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Establishment of a platform for elucidation of molecular pathogenesis of leukemia and antileukemia therapy based on integrated pathway analysis

Research Project

Project/Area Number 24249055
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionThe University of Tokyo

Principal Investigator

KUROKAWA MINEO  東京大学, 医学部附属病院, 教授 (80312320)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2014: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2013: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2012: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
KeywordsRefractory leukemia / Signaling pathway / EVI-1 / BAALC / DNMT3A / NF-kB / JAK2V617F / Lcn2 / Evi1 / オートファジー / 白血病 / Adiponectin / ASXL1
Outline of Final Research Achievements

In this study, we elucidated the down-stream pathway and specific therapeutic target of molecules associated with poor prognosis in acute myeloid leukemia, such as Evi-1 and BAALC, as well as a collaborative factor for Evi-1 induced leukemogenesis and a maintenance mechanism of resistant leukemia initiating cells. By using Evi-1-IRES-GFP knock-in mice, we also showed that Evi-1 marks leukemia initiating cells and Evi-1 is associated with chemoresistance in chronic myeloid leukemia. In addition, we revealed pathogenesis of myeloid malignancies in an integrated manner by demonstrating a mechanisms of leukemia progression, interaction between leukemia cells and surrounding cells and an essential role epigenetic abnormalities play in leukemogenesis. These results provide a foundation to develop novel molecular targeted therapies for refractory hematological malignancies.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (49 results)

All 2014 2013 2012 2011

All Journal Article (37 results) (of which Peer Reviewed: 35 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Invited: 2 results)

  • [Journal Article] Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.2014

    • Author(s)
      Nishikawa S, Arai S, Masamoto Y, Kagoya Y, Toya T, Watanabe-Okochi N, Kurokawa M.
    • Journal Title

      Blood

      Volume: 124 Issue: 24 Pages: 3587-3596

    • DOI

      10.1182/blood-2013-12-546275

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2.2014

    • Author(s)
      Kagoya Y, Yoshimi A, Tsuruta-Kishino T, Arai S, Satoh T, Akira S, Kurokawa M.
    • Journal Title

      Blood

      Volume: 124 Issue: 19 Pages: 2996-3006

    • DOI

      10.1182/blood-2014-04-570572

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.2014

    • Author(s)
      Sato T, Goyama S, Kataoka K, Nasu R, Tsuruta-Kishino T, Kagoya Y, Nukina A, Kumagai K, Kubota N, Nakagawa M, Arai S, Yoshimi A, Honda H, Kadowaki T, Kurokawa M.
    • Journal Title

      Oncogene

      Volume: 33 Issue: 42 Pages: 5028-5038

    • DOI

      10.1038/onc.2014.108

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.2014

    • Author(s)
      Kagoya Y, Yoshimi A, Kataoka K, Nakagawa M, Kumano K, Arai S, Kobayashi H, Saito T, Iwakura Y, Kurokawa M.
    • Journal Title

      J Clin Invest.

      Volume: 124 Issue: 2 Pages: 528-542

    • DOI

      10.1172/jci68101

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of serum erythropoietin levels in lower risk myelodysplastic syndrome cases with anemia.2014

    • Author(s)
      Nakazaki K, Nannya Y, and Kurokawa M.
    • Journal Title

      Int J Hematol

      Volume: 99(1) Issue: 1 Pages: 53-56

    • DOI

      10.1007/s12185-013-1485-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serial Profile of Vitamins and Trace Elements during the Acute Phase of Allogeneic Stem Cell Transplantation.2013

    • Author(s)
      Nannya Y, Shinohara A, Ichikawa M, and Kurokawa M.
    • Journal Title

      Biol Blood Marrow Transplant

      Volume: In Press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell gene expression analysis reveals clonal architecture of blast-phase chronic myeloid leukaemia.2013

    • Author(s)
      Nukina A, Kagoya Y, Watanabe-Okochi N, Arai S, Ueda K, Yoshimi A, Nannya Y, and Kurokawa M.
    • Journal Title

      Br J Haematol

      Volume: In Press Issue: 3 Pages: 580-91

    • DOI

      10.1111/bjh.12726

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder.2013

    • Author(s)
      Ogura M, Ichikawa M, Masuda A, Kandabashi K, Nannya Y, and Kurokawa M.
    • Journal Title

      Ann Hematol.

