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Pre-clinical application of an innovative therapy, "BioKnife", to malignant pleural mesothelioma

Research Project

Project/Area Number 24249071
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKyushu University

Principal Investigator

MAEHARA Yoshihiko  九州大学, 医学(系)研究科(研究院), 教授 (80165662)

Co-Investigator(Kenkyū-buntansha) YONEMITSU Yoshikazu  九州大学, 薬学研究院, 教授 (40315065)
IKEDA Tetsuo  九州大学, 大学病院, 准教授 (60585701)
OKI Eiji  九州大学, 医学研究院, 准教授 (70380392)
SAEKI Hiroshi  九州大学, 大学病院, 講師 (80325448)
OKAMOTO Tatsuro  九州大学, 大学病院, 助教 (80568626)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥36,920,000 (Direct Cost: ¥28,400,000、Indirect Cost: ¥8,520,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2012: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Keywords悪性胸膜中皮腫 / 遺伝子治療 / 腹膜播種 / 胸膜播種 / 中皮腫 / 消化器癌 / バイオナイフ / ウイルス / アリムタ / NF-kB / 臨床試験
Outline of Final Research Achievements

Since malignant pleural mesothelioma (MPM) easily spreads throughout the intrathoracic pleural cavity, and mostly shows resistance to the ordinary chemotherapy, it still one of the most aggressive disease among neoplastic diseases. Alost all MPM cells have been shown to express urokinase-type plasminogen activator receptor (uPAR). Recently, we demonstrated the potential of our new and powerful recombinant Sendai virus (rSeV), which shows uPAR-specific cell-to-cell fusion activity (named “BioKnife”). In the present study, we examined the tumor cell-killing mechanism via BioKnife more precisely to obtain the most sufficient effect on treating MPM that is characterized by frequent uPAR expression in a clinical setting.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(12 results)

All 2015 2014 2013 2012

All Journal Article Presentation

  • [Journal Article] Associations between driver gene mutations and cytotoxic chemosensitivity in patients with non-small cell lung cancer2015

    • Author(s)
      Morodomi Y, Okamoto T, Kohno M, Katsura M, Takada K, Suzuki Y, Fujishita T, Kitahara H, Shimamatsu S, Yoshida T, Tagawa T, Okano S, Maehara Y
    • Journal Title

      Anticancer Research

      Volume: 35 Pages: 1791-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The prognostic impact of the amount of tobacco smoking in non-small cell lung cancer-differences between adenocarcinoma and squamous cell carcinoma.2014

    • Author(s)
      Okamoto T, Suzuki Y, Fujishita T, Kitahara H, Shimamatsu S, Kohno M, Morodomi Y, Kawano D, Maehara Y
    • Journal Title

      Lung Cancer

      Volume: 85 Pages: 125-30

    • DOI

      10.1016/j.lungcan.2014.06.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DVC1-0101 to treat peripheral arterial disease: a Phase I/IIa open-label dose-escalation clinical trial.2013

    • Author(s)
      Yonemitsu Y
    • Journal Title

      Mol Ther.

      Volume: 21(3) Pages: 707-707

    • DOI

      10.1038/mt.2012.279

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ex vivo generation of highly purified and activated natural killer cells from human peripheral blood.2013

    • Author(s)
      Saito S, Harada Y, Morodomi Y, Onimaru M, Yoshida K, Kyuragi R, Matsubara H, Yonemitsu Y.
    • Journal Title

      Hum Gene Ther Methods.

      Volume: 24 Pages: 241-241

    • DOI

      10.1089/hgtb.2012.183

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DVC1-0101 to Treat Peripheral Arterial Disease: A Phase I/IIa Open-label Dose-escalation Clinical Trial.2013

    • Author(s)
      Yonemitsu Y
    • Journal Title

      Mol Ther

      Volume: 21 Pages: 707-714

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of dendritic cell vaccines pulsed with Wilms' tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers.2013

    • Author(s)
      Takahashi H
    • Journal Title

      Eur J Cancer

      Volume: 49 Pages: 852-859

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II Trial of Alternating mFOLFOX6 and FOLFIRI Regimens in the First-Line Treatment for Unresectable or Metastatic Colorectal Cancer (KSCC0701).2013

    • Author(s)
      Oki E
    • Journal Title

      Oncology

      Volume: 84 Pages: 233-239

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BioKnife, a uPA activity-dependent oncolytic Sendai virus, eliminates pleural spread of malignant mesothelioma via simultaneous stimulation of uPA expression.2012

    • Author(s)
      Morodomi Y
    • Journal Title

      Mol Ther

      Volume: 20 Pages: 769-777

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 悪性胸膜中皮腫における線溶系分子の発現と臨床病理学的因子に関する検討2014

    • Author(s)
      諸富洋介、岡本龍郎、高田和樹、桂正和、鈴木雄三、藤下卓才、北原大和、島松晋一郎、田川哲三、岡野慎士、田口健一、竹之山光広、一瀬幸人、前原喜彦
    • Organizer
      第55回日本肺癌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-14 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] BioKnife, a uPA activity-dependent fusogenic Sendai virus, as a new class of oncolytic bio-device to treat malignancies2012

    • Author(s)
      Yoshikazu Yonemitsu
    • Organizer
      BioKnife, a uPA activity-dependent fusogenic Sendai virus, as a new class of oncolytic bio-device to treat malignancies’
    • Place of Presentation
      Versailles, France
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Perspectives in disease models of the Heart and the Brain: of Mice and Men2012

    • Author(s)
      Yoshikazu Yonemitsu
    • Organizer
      SIRIC International Symposium 2012
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 遺伝子治療ベクターの進歩 「センダイウイルスベクター」2012

    • Author(s)
      米満吉和
    • Organizer
      第18回 日本遺伝子治療学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2012 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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