| Co-Investigator(Kenkyū-buntansha) |
鈴木 雅 北海道大学, 大学病院, 助教 (10374290)
今野 哲 北海道大学, 大学病院, 講師 (20399835)
長井 桂 北海道大学, 医学(系)研究科(研究院), その他 (40374293)
牧田 比呂仁 北海道大学, 医学(系)研究科(研究院), その他 (70533537)
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| Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2014: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2013: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
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| Outline of Final Research Achievements |
A total of 206 astmatic subjefts (79 mild-to-moderate、127 severe) were enrolled in this study and several blood biomarkers were measured for all subjets. We found the blood periosrin, osteopntin, and CCL18 were signifiantly assoiated with blood/sputum eosinophils, IgE levels, exhaled nitric oxide fraction, and sinus sore in non-smoking subects. However, in smoking subjects, only periostin was assoiated with Th2-realted asthma phenotypes. In addition, only smoking subjects, these three markers were inversely associated with pulmonary functions. We reported these results in Ann Am Thorac Soc 2017. (in press)
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