| Budget Amount *help |
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2014: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2013: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2012: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
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| Outline of Final Research Achievements |
The mechanisms of immune responses in infectious diseases, autoimmune diseases, inflammatory bowel diseases and allergy are incompletely understood. It is essentially required for the overcome of these intractable diseases to clarify the mechanisms. The aim of this study is to clarify the role of the immunoglobulin-like receptors that we first identified in the pathogenesis of these intractable diseases. We demonstrated that MAIR-I regulates mast cell activation and is involved in the pathogenesis of sepsis in mice. We also demonstrated that MAIR-II regulates the transmigration of inflammatory monocytes into the site of infection and is involved in the peritonitis in mice.
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