| Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2014: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2013: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2012: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Outline of Final Research Achievements |
We implanted autologous myoblast sheets or prostacyclin agonist to animal heart failure model (rat infarction model, DCM canine model) and analyzed serial changes of cardiac performance especially diastolic function and histological modulation. Myoblast sheet ameliorate cardiac fibrosis by the control of several factors such as MMP and TGF-β etc, leading to improvement of cardiac performance especially diastolic function. Prostacyclin impact on IP receptors expressed on endothelial cells and stimulation of this receptor enhance the expression of several cytokines, resulting in improvement of diastolic function by the reduction of fibrosis in DCM or infarction animal model.
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