology

• Project/Area Number: 24249021
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: University of Tsukuba
• Principal Investigator: AKIRA Shibuya 筑波大学, 医学医療系, 教授 (80216027)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000); Fiscal Year 2014: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2013: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000); Fiscal Year 2012: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
• Keywords: 免疫グロブリン様受容体 / 炎症 / 自己免疫病 / 発がん / 感染

Outline of Final Research Achievements

The mechanisms of immune responses in infectious diseases, autoimmune diseases, inflammatory bowel diseases and allergy are incompletely understood. It is essentially required for the overcome of these intractable diseases to clarify the mechanisms. The aim of this study is to clarify the role of the immunoglobulin-like receptors that we first identified in the pathogenesis of these intractable diseases. We demonstrated that MAIR-I regulates mast cell activation and is involved in the pathogenesis of sepsis in mice. We also demonstrated that MAIR-II regulates the transmigration of inflammatory monocytes into the site of infection and is involved in the peritonitis in mice.

Research Products

• [Journal Article] CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammations. (2015)
  • Author(s): Yamashita Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K.
  • Journal Title: J Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] Involvement of CD300a phosphatidylserine immunoreceptor in alum adjuvant-induced Th2 responses. (2015)
  • Author(s): Miki H, Nakahashi-Oda C, Sumida T, Shibuya A.
  • Journal Title: J Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] Increased CD11b+ Gr-1+ cell population in the placenta after infection with Toxoplasma gondii. (2015)
  • Author(s): Takeshima K, Sato K, Nabekura T, Nagamune K, Hamada H, Yoshikawa H, Shibuya A, Shibuya K.
  • Journal Title: Microbiol. immunol Volume: 59 Issue: 2 Pages: 95-98
  • DOI: 10.1111/1348-0421.12225
  • NAID: 120007130301
  • Peer Reviewed / Open Access
• [Journal Article] Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background (2015)
  • Author(s): Kurita N, Honda S, Shibuya A.
  • Journal Title: Mol Immunol Volume: 63 Issue: 2 Pages: 367-372
  • DOI: 10.1016/j.molimm.2014.09.008
  • NAID: 120007136500
  • Peer Reviewed / Open Access
• [Journal Article] Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. (2014)
  • Author(s): Nagumo Y, Iguchi-Manaka A, Shibuya A, Shibuya K.
  • Journal Title: PLoS ONE Volume: 9(11) Issue: 11 Pages: e112415-e112415
  • DOI: 10.1371/journal.pone.0112415
  • NAID: 120007136536
  • Peer Reviewed / Open Access
• [Journal Article] Influence of MILR1 promoter polymorphism on expression levels and the phenotype of atopy. (2014)
  • Author(s): Nanatsue K, Ninomiya T, Tsuchiya M, Tahara-Hanaoka S, Shibuya A, Masuko H, Sakamoto T, Hizawa N, Arinami T, Noguchi E.
  • Journal Title: J Hum Genet Volume: 59(9) Issue: 9 Pages: 480-483
  • DOI: 10.1038/jhg.2014.57
  • Peer Reviewed
• [Journal Article] Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a. (2014)
  • Author(s): Sabato V, Boita M, Shubber S, Bridts CH, Shibuya A, De Clerck LS, Falcone FH, Ebo DG.
  • Journal Title: J Allergy Clin Immunol Volume: 134(3) Issue: 3 Pages: 734-737
  • DOI: 10.1016/j.jaci.2014.03.029
  • Peer Reviewed
• [Journal Article] Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated infammatory monocyte migration (2014)
  • Author(s): Naoya T otsuka, Yun-Gi Kim, Kazumasa Kanemaru, Kouta Niizuma, Eiji Umemoto, Kei Nagai, Satoko T ahara-Hanaoka, Chigusa Nakahasi-Oda, Shin-ichiro Honda, Masayuki Miyasaka, Kazuko Shibuya & Akira Shibuya
  • Journal Title: Nature Communications Volume: 5:4710 Issue: 1 Pages: 4710-4710
  • DOI: 10.1038/ncomms5710
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PPARβ/δ activation of CD300a controls intestinal immunity. (2014)
  • Author(s): Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.
  • Journal Title: Sci Rep Volume: 4 Issue: 1 Pages: 5412-5412
  • DOI: 10.1038/srep05412
  • Peer Reviewed / Open Access
• [Journal Article] Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy. (2014)
  • Author(s): Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y.
  • Journal Title: BMC Nephrology Volume: 15:89 Issue: 1 Pages: 89-89
  • DOI: 10.1186/1471-2369-15-89
  • Peer Reviewed / Open Access
• [Journal Article] Phosphatidylserine inhibits IgE/FcεRI-dependent basophil activation through the inhibitory receptor CD300a (IRp60). (2014)
  • Author(s): Sabato V, Boita M, Shubber S, Bridts CH, Shibuya A, De Clerck LS, Falcone FH, Ebo DG..
