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Structural plasticity of neurons associated with depressive state and its pathophysiological significance

Research Project

Project/Area Number 24249063
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Kato Tadafumi  国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (30214381)

Project Period (FY) 2012-10-31 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywordsうつ病 / 双極性障害 / 神経細胞 / 脳神経疾患
Outline of Final Research Achievements

In this study, we investigated the morphology of neurons of transgenic mice with neuron specific expression of mutant Polg. As a result, apical dendrites of medial prefrontal cortex of transgenic mice showed decreased mushroom spines and increase of filopodia. To further investigate dynamic morphological changes associated with depressive episodes, we established a system to observe morphology of neurons of the transgenic mice in vivo through a cranial window using two photon microscope.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (4 results) (of which Invited: 4 results) Remarks (1 results)

  • [Journal Article] Neurobiological basis of bipolar disorder: Mitochondrial dysfunction hypothesis and beyond2016

    • Author(s)
      Kato T
    • Journal Title

      Schizophrenia Research

      Volume: - Pages: 62-66

    • DOI

      10.1016/j.schres.2016.10.037

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Depression-like Episodes in Mice Harboring mtDNA Deletions in Paraventricular Thalamus2016

    • Author(s)
      Kasahara T, Takata A, Kato TM, Kubota-Sakashita M, Sawada T, Kakita A, Mizukami H, Kaneda D, Ozawa K, Kato T
    • Journal Title

      Molecular Psychiatry

      Volume: 21 Issue: 1 Pages: 39-48

    • DOI

      10.1038/mp.2015.156

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Animal models of recurrent or bipolar depression2016

    • Author(s)
      Kato T, Kasahara T, Kubota-Sakashita M, Kato TM, Nakajima K
    • Journal Title

      Neuroscience

      Volume: 321 Pages: 189

    • DOI

      10.1016/j.neuroscience.2015.08.016

    • URL

      https://pure.teikyo.jp/en/publications/92a3be4a-b113-478f-9a5e-b2853defe89b

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions.2014

    • Author(s)
      Fuke S, Kametani M, Yamada K, Kasahara T, Kubota-Sakashita M, Kujoth GC, Prolla TA, Hitoshi S, Kato T
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 1 Issue: 11 Pages: 909-920

    • DOI

      10.1002/acn3.133

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Neurobiology of bipolar disorder.2015

    • Author(s)
      Kato T
    • Organizer
      The 5th World Congress of Asian Psychiatry
    • Place of Presentation
      Centennial Hall Kyushu University School of Medicine, Fukuoka, JAPAN
    • Year and Date
      2015-03-03 – 2015-03-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Neurobiological basis of bipolar disorder2014

    • Author(s)
      Kato T
    • Organizer
      16th annual conference of the international society for bipolar disorders
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] s bipolar disorder a progressive impairment of “mood stabilizing neurons”?2013

    • Author(s)
      Kato T
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都、日本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Neurobiology of bipolar disorder. Toward development of new mood stabilizers2013

    • Author(s)
      Kato T
    • Organizer
      CINP 2013 Thematic Meeting
    • Place of Presentation
      エルサレム、イスラエル
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 精神疾患動態研究チーム

    • URL

      http://www.brain.riken.go.jp/labs/mdmd/

    • Related Report
      2016 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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