| Budget Amount *help |
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Outline of Final Research Achievements |
In this study, we investigated the morphology of neurons of transgenic mice with neuron specific expression of mutant Polg. As a result, apical dendrites of medial prefrontal cortex of transgenic mice showed decreased mushroom spines and increase of filopodia. To further investigate dynamic morphological changes associated with depressive episodes, we established a system to observe morphology of neurons of the transgenic mice in vivo through a cranial window using two photon microscope.
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