  • Journal Title: J Allergy Clin Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] TIGIT versus CD226: Hegemony or coexistence? (2014)
  • Author(s): Georgiev H, Danisch S, Chambers BJ, Shibuya A, Förster R, Bernhardt G. Eur J.
  • Journal Title: Immunol Volume: 44 Issue: 1 Pages: 307-308
  • DOI: 10.1002/eji.201343925
  • Peer Reviewed
• [Journal Article] Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2. (2014)
  • Author(s): Kim Y, Udayanga K G S, Totsuka N, Weinberg J B, Núñez G, Shibuya A.
  • Journal Title: Cell Host & Microbe Volume: 15(1) Issue: 1 Pages: 95-102
  • DOI: 10.1016/j.chom.2013.12.010
  • Peer Reviewed
• [Journal Article] Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection. (2014)
  • Author(s): Nabekura T, Kanaya M, Shibuya A, Fu G, Gascoigne NR, Lanier LL.
  • Journal Title: Immunity Volume: 40 Issue: 2 Pages: 1-10
  • DOI: 10.1016/j.immuni.2013.12.011
  • NAID: 120007136763
  • Peer Reviewed
• [Journal Article] Involvement of Fcα/μR (CD351) in autoantibody production (2013)
  • Author(s): Yoshizawa Y, Honda S, Shibuya A
  • Journal Title: Mol Immunol Volume: 57(2) Issue: 2 Pages: 216-219
  • DOI: 10.1016/j.molimm.2013.10.002
  • NAID: 120007130578
  • Peer Reviewed
• [Journal Article] Expression and function of Allergin-1 on human primary mast cells (2013)
  • Author(s): Nagai K, Tahara-Hanaoka S, Morishima Y, et al
  • Journal Title: PLoS One Volume: 8(10) Issue: 10 Pages: 1-8
  • DOI: 10.1371/journal.pone.0076160
  • Peer Reviewed
• [Journal Article] Molecular characterization of the dimer formation of Fcα/μ receptor (CD351) (2013)
  • Author(s): Takagaki K, Satoh K, Honda S, Shibuya A
  • Journal Title: Mol Immunol Volume: 56(1-2) Issue: 1-2 Pages: 23-27
  • DOI: 10.1016/j.molimm.2013.04.003
  • NAID: 120007136867
  • Peer Reviewed
• [Journal Article] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells (2013)
  • Author(s): Arai, S., et al.
  • Journal Title: Cell Rep. Volume: 3 Issue: 4 Pages: 1-12
  • DOI: 10.1016/j.celrep.2013.03.006
  • Peer Reviewed
• [Journal Article] Establishment and Characterization of a Novel Anti-DNAM-1 Monoclonal Antibody (2013)
  • Author(s): Yamashita Y, Abe F, Hirochika R, Tahara-Hanaoka S, Shibuya A, Shibuya K.
  • Journal Title: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Volume: 32(1) Issue: 1 Pages: 60-64
  • DOI: 10.1089/mab.2012.0083
  • Peer Reviewed
• [Journal Article] CD226 interaction with CD155 impacts on retention and negative selection of CD8 positive thymocytes as well as T cell differentiation to follicular helper cells in Peyer's Patches. (2013)
  • Author(s): Danisch S et. al.
  • Journal Title: Immunobiology Volume: 218 Issue: 2 Pages: 152-158
  • DOI: 10.1016/j.imbio.2012.02.010
  • Peer Reviewed
• [Journal Article] Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice (2012)
  • Author(s): Yoh K, Morito N, Ojima M, Shibuya K, Yamashita Y, Morishima Y, Ishii Y, Kusakabe M, Nishikii H, Fujita A, Matsunaga E, Okamura M, Hamada M, Suto A, Nakajima H, Shibuya A, Yamagata K, Takahashi S
  • Journal Title: Eur J Immunol Volume: 42 Issue: 8 Pages: 1999-2009
  • DOI: 10.1002/eji.201142250
  • Peer Reviewed
• [Journal Article] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. (2012)
  • Author(s): Nakahashi-Oda, C., Tahara-Hanaoka, S., Shoji, M., Okoshi, Y., Nakano-Yokomizo, T., Ohkohchi, N., Yasui, T., Kikutani, H., Honda, S., Shibuya, K., Nagata, S. and Shibuya, A.
  • Journal Title: J Exp. Med. Volume: 209 Issue: 8 Pages: 1493-1503
  • DOI: 10.1084/jem.20120096
  • Peer Reviewed
• [Journal Article] Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor (2012)
  • Author(s): Chigusa Nakahashi-Oda, et.al.
