Establishment of the concept of broad organ-forming network in cardiovascular formation and models for tissue reconstruction

• Project/Area Number: 24249047
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: KURIHARA Hiroki 東京大学, 大学院医学系研究科, 教授 (20221947)
• Co-Investigator(Kenkyū-buntansha): TOMITA Sachiko ヤマザキ学園大学, 動物看護学部, 教授 (40231451)
• Co-Investigator(Renkei-kenkyūsha): KURIHARA Yukiko 東京大学, 大学院医学系研究科, 講師 (80345040) ; NISHIYAMA Koichi 熊本大学, 国際先端医学研究拠点, 特任准教授 (80398221) ; UCHIJIMA Yasunobu 東京大学, 大学院医学系研究科, 助手 (90272426) ; KAWAMURA Yumiko FMI研究所, Biomedical Research, 海外特別研究員 (70599779) ; ASAI Rieko カリフォルニア大学, CVRI, 海外特別研究員 (90625526)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000); Fiscal Year 2014: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000); Fiscal Year 2013: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000); Fiscal Year 2012: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
• Keywords: 心臓 / 血管 / 発生・分化 / 循環器 / 再生医学

Outline of Final Research Achievements

In this study, we identified the preotic cranial neural crest, which gives rise to craniofacial skeletons especially in the pharyngeal arch-derived structures, as a novel origin of cells constituting the heart to differentiate into coronary artery smooth muscle cells and other various cell types. In addition, we discovered another novel candidate origin of the heart in a region of mesoderm, which may contribute to cardiomyocytes and vascular endothelial cells. These cells from novel origins may participate in cardiovascular differentiation and morphogenesis through cell-to-cell interactions via signaling molecules such as endothelin and semaphorin-plexin. Identification of these cell origins and lineages enables us to analyze a broad cellular network to drive organogenesis and to establish different models for tissue regeneration from a novel viewpoint.

Research Products

• [Journal Article] Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids. (2015)
  • Author(s): Kitazawa T, Takechi M, Hirasawa T, Adachi N, Narboux-Neme N, Kume H, Maeda K, Hirai T, Miyagawa-Tomita S, Kurihara Y, Hitomi J, Levi G, Kuratani S, Kurihara H
  • Journal Title: Nature Communications Volume: 6 Issue: 1 Pages: 6853-6853
  • DOI: 10.1038/ncomms7853
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane. (2015)
  • Author(s): Hamamoto H, Urai M, Ishii K, Yasukawa J, Paudel A, Murai M, Kaji T, Kuranaga T, Hamase K, Katsu T, Su J, Adachi T, Uchida R, Tomoda H, Yamada M, Souma M, Kurihara H, Inoue M, Sekimizu K.
  • Journal Title: Nature Chemical Biology Volume: 11(2) Issue: 2 Pages: 127-133
  • DOI: 10.1038/nchembio.1710
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart (2014)
  • Author(s): Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I
  • Journal Title: Nat Commun Volume: 5 Issue: 1 Pages: 4452-4452
  • DOI: 10.1038/ncomms5552
  • Peer Reviewed / Open Access
• [Journal Article] SIRT3 positively regulates the expression of folliculogenesis- and luteinization-related genes and progesterone secretion by manipulating oxidative stress in human luteinized granulosa cells. (2014)
  • Author(s): Fu H, Wada-Hiraike O, Hirano M, Kawamura Y, Sakurabashi A, Shirane A, Morita Y, Isono W, Oishi H, Koga K, Oda K, Kawana K, Yano T, Kurihara H, Osuga Y, Fujii T.
  • Journal Title: Endocrinology Volume: 155 Issue: 8 Pages: 3079-3087
  • DOI: 10.1210/en.2014-1025
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endothelin regulates neural crest deployment and fate to form great vessels through D1x5/D1x6-independent mechanisms. (2013)
  • Author(s): Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, Kurihara H.
  • Journal Title: Mechanism of Development Volume: 130 Issue: 11-12 Pages: 553-566
  • DOI: 10.1016/j.mod.2013.07.005
  • Peer Reviewed / Open Access
• [Journal Article] Calpain-6 deficiency promotes skeletal muscle development and regeneration. (2013)
  • Author(s): Tonami, K., Hata, S., Ojima, K., Ono, Y., Kurihara, Y., Amano, T., Sato, T., Kawamura, Y., Kurihara, H., Sorimachi, H.