      Volume: In Press Issue: 5 Pages: 869-871

    • DOI

      10.1007/s00277-013-1887-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular reactive oxygen species mark and influence the megakaryocyte-erythrocyte progenitor fate of common myeloid progenitors.2013

    • Author(s)
      Shinohara A, Imai Y, Nakagawa M, Takahashi T, Ichikawa M, and Kurokawa M.
    • Journal Title

      Stem Cells

      Volume: 32 Issue: 2 Pages: 548-557

    • DOI

      10.1002/stem.1588

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.2013

    • Author(s)
      Goyama S, Schibler J, Cunningham L, Zhang Y, Rao Y, Nishimoto N, Nakagawa M, Olsson A, Wunderlich M, Link KA, Mizukawa B, Grimes HL, Kurokawa M, Liu PP, Huang G, and Mulloy JC.
    • Journal Title

      J Clin Invest

      Volume: 123 Issue: 9 Pages: 3876-3888

    • DOI

      10.1172/jci68557

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for RUNX1 in hematopoiesis and myeloid leukemia.2013

    • Author(s)
      Ichikawa M, Yoshimi A, Nakagawa M, Nishimoto N, Watanabe-Okochi N, and Kurokawa M.
    • Journal Title

      Int J Hematol

      Volume: 97 Issue: 6 Pages: 726-734

    • DOI

      10.1007/s12185-013-1347-3

    • NAID

      10031183728

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute myeloid leukemia with cryptic CBFB-MYH11 type D.2013

    • Author(s)
      Kobayashi T, Ichikawa M, Kamikubo Y, and Kurokawa M.
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 6 Pages: 110-112

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of decreased-dose idarubicin for elderly patients with acute myeloid leukemia.2013

    • Author(s)
      Kobayashi T, Ichikawa M, Nannya Y, and Kurokawa M.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43 Issue: 10 Pages: 1047-1051

    • DOI

      10.1093/jjco/hyt111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of iPS cells from normal and malignant hematopoietic cells.2013

    • Author(s)
      Kumano K, Arai S, Kurokawa M.
    • Journal Title

      Int J Hematol.

      Volume: 98 Issue: 2 Pages: 145-182

    • DOI

      10.1007/s12185-013-1385-x

    • NAID

      10031194728

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Moxifloxacin is more effective than tosufloxacin in reducing chemotherapy-induced febrile neutropneia in patients with hematological malignancies.2013

    • Author(s)
      Shinohara A, Yoshiki Y, Masamoto Y, Hangaishi A, Nannya Y, and Kurokawa M.
    • Journal Title

      Leuk Lymphoma

      Volume: 54 Issue: 4 Pages: 794-798

    • DOI

      10.3109/10428194.2012.725848

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous increase in 1,3-β-D-glucan and procalcitonin levels in Pseudomonas aeruginosa infection.2013

    • Author(s)
      Koya J, Nannya Y, Kobayashi H, Okugawa S, Moriya K, Kurokawa M.
    • Journal Title

      J Infect

      Volume: 67 Issue: 2 Pages: 164-166

    • DOI

      10.1016/j.jinf.2013.03.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple but powerful prognostic scoring model for MALT lymphoma: a retrospective study.2013

    • Author(s)
      Morita K, Nannya Y, Yoshizato T, Kurokawa M.
    • Journal Title

      Ann Hematol

      Volume: 92 Issue: 3 Pages: 421-423

    • DOI

      10.1007/s00277-012-1585-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique association of Waldenström macroglobulinemia with optic neuritis and monoclonal T cell expansion.2013