  • Journal Title: BBRC Volume: 417 Issue: 1 Pages: 646-650
  • DOI: 10.1016/j.bbrc.2011.12.025
  • Peer Reviewed
• [Presentation] 抑制性免疫受容体によるアレルギー炎症疾患の制御 (2015)
  • Author(s): 渋谷 彰
  • Organizer: 東北大学加齢医学研究所セミナー
  • Place of Presentation: 東北大学加齢医学研究所（仙台）
  • Year and Date: 2015-03-23
  • Invited
• [Presentation] 自己抗体産生におけるAllergin-1 の機能解析 (2015)
  • Author(s): 飯塚 晃、瀬川 誠司、近藤 裕也、渋谷 彰、柴山 史朗、住田 孝之
  • Organizer: 第3回筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（野田）.
  • Year and Date: 2015-03-20
• [Presentation] Critical role of DNAM-1 in acute and chronic allograft rejection. (2015)
  • Author(s): 阿部 史枝、渋谷 和子、渋谷 彰
  • Organizer: 第3回筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（野田）
  • Year and Date: 2015-03-20
• [Presentation] Soluble CD155 is involved in the escape from tumor immunity. (2015)
  • Author(s): 井口 研子、渋谷 彰、渋谷 和子
  • Organizer: 第3回筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（野田）
  • Year and Date: 2015-03-20
• [Presentation] アトピー性皮膚炎における Clec10a (Mgl1/CD301a)の機能解析 (2015)
  • Author(s): 金丸 和正、田原 聡子、伝田 香里、入村 達郎、野口 恵美子、渋谷 彰
  • Organizer: 第3回筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（野田）
  • Year and Date: 2015-03-20
• [Presentation] TLR4 と免疫受容体MAIR-II は炎症性単球の感染局所への移入を促進する (2015)
  • Author(s): 戸塚 直也、金 倫基、金丸 和正、新妻 耕太、梅本 英司、永井 恵、田原 聡子、小田 ちぐさ、本多 伸一郎、宮坂 昌之、渋谷 和子、渋谷 彰
  • Organizer: 第3回筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（野田）
  • Year and Date: 2015-03-20
• [Presentation] Allergin-1 on mast cells selectively suppresses airway hyperresponsiveness in house dust mite–induced allergic airway inflammation in mice. (2015)
  • Author(s): 人見 香織、田原 聡子、久保 允人、渋谷 彰
  • Organizer: 第3回筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（野田）
  • Year and Date: 2015-03-20
• [Presentation] CD300a on CD11b+ DC inhibits the TRIF pathway mediated by microbiota for production of IFN-b. (2015)
  • Author(s): 中澤 優太、小田 ちぐさ、中村 貴之、渋谷 彰
  • Organizer: 第3回筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（野田）
  • Year and Date: 2015-03-20
• [Presentation] 免疫とがん、アレルギー、炎症 (2015)
  • Author(s): 渋谷 彰
  • Organizer: 第14回筑波大学技術職員 技術発表会
  • Place of Presentation: 筑波大学 総合研究棟B （つくば）
  • Year and Date: 2015-03-10
  • Invited
• [Presentation] Soluble CD155 is involved in the escape from tumor immunity. (2015)
  • Author(s): Iguchi-Manaka A, Shibuya A, Shibuya K.
  • Organizer: 第5回新学術発がんスパイラル国際シンポジウム
  • Place of Presentation: 神戸ポートピアホテル（神戸）
  • Year and Date: 2015-02-26
• [Presentation] DNAM-1 (CD226) plays an important role in antigen presentation by small peritoneal macrophages. (2015)
  • Author(s): Takenaka E, Shibuya A, Shibuya K.