  • Journal Title: PLOS Genetics Volume: 9 Issue: 8 Pages: 1003668-1003668
  • DOI: 10.1371/journal.pgen.1003668
  • Peer Reviewed / Open Access
• [Journal Article] Mouse Hoxa2 mutations provide a model for microtia and auricle duplication. (2013)
  • Author(s): Minoux M, Kratochwil CF, Ducret S, Amin S, Kitazawa T, Kurihara H, Bobola N, Vilain N, Rijli FM.
  • Journal Title: Development Volume: 140 Issue: 21 Pages: 4386-4397
  • DOI: 10.1242/dev.098046
  • Peer Reviewed / Open Access
• [Journal Article] The hypoxia-inducible microRNA cluster miR-199a～214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation. (2013)
  • Author(s): el Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, McClellan EA, Poels E, Sluimer JC, van den Hoogenhof MM, Armand AS, Yin X, Langley S, Bourajjaj M, Olieslagers S, Krishnan J, Vooijs M, Kurihara H, Stubbs A, Pinto YM, Krek W, Mayr M, da Costa Martins PA, Schrauwen P, De Windt LJ.
  • Journal Title: Cell Metab. Volume: 3 Issue: 3 Pages: 341-354
  • DOI: 10.1016/j.cmet.2013.08.009
  • Peer Reviewed / Open Access
• [Journal Article] Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development. (2013)
  • Author(s): Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 33 Issue: 8 Pages: 1986-1993
  • DOI: 10.1161/atvbaha.113.301546
  • Peer Reviewed / Open Access
• [Journal Article] Preotic neural crest cells contribute to coronary smooth muscle involving endothelin signalling. (2012)
  • Author(s): Yuichiro Arima
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 1267-1267
  • DOI: 10.1038/ncomms2258
  • Peer Reviewed
• [Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model (2012)
  • Author(s): Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
  • Journal Title: J Biol Chem Volume: 287 Issue: 53 Pages: 44526-44535
  • DOI: 10.1074/jbc.m112.397133
  • Peer Reviewed
• [Journal Article] Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by expanded polyglutamine (2012)
  • Author(s): Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
  • Journal Title: Nat Med Volume: 18 Issue: 10 Pages: 1531-1538
  • DOI: 10.1038/nm.2932
  • Peer Reviewed
• [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development (2012)
  • Author(s): Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Issue: 2 Pages: 291-298
  • DOI: 10.1161/atvbaha.111.234559
  • Peer Reviewed
• [Journal Article] A soluble form of LMIR5/CD300b amplifies lipopolysaccharide-induced lethal inflammation in sepsis. (2012)
  • Author(s): Yoshinori Yamanishi
  • Journal Title: Journal of Immunology Volume: 189 Issue: 4 Pages: 1773-1779
  • DOI: 10.4049/jimmunol.1201139
  • Peer Reviewed
• [Presentation] 単一細胞ライブイメージングを用いた内皮細胞動態解析 (2015)
  • Author(s): 田久保直子，内島泰信，金井政宏，苗村和明，栗原由紀子，栗原裕基.
  • Organizer: 生命動態システム科学四拠点・CREST・PREST合同シンポジウム
  • Place of Presentation: 京都府京都市
  • Year and Date: 2015-03-16
• [Presentation] The role of Semaphorin3E-PlexinD1 signaling in heart morphogenesis. (2014)
  • Author(s): Kazuaki Maruyama , Sachiko Miyagawa-Tomita , Yuichiro Arima , Daiki Seya , Rieko Asai , Akiyoshi Uemura , Yutaka Yoshida , Mann Fanny , Yukiko Kurihara , Hiroki Kurihara.
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-25
• [Presentation] Preotic neural crest cells contribute to thyroid bilobation. (2014)
  • Author(s): Kazuhiro Maeda, Rieko Asai, Hiroki Kurihara, Sachiko Miyagawa-Tomita.