    • Author(s)
      Morita K, Yoshimi A, Masuda A, Ichikawa M, Yatomi Y, Kurokawa M.
    • Journal Title

      Int J Hematol

      Volume: 98 Issue: 2 Pages: 247-249

    • DOI

      10.1007/s12185-013-1372-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of Schizophyllum commune sinusitis following unrelated cord blood transplantation for acute lymphoblastic leukemia2013

    • Author(s)
      Toya T, Shinohara A, Tatsuno K, Seo S, Nannya Y, Ichikawa M, Makirnura K Moriya K, Kurokawa M
    • Journal Title

      lnternational Journal of Hematology

      Volume: 98 Issue: 2 Pages: 261

    • DOI

      10.1007/s12185-013-1362-4

    • NAID

      10031194746

    • URL

      https://pure.teikyo.jp/en/publications/32eafe0d-fe1e-4276-bb19-4949bb255edf

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment with recombinant thrombomodulin for B-cell lymphoma-associated hemophagocytic syndrome complicated by disseminated intravascular coagulation.2013

    • Author(s)
      Uni M, Yoshimi A, Maki H, Maeda D, Nakazaki K, Nakamura F, Fukayama M, Kurokawa M.
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 6 Pages: 1190-1194

    • NAID

      120007089059

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Transformation of follicular lymphoma in the retroperitoneal muscles demonstrated by CT-guided needle biopsy of FDG-avid lesions; case series.2013

    • Author(s)
      Uni M, Nakamura F, Yoshimi A, Shinozaki-Ushiku A, Hosoi A, Nakazaki K, Nannya Y, Fukayama M, Kurokawa M.
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 7 Pages: 402-406

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP) , collaborates with Evi1 to induce AML in a mouse BMT model2013

    • Author(s)
      Okochi, N., Yoshimi, A., Sato, T., Ikeda, T., Kumano, K., Taoka, K., Sato, Y., Shinohara, A., Tsuruta, A., Masuda, A., Yokota, H., Yatomi, Y., Takahashi, K., Kitaura, J., Kitamura, T. and Kurokawa, M
    • Journal Title

      Blood

      Volume: 121 Issue: 20 Pages: 4142-4155

    • DOI

      10.1182/blood-2011-07-368654

    • NAID

      10031196292

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of HLA-matched unrelated transplantation in adult patients with Ph chromosome-negative ALL in first remission. A decision analysis.2013

    • Author(s)
      Kako S
    • Journal Title

      Bone Marrow Transplantation

      Volume: 未定 Issue: 8 Pages: 1077-1083

    • DOI

      10.1038/bmt.2013.4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of a donor source on adult Philadelphia chromosome-negative acute lymphoblastic leukemia: a retrospective analysis from the Adult Acute Lymphoblastic Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation.2013

    • Author(s)
      Nishiwaki S
    • Journal Title

      Annals of Oncology

      Volume: 未定 Issue: 6 Pages: 1594-1602

    • DOI

      10.1093/annonc/mds655

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.2013

    • Author(s)
      Ueda Y
    • Journal Title

      Leukemia & Lymphoma

      Volume: 未定 Issue: 7 Pages: 1450-1458

    • DOI

      10.3109/10428194.2012.745074

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythroleukemia showing early erythroid and cytogenetic responses to azacitidine therapy2013

    • Author(s)
      Sho Hangai
    • Journal Title

      Annals of Hematology

      Volume: 92 Issue: 5 Pages: 707-709

    • DOI

      10.1007/s00277-012-1603-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early-onset Therapy-related Myelodysplastic Syndrome Originating from Prolonged Myelosuppression after Fludarabine-based Therapy2012

    • Author(s)
      Yamazaki S
    • Journal Title

      Internal Medicine

      Volume: 51 Issue: 24 Pages: 3427-3430

    • DOI

      10.2169/internalmedicine.51.8310

    • NAID

      130003308168

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia2012

    • Author(s)
      Keiki Kumano
    • Journal Title

      BLOOD

      Volume: 119 Issue: 26 Pages: 6234-6242

    • DOI

      10.1182/blood-2011-07-367441

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of procalcitonin with liquid-phase binding assay in hematological malignancy.2012