  • Organizer: 第5回新学術発がんスパイラル国際シンポジウム
  • Place of Presentation: 神戸ポートピアホテル（神戸）
  • Year and Date: 2015-02-26
• [Presentation] 免疫受容体を標的とした同種反応の制御 (2015)
  • Author(s): 渋谷 彰
  • Organizer: 第5回Transplant Immunology Forum
  • Place of Presentation: 広島大学 広仁会館（広島）
  • Year and Date: 2015-02-14
  • Invited
• [Presentation] CD300a regulates regulatory T cell number and is involved in the pathogenesis of atopic dermatitis and allergic airway inflammation. (2014)
  • Author(s): Udayanga K G S, Miki H, Nakahashi-Oda C, Shibuya A.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-12
• [Presentation] CD300a regulates regulatory T cell number in the intestine and involved in the pathogenesis of DSS-induced colitis. (2014)
  • Author(s): Nakamura Y, Nakahashi-Oda C, Nakazawa Y, Iino S, Shibuya A.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-12
• [Presentation] CD300a on CD11b+ DC inhibits the TRIF pathway mediated by microbiota for production of IFN-β. (2014)
  • Author(s): Nakazawa Y, Nakahashi-Oda C, Nakamura Y, Shibuya A.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-12
• [Presentation] Allergin-1 on mast cells selectively suppresses airway hyperresponsiveness in house dust mite-induced allergic airway inflammation in mice. (2014)
  • Author(s): Hitomi K, Tahara-Hanaoka S, Kubo M, Shibuya A.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-11
• [Presentation] DNAM-1 (CD226) plays an important role in antigen presentation by small peritoneal macrophages. (2014)
  • Author(s): Takenaka E, Shibuya A, Shibuya K.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-11
• [Presentation] Identification and characterization of human CD300H, the eighth member of the CD300-family receptors. (2014)
  • Author(s): Niizuma K, Tahara-Hanaoka S, Noguchi E, Shibuya A.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-11
• [Presentation] Soluble CD155 is involved in the escape from tumor immunity. (2014)
  • Author(s): Iguchi-Manaka A, Shibuya A, Shibuya K.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Marginal zone B cells exacerbate endotoxin shock by secretion of interleukin-6. (2014)
  • Author(s): Honda S, Sato K, Fujiyama S, Fujimoto M, Miyake K, Shibuya A.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10
• [Presentation] Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration. (2014)
  • Author(s): Totsuka N, Kim YG, Kanemaru K, Niizuma K, Umemoto E, Nagai K, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Miyasaka M, Shibuya K, Shibuya A.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10
• [Presentation] The role of CD300a (MAIR-I) in allergic airway inflammation. (2014)
  • Author(s): Miki H, Nakahashi-Oda C, Sumida T, Shibuya A.
  • Organizer: 第43 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10
• [Presentation] アレルギー炎症応答と抑制性免疫受容体 (2014)
  • Author(s): 渋谷 彰
  • Organizer: 生命領域学際研究センター設立20周年記念シンポジウム
  • Place of Presentation: 筑波大学 大学会館（つくば）
  • Year and Date: 2014-12-09
• [Presentation] Apoptotic epithelial cells inhibit the commensal microbiota signal for homeostatic control of gut regulatory T cells. (2014)
  • Author(s): Nakahashi-Oda C, Nakazawa Y, Nakamura Y, Shibuya A.
  • Organizer: Immune Homeostasis and Inflammatory Disease: A Herrenhausen Symposium.
  • Place of Presentation: Herrenhausen Palace Conference Center, Hanover, Germany
  • Year and Date: 2014-11-07
• [Presentation] CD155 regulates regulatory T cell population and attenuates acute graft-versus-host disease. (2014)
  • Author(s): Kanaya M, Shibuya K, Abe F, Teshima T, Shibuya A.
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2014-10-31
• [Presentation] 抗生物質による腸内微生物環境破綻と喘息 (2014)
  • Author(s): 渋谷 彰
  • Organizer: 日本食品免疫学会10周年記念学術集会
  • Place of Presentation: 東京大学 伊藤謝恩ホール（東京）
  • Year and Date: 2014-10-16
  • Invited
• [Presentation] 抑制性受容体によるアレルギー、炎症応答の制御 (2014)
  • Author(s): 渋谷 彰
  • Organizer: CREST「免疫機構」第三回公開シンポジウム
  • Place of Presentation: 東京医科歯科大学（東京）
  • Year and Date: 2014-10-08
• [Presentation] 腸内微生物環境破綻によるアレルギー性気道炎症の増悪 (2014)
  • Author(s): 藤山 聡、金 倫基、渋谷 彰
  • Organizer: CREST「免疫機構」第三回公開シンポジウム
  • Place of Presentation: 東京医科歯科大学（東京）
  • Year and Date: 2014-10-08
• [Presentation] TLR4とMAIR-IIによる炎症性単球の感染局所への移入制御 (2014)
  • Author(s): 戸塚 直也、渋谷 彰
  • Organizer: CREST「免疫機構」第三回公開シンポジウム
  • Place of Presentation: 東京医科歯科大学（東京）
  • Year and Date: 2014-10-08
• [Presentation] DNAM-1 による腫瘍免疫監視とDNAM-1リガンドによる腫瘍免疫逃避のパラドックス (2014)
  • Author(s): 渋谷 彰、井口 研子、渋谷 和子
  • Organizer: 第6回血液疾患免疫療法研究会学術集会
  • Place of Presentation: 京都大学医学部 芝蘭会館（京都）
  • Year and Date: 2014-09-06
  • Invited
• [Presentation] 腸内微生物環境破綻によるアレルギー性気道炎症の増悪 (2014)
  • Author(s): 渋谷 彰
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] 腸内微生物環境破綻によるアレルギー性気道炎症の増悪 平 (2014)
  • Author(s): 渋谷 彰
  • Organizer: 成26年度遺伝子病制御研究所国際研究集会
  • Place of Presentation: 北海道大学医学部 学友会館（北海道）
  • Year and Date: 2014-07-03
  • Invited
• [Presentation] Inhibitory Immunoreceptors in Allergic Inflammatory Diseases. (2014)
  • Author(s): 渋谷 彰
  • Organizer: 上原記念生命科学財団シンポジウム2014
  • Place of Presentation: ハイアットリージェンシー東京（東京）
  • Year and Date: 2014-06-15
  • Invited
• [Presentation] Immunoglobulin-like receptors in cancer and allergy. (2014)
  • Author(s): Shibuya A.