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-25
• [Presentation] エンドセリン-Dlx5/6遺伝子変異マウスにおけるIRDS様肺病変 (2014)
  • Author(s): 栗原由紀子、淺井理恵子、河村悠美子、栗栖健、栗原裕基
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-25
• [Presentation] Dlx5-overexpression mice show a homeotic transformation in the upper jaw into lower jaw-like structures.( Dlx5過剰発現マウスにおける顎顔面のトランスフォーメーションと発生学的意義) (2014)
  • Author(s): Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-05
• [Presentation] 単一細胞ライブイメージングを用いた血管新生の細胞動態解析 (2014)
  • Author(s): 田久保 直子，苗村 和明，内島 泰信，栗原 由紀子，栗原 裕基.
  • Organizer: 「生命動態の理解と制御のための基盤技術の創出」研究領域 第3回領域会議
  • Place of Presentation: 沖縄県国頭郡
  • Year and Date: 2014-10-28
• [Presentation] 胚外壁側葉中胚葉は心血管形成に寄与する (2014)
  • Author(s): Rieko Asai, Sachiko Miyagawa-Tomita, Yukiko Kurihara , Hiroki Kurihara.
  • Organizer: 第13回心臓血管発生研究会
  • Place of Presentation: 福島県福島市
  • Year and Date: 2014-10-17
• [Presentation] Semaphorin3E, PlexinD1の心臓血管系発生における役割の解明 (2014)
  • Author(s): Kazuaki Maruyama , Sachiko Miyagawa-Tomita , Yuichiro Arima , Daiki Seya , Rieko Asai , Akiyoshi Uemura , Yutaka Yoshida , Mann Fanny , Yukiko Kurihara , Hiroki Kurihara.
  • Organizer: 第13回心臓血管発生研究会
  • Place of Presentation: 福島県福島市
  • Year and Date: 2014-10-17
• [Presentation] Independent origins of the tympanic membrane and middle ear in different amniote taxa. (2014)
  • Author(s): Taro Kitazawa, Masaki Takechi, Tatsuya Hirasawa, Nicolas Narboux-Neme, Hideaki Kume, Kazuhiro Maeda, Sachiko Miyagawa-Tomita, Yukiko Kurihara, Giovanni Levi, Shigeru Kuratani, Hiroki Kurihara.
  • Organizer: 第47回日本発生生物学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2014-05-27
• [Presentation] Homeotic transformation of the upper jaw into lower jaw-like structures in Dlx5-overexpressing mice. (2014)
  • Author(s): Miki Shimizu, Taro Kitazawa, Yumiko Kawamura, Nicolas Narboux-Nême, Giovanni Levi, Yasunobu Uchijima, Yukiko Kurihara, Hiroki Kurihara.
  • Organizer: 第47回日本発生生物学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2014-05-27
• [Presentation] 腫瘍形成におけるSirt3とp53シグナルの関連 (2014)
  • Author(s): 河村悠美子、北 潔、栗原裕基
  • Organizer: 第33回 日本胸腺研究会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2014-02-08
• [Presentation] 血管新生イメージングと数理モデル化 (2014)
  • Author(s): 西山功一
  • Organizer: 数学協働プログラム「生命ダイナミックスの数理とその応用」
  • Place of Presentation: 東京都目黒区
  • Year and Date: 2014-01-21
• [Presentation] 血管新生の数理モデル (2013)
  • Author(s): 栗原裕基
  • Organizer: 島根大学[数理生物]-東京大学iBMath合同研究会
  • Place of Presentation: 島根県松江市
  • Year and Date: 2013-12-27
• [Presentation] 血管を形づくる血管内皮細胞による集団的運動の数理モデル化 (2013)
  • Author(s): 杉原圭, 西山 功一，三浦 岳，有馬 聡，栗原 裕基
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2013-12-05
• [Presentation] Development of the tympanic membrane and endothelin-Dlx5/6 pathway: Comparative embryology between mammals and reptiles (2013)
  • Author(s): Taro Kitazawa, Masaki Takechi, Hideaki Kume, Yukiko Kurihara, Sachiko Tomita, Shigeru Kuratani and Hiroki Kurihara
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2013-12-05
• [Presentation] 病態生理におけるSirt3とp53シグナルの関連 (2013)
  • Author(s): 河村悠美子、内島泰信、栗原由紀子、北 潔、栗原裕基
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2013-12-05
• [Presentation] Xanthine oxidoreductase is activated by lipid accumulation thereby induces tissue injury via fructose-metabolism derived oxidative stress (2013)
  • Author(s): 櫛山櫻、櫛山暁史、菊池貴子、浅野知一郎、西山功一、栗原裕基
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2013-12-04
• [Presentation] Endothelin receptor type A expressing cell population in the inflow tract contributes to chamber formation (2013)
  • Author(s): Asai R., Arima Y., Seya D., Kim KS., Kawamura Y., Kurihara Y., Miyagawa-Tomita S., Kurihara H.
