Structural plasticity of neurons associated with depressive state and its pathophysiological significance

• Project/Area Number: 24249063
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Kato Tadafumi 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (30214381)
• Project Period (FY): 2012-10-31 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000); Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000); Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000); Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: うつ病 / 双極性障害 / 神経細胞 / 脳神経疾患

Outline of Final Research Achievements

In this study, we investigated the morphology of neurons of transgenic mice with neuron specific expression of mutant Polg. As a result, apical dendrites of medial prefrontal cortex of transgenic mice showed decreased mushroom spines and increase of filopodia. To further investigate dynamic morphological changes associated with depressive episodes, we established a system to observe morphology of neurons of the transgenic mice in vivo through a cranial window using two photon microscope.

Research Products

• [Journal Article] Neurobiological basis of bipolar disorder: Mitochondrial dysfunction hypothesis and beyond (2016)
  • Author(s): Kato T
  • Journal Title: Schizophrenia Research Volume: - Pages: 62-66
  • DOI: 10.1016/j.schres.2016.10.037
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Depression-like Episodes in Mice Harboring mtDNA Deletions in Paraventricular Thalamus (2016)
  • Author(s): Kasahara T, Takata A, Kato TM, Kubota-Sakashita M, Sawada T, Kakita A, Mizukami H, Kaneda D, Ozawa K, Kato T
  • Journal Title: Molecular Psychiatry Volume: 21 Issue: 1 Pages: 39-48
  • DOI: 10.1038/mp.2015.156
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Animal models of recurrent or bipolar depression (2016)
  • Author(s): Kato T, Kasahara T, Kubota-Sakashita M, Kato TM, Nakajima K
  • Journal Title: Neuroscience Volume: 321 Pages: 189-196
  • DOI: 10.1016/j.neuroscience.2015.08.016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions. (2014)
  • Author(s): Fuke S, Kametani M, Yamada K, Kasahara T, Kubota-Sakashita M, Kujoth GC, Prolla TA, Hitoshi S, Kato T
  • Journal Title: Annals of Clinical and Translational Neurology Volume: 1 Issue: 11 Pages: 909-920
  • DOI: 10.1002/acn3.133
  • Peer Reviewed / Open Access
• [Presentation] Neurobiology of bipolar disorder. (2015)
  • Author(s): Kato T
  • Organizer: The 5th World Congress of Asian Psychiatry
  • Place of Presentation: Centennial Hall Kyushu University School of Medicine, Fukuoka, JAPAN
  • Year and Date: 2015-03-03 – 2015-03-05
  • Invited
• [Presentation] Neurobiological basis of bipolar disorder (2014)
  • Author(s): Kato T
  • Organizer: 16th annual conference of the international society for bipolar disorders
  • Place of Presentation: ソウル、韓国
  • Invited
• [Presentation] s bipolar disorder a progressive impairment of “mood stabilizing neurons”? (2013)
  • Author(s): Kato T
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 京都、日本
  • Invited
• [Presentation] Neurobiology of bipolar disorder. Toward development of new mood stabilizers (2013)
  • Author(s): Kato T
  • Organizer: CINP 2013 Thematic Meeting
  • Place of Presentation: エルサレム、イスラエル
  • Invited
• [Remarks] 精神疾患動態研究チーム
  • URL: http://www.brain.riken.go.jp/labs/mdmd/