  • Organizer: リトアニア-日本（つくば）合同科学シンポジウム
  • Place of Presentation: 筑波大学 大学会館（つくば）
  • Year and Date: 2014-06-12
  • Invited
• [Presentation] アレルギー、炎症応答と抑制性受容体 (2014)
  • Author(s): 渋谷 彰
  • Organizer: 第26回千葉基礎・臨床免疫セミナー
  • Place of Presentation: 千葉大亥鼻イノベーションプラザ（千葉）
  • Year and Date: 2014-05-22
  • Invited
• [Presentation] 腫瘍免役逃避機構における可溶型CD155の役割 (2014)
  • Author(s): 井口 研子、清松 裕子、池田 達彦、坂東 裕子、渋谷 彰、渋谷 和子、原 尚人
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] Involvement of soluble CD155 in cancer immune escape. (2013)
  • Author(s): Iguchi A, Shibuya A, Shibuya K
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Involvement of CD300a in the pathogenesis of DSS-induced colitis. (2013)
  • Author(s): Nakazawa Y, Iino S, Nakahashi-Oda C, Shibuya A.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Fca/mR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock. (2013)
  • Author(s): Honda S, Yoshizawa Y, Sato K, Fujimoto M, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Identification and characterization of a novel CD300 molecule, CD300H. (2013)
  • Author(s): Niizuma K, Tahara-Hanaoka S, Shibuya A.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] The role of MAIR-1 in allergic airway inflammation. (2013)
  • Author(s): Miki H, Nakahashi-Oda C, Shibuya A.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Critical role of DNAM-1 in acute and chronic allograft rejection. (2013)
  • Author(s): Abe F, Shibuya K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] A co-stimulatory molecule CD155 on CD4+ T Cells regulates allergic reactions by induction of interferon-γ-dependent th1 development. (2013)
  • Author(s): Yamashita Y, Takahashi Y, Wang Y, Shibuya A, Shibuya K.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Soluble DNAX accessory molecule-1 (sDNAM-1) is a novel predictive biomarker for acute graft-versus-host disease. (2013)
  • Author(s): Kanaya M, Shibuya K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Allergin-1 short-form 1 is dominantly expressed on human primary mast cells and inhibits FceRI-mediated actibation. (2013)
  • Author(s): Nagai K, Tahara-Hanaoka S, Kanemaru K, Shibuya A.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells. (2013)
  • Author(s): Arai S, Honda S, Shibuya A, Li Q-Z, Miyazaki T.
  • Organizer: 第42回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] ヒト肥満細胞活性化制御技術の開発によるアレルギー疾患の克服 (2013)
  • Author(s): 渋谷 彰、田原 聡子、小田 ちぐさ、野口 恵美子
  • Organizer: CREST「アレルギー疾患・自己免疫疾患の発症機構と治療技術」領域 平成25年度中間評価会・領域会議
  • Place of Presentation: JST東京本部（東京）
• [Presentation] Fca/mR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock. (2013)
  • Author(s): Honda S, Satoh K, Matsuoka Y, Matsushita T, Fujimoto M, Shibuya A.
  • Organizer: 15th International Congress of Immunology.
  • Place of Presentation: Mico Milano Congressi, Milan, Italy
• [Presentation] Seven color flow cytometry analyses of Allergin-1 expression and function on human primary bronchoalveolar and nasal mast cells. (2013)
  • Author(s): Nagai K, Tahara-Hanaoka S, Shibuya A.
  • Organizer: 15th International Congress of Immunology.
  • Place of Presentation: Mico Milano Congressi, Milan, Italy
• [Presentation] 免疫が病気をひきおこす理由 (2013)
  • Author(s): 渋谷 彰
  • Organizer: 免疫ふしぎ未来2013
  • Place of Presentation: 日本科学未来館（東京）
• [Presentation] 抑制性受容体を標的としたアレルギー疾患に対する克服戦略 (2013)
  • Author(s): 渋谷 彰
  • Organizer: 上原記念生命科学財団特定研究「革新的医療を創生する医学研究」中間報告会
  • Place of Presentation: 下田セントラルホテル（下田）
  • Invited
• [Presentation] Inhibitory immunoreceptors in inflammatory diseases. (2013)
  • Author(s): Shibuya A.