  • Organizer: The 7th TAKAO International Symposium
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2013-07-14
• [Presentation] Hoxa2 in neural crest cells re-patterns craniofacial structures:crosstalk with endotheline-Dlx5/6 pathway (2013)
  • Author(s): Taro Kitazawa, Kou Fujisawa, Yuichiro Arima, Yumiko Kawamura, Tsuyoshi Inoue, Youichiro Wada, Takahide Kohro, Hiroyuki Aburatani, Tatsuhiko Kodama, Ki-Sung Kim, Takahiro Sato, Yasunobu Uchijima, Nicolas Narboux-Néme, Maryline Minoux, Giovanni Levi, Filippo M. Rijli, Yukiko Kurihara and Hiroki Kurihara
  • Organizer: 第46回日本発生生物学会
  • Place of Presentation: 島根県松江市
  • Year and Date: 2013-05-28 – 2013-05-31
• [Presentation] Endothelin receptor type A expressing cell population in the inflow tract contributes to chamber formation (2013)
  • Author(s): Asai R., Arima Y., Seya D., Kim KS., Kawamura Y., Kurihara Y., Miyagawa-Tomita S., Kurihara H.
  • Organizer: Weinstein Cardiovascular Conference 2013
  • Place of Presentation: USA, Tucson, Arizona
  • Year and Date: 2013-05-17
• [Presentation] The neural crest contributes to coronary artery smooth muscle formation through endothelin signaling.
  • Author(s): Yuichiro Arima
  • Organizer: Weinstein Cardiovascular Development Conference 2012
  • Place of Presentation: シカゴ(アメリカ)
• [Presentation] 神経堤細胞によるエンドセリンシグナルを介した新規の冠動脈発生機構
  • Author(s): 有馬 勇一郎
  • Organizer: 第48回日本小児循環器学会総会・学術集会
  • Place of Presentation: 京都国際会議場（京都府京都市）
• [Presentation] 前耳胞神経堤細胞”Preotic neural crest”の冠動脈発生における寄与
  • Author(s): 有馬 勇一郎
  • Organizer: 第１１回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル 華の湯（福島県 郡山市）
• [Presentation] The novel contribution of preotic neural crest cells in the coronary artery development
  • Author(s): 有馬 勇一郎
  • Organizer: AHA scientific session 2012
  • Place of Presentation: ロサンゼルス(アメリカ)
• [Presentation] Preotic neural crestはエンドセリンシグナリングを介して冠動脈平滑筋形成に寄与する
  • Author(s): 有馬 勇一郎
  • Organizer: 第16回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京大学本郷キャンパス
• [Presentation] Preotic neural crest cells contribute as a novel component of the coronary artery development
  • Author(s): 有馬 勇一郎
  • Organizer: 第20回日本血管生物医学会学術集会
  • Place of Presentation: あわぎんホール（徳島県徳島市）
• [Presentation] Preotic Neural Crest Cells Contribute to Coronary Artery Smooth Muscle Involving Endothelin Signaling
  • Author(s): 有馬 勇一郎
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis
  • Author(s): Taro Kitazawa
  • Organizer: 第45回日本発生生物学会 第64回細胞生物学会 合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
• [Presentation] Ectopic Hox gene expression in cranial neural crest cells results in abnormal craniofacial development revealing a possible Hox/Dlx crosstalk
  • Author(s): Taro Kitazawa
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] Involvement of non-coding RNA : Evf2 in the Endothelin signaling in branchial arch developmentInvolvement of non-coding RNA : Evf2 in the Endothelin signaling in branchial arch development
  • Author(s): Yukiko Kurihara
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] Involvement of non-coding RNA Evf2 in the endothelin signaling in branchial arch development
  • Author(s): Yukiko Kurihara
  • Organizer: Cell Synposia, Functional RNAs
  • Place of Presentation: Hotel Melia, Sitges（スペイン）
• [Presentation] Endothelin-1 regulates branchial arch morphogenesis by regulating integenic enhancer activity of Dlx5 and Dlx6 in mouse embryo
  • Author(s): 内島 泰信
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] A defensive role of Sirt3 against oxidative stress and aging in preimplantation embryos
