Multimodal medical strategies by means of robotic technology according with molecular target imaging
Project/Area Number |
24249073
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NATSUME Atsushi 名古屋大学, 医学系研究科, 准教授 (30362255)
YANAGAWA Hiroshi 慶應義塾大学, 理工学部, 訪問教授 (40327672)
KOYAMA Hiroko 岐阜大学, 大学院医学系研究科, 助教 (50402160)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥44,070,000 (Direct Cost: ¥33,900,000、Indirect Cost: ¥10,170,000)
Fiscal Year 2014: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2013: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2012: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
|
Keywords | 脳神経疾患 / 脳腫瘍 / 分子標的 / 核酸医療 / ナノテクノロジー / ロボティクス / 創薬 / 分子イメージング / イメージング / PET / 分子標的薬 / 薬物送達 / 化学療法 / 分子マーカー / 治療予後 / 神経膠腫 / 核酸療法 / 薬剤送達 |
Outline of Final Research Achievements |
We will describe the development of nanotechnology for treatment against several progressive neuronal diseases towards clinical applications, especially for malignant brain tumors which is still fetal diseases. We have developed gene therapy for glioblastoma which is most aggressive and progressive tumors, using with interferon-beta genes entrapped with nano-liposomes for clinical trial since 2000. Nowadays, numerous diseases will be a candidate for the treatment of cell-therapy, inmmunotherapy , and regenerative therapy using with several kind of factors, for example, siRNA, toxin, immunoadjuvant materials, entrapped with nano-particles as a targeted materials by stereotactic robotics for the brain and spinal cord. We have now gotten several new factors expressing on malignant brain tumors, especially, astrocytoma, and using with such a molecular targeting, we will develop new treatment strategies by tumor specific attack asa a new tools for fetal diseases to prolong survival life.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDHI mutation2014
Author(s)
Ohka F,Ito M,Ranjit M,Senga T,Motomura A,Motomura K,Saito K,Kato Y, Wakabayashi T,Soga T,Natsume A
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Journal Title
Tumor Biol,
Volume: 35(6)
Pages: 5911-5920
Related Report
Peer Reviewed
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[Journal Article] Preclinical evaluation of an O6-methylguanine-DNA methyltrasferase-siRNA/liposome Complex administered by convection-enhanced delivery to rat and porcine brains2014
Author(s)
Tsujiuchi T,Natsume A,Motomura K,Kondo G,Ranjit M,Hachisu R,Sugimura I,Tomita S,Takehara I,Woolley M,Barua N,Gill S,Bienemann A,Yamashita Y,Toyokuni S,Wakabayashi T
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Journal Title
Am J Transl Res
Volume: 6(2)
Pages: 169-178
Related Report
Peer Reviewed
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[Journal Article] Peptide-based inhibition of the HOXA9/PBX interaction retards the growth of human meningioma2014
Author(s)
Ando H, Natsume A, Senga T, Watanabe R, Ito I, Ohno M, Iwami K, Ohka F, Motomura K, Saito K, Morgan R, Wakabayashi T
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Journal Title
Cancer Chemother. Pharmacol.
Volume: 73(1)
Pages: 53-60
Related Report
Peer Reviewed
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[Journal Article] Peptide-based inhibition of the HOXA9/PBX interaction retards the growth of human meningioma2014
Author(s)
Ando H, Natsume A, Senga T, Watanabe R, Ito I, Ohno M, Iwami K, Ohka F, Motomura K, Saito K, Morgan R, Wakabayashi T
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Journal Title
Cancer Chemother Pharmacol
Volume: 73
Pages: 53-60
Related Report
Peer Reviewed / Open Access
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[Journal Article] Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)2013
Author(s)
Shibui S, Narita Y, Mizusawa J, Sawamura Y, Kobayashi H, Nishikawa R, Mishima K, Muragaki Y, Maruyama T, Kuratsu J, Nakamura H, Yamaki T, Kumabe T, Tominaga T, Kayama T, Sakurada K, Nagane M, Kobayashi K, Asai A, Todo T, Wakabayashi T, Sumi M, Miyakita Y, Nakazato Y, Nomura K
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Journal Title
Cancer Chemother Pharmacol
Volume: 71
Pages: 511-521
Related Report
Peer Reviewed / Open Access
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[Journal Article] Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma2013
Author(s)
Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y, Kondo Y
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Journal Title
Cancer Research
Volume: 73
Pages: 4559-4570
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lack of presence of the human cytomegalovirus in human glioblastoma.2013
Author(s)
Yamashita Y, Ito Y, Isomura H, Takemura N, Okamoto A, Motomura K, Tsujiuchi T, Natsume A, Wakabayashi T, Toyokuni S, Tsurumi T
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Journal Title
Mod Pathol
Volume: Dec 13
Issue: 7
Pages: 922-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Adoptive transfer of genetically modified Wilms' tumor 1-specific T cells in a novel malignant skull base meningioma model.2013
Author(s)
Iwami K, Natsume A, Ohno M, Ikeda H, Mineno J, Nukaya I, Okamoto S, Fujiwara H, Yasukawa M, Shiku H, Wakabayashi T.
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Journal Title
Neuro Oncol.
Volume: 15
Issue: 6
Pages: 747-758
DOI
Related Report
Peer Reviewed
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