  • Organizer: American Association of Immunology Annual Meeting.
  • Place of Presentation: Hawaii Convention Center, Honolulu, Hawaii
  • Invited
• [Presentation] Immune regulation by inhibitory immunoglobulin-like receptors. (2013)
  • Author(s): Shibuya A.
  • Organizer: International Symposium Immune Regulation by Immunoreceptors.
  • Place of Presentation: University of Tsukuba.（つくば）
• [Presentation] CD155 is a co-stimulatory molecule involved in Th1 development. (2013)
  • Author(s): Yamashita Y, Takahashi Y, Abe F, Shibuya A, Shibuya K.
  • Organizer: International Symposium Immune Regulation by Immunoreceptors.
  • Place of Presentation: University of Tsukuba.（つくば）
• [Presentation] Involvement of an inhibitory immunoglobulin-like receptor Allergin-1 in the pathogenesis of house dust mite-induced airway hyperreaction. (2013)
  • Author(s): Hitomi K, Tahara-Hanaoka S, Shibuya A.
  • Organizer: International Symposium Immune Regulation by Immunoreceptors.
  • Place of Presentation: University of Tsukuba.（つくば）
• [Presentation] An exploration of a cell-surface receptor which regulates mast cell activation in vivo. (2013)
  • Author(s): Kanemaru K, Tahara-Hanaoka S, Nagai K, Tokunaga T, Noguchi E, Shibuya A.
  • Organizer: International Symposium Immune Regulation by Immunoreceptors.
  • Place of Presentation: University of Tsukuba.（つくば）
• [Presentation] The role of MAIR-1 in ova/alum induced asthma. (2013)
  • Author(s): Miki H, Nakahashi-Oda C, Shibuya A.
  • Organizer: International Symposium Immune Regulation by Immunoreceptors.
  • Place of Presentation: University of Tsukuba.（つくば）
• [Presentation] Seven-color flow cytometry analyses of Allergin-1 expression and function on human primary bronchoalveolar and nasal mast cells. (2013)
  • Author(s): Nagai K, Tahara-Hanaoka S, Kanemaru K, Hitomi K, Shibuya A.
  • Organizer: International Symposium Immune Regulation by Immunoreceptors.
  • Place of Presentation: University of Tsukuba.（つくば）
• [Presentation] Identification and characterization of human MAIR-II. International Symposium Immune Regulation by Immunoreceptors. (2013)
  • Author(s): Niizuma K, Tahara-Hanaoka S, Shibuya A.
  • Organizer: International Symposium Immune Regulation by Immunoreceptors.
  • Place of Presentation: University of Tsukuba.（つくば）
• [Presentation] The role of an activating receptor, DNAM-1 (CD226), on small peritoneal macrophages (SPMs). (2013)
  • Author(s): Takenaka E, Shibuya A, Shibuya K.
  • Organizer: International Symposium Immune Regulation by Immunoreceptors.
  • Place of Presentation: University of Tsukuba.（つくば）
• [Presentation] CD300d on inflammatory monocytes amplifies TLR4-mediated cell migration via FcR©-Syk pathway to protect from polymicrobial sepsis. (2013)
  • Author(s): Totsuka N, Kim YG, Tahara-Hanaoka S, Shibuya A.
  • Organizer: International Symposium Immune Regulation by Immunoreceptors.
  • Place of Presentation: University of Tsukuba.（つくば）
• [Presentation] Small Peritoneal Macrophages (SPMs)上のDNAM-1の機能解析 (2013)
  • Author(s): 竹中 江里
  • Organizer: 筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（千葉）
• [Presentation] MAIR-II (CD300d) on inflammatory monocytes amplifies TLR4-mediated cell migration to protect from polymicrobial sepsis (2013)
  • Author(s): 戸塚 直也
  • Organizer: 筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（千葉）
• [Presentation] 肥満細胞の活性化を制御する新規膜型受容体の探索 (2013)
  • Author(s): 金丸 和正
  • Organizer: 筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（千葉）
• [Presentation] Human MAIR-II相同分子の同定と機能解析 (2013)
  • Author(s): 新妻 耕太
  • Organizer: 筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（千葉）
• [Presentation] Seven-Color Flow Cytometryによるヒトプライマリ肥満細胞におけるAllerign-1の機能解析 (2013)
  • Author(s): 永井 恵
  • Organizer: 筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（千葉）