  • Author(s): Yumiko Kawamura
  • Organizer: the 25th Annual Mouse Molecular Genetics Conference
  • Place of Presentation: Pacific Grove, CA（アメリカ）
• [Presentation] MicroRNA 199/214 cluster is required for normal growth and skeletal development in mice
  • Author(s): Yumiko Kawamura
  • Organizer: Cell Symposia; Functional RNAs
  • Place of Presentation: Hotel Melia, Sitges（スペイン）
• [Presentation] A protective role of Sirt3 against oxidative stress and aging in mouse preimplantation embryos
  • Author(s): Yumiko Kawamura
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] A novel mathematical model of angiogenic morphogenesis: implication of tip cell dynamics
  • Author(s): Kei Sugihara
  • Organizer: 第45回日本発生生物学会 第64回細胞生物学会 合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
• [Presentation] Analysis of cell-based mechanisms involved in angiogenic morphogenesis by biological and computational approaches
  • Author(s): Koichi Nishiyama
  • Organizer: 17th International Vascular Biology Meeting 2012
  • Place of Presentation: Rhein-Main-Hallen Wiesbaden（ドイツ）
• [Presentation] 血管構造をつくる血管内皮細胞動態の可視化と理解
  • Author(s): 西山 功一
  • Organizer: 第34回日本血栓止血学会学術集会
  • Place of Presentation: ハイアットリージェンシー東京
• [Presentation] 血管の形づくりを担う内皮細胞動態
  • Author(s): 西山 功一
  • Organizer: 第22回日本数理生物学会大会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市）
• [Presentation] Cell-based mechanism behind angiogenic morphogenesis: analysis using both experimental and computational approaches
  • Author(s): Koichi Nishiyama
  • Organizer: 7th International Kloster Seeon Meeting ‘Angiogenesis’: Molecular Mechanisms and Functional Interactions
  • Place of Presentation: KLOSTER SEEON（ドイツ）
• [Presentation] Experimental and computational analysis underscores the importance of tip cell dynamics in angiogenic morphogenesis
  • Author(s): Koichi Nishiyama
  • Organizer: 第16回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京大学本郷キャンパス
• [Presentation] Imaging, quantification and modeling of self-organizing behaviors of vascular cells
  • Author(s): Koichi Nishiyama
  • Organizer: 第20回日本血管生物医学会学術集会
  • Place of Presentation: あわぎんホール（徳島県徳島市）
• [Presentation] A novel mathematical model of endothelial cell dynamics during angiogenic morphogenesis: analysis of cell-based mechanisms
  • Author(s): Kei Sugihara
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] Cell-based mechanism behind angiogenic morphogenesis
  • Author(s): Koichi Nishiyama
  • Organizer: The 23rd CDB meeting
  • Place of Presentation: 理化学研究所 発生再生科学総合研究センター（兵庫県神戸市）
• [Presentation] 血管のかたちをつくる血管細胞動態の理解
  • Author(s): 西山 功一
  • Organizer: 第42回日本心脈管作動物質学会
  • Place of Presentation: 奈良県立新公会堂（奈良市）
• [Presentation] 心流入路におけるエンドセリンA型受容体発現細胞群は心室形成および刺激伝導系形成に寄与する
  • Author(s): 淺井 理恵子
  • Organizer: 第１１回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル 華の湯（福島県 郡山市）
• [Presentation] Endothelin type A receptor expressing cell population in the inflow tract contributes to chamber formation and cardiac conduction system development
  • Author(s): 淺井 理恵子
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] Mouse-chick chimeric transplantation reveals the regional contribution of the cell population arising from the inflow tract to cardiac chamber formation
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Development Conference 2012
  • Place of Presentation: シカゴ(アメリカ)
• [Remarks] 東京大学大学院医学系研究科 代謝生理化学教室
  • URL: http://bio.m.u-tokyo.ac.jp/home-j.html
• [Remarks] 東京大学大学院医学系研究科 代謝生理化学教室
  • URL: http://bio.m.u-tokyo.ac.jp/index.html