The development of surgical treatment targeting myocardial stiffness in damaged myocardium
| Project/Area Number |
24249070
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
SAWA Yoshiki 大阪大学, 医学(系)研究科(研究院), 教授 (00243220)
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| Co-Investigator(Kenkyū-buntansha) |
NISHI Hiroyuki 大阪大学, 大学院医学系研究科, 助教 (00529208)
YOSHIKAWA Yasushi 大阪大学, 大学院医学系研究科, 特任准教授(常勤) (40570594)
MIYAGAWA Shigeru 大阪大学, 大学院医学系研究科, 特任准教授(常勤) (70544237)
FUKUSHIMA Sarsuki 大阪大学, 大学院医学系研究科, 助教 (80596867)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2014: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2012: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Keywords | 心筋梗塞 / 細胞外マトリックス / リモデリング / プロスタサイクリン / 心不全 / 拡張能 / 筋芽細胞シート / プロスタグランジン製剤 / 人工心臓 |
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| Outline of Final Research Achievements |
We implanted autologous myoblast sheets or prostacyclin agonist to animal heart failure model (rat infarction model, DCM canine model) and analyzed serial changes of cardiac performance especially diastolic function and histological modulation. Myoblast sheet ameliorate cardiac fibrosis by the control of several factors such as MMP and TGF-β etc, leading to improvement of cardiac performance especially diastolic function. Prostacyclin impact on IP receptors expressed on endothelial cells and stimulation of this receptor enhance the expression of several cytokines, resulting in improvement of diastolic function by the reduction of fibrosis in DCM or infarction animal model.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in rapid-pacing induced canine heart failure model2013
Author(s)
Tomonori Shirasaka, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Motoko Shiozaki, Naomasa Kawaguchi, Nariaki Matsuura, Satoshi Nakatani, Yoshiki Sakai, , and Yoshiki Sawa
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Journal Title
The Journal of Thoracic and Cardiovascular Surgery
Volume: Article in press
Pages: 1-10
Related Report
Peer Reviewed
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