• [Presentation] Involvement of an inhibitory immunoglobulin-like receptor Allergin-1 in the pathogenesis of house dust mite-induced airway hyperreaction (2013)
  • Author(s): 人見 香織
  • Organizer: 筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（千葉）
• [Presentation] CD300a(MAIR-I)によるアレルギー性気道炎症の制御 (2013)
  • Author(s): 三木 春香
  • Organizer: 筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（千葉）
• [Presentation] CD155 is a co-stimulatory molecule involved in Th1 development (2013)
  • Author(s): 山下 由美
  • Organizer: 筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（千葉）
• [Presentation] フォスファチジルセリンを認識するCD300a分子の解析 第22回東京免疫フォーラム (2013)
  • Author(s): 小田 ちぐさ
  • Organizer: 筑波大学・東京理科大学生命医科学研究所合同リトリート
  • Place of Presentation: 東京理科大学セミナーハウス（千葉）
• [Presentation] 急性GVHDにおける活性化受容体DNAM-1の役割 (2013)
  • Author(s): 金谷 穣
  • Organizer: Tsukuba Hematologic Disease Seminar第10回記念シンポジウム
  • Place of Presentation: つくば国際会議場（つくば）
• [Presentation] Control of allergic diseases by regulation of mast cell activation (2013)
  • Author(s): Satoko-Tahara-Hanaoka
  • Organizer: JST-CREST国際シンポジウムFrontiers in Immunology & Inflammation
  • Place of Presentation: 一橋記念講堂（東京）
• [Presentation] CD155 mediates a costimulatory signal for Th1 development and is involved in the development of allergic diseases (2013)
  • Author(s): Yumi Yamashita
  • Organizer: JST-CREST国際シンポジウムFrontiers in Immunology & Inflammation
  • Place of Presentation: 一橋記念講堂（東京）
• [Presentation] Involvement of an inhibitory immunoglobulin-like receptor Allergin-1 in the pathogenesis of house dust mite-induced airway hyperreaction (2012)
  • Author(s): Hitomi K
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor (2012)
  • Author(s): Nakhashi-Oda C
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫）
  • Invited
• [Presentation] Functional analysis of an inhibitory receptor on human primary mast cell (2012)
  • Author(s): Nagai K
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] Follicular dendritc cells (FDC) internalized IgM-coated antigen via Fc receptor for IgA/IgM (Fcα/μR; CD351) (2012)
  • Author(s): Sato K
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] CD155 is a co-stimulatory molecule involved in Th1 differentiation (2012)
  • Author(s): Yamashita Y
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] MAIR-II (CD300d) on inflammatory monocytes amplifies TLR4-mediated cell migration to protect from polymicrobial sepsis (2012)
  • Author(s): Totsuka N
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] Critical role of activating immune receptor DNAM-1 in the development of acute hepatic GVHD (2012)
  • Author(s): Kanaya M
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] ritical role of DNAM-1 in acute and chronic allograft rejection (2012)
  • Author(s): Abe F
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor during sepsis (2012)
  • Author(s): Nakhashi-Oda C
  • Organizer: IEIIS2012 Homeostatic Inflammation Symposium
  • Place of Presentation: National Center of Science Building.（東京）
• [Presentation] MAIR-II (CD300d) on inflammatory monocytes amplifies TLR4-mediated cell migration to protect from polymicrobial sepsis (2012)
  • Author(s): Totsuka N
  • Organizer: IEIIS2012 Homeostatic Inflammation Symposium
  • Place of Presentation: National Center of Science Building.（東京）
• [Presentation] 免疫受容体による肥満細胞活性化制御 (2012)
  • Author(s): 渋谷 彰
  • Organizer: ‐筑波大学、東京理科大学生命医科学研究所合同シンポジウム‐難治性免疫疾患・アレルギー疾患の克服をめざして
  • Place of Presentation: 学士会館（東京）
  • Invited
• [Presentation] 活性化免疫受容体DNAM-1の急性肝GVHDの病態形成における重要な役割 (2012)
  • Author(s): 金谷 穣
  • Organizer: 第4回造血器腫瘍免疫療法研究会学術集会
  • Place of Presentation: 金沢市文化ホール（金沢）
• [Presentation] 可溶型DNAM-1の急性GVHD発症予測マーカーとしての有用性 (2012)
  • Author(s): 金谷 穣
  • Organizer: 第4回造血器腫瘍免疫療法研究会学術集会
  • Place of Presentation: 金沢市文化ホール（金沢）