    • Author(s)
      Koya J
    • Journal Title

      Clinica Chimica Acta

      Volume: 413 Issue: 19-20 Pages: 1633-1636

    • DOI

      10.1016/j.cca.2012.05.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.2012

    • Author(s)
      Pinheiro I
    • Journal Title

      Cell

      Volume: 150 Issue: 5 Pages: 948-960

    • DOI

      10.1016/j.cell.2012.06.048

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thalidomide maintenance therapy for patients with multiple myeloma: meta-analysis.2012

    • Author(s)
      Kagoya Y
    • Journal Title

      Leukemia Research

      Volume: 36 Issue: 8 Pages: 1016-1021

    • DOI

      10.1016/j.leukres.2012.04.001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intensive chemotherapy for elderly patients with acute myelogeneous leukemia: a propensity score analysis by the Japan Hematology and Oncology Clinical Study Group (J-HOCS).2012

    • Author(s)
      Oshima K
    • Journal Title

      Annals of Hematology

      Volume: 91 Issue: 10 Pages: 1533-1539

    • DOI

      10.1007/s00277-012-1487-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation.2012

    • Author(s)
      Yoshimi M, Goyama S, Kawazu M, Nakagawa M, Ichikawa M, Imai Y, Kumano K, Asai T, Mulloy JC, Kraft AS, Takahashi T, Shirafuji N, Kurokawa M.
    • Journal Title

      Eur J Immunol.

      Volume: 42 Issue: 4 Pages: 1044-1050

    • DOI

      10.1002/eji.201040746

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary MALT lymphoma of the urinary bladder in the background of interstitial cystitis2012

    • Author(s)
      Morita K, Nakamura F, Nannya Y, Nomiya A, Arai S, Ichikawa M, Homma Y, Kurokawa M.
    • Journal Title

      Annals of Hematology in press

      Volume: 91 Issue: 9 Pages: 1505-1506

    • DOI

      10.1007/s00277-012-1419-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of primary intraocular lymphoma with rituximab, high dose methotrexate, procarbazine, and vincristine chemotherapy, reduced whole-brain radiotherapy, and local ocular therapy2012

    • Author(s)
      Taoka K
    • Journal Title

      Br J Haematol

      Volume: 157 Issue: 2 Pages: 252-254

    • DOI

      10.1111/j.1365-2141.2011.08938.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ecotropic viral integration site 1, stem cell self-renewal and leukemogenesis.2012

    • Author(s)
      Kataoka K
    • Journal Title

      Cancer Science

      Volume: 103 Issue: 8 Pages: 1371-1377

    • DOI

      10.1111/j.1349-7006.2012.02303.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoma with specific affinity to endocrine organs2011

    • Author(s)
      森田剣
    • Journal Title

      Ann Hematol.

      Volume: Nov 22 Issue: 7 Pages: 1149-1150

    • DOI

      10.1007/s00277-011-1372-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Enhanced autophagy promotes survival of peripheral blast cells from murine acute myeloid leukemia2014

    • Author(s)
      Sumitomo Y, Koya J, Kataoka K, Tsuruta-Kishino T, Morita K, Sato T, Kurokawa M.
    • Organizer
      The 56th ASH Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2014-12-06 – 2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] BAALC promotes leukemogenesis by MAPK-dependent proliferation and KLF4-derived differentiation block2014

    • Author(s)
      Morita K, Masamoto Y, Kagoya Y, Kataoka K, Koya J, Yashiroda H, Sato T, Murata S, Kurokawa M
    • Organizer
      The 76th Annual Meeting of the Japanise Society of Hematology
    • Place of Presentation
      Osaka
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] The Genetic Landscape Of FPD/AML Revealed CDC25C Mutation As a Driver That Promotes Malignant Transformation2013