• [Presentation] CD155 (poliovirus receptor)のTh1分化における役割と疾患への関与 (2012)
  • Author(s): 山下 由美
  • Organizer: 第22回Kyoto T Cell Conference
  • Place of Presentation: 和順会館（京都）
• [Presentation] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor (2012)
  • Author(s): Shibuya A
  • Organizer: 9th International Conference on Innate Immunity
  • Place of Presentation: Rodos Palace Conference Center, Ixia, Rhodes, Greece
• [Presentation] アレルギー疾患の克服戦略 (2012)
  • Author(s): 渋谷 彰
  • Organizer: 第8回特定研究打合せ会
  • Place of Presentation: ハイアットリージェンシー東京（新宿）
• [Presentation] Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor (2012)
  • Author(s): Shibuya A
  • Organizer: The Society for Natural Immunity Meeting
  • Place of Presentation: Asilomar Conference Center, San Francisco, USA
• [Presentation] MAIR-I (CD300a)を分子標的とした敗血症に対する治療法の可能性 (2012)
  • Author(s): 小田（中橋） ちぐさ
  • Organizer: 第112回日本外科学会
  • Place of Presentation: 幕張メッセ（千葉）
• [Remarks] 免疫学研究室ホームページ
  • URL: http://immuno-tsukuba.com/index.html
• [Remarks] つくばリポジトリ
  • URL: https://tsukuba.repo.nii.ac.jp/index.php?action=pages_view_main&active_action=repository_view_main_item_snippet&index_id=543&pn=1&count=20&order=7&lang=japanese&page_id=13&block_id=83
• [Remarks] TRIOS
  • URL: http://trios.tsukuba.ac.jp/researcher/0000001643
• [Remarks] つくばリポジトリ
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/simple-search?query=%E6%B8%8B%E8%B0%B7%E3%80%80%E5%BD%B0&submit=%E6%A4%9C%E7%B4%A2
• [Remarks] TRIOS
  • URL: http://trios.tsukuba.ac.jp/researcher/0000001643
• [Remarks] つくばリポジトリ
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/handle/2241/101766
• [Patent(Industrial Property Rights)] 可溶型CD155タンパク質を用いた癌の検出方法 (2015)
  • Inventor(s): 渋谷 彰、渋谷 和子、井口 研子
  • Industrial Property Rights Holder: 渋谷 彰、渋谷 和子、井口 研子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-01-26
• [Patent(Industrial Property Rights)] 免疫疾患に対する医薬組成物 (2014)
  • Inventor(s): 渋谷和子、渋谷彰、山下由美
  • Industrial Property Rights Holder: 渋谷和子、渋谷彰、山下由美
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-03-13
• [Patent(Industrial Property Rights)] アレルギー性気道炎症の治療・予防薬 (2013)
  • Inventor(s): 渋谷彰、金倫基
  • Industrial Property Rights Holder: 渋谷彰、金倫基
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-07-08
• [Patent(Industrial Property Rights)] アレルギー疾患に関する、CD300a発現細胞の活性調節剤を含有する医薬品、ならびにCD300a遺伝子欠損マウスおよびCD300a発現細胞の活性調節剤の使用 (2013)
  • Inventor(s): 渋谷彰、小田ちぐさ、カンカーナム ウダヤンガ、三木春香
  • Industrial Property Rights Holder: 渋谷彰、小田ちぐさ、カンカーナム ウダヤンガ、三木春香
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-11-05
  • Overseas
• [Patent(Industrial Property Rights)] 活性調節剤、これを含有する医薬品、CD300a遺伝子欠損マウスの使用および (2012)
  • Inventor(s): 渋谷彰、小田ちぐさ、田原聡子、鍋倉宰 他
  • Industrial Property Rights Holder: 渋谷彰、小田ちぐさ、田原聡子、鍋倉宰 他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-11-07
  • Overseas
• [Patent(Industrial Property Rights)] セリアック病に関連する、CD300a遺伝子欠損マウスおよびCD300a発現細 (2012)
  • Inventor(s): 渋谷彰、小田ちぐさ、鍋倉宰
  • Industrial Property Rights Holder: 渋谷彰、小田ちぐさ、鍋倉宰
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-11-07
• [Patent(Industrial Property Rights)] 炎症性腸疾患に関連する、CD300a発現細胞の活性調節剤を含有する医薬品、 (2012)
  • Inventor(s): 渋谷彰、小田ちぐさ、飯野秀一
  • Industrial Property Rights Holder: 渋谷彰、小田ちぐさ、飯野秀一
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-11-07
• [Patent(Industrial Property Rights)] アレルギー疾患に関する、CD300a発現細胞の活性調節剤を含有する医薬品、ならびにCD300a遺伝子欠損マウスおよびCD300a発現細胞の活性調節剤の使用 (2012)
  • Inventor(s): 渋谷彰、小田ちぐさ、ｶﾝｶｰﾅﾑ ｳﾀﾞﾔﾝｶﾞ、三木春香
  • Industrial Property Rights Holder: 渋谷彰、小田ちぐさ、ｶﾝｶｰﾅﾑ ｳﾀﾞﾔﾝｶﾞ、三木春香
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-11-07
• [Patent(Industrial Property Rights)] 同種間での移植心臓、移植血管、または移植腎臓の生着を維持するために用いられる薬剤 (2012)
  • Inventor(s): 渋谷彰、渋谷和子、阿部史枝
  • Industrial Property Rights Holder: 渋谷彰、渋谷和子、阿部史枝
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-05-23