    • Author(s)
      Akihide Yoshimi, Takashi Toya, Masahiro Nakagawa, Masahito Kawazu, Yasuhito Nannya, Motoshi Ichikawa, Shunya Arai, Hironori Harada, Kensuke Usuki, Yasuhide Hayashi, Etsuro Ito, Keita Kirito, Hideaki Nakajima, Hiroyuki Mano, and Mineo Kurokawa.
    • Organizer
      55th ASH Annual Meetingand Exposition
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Modeling Chronic Myelomonocytic Leukemia Through Patient-Derived Induced Pluripotent Stem Cells2013

    • Author(s)
      Keisuke Kataoka, Kazuki Taoka, Masashi Miyauchi, Masataka Hosoi, Keiki Kumano, Shunya Arai, Kazuhiro Toyama, Genta Nagae, Wei Qu, Shinichi Morishita, Hiroyuki Aburatani, and Mineo Kurokawa.
    • Organizer
      55th ASH Annual Meetingand Exposition
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Disease-Specific Induced Pluripotent Stem Cells Recapitulate The Pathophysiology Of Familial Platelet Disorder With Predisposition To Acute Myelogenous Leukemia2013

    • Author(s)
      Shunya Arai, Hiromitsu Iiduka, Naoya Takayama, Miyauchi Masashi, Kazuki Taoka, Keisuke Kataoka, Masataka Hosoi, Keiki Kumano, Koji Eto, and Mineo Kurokawa.
    • Organizer
      55th ASH Annual Meetingand Exposition
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Anti-Obese Hormone Adiponectin Regulates Emergency Hematopoiesis and Antibacterial Response Through Downregulation Of Socs3 In Hematopoietic Progenitor Cells2013

    • Author(s)
      Yosuke Masamoto, Shunya Arai, Tomohiko Sato, Akihide Yoshimi, Iseki Takamoto, Naoto Kubota, Takashi Kadowaki, and Mineo Kurokawa.
    • Organizer
      55th ASH Annual Meetingand Exposition
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Leukemia-Associated Mutations Of DNMT3A Inhibit Differentiation Of Hematopoietic Stem Cells and Promote Leukemic Transformation Through Abberant Recruitment Of Bmi12013

    • Author(s)
      Junji Koya, Keisuke Kataoka, Takako Tsuruta-Kishino, Hiroshi Kobayashi, Kensuke Narukawa, Tomohiko Sato, and Mineo Kurokawa.
    • Organizer
      55th ASH Annual Meetingand Exposition
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Loss Of p53 Induces Leukemic Transformation In a Murine Model Of JAK2V617F-Induced Polycythemia Vera2013

    • Author(s)
      Takako Tsuruta-Kishino, Keisuke Kataoka, Hiroshi Kobayashi, Junji Koya, Kensuke Narukawa, Tomohiko Sato, and Mineo Kurokawa.
    • Organizer
      55th ASH Annual Meetingand Exposition
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] JAK2V617F Mutation Evokes Paracrine DNA Damage To Adjacent Normal Cells Via Secretion Of Lipocalin-22013

    • Author(s)
      Yuki Kagoya, Shunya Arai, Akihide Yoshimi, Takako Tsuruta-Kishino, Keisuke Kataoka, and Mineo Kurokawa.
    • Organizer
      55th ASH Annual Meetingand Exposition
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] BAALC Acts As a Scaffold-Like Protein In The ERK Signaling Pathway and Promotes Leukemogenesis By Facilitating MEK–mediated ERK Activation2013

    • Author(s)
      Ken Morita, Keisuke Kataoka, Junji Koya, Takako Tsuruta, Tomohiko Sato, and Mineo Kurokawa.
    • Organizer
      55th ASH Annual Meetingand Exposition
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] iPS細胞を用いた造血器腫瘍研究2013

    • Author(s)
      黒川 峰夫
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 血液疾患とiPS細胞2012

    • Author(s)
      黒川 峰夫
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2013-05-15   Modified: 2019-07-29  

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